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Term:pibutidine hydrochloride
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Accession:CHEBI:32000 term browser browse the term
Definition:The hydrochloride salt of pibutidine. It is a H2 receptor antagonist which was developed for the treatment of peptic ulcers and duodenal ulcers. It was in phase III clinical trials in Japan (now discontinued).
Synonyms:exact_synonym: 3-amino-4-{[(2Z)-4-{[4-(piperidin-1-ylmethyl)pyridin-2-yl]oxy}but-2-en-1-yl]amino}cyclobut-3-ene-1,2-dione hydrochloride
 related_synonym: 3-amino-4-[4-[4-(1-piperidinomethyl)-2-pyridyloxy]-cis-2- butenylamino]-3-cyclobutene-1,2-dione hydrochloride;   Formula=C19H24N4O3.ClH;   IT 066;   InChI=1S/C19H24N4O3.ClH/c20-16-17(19(25)18(16)24)22-7-2-5-11-26-15-12-14(6-8-21-15)13-23-9-3-1-4-10-23;/h2,5-6,8,12,22H,1,3-4,7,9-11,13,20H2;1H/b5-2-;;   InChIKey=ODBOENMSSFCACZ-PVOKDAACSA-N;   SMILES=Cl.C1CCN(CC1)CC2=CC(=NC=C2)OC/C=C\\CNC=3C(C(C3N)=O)=O;   pibutidine HCl;   pibutidine monohydrochloride
 xref: CAS:126463-66-9 "ChemIDplus";   KEGG:D01861;   PMID:10759252 "Europe PMC";   PMID:11130203 "Europe PMC";   PMID:1686058 "Europe PMC";   PMID:1971169 "Europe PMC";   PMID:1971222 "Europe PMC";   PMID:1972370 "Europe PMC";   PMID:1979811 "Europe PMC";   PMID:8658031 "Europe PMC";   PMID:9467826 "Europe PMC";   PMID:9730007 "Europe PMC"

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  CHEBI ontology 19764
    role 19711
      application 19362
        pharmaceutical 19231
          drug 19231
            anti-ulcer drug 753
              pibutidine hydrochloride 0
Path 2
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  CHEBI ontology 19764
    subatomic particle 19762
      composite particle 19762
        hadron 19762
          baryon 19762
            nucleon 19762
              atomic nucleus 19762
                atom 19762
                  main group element atom 19646
                    main group molecular entity 19646
                      s-block molecular entity 19408
                        hydrogen molecular entity 19397
                          hydrides 18357
                            inorganic hydride 17210
                              pnictogen hydride 17174
                                nitrogen hydride 17008
                                  ammonium 8219
                                    ammonium ion derivative 8214
                                      piperidinium ion 39
                                        pibutidine(1+) 0
                                          pibutidine hydrochloride 0
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