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ONTOLOGY REPORT - ANNOTATIONS


Term:tolfenamic acid
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Accession:CHEBI:32243 term browser browse the term
Definition:An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 3-chloro-2-methylphenyl group. Tolfenamic acid is used specifically for relieving the pain of migraine. It also shows anticancer activity.
Synonyms:exact_synonym: 2-[(3-chloro-2-methylphenyl)amino]benzoic acid
 related_synonym: Formula=C14H12ClNO2;   InChI=1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18);   InChIKey=YEZNLOUZAIOMLT-UHFFFAOYSA-N;   N-(2-Methyl-3-chlorophenyl)anthranilic acid;   N-(3-Chloro-2-methylphenyl)anthranilic acid;   N-(3-Chloro-o-tolyl)-anthranilic acid;   SMILES=Cc1c(Cl)cccc1Nc1ccccc1C(O)=O;   acide tolfenamique;   acido tolfenamico;   acidum tolfenamicum
 xref: CAS:13710-19-5 "ChemIDplus";   CAS:13710-19-5 "KEGG DRUG";   Drug_Central:2698 "DrugCentral";   KEGG:D01183;   LINCS:LSM-5612
 xref_mesh: MESH:C009500
 xref: PMID:20797618 "Europe PMC";   PMID:21392038 "Europe PMC";   PMID:21879384 "Europe PMC";   PMID:22213339 "Europe PMC";   PMID:22815231 "Europe PMC";   PMID:22954807 "Europe PMC";   PMID:23340327 "Europe PMC";   PMID:23576386 "Europe PMC";   PMID:23609055 "Europe PMC";   PMID:23620261 "Europe PMC";   PMID:23639209 "Europe PMC";   PMID:23661145 "Europe PMC";   PMID:23670891 "Europe PMC";   PMID:23686785 "Europe PMC";   PMID:23784084 "Europe PMC";   PMID:23811329 "Europe PMC";   PMID:23864386 "Europe PMC";   PMID:23874066 "Europe PMC";   PMID:23896517 "Europe PMC";   PMID:24030139 "Europe PMC";   PMID:24073394 "Europe PMC";   PMID:24104354 "Europe PMC";   PMID:24216474 "Europe PMC";   Patent:US2003060465;   Reaxys:657821 "Reaxys";   VSDB:1874;   Wikipedia:Tolfenamic_acid


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tolfenamic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1c3 aldo-keto reductase family 1, member C3 JBrowse link 17 69,761,126 69,778,021 RGD:6480464
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:6480464
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:6480464
G Bace1 beta-secretase 1 JBrowse link 8 50,140,092 50,162,388 RGD:6480464
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:6480464
G Cdh1 cadherin 1 JBrowse link 19 38,768,467 38,838,395 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Hk2 hexokinase 2 JBrowse link 4 113,559,396 113,609,897 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:6480464
G Psmb10 proteasome 20S subunit beta 10 JBrowse link 19 37,909,543 37,912,027 RGD:6480464
G Psmb9 proteasome 20S subunit beta 9 JBrowse link 20 3,973,424 3,978,845 RGD:6480464
G Slc2a1 solute carrier family 2 member 1 JBrowse link 5 138,154,677 138,182,897 RGD:6480464
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:6480464
G Snai1 snail family transcriptional repressor 1 JBrowse link 3 164,274,710 164,279,199 RGD:6480464
G Sp1 Sp1 transcription factor JBrowse link 7 144,014,173 144,044,635 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:6480464
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      application 19328
        anti-inflammatory agent 14935
          anti-inflammatory drug 13586
            non-steroidal anti-inflammatory drug 12671
              tolfenamic acid 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic group 18413
                              organic divalent group 18404
                                organodiyl group 18404
                                  carbonyl group 18293
                                    carbonyl compound 18293
                                      carboxylic acid 17960
                                        aromatic carboxylic acid 10732
                                          benzoic acids 10698
                                            aminobenzoic acid 1607
                                              anthranilic acid 1485
                                                tolfenamic acid 18
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.