Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cyclic compound
go back to main search page
Accession:CHEBI:33595 term browser browse the term
Definition:Any molecule that consists of a series of atoms joined together to form a ring.
Synonyms:related_synonym: cyclic compounds
 xref: Wikipedia:Cyclic_compound


show annotations for term's descendants           Sort by:
 
(-)-epigallocatechin 3-gallate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP epigallocatechin gallate inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl affects the localization of and results in increased activity of AHR protein]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased activity of AHR protein]; epigallocatechin gallate inhibits the reaction [[alpha-naphthoflavone co-treated with 3,4,3',4'-tetrachlorobiphenyl] results in increased activity of AHR protein]; epigallocatechin gallate inhibits the reaction [alpha-naphthoflavone results in increased activity of AHR protein] CTD PMID:12970578, PMID:22521609 NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions
decreases expression
EXP epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 protein]; epigallocatechin gallate inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA]; epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; HMOX1 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]
epigallocatechin gallate results in decreased expression of CCL2 mRNA
CTD PMID:20580034, PMID:22521609, PMID:23380242 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G CYP1A1 cytochrome P450 1A1 multiple interactions
decreases activity
decreases expression
EXP epigallocatechin gallate inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased activity of CYP1A1 protein]; epigallocatechin gallate inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 protein]; epigallocatechin gallate inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; epigallocatechin gallate inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
epigallocatechin gallate results in decreased activity of CYP1A1 protein
epigallocatechin gallate results in decreased expression of CYP1A1 mRNA
CTD PMID:12970578, PMID:22521609 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,780,105...58,809,755
JBrowse link
G GSTO1 glutathione S-transferase omega 1 multiple interactions
increases expression
EXP [epigallocatechin gallate co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of GSTO1 mRNA; NFE2L2 protein affects the reaction [epigallocatechin gallate results in increased expression of GSTO1 mRNA] CTD PMID:22521609 NCBI chr14:115,206,434...115,216,624
Ensembl chr14:115,206,188...115,216,613
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions EXP HMOX1 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]] CTD PMID:20580034
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions EXP NFE2L2 protein affects the reaction [epigallocatechin gallate results in increased expression of GSTO1 mRNA]; NFE2L2 protein affects the reaction [epigallocatechin gallate results in increased expression of NQO1 mRNA] CTD PMID:22521609 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
EXP epigallocatechin gallate results in increased expression of NQO1 mRNA
[epigallocatechin gallate co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of NQO1 mRNA; NFE2L2 protein affects the reaction [epigallocatechin gallate results in increased expression of NQO1 mRNA]
CTD PMID:22521609 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,769...17,302,590
JBrowse link
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions EXP epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Penicillins]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid] CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,037,218...52,131,789
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; HMOX1 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]] CTD PMID:20580034 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions
decreases expression
EXP epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 protein]; epigallocatechin gallate inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA]
epigallocatechin gallate results in decreased expression of VCAM1 mRNA
CTD PMID:22521609, PMID:23380242 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,908...117,511,226
JBrowse link
(24S)-24-hydroxycholesterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 affects localization
increases expression
EXP 24-hydroxycholesterol affects the localization of ABCA1 protein
24-hydroxycholesterol results in increased expression of ABCA1 mRNA
CTD PMID:16530456 NCBI chr 1:246,144,277...246,278,492
Ensembl chr 1:246,144,277...246,278,492
JBrowse link
G APOA1 apolipoprotein A1 multiple interactions
increases secretion
EXP 24-hydroxycholesterol promotes the reaction [APOA1 protein results in increased transport of Cholesterol]
24-hydroxycholesterol results in increased secretion of APOA1 protein
CTD PMID:16530456 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,393...44,218,978
JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 increases metabolic processing EXP CYP7A1 protein results in increased metabolism of 24-hydroxycholesterol CTD PMID:11013305 NCBI chr 4:74,343,101...74,372,628
Ensembl chr 4:74,342,856...74,372,638
JBrowse link
G LIPG lipase G, endothelial type decreases expression EXP 24-hydroxycholesterol results in decreased expression of LIPG mRNA; 24-hydroxycholesterol results in decreased expression of LIPG protein CTD PMID:15953354 NCBI chr 1:99,081,940...99,110,671
Ensembl chr 1:99,081,938...99,110,876
JBrowse link
G SCARB1 scavenger receptor class B member 1 affects localization EXP 24-hydroxycholesterol affects the localization of SCARB1 protein CTD PMID:16530456 NCBI chr14:28,301,421...28,393,568
Ensembl chr14:28,301,294...28,393,565
JBrowse link
(25R)-cholest-5-ene-3beta,26-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 increases metabolic processing EXP CYP7A1 protein results in increased metabolism of 27-hydroxycholesterol CTD PMID:10882719 NCBI chr 4:74,343,101...74,372,628
Ensembl chr 4:74,342,856...74,372,638
JBrowse link
(R)-lipoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:24512358 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
(S)-colchicine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMBP alpha-1-microglobulin/bikunin precursor decreases uptake EXP Colchicine results in decreased uptake of AMBP protein CTD PMID:9019736 NCBI chr 1:254,683,885...254,703,220
Ensembl chr 1:254,683,885...254,703,225
JBrowse link
(S)-nicotine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 multiple interactions EXP Nicotine inhibits the reaction [[Carbon Dioxide co-treated with Oxygen deficiency] results in decreased expression of ADCYAP1 protein] CTD PMID:28506824 NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,630...105,422,295
JBrowse link
G ADCYAP1R1 ADCYAP receptor type I decreases expression EXP Nicotine results in decreased expression of ADCYAP1R1 protein CTD PMID:28506824 NCBI chr18:41,915,180...41,972,327
Ensembl chr18:41,917,402...41,972,301
JBrowse link
G CHRNA2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA2 protein] CTD PMID:28235547 NCBI chr14:11,193,732...11,204,334
Ensembl chr14:11,191,842...11,207,381
JBrowse link
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA3 protein] CTD PMID:28235547 NCBI chr 7:47,361,710...47,382,743
Ensembl chr 7:47,361,778...47,384,303
JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA7 protein] CTD PMID:28235547 NCBI chr 1:142,803,697...142,937,124
Ensembl chr 1:142,803,698...142,937,788
JBrowse link
G CHRNA9 cholinergic receptor nicotinic alpha 9 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA9 protein] CTD PMID:28235547 NCBI chr 8:31,430,933...31,456,385
Ensembl chr 8:31,443,043...31,456,384
JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNB2 protein] CTD PMID:28235547 NCBI chr 4:95,196,992...95,211,084
Ensembl chr 4:95,198,717...95,211,037
JBrowse link
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP19A2 cytochrome P450 19A2 increases activity EXP o,p'-DDT results in increased activity of CYP19A1 protein CTD PMID:18195494 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G ESR2 estrogen receptor 2 decreases expression EXP o,p'-DDT results in decreased expression of ESR2 protein CTD PMID:18195494 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,722,164...193,906,565
JBrowse link
1,10-phenanthroline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANPEP alanyl aminopeptidase, membrane multiple interactions
decreases activity
EXP Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein] CTD PMID:17109655 NCBI chr 7:55,351,081...55,373,856
Ensembl chr 7:55,351,083...55,373,881
JBrowse link
G ENPEP glutamyl aminopeptidase multiple interactions EXP 1,10-phenanthroline inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame] CTD PMID:8141778 NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510
JBrowse link
1,3-benzothiazole-2-thiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TPO thyroid peroxidase decreases activity EXP captax results in decreased activity of TPO protein CTD PMID:23959146, PMID:25953703 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,408,943
JBrowse link
1,3-thiazolidine-2,4-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL6 interleukin 6 multiple interactions EXP 2,4-thiazolidinedione inhibits the reaction [Linoleic Acid results in increased expression of IL6 protein]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]] CTD PMID:14519784, PMID:15226458 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP 2,4-thiazolidinedione binds to and results in increased activity of PPARG protein CTD PMID:14519784 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,655...68,433,947
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP 2,4-thiazolidinedione inhibits the reaction [Linoleic Acid results in increased activity of RELA protein] CTD PMID:14519784 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,471
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP [2,4-thiazolidinedione co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]] CTD PMID:15226458 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]] CTD PMID:15226458 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,908...117,511,226
JBrowse link
1-(5-isoquinolinesulfonyl)-2-methylpiperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA] CTD PMID:7564105 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
1-chloro-2,4-dinitrobenzene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100739163 glutathione S-transferase P-like affects metabolic processing EXP GSTP1 protein affects the metabolism of Dinitrochlorobenzene CTD PMID:14573868 NCBI chr 2:4,978,761...4,982,233 JBrowse link
16,16-dimethylprostaglandin E2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 multiple interactions
increases expression
EXP 16,16-Dimethylprostaglandin E2 inhibits the reaction [Ibuprofen results in decreased expression of NOS3 mRNA]
16,16-Dimethylprostaglandin E2 results in increased expression of NOS3 mRNA
CTD PMID:10525081 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
17beta-estradiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACACA acetyl-CoA carboxylase alpha increases phosphorylation EXP Estradiol results in increased phosphorylation of ACACA protein CTD PMID:15967841 NCBI chr12:38,580,916...38,875,067
Ensembl chr12:38,581,449...38,875,134
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions
increases secretion
EXP Benzo(a)pyrene inhibits the reaction [ADIPOQ protein results in increased secretion of Estradiol]; bisphenol A promotes the reaction [ADIPOQ protein results in increased secretion of Estradiol]; Estradiol results in increased expression of and results in increased secretion of ADIPOQ protein; halowax 1051 inhibits the reaction [ADIPOQ protein results in increased secretion of Estradiol]; Hexachlorobenzene inhibits the reaction [ADIPOQ protein results in increased secretion of Estradiol] CTD PMID:28284726 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,684...124,646,648
JBrowse link
G ADIPOR1 adiponectin receptor 1 increases expression EXP Estradiol results in increased expression of ADIPOR1 protein CTD PMID:28284726 NCBI chr10:24,907,491...24,923,540 JBrowse link
G ADIPOR2 adiponectin receptor 2 increases expression EXP Estradiol results in increased expression of ADIPOR2 protein CTD PMID:28284726 NCBI chr 5:68,755,789...68,807,247
Ensembl chr 5:68,755,811...68,807,235
JBrowse link
G AKT1 AKT serine/threonine kinase 1 increases phosphorylation EXP Estradiol results in increased phosphorylation of AKT1 protein CTD PMID:17348974
G CD40 CD40 molecule affects expression EXP Estradiol affects the expression of CD40 protein CTD PMID:15964915 NCBI chr17:48,286,116...48,298,188
Ensembl chr17:48,286,029...48,298,528
JBrowse link
G CD40LG CD40 ligand affects expression EXP Estradiol affects the expression of CD40LG protein CTD PMID:15964915 NCBI chr  X:111,778,666...111,788,901
Ensembl chr  X:111,778,493...111,789,711
JBrowse link
G ESR1 estrogen receptor 1 decreases expression
affects expression
EXP Estradiol results in decreased expression of ESR1 protein; Estradiol results in decreased expression of ESR1 protein alternative form
Estradiol affects the expression of ESR1 protein
CTD PMID:15653758, PMID:16431846, PMID:16680078, PMID:17348974 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363
JBrowse link
G ESR2 estrogen receptor 2 affects expression EXP Estradiol affects the expression of ESR2 protein CTD PMID:15653758, PMID:16680078 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,722,164...193,906,565
JBrowse link
G F3 coagulation factor III, tissue factor affects expression EXP Estradiol affects the expression of F3 mRNA; Estradiol affects the expression of F3 protein CTD PMID:15964915 NCBI chr 4:122,827,018...122,837,673
Ensembl chr 4:122,826,992...122,837,672
JBrowse link
G FGF7 fibroblast growth factor 7 increases expression EXP Estradiol results in increased expression of FGF7 mRNA CTD PMID:15271478 NCBI chr 1:122,215,878...122,278,705
Ensembl chr 1:122,215,878...122,542,224
JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions
increases chemical synthesis
EXP [FSHB protein co-treated with IGF1 protein] results in increased abundance of Estradiol; deoxynivalenol affects the reaction [[FSHB protein co-treated with IGF1 protein] results in increased abundance of Estradiol]; lead acetate inhibits the reaction [FSHB protein results in increased chemical synthesis of Estradiol] CTD PMID:17656051, PMID:29273543 NCBI chr 2:30,395,769...30,399,282
Ensembl chr 2:30,395,018...30,399,274
JBrowse link
G HOXA10 homeobox A10 increases expression
multiple interactions
EXP Estradiol results in increased expression of HOXA10 mRNA
Estradiol promotes the reaction [Progesterone results in increased expression of HOXA10 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of HOXA10 mRNA]
CTD PMID:21705055 NCBI chr18:45,393,525...45,403,259
Ensembl chr18:45,393,712...45,403,257
JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions
increases abundance
EXP [FSHB protein co-treated with IGF1 protein] results in increased abundance of Estradiol; deoxynivalenol affects the reaction [[FSHB protein co-treated with IGF1 protein] results in increased abundance of Estradiol]; deoxynivalenol affects the reaction [IGF1 protein results in increased abundance of Estradiol]; Zearalenone affects the reaction [IGF1 protein results in increased abundance of Estradiol] CTD PMID:17656051 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,037
JBrowse link
G LEP leptin increases secretion
increases expression
EXP Estradiol results in increased secretion of LEP protein
Estradiol results in increased expression of LEP mRNA
CTD PMID:23153703 NCBI chr18:20,106,867...20,124,071
Ensembl chr18:20,106,868...20,123,447
JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions
increases secretion
EXP Biological Products inhibits the reaction [LHB protein results in increased secretion of Estradiol]; Cod Liver Oil inhibits the reaction [LHB protein results in increased secretion of Estradiol]; Industrial Waste inhibits the reaction [LHB protein results in increased secretion of Estradiol] CTD PMID:26055946 NCBI chr 6:54,263,574...54,269,286 JBrowse link
G MMP2 matrix metallopeptidase 2 affects secretion EXP Estradiol affects the secretion of MMP2 protein CTD PMID:15653758 NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,594...30,086,982
JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions
affects expression
increases phosphorylation
decreases expression
EXP Estradiol results in increased phosphorylation of and results in increased activity of NOS3 protein; Fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of NOS3 protein]
Estradiol affects the expression of NOS3 mRNA
Estradiol results in decreased expression of NOS3 mRNA
CTD PMID:15653758, PMID:15967841, PMID:16680078, PMID:17618301 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
G PDGFB platelet derived growth factor subunit B multiple interactions EXP Estradiol affects the secretion of [PDGFB protein binds to PDGFB protein] CTD PMID:15653758 Ensembl chr 5:8,986,461...9,007,446 JBrowse link
