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ONTOLOGY REPORT - ANNOTATIONS


Term:butenafine
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Accession:CHEBI:3238 term browser browse the term
Definition:Trimethylamine in which hydrogen atoms attached to different methyl groups are substituted by 1-naphthyl and 4-tert-butylphenyl groups. It is an inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes, and is used as its hydrochloride salt for treatment of dermatological fungal infections.
Synonyms:exact_synonym: 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine
 related_synonym: (4-tert-Butyl-benzyl)-methyl-naphthalen-1-ylmethyl-amine;   (4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine;   4-tert-butylbenzyl(methyl)(1-naphthalenemethyl)amine;   Formula=C23H27N;   InChI=1S/C23H27N/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20/h5-15H,16-17H2,1-4H3;   InChIKey=ABJKWBDEJIDSJZ-UHFFFAOYSA-N;   N-(p-tert-butylbenzyl)-N-methyl-1-naphthalenemethylamine;   SMILES=CN(Cc1ccc(cc1)C(C)(C)C)Cc1cccc2ccccc12;   butenafina;   butenafinum
 alt_id: CHEBI:205442
 xref: Beilstein:6334654 "Beilstein";   CAS:101828-21-1 "KEGG COMPOUND";   DrugBank:DB01091;   Drug_Central:444 "DrugCentral";   KEGG:C08067;   KEGG:D07596;   LINCS:LSM-5956
 xref_mesh: MESH:C067594
 xref: PMID:17371821 "ChEMBL";   PMID:8340915 "ChEMBL";   Patent:EP164697;   Patent:US5021458;   Wikipedia:Butenafine


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butenafine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:6480464
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6480464
G Tslp thymic stromal lymphopoietin JBrowse link 18 25,613,601 25,618,066 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      application 19328
        pharmaceutical 19202
          drug 19202
            antifungal drug 5101
              butenafine 7
                butenafine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    main group molecular entity 19610
                      s-block molecular entity 19378
                        hydrogen molecular entity 19367
                          hydrides 18278
                            inorganic hydride 17205
                              pnictogen hydride 17167
                                nitrogen hydride 17003
                                  azane 16694
                                    ammonia 16691
                                      organic amino compound 16690
                                        tertiary amino compound 8547
                                          tertiary amine 600
                                            butenafine 7
                                              butenafine hydrochloride 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.