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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-nitrotoluene
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Accession:CHEBI:33098 term browser browse the term
Definition:A mononitrotoluene that is toluene carrying a nitro substituent at position 2.
Synonyms:related_synonym: 2-Nitrotoluol;   2-methyl-1-nitrobenzene;   Formula=C7H7NO2;   InChI=1S/C7H7NO2/c1-6-4-2-3-5-7(6)8(9)10/h2-5H,1H3;   InChIKey=PLAZTCDQAHEYBI-UHFFFAOYSA-N;   ONT;   SMILES=Cc1ccccc1[N+]([O-])=O;   o-Nitrotoluol;   o-methylnitrobenzene;   o-nitrotoluene;   ortho-Nitrotoluol
 xref: CAS:88-72-2;   KEGG:C19597
 xref_mesh: MESH:C029955
 xref: MetaCyc:2-NITROTOLUENE;   PMID:20582618;   PMID:21432561;   PMID:23153775;   PMID:7944378;   Reaxys:1907580;   Wikipedia:2-Nitrotoluene


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2-nitrotoluene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actg2 actin gamma 2, smooth muscle decreases expression EXP 2-nitrotoluene results in decreased expression of ACTG2 mRNA CTD PMID:16460773 NCBI chr 4:115,215,160...115,239,746
Ensembl chr 4:115,215,060...115,239,723
JBrowse link
G Actn1 actinin, alpha 1 decreases expression EXP 2-nitrotoluene results in decreased expression of ACTN1 mRNA CTD PMID:16460773 NCBI chr 6:103,376,557...103,470,497
Ensembl chr 6:103,375,799...103,470,555
JBrowse link
G Actn4 actinin alpha 4 decreases expression EXP 2-nitrotoluene results in decreased expression of ACTN4 mRNA CTD PMID:16460773 NCBI chr 1:87,078,012...87,147,347
Ensembl chr 1:87,078,020...87,147,333
JBrowse link
G Akap10 A-kinase anchoring protein 10 decreases expression ISO 2-nitrotoluene results in decreased expression of AKAP10 mRNA CTD PMID:15612046 NCBI chr10:48,150,902...48,210,074
Ensembl chr10:48,150,902...48,210,074
JBrowse link
G Akt2 AKT serine/threonine kinase 2 increases expression EXP 2-nitrotoluene results in increased expression of AKT2 mRNA CTD PMID:16460773 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Arf4 ADP-ribosylation factor 4 decreases expression EXP 2-nitrotoluene results in decreased expression of ARF4 mRNA CTD PMID:16460773 NCBI chr16:2,338,333...2,354,909
Ensembl chr16:2,338,333...2,354,909
JBrowse link
G Arid3a AT-rich interaction domain 3A increases expression ISO 2-nitrotoluene results in increased expression of ARID3A mRNA CTD PMID:15612046 NCBI chr 7:12,573,604...12,602,407
Ensembl chr 7:12,574,198...12,601,674
JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression EXP 2-nitrotoluene results in increased expression of BNIP3L mRNA CTD PMID:16460773 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029
JBrowse link
G Ccn3 cellular communication network factor 3 decreases expression EXP 2-nitrotoluene results in decreased expression of CCN3 mRNA CTD PMID:16460773 NCBI chr 7:94,375,134...94,382,154
Ensembl chr 7:94,375,020...94,383,024
JBrowse link
G Ccng1 cyclin G1 increases expression ISO 2-nitrotoluene results in increased expression of CCNG1 mRNA CTD PMID:15618236 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
increases expression
EXP
ISO
2-nitrotoluene results in decreased expression of CDKN1A mRNA
2-nitrotoluene results in increased expression of CDKN1A mRNA
CTD PMID:15618236, PMID:16460773 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cish cytokine inducible SH2-containing protein decreases expression ISO 2-nitrotoluene results in decreased expression of CISH mRNA CTD PMID:15618236 NCBI chr 8:116,054,547...116,059,494
Ensembl chr 8:116,054,465...116,060,723
JBrowse link
G Col1a2 collagen type I alpha 2 chain decreases expression EXP 2-nitrotoluene results in decreased expression of COL1A2 mRNA CTD PMID:16460773 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Ctnnb1 catenin beta 1 increases mutagenesis ISO 2-nitrotoluene results in increased mutagenesis of CTNNB1 gene CTD PMID:13678655 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression ISO 2-nitrotoluene results in increased expression of CYP2B10 mRNA CTD PMID:15618236 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Ecm1 extracellular matrix protein 1 decreases expression ISO 2-nitrotoluene results in decreased expression of ECM1 mRNA CTD PMID:15612046 NCBI chr 2:197,855,468...197,860,973
Ensembl chr 2:197,855,460...197,860,699
JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO 2-nitrotoluene results in decreased expression of EGFR mRNA CTD PMID:15618236 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Fas Fas cell surface death receptor decreases expression EXP 2-nitrotoluene results in decreased expression of FAS mRNA CTD PMID:16460773 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fat1 FAT atypical cadherin 1 decreases expression EXP 2-nitrotoluene results in decreased expression of FAT1 mRNA CTD PMID:16460773 NCBI chr16:50,372,150...50,501,716
Ensembl chr16:50,372,128...50,501,921
JBrowse link