G PGR progesterone receptor increases expression EXP Estradiol results in increased expression of PGR mRNA CTD PMID:16431846 NCBI chr 9:32,035,684...32,129,776
Ensembl chr 9:32,035,684...32,129,221
JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP Estradiol results in increased phosphorylation of and results in increased activity of PRKAA1 protein CTD PMID:15967841 NCBI chr16:25,745,902...25,783,524
Ensembl chr16:25,745,321...25,783,610
JBrowse link
G PRLR prolactin receptor increases expression EXP Estradiol results in increased expression of PRLR protein alternative form CTD PMID:18492821 NCBI chr16:20,637,568...20,655,881
Ensembl chr16:20,618,875...20,810,140
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP Estradiol results in increased expression of PTGS2 mRNA
Fulvestrant inhibits the reaction [Estradiol results in increased expression of PTGS2 mRNA]
CTD PMID:21705055 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
G SPP1 secreted phosphoprotein 1 decreases expression EXP Estradiol results in decreased expression of SPP1 protein CTD PMID:15713688 NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340
JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b increases expression EXP Estradiol results in increased expression of TNFRSF11B protein CTD PMID:15713688 NCBI chr 4:19,850,212...19,879,132 JBrowse link
17beta-estradiol 3-benzoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGF7 fibroblast growth factor 7 affects expression EXP estradiol 3-benzoate affects the expression of FGF7 mRNA CTD PMID:15976484 NCBI chr 1:122,215,878...122,278,705
Ensembl chr 1:122,215,878...122,542,224
JBrowse link
G FGFR2 fibroblast growth factor receptor 2 decreases expression
multiple interactions
EXP estradiol 3-benzoate results in decreased expression of FGFR2 mRNA alternative form
[Progesterone co-treated with estradiol 3-benzoate] results in decreased expression of FGFR2 mRNA alternative form
CTD PMID:15976484 NCBI chr14:131,183,095...131,285,001
Ensembl chr14:131,181,710...131,579,703
JBrowse link
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 multiple interactions EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [ADCYAP1 protein alternative form results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] CTD PMID:14662737 NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,630...105,422,295
JBrowse link
G GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions
increases degradation
EXP BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1A1 protein] CTD PMID:19466990 NCBI chr 8:44,448,758...44,520,737
Ensembl chr 8:44,449,232...44,518,135
JBrowse link
G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 increases degradation
multiple interactions
EXP 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1B1 protein
BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1B1 protein]
CTD PMID:19466990 NCBI chr 8:44,544,364...44,604,690
Ensembl chr 8:44,544,179...44,604,704
JBrowse link
2,2',4,4',5,5'-hexachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 decreases activity EXP 2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CYP11A1 protein CTD PMID:16151981 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
G CYP19A2 cytochrome P450 19A2 multiple interactions
decreases activity
EXP [2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Testosterone] affects the activity of CYP19A1 protein
2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CYP19A1 protein
CTD PMID:16151981 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 multiple interactions
decreases activity
EXP [2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Androstenedione] results in increased activity of HSD17B1 protein
2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of HSD17B1 protein
CTD PMID:16151981 NCBI chr12:20,269,468...20,271,349
Ensembl chr12:20,269,056...20,279,569
JBrowse link
2,2',4,4'-Tetrabromodiphenyl ether term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions EXP 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [ADIPOQ protein results in increased expression of CYP19A1 protein]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [ADIPOQ protein results in increased secretion of Testosterone]; 2,2',4,4'-tetrabromodiphenyl ether results in increased expression of and results in increased secretion of ADIPOQ protein CTD PMID:28284726 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,684...124,646,648
JBrowse link
G ADIPOR1 adiponectin receptor 1 increases expression EXP 2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ADIPOR1 protein CTD PMID:28284726 NCBI chr10:24,907,491...24,923,540 JBrowse link
G ADIPOR2 adiponectin receptor 2 increases expression EXP 2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ADIPOR2 protein CTD PMID:28284726 NCBI chr 5:68,755,789...68,807,247
Ensembl chr 5:68,755,811...68,807,235
JBrowse link
G COMT catechol-O-methyltransferase increases activity EXP 2,2',4,4'-tetrabromodiphenyl ether results in increased activity of COMT protein CTD PMID:22750137 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,133...51,403,998
JBrowse link
G CYP19A2 cytochrome P450 19A2 increases expression
multiple interactions
EXP 2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of CYP19A1 mRNA; 2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYP19A1 protein
2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of and results in increased activity of CYP19A1 protein; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [ADIPOQ protein results in increased expression of CYP19A1 protein]; Fadrozole inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of and results in increased activity of CYP19A1 protein]
CTD PMID:23146758, PMID:28284726 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G ESR1 estrogen receptor 1 increases expression EXP 2,2',4,4'-tetrabromodiphenyl ether metabolite results in increased expression of ESR1 mRNA; 2,2',4,4'-tetrabromodiphenyl ether metabolite results in increased expression of ESR1 protein CTD PMID:24956591 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363
JBrowse link
G ESR2 estrogen receptor 2 increases expression
decreases expression
EXP 2,2',4,4'-tetrabromodiphenyl ether metabolite results in increased expression of ESR2 mRNA; 2,2',4,4'-tetrabromodiphenyl ether metabolite results in increased expression of ESR2 protein
2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ESR2 mRNA; 2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ESR2 protein
CTD PMID:24956591 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,722,164...193,906,565
JBrowse link
G HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 increases expression EXP 2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HSD17B1 protein CTD PMID:21871953 NCBI chr12:20,269,468...20,271,349
Ensembl chr12:20,269,056...20,279,569
JBrowse link
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP19A2 cytochrome P450 19A2 increases activity EXP 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased activity of CYP19A1 protein CTD PMID:18195494 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G ESR2 estrogen receptor 2 decreases expression EXP 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in decreased expression of ESR2 protein CTD PMID:18195494 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,722,164...193,906,565
JBrowse link
2,3,7,8-tetrachlorodibenzodioxine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor decreases expression
increases expression
affects localization
EXP Tetrachlorodibenzodioxin results in decreased expression of AHR mRNA
Tetrachlorodibenzodioxin results in increased expression of AHR protein
Tetrachlorodibenzodioxin affects the localization of AHR protein
CTD PMID:16431846, PMID:16552988 NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 increases expression EXP Tetrachlorodibenzodioxin results in increased expression of CCL2 mRNA CTD PMID:19265715 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G CTSB cathepsin B decreases expression EXP Tetrachlorodibenzodioxin results in decreased expression of CTSB mRNA CTD PMID:16291828 NCBI chr14:15,014,139...15,035,081
Ensembl chr14:15,011,711...15,034,737
JBrowse link
G CYP1A1 cytochrome P450 1A1 increases expression EXP Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA; Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein CTD PMID:16291828, PMID:16431846 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,780,105...58,809,755
JBrowse link
G ESR1 estrogen receptor 1 decreases expression EXP Tetrachlorodibenzodioxin results in decreased expression of ESR1 mRNA; Tetrachlorodibenzodioxin results in decreased expression of ESR1 protein CTD PMID:16431846 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363
JBrowse link
G SLC5A5 solute carrier family 5 member 5 decreases expression EXP Tetrachlorodibenzodioxin results in decreased expression of SLC5A5 mRNA CTD PMID:16291828 NCBI chr 2:59,869,157...59,885,086
Ensembl chr 2:59,869,154...59,885,265
JBrowse link
2,3-dimethoxynaphthalene-1,4-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP 2,3-dimethoxy-1,4-naphthoquinone inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; 2,3-dimethoxy-1,4-naphthoquinone inhibits the reaction [TNF protein results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,181...190,674,850
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP 2,3-dimethoxy-1,4-naphthoquinone inhibits the reaction [TNF protein results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G TPO thyroid peroxidase decreases activity EXP 2,3-dimethoxy-1,4-naphthoquinone results in decreased activity of TPO protein CTD PMID:11815678 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,408,943
JBrowse link
2,4-dinitrophenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMBP alpha-1-microglobulin/bikunin precursor decreases uptake EXP 2,4-Dinitrophenol results in decreased uptake of AMBP protein CTD PMID:9019736 NCBI chr 1:254,683,885...254,703,220
Ensembl chr 1:254,683,885...254,703,225
JBrowse link
G NOS3 nitric oxide synthase 3 increases expression EXP 2,4-Dinitrophenol results in increased expression of NOS3 mRNA CTD PMID:11382920 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
2,6-di-tert-butyl-4-methylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCLC glutamate-cysteine ligase catalytic subunit increases expression EXP Butylated Hydroxytoluene results in increased expression of GCLC mRNA CTD PMID:9535746 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,564...27,253,535
JBrowse link
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 multiple interactions EXP Verapamil inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines] CTD PMID:21056966 NCBI chr 9:93,171,371...93,262,124 JBrowse link
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 multiple interactions EXP Itraconazole inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines] CTD PMID:21056966 NCBI chr 9:93,171,371...93,262,124 JBrowse link
2-isobutyl-3-methoxypyrazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G OBP odorant binding protein affects binding EXP 2-isobutyl-3-methoxypyrazine binds to OBP protein CTD PMID:10825538 NCBI chr  X:2,012,066...2,019,074
NCBI chr  Y:1,145,927...1,179,835
Ensembl chr  X:2,012,032...2,019,488
JBrowse link
20-hydroxycholesterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 increases metabolic processing EXP CYP7A1 protein results in increased metabolism of 20-hydroxycholesterol CTD PMID:10882719 NCBI chr 4:74,343,101...74,372,628
Ensembl chr 4:74,342,856...74,372,638
JBrowse link
25-hydroxycholesterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 increases metabolic processing EXP CYP7A1 protein results in increased metabolism of 25-hydroxycholesterol CTD PMID:10882719 NCBI chr 4:74,343,101...74,372,628
Ensembl chr 4:74,342,856...74,372,638
JBrowse link
26-hydroxycholesterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 increases metabolic processing EXP CYP7A1 protein results in increased metabolism of 27-hydroxycholesterol CTD PMID:10882719 NCBI chr 4:74,343,101...74,372,628
Ensembl chr 4:74,342,856...74,372,638
JBrowse link
3',5'-cyclic AMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7B ATPase copper transporting beta multiple interactions EXP Cyclic AMP inhibits the reaction [Copper binds to ATP7B protein] CTD PMID:21084060 NCBI chr11:15,892,549...15,942,070 JBrowse link
G CALCB calcitonin-related polypeptide beta increases abundance EXP CALCA protein results in increased abundance of Cyclic AMP CTD PMID:18463244 NCBI chr 2:44,043,135...44,048,651 JBrowse link
G DUOX2 dual oxidase 2 increases expression EXP Cyclic AMP results in increased expression of DUOX2 mRNA CTD PMID:10601291 NCBI chr 1:126,620,468...126,641,406
Ensembl chr 1:126,620,477...126,641,419
JBrowse link
G GCG glucagon affects response to substance
increases abundance
EXP Cyclic AMP affects the susceptibility to GCG protein
GCG protein results in increased abundance of Cyclic AMP
CTD PMID:6253273 NCBI chr15:68,800,557...68,810,268
Ensembl chr15:68,800,561...68,810,244
JBrowse link
G GNRH1 gonadotropin releasing hormone 1 multiple interactions
increases abundance
EXP [Cobalt binds to GNRH1 protein] which results in increased abundance of Cyclic AMP
GNRH1 protein results in increased abundance of Cyclic AMP
CTD PMID:15833593 NCBI chr14:9,442,971...9,447,521
Ensembl chr14:9,442,971...9,447,521
JBrowse link
3',5'-cyclic GMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDE5A phosphodiesterase 5A increases degradation EXP PDE5 protein results in increased degradation of Cyclic GMP CTD PMID:18669600 NCBI chr 8:104,270,858...104,420,955
Ensembl chr 8:104,270,881...104,420,947
JBrowse link
G PDE6C phosphodiesterase 6C increases degradation EXP PDE6C protein results in increased degradation of Cyclic GMP CTD PMID:18669600 NCBI chr14:105,010,974...105,122,628
Ensembl chr14:105,011,922...105,037,498
Ensembl chr14:105,011,922...105,037,498
JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 increases activity EXP Cyclic GMP results in increased activity of PRKG1 protein CTD PMID:18037907 NCBI chr14:97,558,531...98,793,080
Ensembl chr14:97,560,785...98,793,318
JBrowse link
3,3',4,4',5-pentachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor increases expression
multiple interactions
increases activity
EXP 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of AHR protein
epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased activity of AHR protein]
CTD PMID:16552988, PMID:22521609 NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943
JBrowse link
G CAV1 caveolin 1 multiple interactions EXP CAV1 mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]; CAV1 mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA]; CAV1 mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 protein]; CAV1 mutant form promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NQO1 mRNA] CTD PMID:19265715, PMID:20406653, PMID:24709675 NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 increases expression
multiple interactions
EXP 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA; 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 protein
CAV1 mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 protein]; NFE2L2 protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]
CTD PMID:19265715, PMID:22521609 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G CTSB cathepsin B decreases expression EXP 3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CTSB mRNA CTD PMID:16291828 NCBI chr14:15,014,139...15,035,081
Ensembl chr14:15,011,711...15,034,737
JBrowse link
G CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 decreases activity EXP 3,4,5,3',4'-pentachlorobiphenyl results in decreased activity of CYP11A1 protein CTD PMID:16151981 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
G CYP19A2 cytochrome P450 19A2 increases activity
multiple interactions
EXP 3,4,5,3',4'-pentachlorobiphenyl results in increased activity of CYP19A1 protein
[3,4,5,3',4'-pentachlorobiphenyl co-treated with Testosterone] results in increased activity of CYP19A1 protein
CTD PMID:16151981 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G CYP1A1 cytochrome P450 1A1 multiple interactions
increases expression
EXP epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 protein]; NFE2L2 protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA]; Quercetin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 protein]
3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA; 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 protein
CTD PMID:16291828, PMID:19608276, PMID:22521609 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,780,105...58,809,755
JBrowse link
G GSTO1 glutathione S-transferase omega 1 multiple interactions EXP [epigallocatechin gallate co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of GSTO1 mRNA CTD PMID:22521609 NCBI chr14:115,206,434...115,216,624
Ensembl chr14:115,206,188...115,216,613
JBrowse link
G HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 decreases activity EXP 3,4,5,3',4'-pentachlorobiphenyl results in decreased activity of HSD17B1 protein CTD PMID:16151981 NCBI chr12:20,269,468...20,271,349
