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Term:calcein am
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Accession:CHEBI:3303 term browser browse the term
Definition:An organic heteropentacyclic compound that is calcein in which all four carboxy group hydrogens have been substituted by (acetyloxy)methoxy groups and the hyrodgens of the two hydroxy groups have been substituted by acetyl groups. It is a a non-fluorescent probe cleaved to a fluorescent probe by non-specific intracellular esterases.
Synonyms:exact_synonym: tetrakis[(acetyloxy)methyl] 2,2',2'',2'''-{[3',6'-bis(acetyloxy)-3-oxo-3H-spiro[[2]benzofuran-1,9'-xanthene]-2',7'-diyl]bis(methanediylnitrilo)}tetraacetate
 related_synonym: Formula=C46H46N2O23;   InChI=1S/C46H46N2O23/c1-25(49)60-21-64-41(55)17-47(18-42(56)65-22-61-26(2)50)15-31-11-35-39(13-37(31)68-29(5)53)70-40-14-38(69-30(6)54)32(12-36(40)46(35)34-10-8-7-9-33(34)45(59)71-46)16-48(19-43(57)66-23-62-27(3)51)20-44(58)67-24-63-28(4)52/h7-14H,15-24H2,1-6H3;   InChIKey=BQRGNLJZBFXNCZ-UHFFFAOYSA-N;   SMILES=O(C1=C(C=C2C3(OC(C4=C3C=CC=C4)=O)C=5C(OC2=C1)=CC(=C(C5)CN(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)OC(C)=O)CN(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)C(C)=O;   [({[3',6'-bis(acetyloxy)-3-oxo-3H-spiro[[2]benzofuran-1,9'-xanthene]-2',7'-diyl]bis(methylene)nitrilo}bis[(1-oxoethane-2,1-diyl)oxy]methylene)] tetraacetate;   calcein O,O'-diacetate tetrakis(acetoxymethyl) ester
 alt_id: CHEBI:51904
 xref: CAS:148504-34-1 "ChemIDplus";   CAS:148504-34-1 "KEGG COMPOUND";   KEGG:C11257
 xref_mesh: MESH:C085925
 xref: PMID:30925062 "Europe PMC";   PMID:31188648 "Europe PMC";   PMID:31489142 "Europe PMC";   PMID:8107502 "Europe PMC"

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calcein am term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCB1 ATP binding cassette subfamily B member 1 JBrowse link 7 87,503,017 87,713,323 RGD:6480464
G ABCB11 ATP binding cassette subfamily B member 11 JBrowse link 2 168,915,468 169,031,396 RGD:6480464
G ABCC1 ATP binding cassette subfamily C member 1 JBrowse link 16 15,949,616 16,143,062 RGD:6480464
G ABCC2 ATP binding cassette subfamily C member 2 JBrowse link 10 99,782,602 99,853,741 RGD:6480464
G ABCC3 ATP binding cassette subfamily C member 3 JBrowse link 17 50,634,881 50,692,253 RGD:6480464
G ABCC4 ATP binding cassette subfamily C member 4 JBrowse link 13 95,019,835 95,301,451 RGD:6480464
G ABCC6 ATP binding cassette subfamily C member 6 JBrowse link 16 16,149,565 16,223,617 RGD:6480464
G MYC MYC proto-oncogene, bHLH transcription factor JBrowse link 8 127,735,434 127,742,951 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23785
    role 23672
      application 23055
        dye 1292
          xanthene dye 84
            calcein am 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 23785
    subatomic particle 23736
      composite particle 23736
        hadron 23736
          baryon 23736
            nucleon 23736
              atomic nucleus 23736
                atom 23736
                  main group element atom 23555
                    p-block element atom 23555
                      carbon group element atom 23269
                        carbon atom 23223
                          organic molecular entity 23223
                            organic group 21898
                              organic divalent group 21870
                                organodiyl group 21870
                                  carbonyl group 21842
                                    carbonyl compound 21842
                                      carboxylic acid 20887
                                        monocarboxylic acid 19771
                                          acetic acid 10982
                                            acetate ester 3491
                                              calcein am 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.