G Fgfrl1 fibroblast growth factor receptor-like 1 decreases expression ISO 2-nitrotoluene results in decreased expression of FGFRL1 protein CTD PMID:22434383 NCBI chr14:2,020,110...2,032,169
Ensembl chr14:2,018,500...2,032,593
JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase decreases expression ISO 2-nitrotoluene results in decreased expression of FHIT mRNA; 2-nitrotoluene results in decreased expression of FHIT protein CTD PMID:15618236 NCBI chr15:15,697,292...16,862,873 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression EXP 2-nitrotoluene results in decreased expression of FOS mRNA CTD PMID:16460773 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit decreases expression EXP 2-nitrotoluene results in decreased expression of FOSL1 mRNA CTD PMID:16460773 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Fzd2 frizzled class receptor 2 decreases expression EXP 2-nitrotoluene results in decreased expression of FZD2 mRNA CTD PMID:16460773 NCBI chr10:90,550,147...90,552,057
Ensembl chr10:90,550,147...90,552,057
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha decreases expression EXP 2-nitrotoluene results in decreased expression of GADD45A mRNA CTD PMID:16460773 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO 2-nitrotoluene results in increased expression of GADD45B mRNA CTD PMID:15618236 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Gnaq G protein subunit alpha q decreases expression EXP 2-nitrotoluene results in decreased expression of GNAQ mRNA CTD PMID:16460773 NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta affects expression EXP 2-nitrotoluene affects the expression of GSK3B mRNA CTD PMID:16460773 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gtf2ird1 GTF2I repeat domain containing 1 decreases expression ISO 2-nitrotoluene results in decreased expression of GTF2IRD1 protein CTD PMID:22434383 NCBI chr12:25,264,052...25,370,947
Ensembl chr12:25,264,192...25,371,001
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression EXP 2-nitrotoluene results in increased expression of IGF1 mRNA CTD PMID:16460773 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression EXP 2-nitrotoluene results in increased expression of IGFBP2 mRNA CTD PMID:16460773 NCBI chr 9:80,118,029...80,144,804
Ensembl chr 9:80,118,029...80,144,789
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 increases expression EXP 2-nitrotoluene results in increased expression of IGFBP3 mRNA CTD PMID:16460773 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Igfbp6 insulin-like growth factor binding protein 6 increases expression EXP 2-nitrotoluene results in increased expression of IGFBP6 mRNA CTD PMID:16460773 NCBI chr 7:143,749,385...143,754,018
Ensembl chr 7:143,749,221...143,754,054
JBrowse link
G Il7 interleukin 7 increases expression ISO 2-nitrotoluene results in increased expression of IL7 mRNA CTD PMID:15612046 NCBI chr 2:96,427,884...96,474,979
Ensembl chr 2:96,439,286...96,474,977
JBrowse link
G Ilk integrin-linked kinase decreases expression EXP 2-nitrotoluene results in decreased expression of ILK mRNA CTD PMID:16460773 NCBI chr 1:170,578,941...170,585,192
Ensembl chr 1:170,578,889...170,585,189
JBrowse link
G Inhba inhibin subunit beta A decreases expression ISO 2-nitrotoluene results in decreased expression of INHBA mRNA CTD PMID:15618236 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496
JBrowse link
G Itga8 integrin subunit alpha 8 decreases expression EXP 2-nitrotoluene results in decreased expression of ITGA8 mRNA CTD PMID:16460773 NCBI chr17:79,321,893...79,676,927
Ensembl chr17:79,321,900...79,676,499
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression EXP 2-nitrotoluene results in decreased expression of ITGB1 mRNA CTD PMID:16460773 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Itgb2 integrin subunit beta 2 increases expression EXP 2-nitrotoluene results in increased expression of ITGB2 mRNA CTD PMID:16460773 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Krt10 keratin 10 decreases expression ISO 2-nitrotoluene results in decreased expression of KRT10 protein CTD PMID:22434383 NCBI chr10:87,296,445...87,301,307
Ensembl chr10:87,296,451...87,300,736
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 decreases expression ISO 2-nitrotoluene results in decreased expression of LEF1 mRNA CTD PMID:15612046 NCBI chr 2:236,232,115...236,345,061
Ensembl chr 2:236,233,239...236,345,056
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 increases expression EXP 2-nitrotoluene results in increased expression of MAPKAPK2 mRNA CTD PMID:16460773 NCBI chr13:47,785,157...47,871,684
Ensembl chr13:47,785,161...47,831,110
JBrowse link
G Msln mesothelin increases expression EXP 2-nitrotoluene results in increased expression of MSLN mRNA CTD PMID:16460773 NCBI chr10:15,119,700...15,129,129
Ensembl chr10:15,119,663...15,125,408