Ensembl chr12:20,269,056...20,279,569
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 3,4,5,3',4'-pentachlorobiphenyl results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:20406653 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 3,4,5,3',4'-pentachlorobiphenyl results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:20406653 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions EXP NFE2L2 protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]; NFE2L2 protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA]; NFE2L2 protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA] CTD PMID:22521609 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
EXP 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NQO1 mRNA
[epigallocatechin gallate co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of NQO1 mRNA; CAV1 mutant form promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NQO1 mRNA]
CTD PMID:22521609, PMID:24709675 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,769...17,302,590
JBrowse link
G SLC5A5 solute carrier family 5 member 5 decreases expression EXP 3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SLC5A5 mRNA CTD PMID:16291828 NCBI chr 2:59,869,157...59,885,086
Ensembl chr 2:59,869,154...59,885,265
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA]; CAV1 mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA]; CAV1 mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 protein]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 protein]; NFE2L2 protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA]
3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA; 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 protein
CTD PMID:20406653, PMID:22521609, PMID:24709675 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,908...117,511,226
JBrowse link
3,3',4,4'-tetrachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP 3,4,3',4'-tetrachlorobiphenyl affects the localization of and results in increased activity of AHR protein; [alpha-naphthoflavone co-treated with 3,4,3',4'-tetrachlorobiphenyl] results in increased activity of AHR protein; epigallocatechin gallate inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl affects the localization of and results in increased activity of AHR protein]; epigallocatechin gallate inhibits the reaction [[alpha-naphthoflavone co-treated with 3,4,3',4'-tetrachlorobiphenyl] results in increased activity of AHR protein]; Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl affects the localization of and results in increased activity of AHR protein] CTD PMID:12970578 NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943
JBrowse link
G CAV1 caveolin 1 multiple interactions EXP 3,4,3',4'-tetrachlorobiphenyl results in increased expression of and results in increased phosphorylation of CAV1 protein; CAV1 mutant form inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of VCAM1 protein]; Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of and results in increased phosphorylation of CAV1 protein] CTD PMID:19608276, PMID:20406653 NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 increases secretion
increases expression
multiple interactions
EXP 3,4,3',4'-tetrachlorobiphenyl results in increased secretion of CCL2 protein
3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA
[2,2'-azobis(2-amidinopropane) results in increased oxidation of Docosahexaenoic Acids] inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; [2,2'-azobis(2-amidinopropane) results in increased oxidation of Docosahexaenoic Acids] inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 protein]; [2,2'-azobis(2-amidinopropane) results in increased oxidation of Eicosapentaenoic Acid] inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; [2,2'-azobis(2-amidinopropane) results in increased oxidation of Eicosapentaenoic Acid] inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 protein]; Acetylcysteine inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; alpha-naphthoflavone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; pyrazolanthrone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; sodium borohydride inhibits the reaction [[2,2'-azobis(2-amidinopropane) results in increased oxidation of Docosahexaenoic Acids] inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]]; sulforafan inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; Tretinoin promotes the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 protein]
CTD PMID:19265715, PMID:21130106 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G CYP1A1 cytochrome P450 1A1 increases activity
increases expression
multiple interactions
EXP 3,4,3',4'-tetrachlorobiphenyl results in increased activity of CYP1A1 protein
3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA; 3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 protein
alpha-naphthoflavone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased activity of CYP1A1 protein]; epigallocatechin gallate inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA]; Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased activity of CYP1A1 protein]; Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA]; Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 protein]
CTD PMID:12970578, PMID:19608276 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,780,105...58,809,755
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased phosphorylation of MAPK1 protein] CTD PMID:20406653 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased phosphorylation of MAPK3 protein] CTD PMID:20406653 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit increases activity
multiple interactions
EXP 3,4,3',4'-tetrachlorobiphenyl results in increased activity of RELA protein
[2,2'-azobis(2-amidinopropane) results in increased oxidation of Docosahexaenoic Acids] inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased activity of RELA protein]
CTD PMID:21130106 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,471
JBrowse link
G SELE selectin E increases expression
multiple interactions
EXP 3,4,3',4'-tetrachlorobiphenyl results in increased expression of SELE mRNA
Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of SELE mRNA]
CTD PMID:19608276 NCBI chr 4:81,289,061...81,299,657 JBrowse link
G SELP selectin P multiple interactions
increases expression
EXP Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of SELP mRNA] CTD PMID:19608276 NCBI chr 4:81,376,804...81,401,240
Ensembl chr 4:81,365,740...81,406,203
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of VCAM1 mRNA]; CAV1 mutant form inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of VCAM1 protein]; Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of VCAM1 mRNA]
3,4,3',4'-tetrachlorobiphenyl results in increased expression of VCAM1 mRNA; 3,4,3',4'-tetrachlorobiphenyl results in increased expression of VCAM1 protein
CTD PMID:19608276, PMID:20406653 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,908...117,511,226
JBrowse link
3,3',5,5'-tetrabromobisphenol A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGO2 argonaute RISC catalytic component 2 decreases expression
multiple interactions
EXP tetrabromobisphenol A results in decreased expression of AGO2 protein
[tetrabromobisphenol A co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] results in decreased expression of AGO2 protein
CTD PMID:31266599 NCBI chr 4:2,966,794...3,012,388
Ensembl chr 4:2,919,529...3,015,367
JBrowse link
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 decreases activity EXP tetrabromobisphenol A results in decreased activity of ATP2A2 protein CTD PMID:17784851 NCBI chr14:31,674,659...31,744,981
Ensembl chr14:31,674,757...31,744,973
JBrowse link
G ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 decreases activity EXP tetrabromobisphenol A results in decreased activity of ATP2A3 protein CTD PMID:17784851 NCBI chr12:49,980,488...50,014,006
Ensembl chr12:49,980,490...50,025,171
JBrowse link
G DICER1 dicer 1, ribonuclease III decreases expression
multiple interactions
EXP tetrabromobisphenol A results in decreased expression of DICER1 mRNA; tetrabromobisphenol A results in decreased expression of DICER1 protein
[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with tetrabromobisphenol A] results in decreased expression of DICER1 mRNA; [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with tetrabromobisphenol A] results in decreased expression of DICER1 protein
CTD PMID:31266599 NCBI chr 7:116,361,630...116,436,471
Ensembl chr 7:116,361,630...116,436,519
JBrowse link
G DROSHA drosha ribonuclease III increases expression EXP tetrabromobisphenol A results in increased expression of DROSHA mRNA CTD PMID:31266599 NCBI chr16:17,727,695...17,847,954
Ensembl chr16:17,565,137...17,848,073
JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 decreases expression
multiple interactions
EXP tetrabromobisphenol A results in decreased expression of GPER1 protein
[tetrabromobisphenol A co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] results in decreased expression of GPER1 protein
CTD PMID:31266599 NCBI chr 3:711,427...715,982
Ensembl chr 3:712,160...715,982
JBrowse link
G LOC100623720 collagen alpha-1(VI) chain increases expression
multiple interactions
EXP tetrabromobisphenol A results in increased expression of COL6A1 protein
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [tetrabromobisphenol A results in increased expression of COL6A1 protein]; tetrabromobisphenol A inhibits the reaction [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline results in decreased expression of COL6A1 protein]
CTD PMID:31266599 NCBI chr13:208,295,245...208,321,789
Ensembl chr13:208,295,240...208,313,127
JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions
increases expression
EXP [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with tetrabromobisphenol A] results in increased expression of MAP1LC3B protein
tetrabromobisphenol A results in increased expression of MAP1LC3B protein
CTD PMID:31266599 NCBI chr 6:1,919,879...1,941,069
Ensembl chr 6:1,915,387...1,941,077
JBrowse link
G PLIN1 perilipin 1 multiple interactions
increases expression
EXP [tetrabromobisphenol A co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] results in increased expression of PLIN1 protein
tetrabromobisphenol A results in increased expression of PLIN1 protein
CTD PMID:31266599 NCBI chr 7:55,237,517...55,250,797
Ensembl chr 7:55,235,426...55,250,797
JBrowse link
G XPO5 exportin 5 multiple interactions
decreases expression
EXP [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with tetrabromobisphenol A] results in decreased expression of XPO5 mRNA; [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with tetrabromobisphenol A] results in decreased expression of XPO5 protein
tetrabromobisphenol A results in decreased expression of XPO5 protein
CTD PMID:31266599 NCBI chr 7:38,530,704...38,569,558
Ensembl chr 7:38,530,725...38,569,570
JBrowse link
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5AP arachidonate 5-lipoxygenase activating protein multiple interactions EXP MK-886 inhibits the reaction [aristolochic acid I results in increased expression of ALOX5AP protein] CTD PMID:21658425 NCBI chr11:7,371,328...7,438,111
Ensembl chr11:7,411,644...7,438,108
JBrowse link
G CASP3 caspase 3 multiple interactions EXP MK-886 inhibits the reaction [aristolochic acid I results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:21658425 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP bisindolylmaleimide I inhibits the reaction [sodium arsenite results in increased expression of HIF1A mRNA] CTD PMID:15089098 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,181...190,674,850
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP bisindolylmaleimide I inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA] CTD PMID:15089098 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,038
JBrowse link
3-methyladenine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BAX mRNA] CTD PMID:28803810 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G BECN1 beclin 1 multiple interactions EXP 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BECN1 protein] CTD PMID:28803810 NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373
JBrowse link
G CASP3 caspase 3 multiple interactions EXP 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein] CTD PMID:28803810, PMID:30287338 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CASP8 caspase 8 multiple interactions EXP 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP8 protein] CTD PMID:28803810 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,470
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of CYCS mRNA] CTD PMID:28803810 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP 3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein] CTD PMID:30287338 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,159...14,241,197
JBrowse link
G SQSTM1 sequestosome 1 multiple interactions EXP 3-methyladenine inhibits the reaction [Zinc Sulfate results in decreased expression of SQSTM1 protein] CTD PMID:28803810 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,768...78,784,256
JBrowse link
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC4A2 solute carrier family 4 member 2 multiple interactions EXP 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid promotes the reaction [SLC4A2 protein binds to SLC4A2 protein] CTD PMID:10387099 NCBI chr18:6,149,459...6,166,622
Ensembl chr18:6,149,458...6,165,212
JBrowse link
4,4'-sulfonyldiphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP19A2 cytochrome P450 19A2 decreases expression
affects expression
EXP bis(4-hydroxyphenyl)sulfone results in decreased expression of CYP19A1 mRNA
bis(4-hydroxyphenyl)sulfone affects the expression of CYP19A1 protein
CTD PMID:28352085 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G ESR1 estrogen receptor 1 decreases expression
increases expression
EXP bis(4-hydroxyphenyl)sulfone results in decreased expression of ESR1 mRNA
bis(4-hydroxyphenyl)sulfone results in increased expression of ESR1 protein
CTD PMID:28352085 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363
JBrowse link
G ESR2 estrogen receptor 2 increases expression
decreases expression
EXP bis(4-hydroxyphenyl)sulfone results in increased expression of ESR2 protein
bis(4-hydroxyphenyl)sulfone results in decreased expression of ESR2 mRNA
CTD PMID:28352085 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,722,164...193,906,565
JBrowse link
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP19A2 cytochrome P450 19A2 multiple interactions EXP Fadrozole inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of and results in increased activity of CYP19A1 protein] CTD PMID:23146758 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
4-methylumbelliferone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD44 CD44 molecule decreases expression EXP Hymecromone results in decreased expression of CD44 mRNA CTD PMID:23139787 NCBI chr 2:25,788,699...25,884,209
Ensembl chr 2:25,788,704...25,884,153
JBrowse link
G FBN1 fibrillin 1 decreases expression EXP Hymecromone results in decreased expression of FBN1 mRNA CTD PMID:23139787 NCBI chr 1:123,102,011...123,359,649
Ensembl chr 1:123,102,009...123,359,649
JBrowse link
G FN1 fibronectin 1 decreases expression EXP Hymecromone results in decreased expression of FN1 mRNA; Hymecromone results in decreased expression of FN1 protein CTD PMID:23139787 NCBI chr15:117,658,158...117,737,145
Ensembl chr15:117,658,099...117,731,014
JBrowse link
G TNC tenascin C decreases expression EXP Hymecromone results in decreased expression of TNC mRNA CTD PMID:23139787 NCBI chr 1:255,533,235...255,630,381
Ensembl chr 1:255,532,449...255,630,377
JBrowse link
G VCAN versican decreases expression EXP Hymecromone results in decreased expression of VCAN mRNA; Hymecromone results in decreased expression of VCAN protein CTD PMID:23139787 NCBI chr 2:91,682,177...91,811,674
Ensembl chr 2:91,358,399...91,811,208
JBrowse link
4-nitrocatechol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 multiple interactions EXP 2-aminoacetophenone inhibits the reaction [[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]; [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol; Skatole inhibits the reaction [[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol] CTD PMID:30599194 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,818
JBrowse link
4-nitrophenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 multiple interactions
increases hydroxylation
EXP 2-aminoacetophenone inhibits the reaction [[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]; 2-aminoacetophenone inhibits the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]; [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol; Skatole inhibits the reaction [[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]; Skatole inhibits the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] CTD PMID:30599194 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,818
JBrowse link
