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ONTOLOGY REPORT - ANNOTATIONS


Term:cabergoline
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Accession:CHEBI:3286 term browser browse the term
Definition:An N-acylurea that is (8R)-ergoline-8-carboxamide in which the hydrogen attached to the piperidine nitrogen (position 6) is substituted by an allyl group and the hydrogens attached to the carboxamide nitrogen are substituted by a 3-(dimethylamino)propyl group and an N-ethylcarbamoyl group. A dopamine D2 receptor agonist, cabergoline is used in the management of Parkinson's disease and of disorders associated with hyperprolactinaemia.
Synonyms:exact_synonym: (8beta)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-6-(prop-2-en-1-yl)ergoline-8-carboxamide
 related_synonym: (8R)-6-allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide;   (8beta)-N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide;   1-((6-allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea;   1-[(6-allylergoline-8beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea;   1-ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'beta-carbonyl)urea;   Formula=C26H37N5O2;   InChI=1S/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33)/t19-,21-,23-/m1/s1;   InChIKey=KORNTPPJEAJQIU-KJXAQDMKSA-N;   SMILES=[H][C@@]12Cc3c[nH]c4cccc(c34)[C@@]1([H])C[C@H](CN2CC=C)C(=O)N(CCCN(C)C)C(=O)NCC;   cabergolina;   cabergolinum
 xref: Beilstein:6020775 "Beilstein";   CAS:81409-90-7 "ChemIDplus";   CAS:81409-90-7 "KEGG COMPOUND";   DrugBank:DB00248;   Drug_Central:460 "DrugCentral";   HMDB:HMDB0014393;   KEGG:C08187;   KEGG:D00987;   LINCS:LSM-3939
 xref_mesh: MESH:C047047
 xref: PMID:22075008 "Europe PMC";   PMID:22336848 "Europe PMC";   PMID:22740242 "Europe PMC";   PMID:23110560 "Europe PMC";   PMID:23743769 "Europe PMC";   Patent:BE888243;   Patent:US4526892;   VSDB:1830;   Wikipedia:Cabergoline


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cabergoline term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gdnf glial cell derived neurotrophic factor JBrowse link 2 56,884,181 56,912,964 RGD:6480464
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:6480464
G Prl prolactin JBrowse link 17 39,814,236 39,824,299 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19734
    role 19680
      application 19336
        pharmaceutical 19211
          drug 19211
            antineoplastic agent 16895
              cabergoline 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19734
    subatomic particle 19730
      composite particle 19730
        hadron 19730
          baryon 19730
            nucleon 19730
              atomic nucleus 19730
                atom 19730
                  main group element atom 19614
                    p-block element atom 19614
                      carbon group element atom 19506
                        carbon atom 19500
                          organic molecular entity 19500
                            organic group 18414
                              organic divalent group 18406
                                organodiyl group 18406
                                  carbonyl group 18295
                                    carbonyl compound 18295
                                      carboxylic acid 17963
                                        carboacyl group 17074
                                          univalent carboacyl group 17074
                                            carbamoyl group 16804
                                              carboxamide 16804
                                                monocarboxylic acid amide 14167
                                                  urea 4955
                                                    ureas 4952
                                                      N-acylurea 25
                                                        cabergoline 3
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