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP 2-nitrotoluene results in increased expression of MYC mRNA CTD PMID:16460773 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nras NRAS proto-oncogene, GTPase increases expression EXP 2-nitrotoluene results in increased expression of NRAS mRNA CTD PMID:16460773 NCBI chr 2:205,553,119...205,563,716
Ensembl chr 2:205,553,163...205,560,791
JBrowse link
G Pard3 par-3 family cell polarity regulator increases expression ISO 2-nitrotoluene results in increased expression of PARD3 protein CTD PMID:22434383 NCBI chr19:60,017,746...60,580,628
Ensembl chr19:60,017,746...60,580,651
JBrowse link
G Pld3 phospholipase D family, member 3 increases expression ISO 2-nitrotoluene results in increased expression of PLD3 mRNA CTD PMID:15612046 NCBI chr 1:84,339,269...84,361,686
Ensembl chr 1:84,339,261...84,353,725
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A decreases expression EXP 2-nitrotoluene results in decreased expression of PPP1R12A mRNA CTD PMID:16460773 NCBI chr 7:51,404,971...51,515,382
Ensembl chr 7:51,404,919...51,515,373
JBrowse link
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta increases expression EXP 2-nitrotoluene results in increased expression of PPP2R2B mRNA CTD PMID:16460773 NCBI chr18:36,985,709...37,421,383
Ensembl chr18:36,985,714...37,245,809
JBrowse link
G Prkcz protein kinase C, zeta increases expression EXP 2-nitrotoluene results in increased expression of PRKCZ mRNA CTD PMID:16460773 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
G Rad18 RAD18 E3 ubiquitin protein ligase decreases expression ISO 2-nitrotoluene results in decreased expression of RAD18 protein CTD PMID:22434383 NCBI chr 4:144,537,329...144,620,606
Ensembl chr 4:144,536,729...144,620,731
JBrowse link
G Rala RAS like proto-oncogene A decreases expression EXP 2-nitrotoluene results in decreased expression of RALA mRNA CTD PMID:16460773 NCBI chr17:49,676,073...49,729,133
Ensembl chr17:49,714,294...49,727,664
JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression ISO 2-nitrotoluene results in increased expression of S100A4 mRNA CTD PMID:15612046 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 increases expression ISO 2-nitrotoluene results in increased expression of SLC9A3R1 protein CTD PMID:22434383 NCBI chr10:103,713,045...103,730,145
Ensembl chr10:103,713,045...103,730,145
JBrowse link
G St7l suppression of tumorigenicity 7-like decreases expression ISO 2-nitrotoluene results in decreased expression of ST7L mRNA CTD PMID:15612046 NCBI chr 2:207,350,651...207,421,082
Ensembl chr 2:207,350,651...207,473,857
JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases activity ISO 2-nitrotoluene results in decreased activity of STAT5B protein CTD PMID:30114225 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829
JBrowse link
G Tgfb2 transforming growth factor, beta 2 decreases expression EXP 2-nitrotoluene results in decreased expression of TGFB2 mRNA CTD PMID:16460773 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression EXP 2-nitrotoluene results in decreased expression of TGFB3 mRNA CTD PMID:16460773 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 increases expression EXP 2-nitrotoluene results in increased expression of TGFBR2 mRNA CTD PMID:16460773 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Tp53 tumor protein p53 increases mutagenesis ISO 2-nitrotoluene results in increased mutagenesis of TRP53 gene CTD PMID:13678655 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tph1 tryptophan hydroxylase 1 increases expression ISO 2-nitrotoluene results in increased expression of TPH1 mRNA CTD PMID:15612046 NCBI chr 1:102,669,868...102,699,442
Ensembl chr 1:102,669,868...102,699,442
JBrowse link
G Wnt4 Wnt family member 4 increases expression EXP 2-nitrotoluene results in increased expression of WNT4 mRNA CTD PMID:16460773 NCBI chr 5:155,649,238...155,668,065
Ensembl chr 5:155,649,217...155,672,579
JBrowse link
G Wwox WW domain-containing oxidoreductase decreases expression ISO 2-nitrotoluene results in decreased expression of WWOX mRNA; 2-nitrotoluene results in decreased expression of WWOX protein CTD PMID:15618236 NCBI chr19:46,761,353...47,695,247 JBrowse link

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  CHEBI ontology 19816
    role 19764
      chemical role 19288
        environmental contaminant 18613
          2-nitrotoluene 63
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                carbocyclic compound 18222
                                  benzenoid aromatic compound 17254
                                    benzenes 17010
                                      toluenes 6230
                                        nitrotoluene 3879
                                          mononitrotoluene 68
                                            2-nitrotoluene 63
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.