5-(2-methylpiperazine-1-sulfonyl)isoquinoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA] CTD PMID:7564105 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
5-aza-2'-deoxycytidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DNMT1 DNA methyltransferase 1 multiple interactions EXP Decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 protein] CTD PMID:29080797, PMID:30923867 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,564...69,029,919
JBrowse link
G JAK2 Janus kinase 2 multiple interactions
decreases phosphorylation
EXP Decitabine inhibits the reaction [ochratoxin A results in increased phosphorylation of JAK2 protein]
Decitabine results in decreased phosphorylation of JAK2 protein
CTD PMID:30923867 NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,686...217,002,148
JBrowse link
G LOC100522201 histone H2AX multiple interactions EXP Decitabine inhibits the reaction [ochratoxin A results in increased expression of H2AX protein] CTD PMID:30923867 NCBI chr 9:46,308,824...46,310,494
Ensembl chr 9:46,309,653...46,310,084
JBrowse link
G NEIL1 nei like DNA glycosylase 1 multiple interactions
increases expression
EXP Decitabine inhibits the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]
Decitabine results in increased expression of NEIL1 mRNA
CTD PMID:30923867 NCBI chr 7:58,261,761...58,269,001
Ensembl chr 7:58,261,761...58,283,092
JBrowse link
G NEIL3 nei like DNA glycosylase 3 multiple interactions
increases expression
EXP Decitabine inhibits the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]
Decitabine results in increased expression of NEIL3 mRNA
CTD PMID:30923867 NCBI chr15:39,416,073...39,632,313
Ensembl chr15:39,581,856...39,632,310
JBrowse link
G OGG1 8-oxoguanine DNA glycosylase increases expression
multiple interactions
EXP Decitabine results in increased expression of OGG1 mRNA
Decitabine inhibits the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]
CTD PMID:30923867 NCBI chr13:66,038,669...66,045,478 JBrowse link
G SOCS3 suppressor of cytokine signaling 3 multiple interactions EXP Decitabine promotes the reaction [ochratoxin A results in increased expression of SOCS3 mRNA]; Decitabine promotes the reaction [ochratoxin A results in increased expression of SOCS3 protein] CTD PMID:30923867 NCBI chr12:3,643,832...3,647,015
Ensembl chr12:3,643,929...3,647,012
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions EXP Decitabine inhibits the reaction [ochratoxin A results in increased phosphorylation of STAT3 protein] CTD PMID:30923867 NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,993
JBrowse link
5-methyl-pyrazole-3-carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DAO D-amino acid oxidase decreases activity EXP 5-methylpyrazole-3-carboxylic acid results in decreased activity of DAO protein CTD PMID:20952482 NCBI chr14:41,931,549...41,950,628
Ensembl chr14:41,929,215...41,950,633
JBrowse link
6-anilino-5,8-quinolinedione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SOD1 superoxide dismutase 1 multiple interactions EXP SOD1 protein affects the susceptibility to [Ditiocarb co-treated with 6-anilino-5,8-quinolinedione] CTD PMID:11861319 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
6-propyl-2-thiouracil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TPO thyroid peroxidase decreases activity EXP Propylthiouracil results in decreased activity of TPO protein CTD PMID:23959146 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,408,943
JBrowse link
6beta-hydroxytestosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A29 cytochrome P450 3A29 increases chemical synthesis
multiple interactions
EXP CYP3A29 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone
Ketoconazole inhibits the reaction [CYP3A29 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Troleandomycin inhibits the reaction [CYP3A29 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]
CTD PMID:20863320 NCBI chr 3:6,738,502...6,778,121 JBrowse link
7,12-dimethyltetraphene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 1A1 multiple interactions EXP 7-ketocholesterol inhibits the reaction [[Benzo(a)pyrene co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of CYP1A1 protein]; [Benzo(a)pyrene co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of CYP1A1 protein CTD PMID:11042205 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,780,105...58,809,755
JBrowse link
7-ketocholesterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 1A1 multiple interactions EXP 7-ketocholesterol inhibits the reaction [[Benzo(a)pyrene co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of CYP1A1 protein] CTD PMID:11042205 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,780,105...58,809,755
JBrowse link
acetylsalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Aspirin inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA5 protein] CTD PMID:20665602 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G PLA2G1B phospholipase A2 group IB multiple interactions EXP Aspirin promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,444...40,322,319
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Aspirin promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
acifluorfen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPOX protoporphyrinogen oxidase decreases activity EXP acifluorfen results in decreased activity of PPOX protein CTD PMID:7697001 NCBI chr 4:89,277,984...89,288,946
Ensembl chr 4:89,277,117...89,288,902
JBrowse link
adenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYL9 myosin light chain 9 decreases phosphorylation
multiple interactions
EXP Adenosine results in decreased phosphorylation of MYL9 protein
8-phenyltheophylline inhibits the reaction [Adenosine results in decreased phosphorylation of MYL9 protein]
CTD PMID:10942722 NCBI chr17:39,788,165...39,795,240
Ensembl chr17:39,788,199...39,795,296
JBrowse link
ageladine A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CSNK1A1 casein kinase 1 alpha 1 decreases activity
affects activity
EXP Ageladine A analog results in decreased activity of CSNK1A1 protein
Ageladine A affects the activity of CSNK1A1 protein
CTD PMID:21413800 NCBI chr 2:150,612,845...150,662,431
Ensembl chr 2:150,612,844...150,662,351
JBrowse link
alachlor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C49 cytochrome P450 2C49 decreases response to substance EXP CYP2C49 protein results in decreased susceptibility to alachlor CTD PMID:16315095 NCBI chr14:106,571,803...106,612,082 JBrowse link
aldosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen multiple interactions
increases secretion
EXP 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer inhibits the reaction [AGT protein results in increased secretion of Aldosterone]; Enkephalin, D-Penicillamine (2,5)- inhibits the reaction [AGT protein results in increased secretion of Aldosterone] CTD PMID:22100847 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428
JBrowse link
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 increases expression EXP Aldosterone results in increased expression of ATP1A1 protein CTD PMID:28438630 NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,506...104,384,606
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression EXP Aldosterone results in increased expression of GCLC protein CTD PMID:24512358 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,564...27,253,535
JBrowse link
G HMOX1 heme oxygenase 1 increases expression EXP Aldosterone results in increased expression of HMOX1 protein CTD PMID:24512358
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; acetovanillone inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; Aldosterone results in increased expression of and results in increased activity of NFE2L2 protein; diphenyleneiodonium inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; Eplerenone inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; Ro 32-0432 inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; tempol inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; W 7 inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:24512358 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
G SOD1 superoxide dismutase 1 increases expression EXP Aldosterone results in increased expression of SOD1 protein CTD PMID:24512358 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression EXP Aldosterone results in increased expression of TXNRD1 protein CTD PMID:24512358 NCBI chr 5:80,170,334...80,213,889
Ensembl chr 5:80,168,523...80,288,075
JBrowse link
alfacalcidol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2D25 vitamin D3 25-Hydroxylase increases hydroxylation EXP CYP2D25 protein results in increased hydroxylation of alfacalcidol CTD PMID:11880238 NCBI chr 5:6,539,021...6,543,643
Ensembl chr 5:6,538,907...6,543,643
JBrowse link
alpha-mangostin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TP53 tumor protein p53 multiple interactions EXP mangostin inhibits the reaction [Cisplatin results in increased expression of TP53] CTD PMID:20603111 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819
JBrowse link
alpha-naphthoflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions
increases activity
EXP [alpha-naphthoflavone co-treated with 3,4,3',4'-tetrachlorobiphenyl] results in increased activity of AHR protein; epigallocatechin gallate inhibits the reaction [[alpha-naphthoflavone co-treated with 3,4,3',4'-tetrachlorobiphenyl] results in increased activity of AHR protein]; epigallocatechin gallate inhibits the reaction [alpha-naphthoflavone results in increased activity of AHR protein] CTD PMID:12970578 NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions EXP alpha-naphthoflavone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA] CTD PMID:19265715 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G CYP1A1 cytochrome P450 1A1 multiple interactions
increases expression
decreases activity
EXP alpha-naphthoflavone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA]
alpha-naphthoflavone results in increased expression of CYP1A1 mRNA
alpha-naphthoflavone results in decreased activity of CYP1A1 protein
CTD PMID:12970578 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,780,105...58,809,755
JBrowse link
alternariol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 decreases expression EXP alternariol results in decreased expression of CYP11A1 protein CTD PMID:19429235 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
ambrisentan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 decreases expression EXP ambrisentan results in decreased expression of EDN1 mRNA; ambrisentan results in decreased expression of EDN1 protein CTD PMID:16364719 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
G EDNRA endothelin receptor type A decreases expression EXP ambrisentan results in decreased expression of EDNRA mRNA CTD PMID:16364719 NCBI chr 8:81,210,750...81,279,053
Ensembl chr 8:81,209,327...81,276,853
JBrowse link
G IL6 interleukin 6 decreases expression EXP ambrisentan results in decreased expression of IL6 mRNA CTD PMID:16364719 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G LOC110258578 interleukin-1 beta-like decreases expression EXP ambrisentan results in decreased expression of IL1B mRNA CTD PMID:16364719
G NOS3 nitric oxide synthase 3 decreases expression EXP ambrisentan results in decreased expression of NOS3 mRNA CTD PMID:16364719 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
G TNF tumor necrosis factor decreases expression EXP ambrisentan results in decreased expression of TNF mRNA CTD PMID:16364719 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
amiloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator increases activity EXP Amiloride results in increased activity of CFTR protein CTD PMID:15246976 NCBI chr18:28,627,717...28,818,209
Ensembl chr18:28,627,728...28,817,950
JBrowse link
G SLC2A1 solute carrier family 2 member 1 multiple interactions EXP Amiloride promotes the reaction [Cyclosporine results in increased expression of SLC2A1 mRNA] CTD PMID:12081571 NCBI chr 6:168,535,398...168,561,170
Ensembl chr 6:168,534,655...168,690,095
JBrowse link
aminoglutethimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GHRL ghrelin and obestatin prepropeptide multiple interactions EXP Aminoglutethimide promotes the reaction [GHRL protein results in decreased secretion of Progesterone] CTD PMID:22341706 NCBI chr13:66,442,106...66,453,576
Ensembl chr13:66,316,436...66,452,917
JBrowse link
amoxicillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions
increases uptake
EXP Amoxicillin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Amoxicillin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]
SLCO1A2 protein results in increased uptake of Amoxicillin
CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,037,218...52,131,789
JBrowse link
amphotericin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL6 interleukin 6 increases expression
multiple interactions
EXP Amphotericin B results in increased expression of IL6 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of IL6 protein]
CTD PMID:24105867 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G PRKACB protein kinase cAMP-activated catalytic subunit beta multiple interactions
increases expression
EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of PRKACG protein] CTD PMID:24105867 NCBI chr 6:129,520,397...129,636,207
Ensembl chr 6:129,519,962...129,635,517
JBrowse link
amprenavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 decreases expression EXP amprenavir results in decreased expression of NOS3 mRNA CTD PMID:16123675 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
androst-4-ene-3,17-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 multiple interactions EXP [2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Androstenedione] results in increased activity of HSD17B1 protein CTD PMID:16151981 NCBI chr12:20,269,468...20,271,349
Ensembl chr12:20,269,056...20,279,569
JBrowse link
G INS insulin multiple interactions EXP 9-deoxy-delta-9-prostaglandin D2 inhibits the reaction [[LHB protein co-treated with INS protein] results in increased abundance of Androstenedione]; [LHB protein co-treated with INS protein] results in increased abundance of Androstenedione; Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased abundance of Androstenedione] CTD PMID:11889176 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841
JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions EXP 9-deoxy-delta-9-prostaglandin D2 inhibits the reaction [[LHB protein co-treated with INS protein] results in increased abundance of Androstenedione]; [LHB protein co-treated with INS protein] results in increased abundance of Androstenedione; Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased abundance of Androstenedione] CTD PMID:11889176 NCBI chr 6:54,263,574...54,269,286 JBrowse link
anthra[1,9-cd]pyrazol-6(2H)-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions
decreases expression
EXP pyrazolanthrone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; pyrazolanthrone inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA]
pyrazolanthrone results in decreased expression of CCL2 mRNA
CTD PMID:19265715, PMID:21176401, PMID:23380242 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 decreases secretion
decreases expression
EXP pyrazolanthrone results in decreased secretion of CXCL8 protein
pyrazolanthrone results in decreased expression of CXCL8 mRNA
CTD PMID:21176401 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G FN1 fibronectin 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Arecoline results in increased expression of FN1 protein] CTD PMID:26908192 NCBI chr15:117,658,158...117,737,145
Ensembl chr15:117,658,099...117,731,014
JBrowse link
G IFNG interferon gamma decreases expression EXP pyrazolanthrone results in decreased expression of IFNG mRNA CTD PMID:21176401 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,848...32,482,752
JBrowse link
G IL6 interleukin 6 decreases expression EXP pyrazolanthrone results in decreased expression of IL6 mRNA CTD PMID:21176401 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G LOC110258578 interleukin-1 beta-like decreases secretion
decreases expression
EXP pyrazolanthrone results in decreased secretion of IL1B protein
pyrazolanthrone results in decreased expression of IL1B mRNA
CTD PMID:21176401
G SERPINE1 serpin family E member 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Arecoline results in increased expression of SERPINE1 protein] CTD PMID:26908192 NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,564
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Arecoline results in increased expression of TGFB1 mRNA] CTD PMID:26908192 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,169...49,349,048
JBrowse link
G TNF tumor necrosis factor decreases expression EXP pyrazolanthrone results in decreased expression of TNF mRNA CTD PMID:21176401 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA] CTD PMID:23380242 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,908...117,511,226
JBrowse link
antimycin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMBP alpha-1-microglobulin/bikunin precursor decreases uptake EXP Antimycin A results in decreased uptake of AMBP protein CTD PMID:9019736 NCBI chr 1:254,683,885...254,703,220
