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ONTOLOGY REPORT - ANNOTATIONS


Term:pyruvic acid
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Accession:CHEBI:32816 term browser browse the term
Definition:A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Synonyms:related_synonym: 2-Oxopropansaeure;   2-Oxopropionsaeure;   2-ketopropionic acid;   2-oxopropanoic acid;   Acetylformic acid;   BTS;   Brenztraubensaeure;   CH3COCOOH;   Formula=C3H4O3;   InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6);   InChIKey=LCTONWCANYUPML-UHFFFAOYSA-N;   Pyroracemic acid;   SMILES=CC(=O)C(O)=O;   acide pyruvique;   alpha-Oxopropionsaeure;   alpha-ketopropionic acid
 alt_id: CHEBI:26466;   CHEBI:45253;   CHEBI:8685
 xref: Beilstein:506211 "Beilstein";   CAS:127-17-3 "ChemIDplus";   CAS:127-17-3 "NIST Chemistry WebBook";   DrugBank:DB00119;   ECMDB:ECMDB00243;   Gmelin:101087 "Gmelin";   HMDB:HMDB0000243;   KEGG:C00022;   KNApSAcK:C00001200;   LIPID_MAPS_instance:LMFA01060077 "LIPID MAPS"
 xref_mesh: MESH:D019289
 xref: MetaCyc:PYRUVATE;   PDBeChem:PYR;   PMID:11762589 "Europe PMC";   PMID:19260671 "Europe PMC";   PMID:22150460 "Europe PMC";   PMID:22233273 "Europe PMC";   PMID:22735334 "Europe PMC";   PMID:22770225 "Europe PMC";   Reaxys:506211 "Reaxys";   Wikipedia:Pyruvic_acid;   YMDB:YMDB00175
 cyclic_relationship: is_conjugate_acid_of CHEBI:15361


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pyruvic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acaca acetyl-CoA carboxylase alpha JBrowse link 10 71,519,392 71,719,910 RGD:6480464
G Adrb3 adrenoceptor beta 3 JBrowse link 16 69,003,541 69,006,632 RGD:6480464
G Atp5f1a ATP synthase F1 subunit alpha JBrowse link 18 74,156,553 74,164,490 RGD:6480464
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Ctbp1 C-terminal binding protein 1 JBrowse link 14 82,762,109 82,789,350 RGD:6480464
G Ctbp2 C-terminal binding protein 2 JBrowse link 1 205,001,354 205,030,565 RGD:6480464
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 JBrowse link 1 266,422,127 266,429,947 RGD:6480464
G Dek DEK proto-oncogene JBrowse link 17 17,965,872 17,987,836 RGD:6480464
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:6480464
G Gcg glucagon JBrowse link 3 48,442,635 48,451,650 RGD:6480464
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 JBrowse link 1 141,874,354 141,893,674 RGD:6480464
G Il22 interleukin 22 JBrowse link 7 61,236,037 61,240,502 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:6480464
G Mt-co1 mitochondrially encoded cytochrome c oxidase I JBrowse link MT 5,323 6,867 RGD:6480464
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 JBrowse link 1 264,298,671 264,303,712 RGD:6480464
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 JBrowse link 3 22,998,900 23,020,441 RGD:6480464
G Pdk4 pyruvate dehydrogenase kinase 4 JBrowse link 4 30,546,772 30,556,774 RGD:6480464
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6480464
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:6480464
G Slc16a1 solute carrier family 16 member 1 JBrowse link 2 207,108,552 207,129,352 RGD:6480464
G Slc2a4 solute carrier family 2 member 4 JBrowse link 10 56,552,921 56,558,562 RGD:6480464
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:6480464
G Tfam transcription factor A, mitochondrial JBrowse link 20 18,594,057 18,606,106 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
3-bromopyruvic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Gapdh glyceraldehyde-3-phosphate dehydrogenase JBrowse link 4 157,676,336 157,680,322 RGD:6480464
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6480464
G Hk1 hexokinase 1 JBrowse link 20 31,911,460 31,979,780 RGD:6480464
G Hk2 hexokinase 2 JBrowse link 4 113,559,396 113,609,897 RGD:6480464
G Ldha lactate dehydrogenase A JBrowse link 1 102,900,288 102,909,713 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 2 197,786,212 197,788,992 RGD:6480464
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:6480464
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6480464
G Sdha succinate dehydrogenase complex flavoprotein subunit A JBrowse link 1 31,545,631 31,570,601 RGD:6480464
G Slc16a1 solute carrier family 16 member 1 JBrowse link 2 207,108,552 207,129,352 RGD:6480464
G Slc2a1 solute carrier family 2 member 1 JBrowse link 5 138,154,677 138,182,897 RGD:6480464
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:6480464
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
