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Term:sapropterin dihydrochloride
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Accession:CHEBI:32120 term browser browse the term
Definition:The dihydrochloride salt of sapropterin. It is used for the diagnosis and treatment of variant forms of phenylketonuria (hyperphenylalaninaemia) associated with tetrahydrobiopterin deficiency. Natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, and nitric oxide synthetase.
Synonyms:exact_synonym: (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3H)-one dihydrochloride
 related_synonym: (6R)-tetrahydrobiopterin dihydrochloride;   (6R)-tetrahydrobiopterin hydrochloride;   Formula=C9H17Cl2N5O3;   InChI=1S/C9H15N5O3.2ClH/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7;;/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17);2*1H/t3-,4+,6-;;/m0../s1;   InChIKey=RKSUYBCOVNCALL-NTVURLEBSA-N;   SMILES=Cl.Cl.[H][C@@]1(CNc2nc(N)[nH]c(=O)c2N1)[C@@H](O)[C@H](C)O;   sapropterin 2HCl;   sapropterin hydrochloride
 xref: Beilstein:4613446;   CAS:69056-38-8;   KEGG:D01798;   PMID:20179079;   PMID:20206791;   PMID:20418136;   PMID:20556789;   PMID:20667834;   PMID:20714359;   PMID:20830319;   PMID:21077779;   PMID:21645517;   PMID:21646032;   PMID:21967857;   PMID:22112818;   PMID:22310224;   Reaxys:12490572

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  CHEBI ontology 19758
    role 19705
      application 19359
        pharmaceutical 19228
          diagnostic agent 654
            sapropterin dihydrochloride 0
Path 2
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  CHEBI ontology 19758
    subatomic particle 19756
      composite particle 19756
        hadron 19756
          baryon 19756
            nucleon 19756
              atomic nucleus 19756
                atom 19756
                  main group element atom 19641
                    p-block element atom 19641
                      carbon group element atom 19532
                        carbon atom 19521
                          organic molecular entity 19521
                            organic molecule 19441
                              organic cyclic compound 19203
                                organic heterocyclic compound 18278
                                  organic heteropolycyclic compound 17585
                                    organic heterobicyclic compound 16255
                                      pteridines 5271
                                        pterins 3720
                                          biopterins 11
                                            5,6,7,8-tetrahydrobiopterin 9
                                              sapropterin 9
                                                sapropterin dihydrochloride 0
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