Ensembl chr 1:254,683,885...254,703,225
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP [Antimycin A co-treated with Deoxyglucose] results in increased expression of BAX protein; Quercetin inhibits the reaction [[Antimycin A co-treated with Deoxyglucose] results in increased expression of BAX protein] CTD PMID:25087994 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions EXP [Antimycin A co-treated with Deoxyglucose] results in decreased phosphorylation of MTOR protein; Quercetin promotes the reaction [[Antimycin A co-treated with Deoxyglucose] results in decreased phosphorylation of MTOR protein] CTD PMID:25087994 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888
JBrowse link
apigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA] CTD PMID:26180592 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G IL6 interleukin 6 multiple interactions EXP Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:26180592 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:26180592 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
arecoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FN1 fibronectin 1 multiple interactions
increases expression
EXP pyrazolanthrone inhibits the reaction [Arecoline results in increased expression of FN1 protein] CTD PMID:26908192 NCBI chr15:117,658,158...117,737,145
Ensembl chr15:117,658,099...117,731,014
JBrowse link
G SERPINE1 serpin family E member 1 increases expression
multiple interactions
EXP Arecoline results in increased expression of SERPINE1 protein
pyrazolanthrone inhibits the reaction [Arecoline results in increased expression of SERPINE1 protein]
CTD PMID:26908192 NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,564
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions
increases expression
EXP Arecoline results in increased secretion of and results in increased activity of TGFB1 protein; pyrazolanthrone inhibits the reaction [Arecoline results in increased expression of TGFB1 mRNA] CTD PMID:26908192 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,169...49,349,048
JBrowse link
aristolochic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5AP arachidonate 5-lipoxygenase activating protein increases expression
multiple interactions
EXP aristolochic acid I results in increased expression of ALOX5AP protein
MK-886 inhibits the reaction [aristolochic acid I results in increased expression of ALOX5AP protein]; U 0126 inhibits the reaction [aristolochic acid I results in increased expression of ALOX5AP protein]
CTD PMID:21658425 NCBI chr11:7,371,328...7,438,111
Ensembl chr11:7,411,644...7,438,108
JBrowse link
G CASP3 caspase 3 multiple interactions EXP aristolochic acid I results in increased cleavage of and results in increased activity of CASP3 protein; MK-886 inhibits the reaction [aristolochic acid I results in increased cleavage of and results in increased activity of CASP3 protein]; U 0126 inhibits the reaction [aristolochic acid I results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:21658425 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G LTC4S leukotriene C4 synthase decreases expression EXP aristolochic acid I results in decreased expression of LTC4S protein CTD PMID:21658425 NCBI chr 2:78,799,446...78,802,281
Ensembl chr 2:78,799,448...78,802,256
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP aristolochic acid I results in increased phosphorylation of and results in increased activity of MAPK1 protein; U 0126 inhibits the reaction [aristolochic acid I results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:21658425 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP aristolochic acid I results in increased phosphorylation of and results in increased activity of MAPK3 protein; U 0126 inhibits the reaction [aristolochic acid I results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:21658425 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G MGST3 microsomal glutathione S-transferase 3 increases expression
multiple interactions
EXP aristolochic acid I results in increased expression of MGST3 protein
U 0126 inhibits the reaction [aristolochic acid I results in increased expression of MGST3 protein]
CTD PMID:21658425 NCBI chr 4:85,069,603...85,095,022
Ensembl chr 4:85,069,603...85,095,004
JBrowse link
arotinoid acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FABP4 fatty acid binding protein 4, adipocyte decreases expression EXP 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of FABP4 mRNA CTD PMID:15583048 NCBI chr 4:55,096,400...55,101,209
Ensembl chr 4:55,096,404...55,101,897
JBrowse link
G GPD1 glycerol-3-phosphate dehydrogenase 1 decreases activity EXP 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased activity of GPD1 protein CTD PMID:15583048 NCBI chr 5:16,008,179...16,021,676
Ensembl chr 5:16,007,448...16,017,825
JBrowse link
G NR2F1 nuclear receptor subfamily 2 group F member 1 increases expression EXP 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of NR2F1 mRNA CTD PMID:15583048 NCBI chr 2:100,447,661...100,457,510
Ensembl chr 2:100,447,847...100,457,904
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma decreases expression EXP 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of PPARG mRNA CTD PMID:15583048 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,655...68,433,947
JBrowse link
G RXRA retinoid X receptor alpha decreases expression EXP 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of RXRA mRNA CTD PMID:15583048 NCBI chr 1:273,698,842...273,797,622
Ensembl chr 1:273,705,503...273,797,622
JBrowse link
G SREBP-1 sterol regulatory element binding protein 1 decreases expression EXP 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of SREBP-1 mRNA CTD PMID:15583048
aspartame term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPEP glutamyl aminopeptidase multiple interactions
increases hydrolysis
EXP 1,10-phenanthroline inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; amastatin inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; Calcium Chloride promotes the reaction [ENPEP protein results in increased hydrolysis of Aspartame] CTD PMID:8141778 NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510
JBrowse link
ATP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator multiple interactions
increases expression
EXP tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate results in increased expression of BCL2 protein] CTD PMID:17997382 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G CASP8 caspase 8 increases activity
multiple interactions
EXP Adenosine Triphosphate results in increased activity of CASP8 protein
tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate results in increased activity of CASP8 protein]
CTD PMID:17997382 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,470
JBrowse link
G CYCS cytochrome c, somatic affects localization
multiple interactions
EXP Adenosine Triphosphate affects the localization of CYCS protein
[Calcium co-treated with Phosphates co-treated with Adenosine Triphosphate] affects the localization of CYCS protein; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate affects the localization of CYCS protein]
CTD PMID:16489745, PMID:17997382 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G MYL9 myosin light chain 9 decreases phosphorylation
multiple interactions
EXP Adenosine Triphosphate results in decreased phosphorylation of MYL9 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [calyculin A results in increased phosphorylation of MYL9 protein]]; Adenosine Triphosphate promotes the reaction [calyculin A results in increased phosphorylation of MYL9 protein]
CTD PMID:10942722 NCBI chr17:39,788,165...39,795,240
Ensembl chr17:39,788,199...39,795,296
JBrowse link
G TNF tumor necrosis factor increases expression
multiple interactions
EXP Adenosine Triphosphate results in increased expression of TNF protein
tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate results in increased expression of TNF protein]
CTD PMID:17997382 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
beauvericin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 increases expression
decreases activity
EXP beauvericin results in increased expression of ABCB1 mRNA
beauvericin results in decreased activity of ABCB1 protein
CTD PMID:27474255 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 increases expression EXP beauvericin results in increased expression of CYP11A1 mRNA CTD PMID:27474255 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
G MT-CO1 mitochondrially encoded cytochrome c oxidase I increases expression EXP beauvericin results in increased expression of COX1 mRNA CTD PMID:27474255 NCBI chr MT:6,511...8,055
Ensembl chr MT:6,511...8,055
JBrowse link
benazepril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KNG1 kininogen 1 increases activity EXP benazepril results in increased activity of KNG1 protein modified form CTD PMID:7890486 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,277...124,557,376
JBrowse link
benzamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC9A1 solute carrier family 9 member A1 decreases activity EXP benzamide analog results in decreased activity of SLC9A1 protein CTD PMID:17724433 NCBI chr 6:84,373,921...84,426,447
Ensembl chr 6:84,372,649...84,426,997
JBrowse link
benzamidoxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MOCOS molybdenum cofactor sulfurase affects reduction EXP MOCOS protein affects the reduction of benzamidoxime CTD PMID:16973608 NCBI chr 6:119,945,076...120,018,332
Ensembl chr 6:119,945,076...120,018,120
JBrowse link
benzo[a]pyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions EXP Benzo(a)pyrene inhibits the reaction [ADIPOQ protein results in increased expression of CYP19A1 protein]; Benzo(a)pyrene inhibits the reaction [ADIPOQ protein results in increased secretion of Estradiol]; Benzo(a)pyrene results in decreased expression of and results in decreased secretion of ADIPOQ protein CTD PMID:28284726 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,684...124,646,648
JBrowse link
G ADIPOR1 adiponectin receptor 1 decreases expression EXP Benzo(a)pyrene results in decreased expression of ADIPOR1 protein CTD PMID:28284726 NCBI chr10:24,907,491...24,923,540 JBrowse link
G ADIPOR2 adiponectin receptor 2 decreases expression EXP Benzo(a)pyrene results in decreased expression of ADIPOR2 protein CTD PMID:28284726 NCBI chr 5:68,755,789...68,807,247
Ensembl chr 5:68,755,811...68,807,235
JBrowse link
G CYP19A2 cytochrome P450 19A2 multiple interactions EXP Benzo(a)pyrene inhibits the reaction [ADIPOQ protein results in increased expression of CYP19A1 protein] CTD PMID:28284726 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G CYP1A1 cytochrome P450 1A1 increases expression
multiple interactions
EXP Benzo(a)pyrene results in increased expression of CYP1A1 protein
7-ketocholesterol inhibits the reaction [[Benzo(a)pyrene co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of CYP1A1 protein]; [Benzo(a)pyrene co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of CYP1A1 protein
CTD PMID:11042205, PMID:18636242 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,780,105...58,809,755
JBrowse link
benzothiazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TPO thyroid peroxidase decreases activity EXP benzothiazole results in decreased activity of TPO protein CTD PMID:25953703 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,408,943
JBrowse link
beta-naphthoflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 1A1 increases expression
increases activity
multiple interactions
EXP beta-Naphthoflavone results in increased expression of CYP1A1 mRNA; beta-Naphthoflavone results in increased expression of CYP1A1 protein
beta-Naphthoflavone results in increased activity of CYP1A1 protein
epigallocatechin gallate inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; epigallocatechin gallate inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
CTD PMID:12970578, PMID:19464568, PMID:19786062 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,780,105...58,809,755
JBrowse link
G CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 increases expression EXP beta-Naphthoflavone results in increased expression of CYP1A2 mRNA CTD PMID:19464568 NCBI chr 7:58,779,529...58,786,155
Ensembl chr 7:58,779,475...58,786,100
JBrowse link
G LOC100625479 cytochrome P450 1B1 increases expression EXP beta-Naphthoflavone results in increased expression of CYP1B1 mRNA CTD PMID:19464568, PMID:19786062 NCBI chr 3:102,195,743...102,205,687
Ensembl chr 3:102,195,741...102,206,750
JBrowse link
betamethasone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HMOX2 heme oxygenase 2 increases expression EXP Betamethasone results in increased expression of HMOX2 protein CTD PMID:11698254 NCBI chr 3:37,829,044...37,868,163
Ensembl chr 3:37,831,434...37,868,128
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP Betamethasone results in decreased expression of PTGS2 protein CTD PMID:11698254 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
bezafibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOA1 apolipoprotein A1 increases expression
increases secretion
EXP Bezafibrate results in increased expression of APOA1 mRNA
Bezafibrate results in increased secretion of APOA1 protein
CTD PMID:16530456 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,393...44,218,978
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP Bezafibrate inhibits the reaction [Cisplatin affects the localization of BAX protein] CTD PMID:16316343 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression EXP Bezafibrate results in increased expression of BCL2 CTD PMID:16316343 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G CASP3 caspase 3 multiple interactions EXP Bezafibrate inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:16316343 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP Bezafibrate inhibits the reaction [Cisplatin affects the localization of CYCS protein] CTD PMID:16316343 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G LIPG lipase G, endothelial type decreases expression EXP Bezafibrate results in decreased expression of LIPG mRNA; Bezafibrate results in decreased expression of LIPG protein CTD PMID:15953354 NCBI chr 1:99,081,940...99,110,671
Ensembl chr 1:99,081,938...99,110,876
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions EXP Bezafibrate inhibits the reaction [[Cisplatin results in decreased activity of PPARA protein] which results in increased abundance of Fatty Acids, Nonesterified]; Bezafibrate inhibits the reaction [Cisplatin results in decreased activity of PPARA protein] CTD PMID:16316343 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,708...3,366,361
JBrowse link
G SCARB1 scavenger receptor class B member 1 affects localization
increases expression
EXP Bezafibrate affects the localization of SCARB1 protein
Bezafibrate results in increased expression of SCARB1 mRNA
CTD PMID:16530456 NCBI chr14:28,301,421...28,393,568
Ensembl chr14:28,301,294...28,393,565
JBrowse link
bilirubin IXalpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions EXP Bilirubin inhibits the reaction [Excitatory Amino Acid Agents results in increased activity of CASP3 protein] CTD PMID:16371440 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G GH1 growth hormone 1 multiple interactions EXP GH1 protein inhibits the reaction [Lipopolysaccharides results in increased abundance of Bilirubin] CTD PMID:9185964 NCBI chr12:15,064,965...15,066,698
Ensembl chr12:15,064,909...15,066,696
JBrowse link
bisphenol A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 increases expression EXP bisphenol A results in increased expression of ADCYAP1 protein CTD PMID:29569701 NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,630...105,422,295
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions EXP bisphenol A inhibits the reaction [ADIPOQ protein results in increased expression of CYP19A1 protein]; bisphenol A inhibits the reaction [ADIPOQ protein results in increased secretion of Testosterone]; bisphenol A promotes the reaction [ADIPOQ protein results in increased secretion of Estradiol]; bisphenol A results in increased expression of and results in increased secretion of ADIPOQ protein CTD PMID:28284726 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,684...124,646,648
JBrowse link
G ADIPOR1 adiponectin receptor 1 increases expression EXP bisphenol A results in increased expression of ADIPOR1 protein CTD PMID:28284726 NCBI chr10:24,907,491...24,923,540 JBrowse link
G ADIPOR2 adiponectin receptor 2 increases expression EXP bisphenol A results in increased expression of ADIPOR2 protein CTD PMID:28284726 NCBI chr 5:68,755,789...68,807,247
Ensembl chr 5:68,755,811...68,807,235
JBrowse link
G AGO2 argonaute RISC catalytic component 2 decreases expression
multiple interactions
EXP bisphenol A results in decreased expression of AGO2 protein
[bisphenol A co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] results in decreased expression of AGO2 protein
CTD PMID:31266599 NCBI chr 4:2,966,794...3,012,388