3-hydroxypyruvic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aldh2 aldehyde dehydrogenase 2 family member JBrowse link 12 40,466,418 40,498,813 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
keto-phenylpyruvic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Col2a1 collagen type II alpha 1 chain JBrowse link 7 139,454,945 139,484,403 RGD:6480464
G Slc22a7 solute carrier family 22 member 7 JBrowse link 9 16,925,321 16,931,119 RGD:6480464
methyl pyruvate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Slc2a4 solute carrier family 2 member 4 JBrowse link 10 56,552,921 56,558,562 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        biochemical role 19133
          cofactor 15860
            pyruvic acid 47
              (3,5-diiodo-4-hydroxyphenyl)pyruvic acid 0
              (3E)-3-[(1R,5R,6S)-5-hydroxy-7-oxabicyclo[4.1.0]heptan-2-ylidene]pyruvic acid 0
              (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoic acid 0
              (3S)-3-methyl-2-oxo-3-phenylpropanoic acid 0
              (4-bromophenylsulfanyl)pyruvic acid 0
              (4-hydroxyphenyl)pyruvic acid + 0
              (S)-3-hydroxy-2-oxo-3-phenylpropanoic acid 0
              2-hydroxy-3-carboxybenzylidenepyruvic acid 0
              2-hydroxy-3-methylbenzylidenepyruvic acid 0
              2-hydroxy-4-hydroxymethylbenzylidenepyruvic acid 0
              2-oxo-3-(5-oxofuran-2-ylidene)propanoic acid 0
              3,4-dihydro-4-hydroxyphenylpyruvic acid + 0
              3,4-dihydroxyphenylpyruvic acid 0
              3,5,3'-triiodothyropyruvic acid 0
              3,5-dibromo-4-hydroxyphenylpyruvic acid 0
              3,5-dichloro-4-hydroxyphenylpyruvic acid 0
              3,5-dinitro-4-hydroxyphenylpyruvic acid 0
              3-(3-methoxy-4-phenylmethoxyphenyl)-2-oxopropanoic acid 0
              3-(4-aminophenyl)pyruvic acid 0
              3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvic acid + 0
              3-(5-benzyloxyindol-3-yl)pyruvic acid 0
              3-(5-hydroxyindol-3-yl)pyruvic acid 0
              3-(imidazol-1-yl)pyruvic acid 0
              3-(imidazol-4-yl)pyruvic acid 0
              3-(imidazol-5-yl)pyruvic acid 0
              3-(indol-3-yl)pyruvic acid 0
              3-[(1R,2S,5R,6S)-5-hydroxy-7-oxabicyclo[4.1.0]heptan-2-yl]pyruvic acid 0
              3-[hydroxy(oxido)phosphoranyl]pyruvic acid 0
              3-acylpyruvic acid 0
              3-bromopyruvic acid 17
              3-dimethylallyl-4-hydroxyphenylpyruvic acid 0
              3-fluoropyruvic acid 0
              3-fumarylpyruvic acid 0
              3-hydroxypyruvic acid 2
              3-mercaptopyruvic acid 0
              3-phosphonooxypyruvic acid 0
              3-phosphonopyruvic acid 0
              3-sulfinylpyruvic acid 0
              3-sulfopyruvic acid 0
              4-hydroxy-3-iodophenylpyruvate 0
              4-hydroxy-3-iodophenylpyruvic acid 0
              Loniphenyruviridoside B, (rel)- 0
              Loniphenyruviridoside C 0
              Vanillactic acid 0
              Vanilpyruvic acid 0
              beta-(methylenecyclopropyl)pyruvic acid 0
              keto-phenylpyruvic acid + 2
              lignin cw compound-2040 0
              lignin cw compound-2041 0
              lignin cw compound-2042 0
              lignin cw compound-3052 0
              lignin cw compound-3056 0
              methyl pyruvate 2
              pyruvate ester + 2
              pyruvoyl group 0
              tetrahydro-4-hydroxyphenylpyruvic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic group 18340
                              organic divalent group 18330
                                organodiyl group 18330
                                  carbonyl group 18217
                                    carbonyl compound 18217
                                      carboxylic acid 17921
                                        monocarboxylic acid 17256
                                          fatty acid 15817
                                            saturated fatty acid 15784
                                              propionic acid 3635
                                                pyruvic acid 47
                                                  (3,5-diiodo-4-hydroxyphenyl)pyruvic acid 0
                                                  (3E)-3-[(1R,5R,6S)-5-hydroxy-7-oxabicyclo[4.1.0]heptan-2-ylidene]pyruvic acid 0
                                                  (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoic acid 0
