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ONTOLOGY REPORT - ANNOTATIONS


Term:tazarotene
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Accession:CHEBI:32184 term browser browse the term
Definition:The ethyl ester of tazarotenic acid. A prodrug for tazarotenic acid, it is used for the treatment of psoriasis, acne, and sun-damaged skin.
Synonyms:exact_synonym: ethyl 6-[(4,4-dimethyl-3,4-dihydro-2H-thiochromen-6-yl)ethynyl]nicotinate
 related_synonym: Avage;   Formula=C21H21NO2S;   InChI=1S/C21H21NO2S/c1-4-24-20(23)16-7-9-17(22-14-16)8-5-15-6-10-19-18(13-15)21(2,3)11-12-25-19/h6-7,9-10,13-14H,4,11-12H2,1-3H3;   InChIKey=OGQICQVSFDPSEI-UHFFFAOYSA-N;   SMILES=CCOC(=O)c1ccc(nc1)C#Cc1ccc2SCCC(C)(C)c2c1;   Tazorac;   Zorac;   tazaroteno;   tazarotenum
 xref: Beilstein:8159145 "Beilstein";   CAS:118292-40-3 "ChemIDplus";   DrugBank:DB00799;   Drug_Central:2571 "DrugCentral";   HMDB:HMDB0014937;   KEGG:C12531;   KEGG:D01132
 xref_mesh: MESH:C086827
 xref: Patent:EP284288;   Patent:US5089509;   Wikipedia:Tazarotene


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tazarotene term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Rarb retinoic acid receptor, beta JBrowse link 15 9,915,223 10,262,599 RGD:6480464
G Rarg retinoic acid receptor, gamma JBrowse link 7 143,840,739 143,863,206 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6480464
G Slc5a5 solute carrier family 5 member 5 JBrowse link 16 20,297,414 20,307,401 RGD:6480464
G Sts steroid sulfatase JBrowse link X 45,420,418 45,428,748 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19734
    role 19680
      application 19336
        pro-agent 8821
          prodrug 8610
            tazarotene 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19734
    subatomic particle 19730
      composite particle 19730
        hadron 19730
          baryon 19730
            nucleon 19730
              atomic nucleus 19730
                atom 19730
                  main group element atom 19614
                    p-block element atom 19614
                      carbon group element atom 19506
                        carbon atom 19500
                          organic molecular entity 19500
                            organic group 18414
                              organic divalent group 18406
                                organodiyl group 18406
                                  carbonyl group 18295
                                    carbonyl compound 18295
                                      carboxylic acid 17963
                                        monocarboxylic acid 17265
                                          tazarotenic acid 11
                                            tazarotene 11
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