Ensembl chr 4:2,919,529...3,015,367
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP bisphenol A results in decreased expression of BCL2 mRNA CTD PMID:28819136 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G BCL2L1 BCL2 like 1 decreases expression EXP bisphenol A results in decreased expression of BCL2L1 mRNA CTD PMID:28819136 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,141...35,415,359
JBrowse link
G BECN1 beclin 1 increases expression EXP bisphenol A results in increased expression of BECN1 mRNA CTD PMID:28819136 NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373
JBrowse link
G CARTPT CART prepropeptide increases expression
decreases expression
EXP bisphenol A results in increased expression of CARTPT protein
bisphenol A results in decreased expression of CARTPT protein
CTD PMID:29558425, PMID:29569701, PMID:29577965, PMID:29888781 NCBI chr16:48,043,558...48,045,592
Ensembl chr16:48,043,407...48,045,590
JBrowse link
G CASP3 caspase 3 multiple interactions
increases expression
EXP [bisphenol A co-treated with fisetin] results in increased expression of CASP3 mRNA
bisphenol A results in increased expression of CASP3 mRNA
CTD PMID:29544186 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CAT catalase multiple interactions
decreases expression
EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] promotes the reaction [bisphenol A results in decreased expression of CAT protein] CTD PMID:29129240 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP bisphenol A results in increased expression of CDKN1A protein CTD PMID:28819136 NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,359,455...32,363,761
JBrowse link
G CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 multiple interactions
decreases expression
EXP [bisphenol A co-treated with fisetin] results in decreased expression of CYP11A1 mRNA; fisetin promotes the reaction [bisphenol A results in decreased expression of CYP11A1 mRNA] CTD PMID:29544186 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
G CYP19A2 cytochrome P450 19A2 increases expression
multiple interactions
EXP bisphenol A results in increased expression of CYP19A1 protein
bisphenol A inhibits the reaction [ADIPOQ protein results in increased expression of CYP19A1 protein]
CTD PMID:28284726 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G DBH dopamine beta-hydroxylase increases expression EXP bisphenol A results in increased expression of DBH protein CTD PMID:29888781 NCBI chr 1:273,204,407...273,225,562
Ensembl chr 1:273,204,400...273,225,558
JBrowse link
G DICER1 dicer 1, ribonuclease III decreases expression
multiple interactions
EXP bisphenol A results in decreased expression of DICER1 mRNA; bisphenol A results in decreased expression of DICER1 protein
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bisphenol A results in decreased expression of DICER1 protein]; [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with bisphenol A] results in decreased expression of DICER1 mRNA
CTD PMID:31266599 NCBI chr 7:116,361,630...116,436,471
Ensembl chr 7:116,361,630...116,436,519
JBrowse link
G DNMT3A DNA methyltransferase 3 alpha multiple interactions
decreases expression
EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA] CTD PMID:28445388, PMID:28819136 NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,609,139
JBrowse link
G DNMT3B DNA methyltransferase 3 beta decreases expression EXP bisphenol A results in decreased expression of DNMT3B mRNA CTD PMID:28819136 NCBI chr17:36,345,715...36,386,076
Ensembl chr17:36,332,801...36,386,074
JBrowse link
G DROSHA drosha ribonuclease III multiple interactions
decreases expression
EXP 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bisphenol A results in decreased expression of DROSHA protein]; [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with bisphenol A] results in increased expression of DROSHA mRNA; bisphenol A inhibits the reaction [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline results in decreased expression of DROSHA protein] CTD PMID:31266599 NCBI chr16:17,727,695...17,847,954
Ensembl chr16:17,565,137...17,848,073
JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions EXP bisphenol A inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]; bisphenol A promotes the reaction [fisetin inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]]; fisetin promotes the reaction [bisphenol A inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]] CTD PMID:29544186 NCBI chr 2:30,395,769...30,399,282
Ensembl chr 2:30,395,018...30,399,274
JBrowse link
G GAL galanin and GMAP prepropeptide increases expression
affects expression
EXP bisphenol A results in increased expression of GAL protein
bisphenol A affects the expression of GAL protein
CTD PMID:29558425, PMID:29569701, PMID:29577965, PMID:29888781 NCBI chr 2:4,351,113...4,357,167
Ensembl chr 2:4,350,909...4,357,170
JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 multiple interactions EXP [bisphenol A co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] results in decreased expression of GPER1 protein CTD PMID:31266599 NCBI chr 3:711,427...715,982
Ensembl chr 3:712,160...715,982
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions
decreases expression
EXP [bisphenol A co-treated with [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12]] results in increased expression of GPX1 mRNA
bisphenol A results in decreased expression of GPX1 mRNA
CTD PMID:28819136, PMID:29129240 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,914,932...31,917,335
JBrowse link
G GYS1 glycogen synthase 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Folic Acid co-treated with bisphenol A] results in increased methylation of GYS1 promoter CTD PMID:29065941 NCBI chr 6:54,234,600...54,250,211
Ensembl chr 6:54,233,050...54,250,261
JBrowse link
G HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions
decreases expression
EXP bisphenol A promotes the reaction [fisetin results in decreased expression of HSD3B1 mRNA]; fisetin promotes the reaction [bisphenol A results in decreased expression of HSD3B1 mRNA] CTD PMID:29544186 NCBI chr 4:101,565,229...101,574,110 JBrowse link
G LDHA lactate dehydrogenase A increases expression
multiple interactions
decreases methylation
EXP bisphenol A results in increased expression of LDHA mRNA
[bisphenol A co-treated with Choline co-treated with Folic Acid co-treated with Betaine] results in decreased methylation of LDHA promoter
bisphenol A results in decreased methylation of LDHA promoter
CTD PMID:29065941 NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,812,453...40,826,715
JBrowse link
G LOC100623720 collagen alpha-1(VI) chain multiple interactions
decreases expression
EXP bisphenol A inhibits the reaction [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline results in decreased expression of COL6A1 protein]
bisphenol A results in decreased expression of COL6A1 protein
CTD PMID:31266599 NCBI chr13:208,295,245...208,321,789
Ensembl chr13:208,295,240...208,313,127
JBrowse link
G LOC110258578 interleukin-1 beta-like increases expression EXP bisphenol A results in increased expression of IL1B protein CTD PMID:29558425
G MAP1LC3B microtubule associated protein 1 light chain 3 beta increases expression EXP bisphenol A results in increased expression of MAP1LC3B protein CTD PMID:31266599 NCBI chr 6:1,919,879...1,941,069
Ensembl chr 6:1,915,387...1,941,077
JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 affects expression EXP bisphenol A affects the expression of TAK1 protein CTD PMID:29577965 NCBI chr 1:58,482,046...58,548,087
Ensembl chr 1:58,481,956...58,548,057
JBrowse link
G NANOG Nanog homeobox decreases expression EXP bisphenol A results in decreased expression of NANOG mRNA CTD PMID:28819136 NCBI chr 5:62,931,642...62,939,086
Ensembl chr 5:62,932,382...62,939,082
JBrowse link
G PLIN1 perilipin 1 increases expression
multiple interactions
EXP bisphenol A results in increased expression of PLIN1 protein
[bisphenol A co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] results in increased expression of PLIN1 protein
CTD PMID:31266599 NCBI chr 7:55,237,517...55,250,797
Ensembl chr 7:55,235,426...55,250,797
JBrowse link
G POU5F1 POU class 5 homeobox 1 decreases expression EXP bisphenol A results in decreased expression of POU5F1 mRNA; bisphenol A results in decreased expression of POU5F1 protein CTD PMID:28819136 NCBI chr 7:23,564,654...23,570,691 JBrowse link
G SI sucrase-isomaltase decreases expression EXP bisphenol A results in decreased expression of SI mRNA CTD PMID:28445388 NCBI chr13:104,296,281...104,379,558
Ensembl chr13:104,296,283...104,379,478
JBrowse link
G SLC15A1 solute carrier family 15 member 1 decreases expression
decreases methylation
multiple interactions
EXP bisphenol A results in decreased expression of SLC15A1 mRNA
bisphenol A results in decreased methylation of SLC15A1 promoter
[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of SLC15A1 mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased methylation of SLC15A1 promoter]
CTD PMID:28445388 NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933
JBrowse link
G SLC18A3 solute carrier family 18 member A3 decreases expression EXP bisphenol A results in decreased expression of SLC18A3 protein CTD PMID:29558425, PMID:29577965 NCBI chr14:90,113,534...90,115,813
Ensembl chr14:90,113,844...90,115,430
JBrowse link
G SLC5A1 solute carrier family 5 member 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with bisphenol A] results in increased expression of SLC5A1 mRNA CTD PMID:28445388 NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,566,343...48,705,841
JBrowse link
G SOD1 superoxide dismutase 1 decreases expression EXP bisphenol A results in decreased expression of SOD1 mRNA CTD PMID:29129240 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
G SOX2 SRY-box transcription factor 2 decreases expression EXP bisphenol A results in decreased expression of SOX2 mRNA CTD PMID:28819136 NCBI chr13:119,668,476...119,669,435 JBrowse link
G STAR steroidogenic acute regulatory protein multiple interactions
decreases expression
EXP [bisphenol A co-treated with fisetin] results in decreased expression of STAR mRNA; fisetin promotes the reaction [bisphenol A results in decreased expression of STAR mRNA] CTD PMID:29544186 NCBI chr15:48,377,597...48,385,398
Ensembl chr15:48,347,864...48,385,464
JBrowse link
G TAC1 tachykinin precursor 1 increases expression EXP bisphenol A results in increased expression of TAC1 protein CTD PMID:29558425, PMID:29569701, PMID:29888781 NCBI chr 9:77,197,403...77,206,529
Ensembl chr 9:77,197,535...77,206,526
JBrowse link
G TFAM transcription factor A, mitochondrial decreases expression EXP bisphenol A results in decreased expression of TFAM mRNA CTD PMID:28819136 NCBI chr14:92,261,713...92,279,731
Ensembl chr14:92,259,403...92,279,550
JBrowse link
G TNF tumor necrosis factor increases expression EXP bisphenol A results in increased expression of TNF protein CTD PMID:29558425 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G TP53 tumor protein p53 increases expression EXP bisphenol A results in increased expression of TP53 protein CTD PMID:28819136 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819
JBrowse link
G VEGFA vascular endothelial growth factor A increases expression EXP bisphenol A results in increased expression of VEGFA protein CTD PMID:20172683 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,038
JBrowse link
G VIP vasoactive intestinal peptide decreases expression
increases expression
EXP bisphenol A results in decreased expression of VIP protein
bisphenol A results in increased expression of VIP protein
CTD PMID:29558425, PMID:29577965 NCBI chr 1:13,611,786...13,620,250
Ensembl chr 1:13,611,311...13,620,269
JBrowse link
G XPO5 exportin 5 multiple interactions
decreases expression
EXP [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with bisphenol A] results in decreased expression of XPO5 mRNA; [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with bisphenol A] results in decreased expression of XPO5 protein
bisphenol A results in decreased expression of XPO5 mRNA; bisphenol A results in decreased expression of XPO5 protein
CTD PMID:31266599 NCBI chr 7:38,530,704...38,569,558
Ensembl chr 7:38,530,725...38,569,570
JBrowse link
Bisphenol A diglycidyl ether term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALPL alkaline phosphatase, biomineralization associated multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of ALPL mRNA] CTD PMID:30481989 NCBI chr 6:79,589,695...79,649,646
Ensembl chr 6:79,588,659...79,649,648
JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of COL1A1 mRNA] CTD PMID:30481989 NCBI chr12:26,379,087...26,397,180
Ensembl chr12:26,379,090...26,397,003
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of CTNNB1 mRNA] CTD PMID:30481989 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,137,173...25,208,311
JBrowse link
G FABP4 fatty acid binding protein 4, adipocyte multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of FABP4 mRNA] CTD PMID:30481989 NCBI chr 4:55,096,400...55,101,209
Ensembl chr 4:55,096,404...55,101,897
JBrowse link
G IL6 interleukin 6 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Rosiglitazone promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Rosiglitazone promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]] CTD PMID:19474210 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane binds to and results in decreased activity of PPARG protein; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of PPARG mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Troglitazone results in increased activity of PPARG protein] CTD PMID:14506076, PMID:14519784, PMID:30481989 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,655...68,433,947
JBrowse link
G RUNX2 RUNX family transcription factor 2 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of RUNX2 mRNA] CTD PMID:30481989 NCBI chr 7:40,106,581...40,353,304
Ensembl chr 7:40,106,513...40,459,686
JBrowse link
G SPP1 secreted phosphoprotein 1 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SPP1 mRNA] CTD PMID:30481989 NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Rosiglitazone promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Rosiglitazone promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [trans-10,cis-12-conjugated linoleic acid results in increased expression of TNF mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [trans-10,cis-12-conjugated linoleic acid results in increased expression of TNF protein] CTD PMID:17217567, PMID:19474210 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
brimonidine tartrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CREB1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions
EXP Brimonidine Tartrate results in increased phosphorylation of CREB1 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Brimonidine Tartrate results in increased phosphorylation of CREB1 protein]
CTD PMID:17680988 NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,697,408...110,771,755
JBrowse link
brucine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHRM2 cholinergic receptor muscarinic 2 multiple interactions EXP brucine analog promotes the reaction [N-Methylscopolamine binds to CHRM2 protein] CTD PMID:12757728 NCBI chr18:12,455,139...12,600,314
Ensembl chr18:12,455,150...12,600,249
JBrowse link
bucladesine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 increases expression EXP Bucladesine results in increased expression of ATP1A1 protein CTD PMID:28438630 NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,506...104,384,606
JBrowse link
caffeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RYR1 ryanodine receptor 1 increases activity
multiple interactions
EXP Caffeine results in increased activity of RYR1 protein; Caffeine results in increased activity of RYR1 protein mutant form
Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]; Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein mutant form]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein]
CTD PMID:11278295 NCBI chr 6:47,339,759...47,458,457 JBrowse link
calcidiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2D25 vitamin D3 25-Hydroxylase increases hydroxylation EXP CYP2D25 protein results in increased hydroxylation of Calcifediol CTD PMID:11880238 NCBI chr 5:6,539,021...6,543,643
Ensembl chr 5:6,538,907...6,543,643
JBrowse link
capsazepine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRPV1 transient receptor potential cation channel subfamily V member 1 multiple interactions EXP capsazepine inhibits the reaction [Sodium affects the reaction [TRPV1 protein results in increased abundance of Calcium]] CTD PMID:18230619 NCBI chr12:49,676,536...49,709,634
Ensembl chr12:49,677,291...49,701,325
JBrowse link
carvacrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RYR1 ryanodine receptor 1 increases activity EXP carvacrol results in increased activity of RYR1 protein CTD PMID:17641978 NCBI chr 6:47,339,759...47,458,457 JBrowse link
carvedilol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDH5 cadherin 5 decreases expression
increases expression