                                                  (3S)-3-methyl-2-oxo-3-phenylpropanoic acid 0
                                                  (4-bromophenylsulfanyl)pyruvic acid 0
                                                  (4-hydroxyphenyl)pyruvic acid + 0
                                                  (S)-3-hydroxy-2-oxo-3-phenylpropanoic acid 0
                                                  2-hydroxy-3-carboxybenzylidenepyruvic acid 0
                                                  2-hydroxy-3-methylbenzylidenepyruvic acid 0
                                                  2-hydroxy-4-hydroxymethylbenzylidenepyruvic acid 0
                                                  2-oxo-3-(5-oxofuran-2-ylidene)propanoic acid 0
                                                  3,4-dihydro-4-hydroxyphenylpyruvic acid + 0
                                                  3,4-dihydroxyphenylpyruvic acid 0
                                                  3,5,3'-triiodothyropyruvic acid 0
                                                  3,5-dibromo-4-hydroxyphenylpyruvic acid 0
                                                  3,5-dichloro-4-hydroxyphenylpyruvic acid 0
                                                  3,5-dinitro-4-hydroxyphenylpyruvic acid 0
                                                  3-(3-methoxy-4-phenylmethoxyphenyl)-2-oxopropanoic acid 0
                                                  3-(4-aminophenyl)pyruvic acid 0
                                                  3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvic acid + 0
                                                  3-(5-benzyloxyindol-3-yl)pyruvic acid 0
                                                  3-(5-hydroxyindol-3-yl)pyruvic acid 0
                                                  3-(imidazol-1-yl)pyruvic acid 0
                                                  3-(imidazol-4-yl)pyruvic acid 0
                                                  3-(imidazol-5-yl)pyruvic acid 0
                                                  3-(indol-3-yl)pyruvic acid 0
                                                  3-[(1R,2S,5R,6S)-5-hydroxy-7-oxabicyclo[4.1.0]heptan-2-yl]pyruvic acid 0
                                                  3-[hydroxy(oxido)phosphoranyl]pyruvic acid 0
                                                  3-acylpyruvic acid 0
                                                  3-bromopyruvic acid 17
                                                  3-dimethylallyl-4-hydroxyphenylpyruvic acid 0
                                                  3-fluoropyruvic acid 0
                                                  3-fumarylpyruvic acid 0
                                                  3-hydroxypyruvic acid 2
                                                  3-mercaptopyruvic acid 0
                                                  3-phosphonooxypyruvic acid 0
                                                  3-phosphonopyruvic acid 0
                                                  3-sulfinylpyruvic acid 0
                                                  3-sulfopyruvic acid 0
                                                  4-hydroxy-3-iodophenylpyruvate 0
                                                  4-hydroxy-3-iodophenylpyruvic acid 0
                                                  Loniphenyruviridoside B, (rel)- 0
                                                  Loniphenyruviridoside C 0
                                                  Vanillactic acid 0
                                                  Vanilpyruvic acid 0
                                                  beta-(methylenecyclopropyl)pyruvic acid 0
                                                  keto-phenylpyruvic acid + 2
                                                  lignin cw compound-2040 0
                                                  lignin cw compound-2041 0
                                                  lignin cw compound-2042 0
                                                  lignin cw compound-3052 0
                                                  lignin cw compound-3056 0
                                                  methyl pyruvate 2
                                                  pyruvate ester + 2
                                                  pyruvoyl group 0
                                                  tetrahydro-4-hydroxyphenylpyruvic acid + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.