EXP Carvedilol results in decreased expression of CDH5 mRNA
Carvedilol results in increased expression of CDH5 protein
CTD PMID:16824628 NCBI chr 6:27,108,560...27,142,145
Ensembl chr 6:27,108,609...27,142,180
JBrowse link
G CTNNB1 catenin beta 1 decreases expression
increases expression
EXP Carvedilol results in decreased expression of CTNNB1 mRNA
Carvedilol results in increased expression of CTNNB1 protein
CTD PMID:16824628 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,137,173...25,208,311
JBrowse link
G EDN1 endothelin 1 decreases expression
multiple interactions
EXP Carvedilol results in decreased expression of EDN1 protein
Glyburide inhibits the reaction [Carvedilol results in decreased expression of EDN1 protein]
CTD PMID:18840580 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
G JUP junction plakoglobin increases expression
decreases expression
EXP Carvedilol results in increased expression of JUP protein
Carvedilol results in decreased expression of JUP mRNA
CTD PMID:16824628 NCBI chr12:20,902,395...20,931,208
Ensembl chr12:20,901,396...20,931,211
JBrowse link
catechol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase multiple interactions EXP [S-Adenosylmethionine analog co-treated with COMT protein] results in increased methylation of catechol CTD PMID:20196537 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,133...51,403,998
JBrowse link
cefaloridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase decreases activity EXP Cephaloridine results in decreased activity of CAT protein CTD PMID:11039594 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
chenodeoxycholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase increases activity EXP Chenodeoxycholic Acid results in increased activity of ACHE protein CTD PMID:3697337 NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,324...8,739,149
JBrowse link
G LRP2 LDL receptor related protein 2 increases expression EXP Chenodeoxycholic Acid results in increased expression of LRP2 protein CTD PMID:15375181 NCBI chr15:75,565,299...75,754,604
Ensembl chr15:75,565,301...75,716,694
JBrowse link
chlorogenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase decreases activity EXP Chlorogenic Acid results in decreased activity of COMT protein CTD PMID:27270453 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,133...51,403,998
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CXCL8 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA] CTD PMID:27861533 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G IL6 interleukin 6 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:27861533 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:27861533 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:27861533 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
chloroquine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions EXP Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein] CTD PMID:30287338 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G HSPA6 heat shock protein family A (Hsp70) member 6 multiple interactions EXP Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of HSP70 protein] CTD PMID:17727805 NCBI chr 4:88,970,592...88,973,109
Ensembl chr 4:88,970,591...88,985,586
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of HSPD1 protein] CTD PMID:17727805 NCBI chr15:101,360,355...101,373,498
Ensembl chr15:101,360,094...101,373,527
JBrowse link
G IFNB1 interferon beta 1 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFNB1 mRNA] CTD PMID:27079946 NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495
JBrowse link
G IFNG interferon gamma multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFNG mRNA] CTD PMID:27079946 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,848...32,482,752
JBrowse link
G IL12B interleukin 12B multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL12B mRNA] CTD PMID:27079946 NCBI chr16:64,143,268...64,158,929
Ensembl chr16:64,147,247...64,158,952
JBrowse link
G IL6 interleukin 6 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL6 mRNA] CTD PMID:27079946 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G IRF7 interferon regulatory factor 7 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IRF7 mRNA] CTD PMID:27079946 NCBI chr 2:372,235...375,572
Ensembl chr 2:371,606...375,381
JBrowse link
G ISG15 ISG15 ubiquitin like modifier multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of ISG15 mRNA] CTD PMID:27079946 NCBI chr 6:63,363,201...63,364,211
Ensembl chr 6:63,363,173...63,364,208
JBrowse link
G LOC100151816 interferon-induced protein with tetratricopeptide repeats 5 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFIT1 mRNA] CTD PMID:27079946 NCBI chr14:101,254,818...101,266,105
Ensembl chr14:101,254,768...101,267,654
JBrowse link
G LOC110258578 interleukin-1 beta-like multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL1B mRNA] CTD PMID:27079946
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein] CTD PMID:30287338 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,159...14,241,197
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of RELA protein] CTD PMID:27079946 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,471
JBrowse link
G SQSTM1 sequestosome 1 increases expression
multiple interactions
EXP Chloroquine results in increased expression of SQSTM1 protein
Chloroquine inhibits the reaction [ochratoxin A results in decreased expression of SQSTM1 protein]
CTD PMID:30287338 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,768...78,784,256
JBrowse link
G TLR7 toll like receptor 7 multiple interactions EXP Chloroquine affects the localization of and results in decreased activity of TLR7 protein CTD PMID:27079946 NCBI chr  X:9,573,178...9,576,987 JBrowse link
chlorotoluron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B22 cytochrome P450 2B22 decreases response to substance EXP CYP2B22 protein results in decreased susceptibility to chlortoluron CTD PMID:16315095 NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,413
JBrowse link
G CYP2C49 cytochrome P450 2C49 decreases response to substance EXP CYP2C49 protein results in decreased susceptibility to chlortoluron CTD PMID:16315095 NCBI chr14:106,571,803...106,612,082 JBrowse link
chlorpromazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DAO D-amino acid oxidase decreases activity EXP Chlorpromazine results in decreased activity of DAO protein CTD PMID:18615285 NCBI chr14:41,931,549...41,950,628
Ensembl chr14:41,929,215...41,950,633
JBrowse link
G FMO1 flavin containing dimethylaniline monoxygenase 1 increases oxidation EXP FMO1 protein results in increased oxidation of Chlorpromazine CTD PMID:6439199 NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,812,103...63,895,077
JBrowse link
chlorpyrifos-methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APEH acylaminoacyl-peptide hydrolase decreases activity EXP chlorpyrifos-methyl results in decreased activity of APEH protein CTD PMID:10953051 NCBI chr13:32,205,863...32,214,517
Ensembl chr13:32,205,609...32,214,523
JBrowse link
chlortetracycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions
increases uptake
EXP Chlortetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; Genistein inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; Oxytetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline] CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,037,218...52,131,789
JBrowse link
cholesterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOA1 apolipoprotein A1 increases transport
multiple interactions
EXP APOA1 protein results in increased transport of Cholesterol
24-hydroxycholesterol promotes the reaction [APOA1 protein results in increased transport of Cholesterol]; Fenofibrate inhibits the reaction [APOA1 protein results in increased transport of Cholesterol]; Fenofibrate promotes the reaction [APOA1 protein results in increased transport of Cholesterol]; Pioglitazone promotes the reaction [APOA1 protein results in increased transport of Cholesterol]; TO-901317 promotes the reaction [APOA1 protein results in increased transport of Cholesterol]; Troglitazone promotes the reaction [APOA1 protein results in increased transport of Cholesterol]
CTD PMID:16530456 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,393...44,218,978
JBrowse link
cholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase increases activity EXP Cholic Acid results in increased activity of ACHE protein CTD PMID:3697337 NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,324...8,739,149
JBrowse link
G LRP2 LDL receptor related protein 2 increases expression EXP Cholic Acid results in increased expression of LRP2 protein CTD PMID:15375181 NCBI chr15:75,565,299...75,754,604
Ensembl chr15:75,565,301...75,716,694
JBrowse link
cinaciguat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions EXP BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1A1 protein] CTD PMID:19466990 NCBI chr 8:44,448,758...44,520,737
Ensembl chr 8:44,449,232...44,518,135
JBrowse link
G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions EXP BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1B1 protein] CTD PMID:19466990 NCBI chr 8:44,544,364...44,604,690
Ensembl chr 8:44,544,179...44,604,704
JBrowse link
ciprofibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNF tumor necrosis factor multiple interactions EXP [ciprofibrate co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein] CTD PMID:15226458 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
clarithromycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions EXP Clarithromycin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Clarithromycin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid] CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,037,218...52,131,789
JBrowse link
clofibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACO1 aconitase 1 increases expression EXP Clofibrate results in increased expression of ACO1 mRNA CTD PMID:17363680 NCBI chr10:33,937,833...34,001,895
Ensembl chr10:33,937,833...34,001,900
JBrowse link
G ACOX1 acyl-CoA oxidase 1 increases expression EXP Clofibrate results in increased expression of ACOX1 mRNA CTD PMID:16896063, PMID:17437637 NCBI chr12:5,450,913...5,479,550
Ensembl chr12:5,428,360...5,479,544
JBrowse link
G AGT angiotensinogen multiple interactions EXP Clofibrate inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein] CTD PMID:17105827 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428
JBrowse link
G ALB albumin decreases expression EXP Clofibrate results in decreased expression of ALB mRNA CTD PMID:16896063 NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,718,304
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP Clofibrate results in increased expression of BAX mRNA CTD PMID:17437637 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G BCL2L1 BCL2 like 1 decreases expression EXP Clofibrate results in decreased expression of BCL2L1 mRNA CTD PMID:17437637 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,141...35,415,359
JBrowse link
G CAT catalase increases expression EXP Clofibrate results in increased expression of CAT mRNA CTD PMID:17437637 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A increases expression EXP Clofibrate results in increased expression of CPT1A mRNA CTD PMID:16896063, PMID:17363680 NCBI chr 2:4,250,642...4,293,914
Ensembl chr 2:4,233,099...4,293,984
JBrowse link
G CTSB cathepsin B increases expression EXP Clofibrate results in increased expression of CTSB mRNA CTD PMID:16896063 NCBI chr14:15,014,139...15,035,081
Ensembl chr14:15,011,711...15,034,737
JBrowse link
G DIO2 iodothyronine deiodinase 2 decreases expression EXP Clofibrate results in decreased expression of DIO2 mRNA CTD PMID:16896063 NCBI chr 7:103,096,414...103,110,749
Ensembl chr 7:103,096,425...103,323,258
JBrowse link
G EDN1 endothelin 1 decreases expression
multiple interactions
EXP Clofibrate results in decreased expression of EDN1 protein
Clofibrate inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]; Clofibrate inhibits the reaction [KNG1 protein modified form results in increased expression of EDN1 protein]; Clofibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EDN1 protein]; Nitric Oxide deficiency inhibits the reaction [Clofibrate results in decreased expression of EDN1 protein]
CTD PMID:17105827 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
G FABP1 fatty acid binding protein 1 increases expression EXP Clofibrate results in increased expression of FABP1 mRNA CTD PMID:17363680 NCBI chr 3:57,850,511...57,854,966
Ensembl chr 3:57,850,499...57,854,964
JBrowse link
G GPX1 glutathione peroxidase 1 decreases expression EXP Clofibrate results in decreased expression of GPX1 mRNA CTD PMID:17437637 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,914,932...31,917,335
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Clofibrate results in increased expression of JUN mRNA CTD PMID:17437637 NCBI chr 6:153,686,425...153,687,635 JBrowse link
G KNG1 kininogen 1 multiple interactions EXP Clofibrate inhibits the reaction [KNG1 protein modified form results in increased expression of EDN1 protein] CTD PMID:17105827 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,277...124,557,376
JBrowse link
G LOC110260333 hydroxymethylglutaryl-CoA synthase, mitochondrial-like increases expression EXP Clofibrate results in increased expression of HMGCS2 mRNA CTD PMID:17363680 NCBI chr 4:101,385,486...101,404,273
Ensembl chr 4:101,385,512...101,443,405
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor increases expression EXP Clofibrate results in increased expression of MYC mRNA CTD PMID:17437637 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,119...12,461,078
JBrowse link
G NOS3 nitric oxide synthase 3 increases expression
multiple interactions
EXP Clofibrate results in increased expression of NOS3 protein
calphostin C inhibits the reaction [Clofibrate results in increased expression of NOS3 protein]
CTD PMID:17105827 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha increases expression
multiple interactions
EXP Clofibrate results in increased expression of PPARA; Clofibrate results in increased expression of PPARA protein
calphostin C inhibits the reaction [Clofibrate results in increased expression of PPARA protein]; calphostin C inhibits the reaction [Clofibrate results in increased expression of PPARA]; Tetradecanoylphorbol Acetate inhibits the reaction [Clofibrate results in increased expression of PPARA]
CTD PMID:17105827, PMID:20568414 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,708...3,366,361
JBrowse link
G SCD stearoyl-CoA desaturase increases expression EXP Clofibrate results in increased expression of SCD mRNA CTD PMID:17363680 NCBI chr14:111,461,560...111,478,033
Ensembl chr14:111,461,560...111,478,031
JBrowse link
G SLC5A5 solute carrier family 5 member 5 increases expression EXP Clofibrate results in increased expression of SLC5A5 mRNA CTD PMID:16896063 NCBI chr 2:59,869,157...59,885,086
Ensembl chr 2:59,869,154...59,885,265
JBrowse link
G SOD1 superoxide dismutase 1 increases expression EXP Clofibrate results in increased expression of SOD1 mRNA CTD PMID:17437637 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
G THRA thyroid hormone receptor alpha decreases expression EXP Clofibrate results in decreased expression of THRA mRNA CTD PMID:16896063 NCBI chr12:22,270,506...22,296,684
Ensembl chr12:22,270,062...22,296,618
JBrowse link
G TNF tumor necrosis factor decreases expression EXP Clofibrate results in decreased expression of TNF mRNA CTD PMID:17437637 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G TPO thyroid peroxidase increases expression EXP Clofibrate results in increased expression of TPO mRNA CTD PMID:16896063 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,408,943
JBrowse link
G TSHR thyroid stimulating hormone receptor increases expression EXP Clofibrate results in increased expression of TSHR mRNA CTD PMID:16896063 NCBI chr 7:103,768,260...103,925,777
Ensembl chr 7:103,768,296...103,925,922
JBrowse link
G TTR transthyretin decreases expression EXP Clofibrate results in decreased expression of TTR mRNA CTD PMID:16896063 NCBI chr 6:115,496,338...115,503,974
Ensembl chr 6:115,496,193...115,503,977
JBrowse link
cocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 increases expression
multiple interactions
EXP Cocaine results in increased expression of EDN1 protein
1,3-ditolylguanidine inhibits the reaction [Cocaine results in increased expression of EDN1 protein]; Haloperidol inhibits the reaction [Cocaine results in increased expression of EDN1 protein]
CTD PMID:9714087 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
cortisol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen multiple interactions
increases secretion
EXP D-Ala(2),MePhe(4),Met(0)-ol-enkephalin promotes the reaction [AGT protein results in increased secretion of Hydrocortisone] CTD PMID:22100847 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428
JBrowse link
G POMC proopiomelanocortin multiple interactions
increases abundance
increases secretion
EXP Ditiocarb promotes the reaction [Sodium Selenite inhibits the reaction [POMC protein results in increased secretion of Hydrocortisone]]; Sodium Selenite inhibits the reaction [POMC protein results in increased secretion of Hydrocortisone]
POMC protein alternative form results in increased abundance of Hydrocortisone
CTD PMID:1666317, PMID:21466817, PMID:22100847 NCBI chr 3:113,661,712...113,668,558 JBrowse link
coumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2A19 cytochrome P450 2A19 increases hydroxylation
multiple interactions
EXP CYP2A19 protein results in increased hydroxylation of coumarin
2-aminoacetophenone inhibits the reaction [[CYP2A19 protein results in increased hydroxylation of coumarin] which results in increased chemical synthesis of 7-hydroxycoumarin]; 2-aminoacetophenone inhibits the reaction [CYP2A19 protein results in increased hydroxylation of coumarin]; [CYP2A19 protein results in increased hydroxylation of coumarin] which results in increased chemical synthesis of 7-hydroxycoumarin; Skatole inhibits the reaction [[CYP2A19 protein results in increased hydroxylation of coumarin] which results in increased chemical synthesis of 7-hydroxycoumarin]; Skatole inhibits the reaction [CYP2A19 protein results in increased hydroxylation of coumarin]
CTD PMID:30599194 NCBI chr 6:49,056,579...49,064,111
Ensembl chr 6:49,056,578...49,064,107
JBrowse link
crizotinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NTRK1 neurotrophic receptor tyrosine kinase 1 decreases activity EXP Crizotinib results in decreased activity of NTRK1 protein CTD PMID:21812414 NCBI chr 4:93,219,509...93,237,944
Ensembl chr 4:93,219,516...93,237,930
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 decreases activity EXP Crizotinib results in decreased activity of NTRK2 protein CTD PMID:21812414 NCBI chr10:30,030,050...30,429,938
Ensembl chr10:30,033,379...30,429,882
JBrowse link
curcumin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACO2 aconitase 2 multiple interactions EXP Curcumin inhibits the reaction [maleic acid results in decreased activity of ACO2 protein] CTD PMID:25119790 NCBI chr 5:7,014,383...7,071,023
Ensembl chr 5:7,002,124...7,070,999
JBrowse link
cyanocob(III)alamin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] promotes the reaction [bisphenol A results in decreased expression of CAT protein]; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT mRNA; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT protein CTD PMID:29129240 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G DNMT1 DNA methyltransferase 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA CTD PMID:28445388 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,564...69,029,919
JBrowse link
G DNMT3A DNA methyltransferase 3 alpha multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA CTD PMID:28445388 NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,609,139
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of GPX1 mRNA; [bisphenol A co-treated with [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12]] results in increased expression of GPX1 mRNA CTD PMID:29129240 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,914,932...31,917,335
JBrowse link
G MTHFR methylenetetrahydrofolate reductase multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA CTD PMID:28445388 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,636...71,881,820
JBrowse link
G SI sucrase-isomaltase multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA CTD PMID:28445388 NCBI chr13:104,296,281...104,379,558
Ensembl chr13:104,296,283...104,379,478
JBrowse link
G SLC15A1 solute carrier family 15 member 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of SLC15A1 mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased methylation of SLC15A1 promoter]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC15A1 mRNA CTD PMID:28445388 NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933
JBrowse link
G SLC5A1 solute carrier family 5 member 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with bisphenol A] results in increased expression of SLC5A1 mRNA; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC5A1 mRNA CTD PMID:28445388 NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,566,343...48,705,841
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of SOD1 mRNA CTD PMID:29129240 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
cycloheximide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 multiple interactions EXP Cycloheximide inhibits the reaction [Cadmium Chloride results in increased expression of ATF4 protein]; Cycloheximide inhibits the reaction [Cadmium results in increased expression of ATF4 protein] CTD PMID:16759985 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,738,880...8,745,225
JBrowse link
G CLIC5 chloride intracellular channel 5 multiple interactions
decreases expression
EXP Cycloheximide promotes the reaction [Cadmium Chloride results in decreased expression of CLIC5 protein]
Cycloheximide results in decreased expression of CLIC5 protein
CTD PMID:20576581 NCBI chr 7:40,683,044...40,808,017
Ensembl chr 7:40,682,907...40,863,886
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Cycloheximide inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]; Cycloheximide inhibits the reaction [Cadmium results in increased expression of HSPA5 protein] CTD PMID:16759985 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G LRP2 LDL receptor related protein 2 multiple interactions
decreases expression
EXP Cycloheximide promotes the reaction [Cadmium Chloride results in decreased expression of LRP2 protein]
Cycloheximide results in decreased expression of LRP2 protein
CTD PMID:20576581 NCBI chr15:75,565,299...75,754,604
Ensembl chr15:75,565,301...75,716,694
JBrowse link
daidzein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ESR1 estrogen receptor 1 increases expression EXP daidzein results in increased expression of ESR1 mRNA CTD PMID:19617652 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363
JBrowse link
G ESR2 estrogen receptor 2 increases expression EXP daidzein results in increased expression of ESR2 mRNA; daidzein results in increased expression of ESR2 protein CTD PMID:19617652 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,722,164...193,906,565
JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions EXP daidzein inhibits the reaction [LHB protein results in increased abundance of Progesterone] CTD PMID:19617652 NCBI chr 6:54,263,574...54,269,286 JBrowse link
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions EXP daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of Penicillins]; daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid] CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,037,218...52,131,789
JBrowse link
dantrolene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RYR1 ryanodine receptor 1 decreases activity
multiple interactions
EXP Dantrolene results in decreased activity of RYR1 protein
5'-adenylyl (beta,gamma-methylene)diphosphonate affects the reaction [Dantrolene results in decreased activity of RYR1 protein]; [Dantrolene inhibits the reaction [Calcium results in increased activity of RYR1 protein]] which results in decreased secretion of Calcium; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein mutant form]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein]; Dantrolene inhibits the reaction [Calcium results in increased activity of RYR1 protein]; Dantrolene inhibits the reaction [Ryanodine binds to RYR1 protein mutant form]; Dantrolene inhibits the reaction [Ryanodine binds to RYR1 protein]; Dantrolene inhibits the reaction [Strontium promotes the reaction [Ryanodine binds to RYR1 protein]]
CTD PMID:11278295 NCBI chr 6:47,339,759...47,458,457 JBrowse link
DDE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 decreases expression
multiple interactions
EXP Dichlorodiphenyl Dichloroethylene results in decreased expression of CYP11A1 mRNA
Dichlorodiphenyl Dichloroethylene inhibits the reaction [Cholera Toxin results in increased expression of CYP11A1 mRNA]
CTD PMID:11226075 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
G CYP19A2 cytochrome P450 19A2 increases activity EXP Dichlorodiphenyl Dichloroethylene results in increased activity of CYP19A1 protein CTD PMID:18195494 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
deoxycholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase increases activity EXP Deoxycholic Acid results in increased activity of ACHE protein CTD PMID:3697337 NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,324...8,739,149
JBrowse link
deoxynivalenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTB actin beta increases expression EXP deoxynivalenol results in increased expression of ACTB mRNA CTD PMID:26417708 NCBI chr 3:4,084,275...4,090,383
Ensembl chr 3:4,082,216...4,090,356
JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases expression
decreases phosphorylation
EXP deoxynivalenol results in decreased expression of AKT1 mRNA; deoxynivalenol results in decreased expression of AKT1 protein
deoxynivalenol results in decreased phosphorylation of AKT1 protein
CTD PMID:16099139, PMID:32229166
G ALB albumin decreases expression EXP deoxynivalenol results in decreased expression of ALB protein CTD PMID:19477247 NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,718,304
JBrowse link
G AXIN2 axin 2 increases expression EXP deoxynivalenol results in increased expression of AXIN2 protein CTD PMID:30690062 NCBI chr12:12,311,293...12,343,207
Ensembl chr12:12,311,293...12,343,200
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions
EXP deoxynivalenol results in decreased expression of BCL2 mRNA; deoxynivalenol results in decreased expression of BCL2 protein
[Acetylcysteine co-treated with fumonisin B1 co-treated with deoxynivalenol] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone co-treated with deoxynivalenol] results in increased expression of BCL2 protein; [fumonisin B1 co-treated with deoxynivalenol] results in decreased expression of BCL2 mRNA; [fumonisin B1 co-treated with Zearalenone co-treated with deoxynivalenol] results in decreased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; fumonisin B1 inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; fumonisin B1 inhibits the reaction [Zearalenone inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 mRNA]]; Zearalenone inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 mRNA]; Zearalenone inhibits the reaction [fumonisin B1 inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]]
CTD PMID:25701311, PMID:29109043 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G BMI1 BMI1 proto-oncogene, polycomb ring finger decreases expression EXP deoxynivalenol results in decreased expression of BMI1 protein CTD PMID:30690062 NCBI chr10:52,586,089...52,596,154 JBrowse link
G CASP3 caspase 3 multiple interactions
increases expression
increases activity
EXP [fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 mRNA; [fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 protein; [fumonisin B1 co-treated with Zearalenone] promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]]; deoxynivalenol promotes the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 mRNA]; deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CASP3 mRNA]; fumonisin B1 promotes the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CASP3 mRNA]]; fumonisin B1 promotes the reaction [Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 mRNA]]; Zearalenone promotes the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 mRNA]; Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 mRNA]; Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]
deoxynivalenol results in increased expression of CASP3 mRNA; deoxynivalenol results in increased expression of CASP3 protein
deoxynivalenol results in increased activity of CASP3 protein
CTD PMID:20937367, PMID:24394488, PMID:29109043 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 increases expression
multiple interactions
decreases expression
EXP deoxynivalenol results in increased expression of CCL2 mRNA
[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; [deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL2 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone] results in increased expression of CCL2 mRNA; [deoxynivalenol co-treated with nivalenol] results in increased expression of CCL2 mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; [deoxynivalenol co-treated with Zearalenone] results in increased expression of CCL2 mRNA; fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL2 mRNA]; fumonisin B1 promotes the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL2 mRNA]
deoxynivalenol results in decreased expression of CCL2 mRNA
CTD PMID:23688591, PMID:30708112 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G CCL20 C-C motif chemokine ligand 20 multiple interactions
increases expression
EXP [deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL20 mRNA; fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL20 mRNA]; fumonisin B1 promotes the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL20 mRNA]
deoxynivalenol results in increased expression of CCL20 mRNA
CTD PMID:23326479, PMID:30708112 NCBI chr15:129,172,743...129,176,069 JBrowse link
G CCND1 cyclin D1 decreases expression EXP deoxynivalenol results in decreased expression of CCND1 protein CTD PMID:30690062 NCBI chr 2:3,621,242...3,633,380
Ensembl chr 2:3,621,246...3,633,296
JBrowse link
G CCR6 C-C motif chemokine receptor 6 increases expression EXP deoxynivalenol results in increased expression of CCR6 mRNA CTD PMID:23326479 NCBI chr 1:2,016,600...2,034,172
Ensembl chr 1:2,018,608...2,019,821
JBrowse link
G CLDN3 claudin 3 decreases expression EXP deoxynivalenol analog results in decreased expression of CLDN3 protein; deoxynivalenol results in decreased expression of CLDN3 protein CTD PMID:19289138, PMID:22859312 NCBI chr 3:11,019,073...11,020,102
Ensembl chr 3:11,019,295...11,019,960
JBrowse link
G CLDN4 claudin 4 decreases expression EXP deoxynivalenol analog results in decreased expression of CLDN4 protein; deoxynivalenol results in decreased expression of CLDN4 protein CTD PMID:19289138, PMID:22859312 NCBI chr 3:11,039,711...11,053,930
Ensembl chr 3:11,039,706...11,053,925
JBrowse link
G CRP C-reactive protein, pentraxin-related decreases expression EXP deoxynivalenol results in decreased expression of CRP protein CTD PMID:25701311 NCBI chr 4:90,793,361...90,801,020
Ensembl chr 4:90,722,352...90,805,236
JBrowse link
G CTNNB1 catenin beta 1 decreases expression EXP deoxynivalenol results in decreased expression of CTNNB1 protein CTD PMID:30690062 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,137,173...25,208,311
JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 increases expression EXP deoxynivalenol results in increased expression of CX3CL1 mRNA CTD PMID:23326479 NCBI chr 6:19,312,351...19,324,439 JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 increases expression EXP deoxynivalenol results in increased expression of CXCL10 mRNA CTD PMID:25701311 NCBI chr 8:71,693,641...71,695,948
Ensembl chr 8:71,693,339...71,695,948
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression
decreases expression
multiple interactions
EXP deoxynivalenol results in increased expression of CXCL8 mRNA; deoxynivalenol results in increased expression of CXCL8 protein
deoxynivalenol results in decreased expression of CXCL8 protein
[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CXCL8 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone] results in increased expression of CXCL8 mRNA; [deoxynivalenol co-treated with nivalenol] results in increased expression of CXCL8 mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [deoxynivalenol co-treated with Zearalenone] results in increased expression of CXCL8 mRNA; deoxynivalenol promotes the reaction [nivalenol results in increased expression of CXCL8 mRNA]; fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CXCL8 mRNA]; fumonisin B1 promotes the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CXCL8 mRNA]
CTD PMID:23326479, PMID:23688591, PMID:25701311, PMID:26417708, PMID:27915442, PMID:30708112 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP [deoxynivalenol co-treated with fumonisin B1] results in increased expression of CYCS mRNA; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[Zearalenone co-treated with fumonisin B1] results in increased expression of CYCS mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CYCS mRNA]]; deoxynivalenol promotes the reaction [[Zearalenone co-treated with fumonisin B1] results in increased expression of CYCS mRNA]; deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]; fumonisin B1 promotes the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]; Zearalenone promotes the reaction [[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CYCS mRNA] CTD PMID:29109043 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 multiple interactions EXP deoxynivalenol inhibits the reaction [[FSHB protein co-treated with IGF1 protein] results in increased expression of CYP11A1 mRNA] CTD PMID:17656051 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
G CYP19A2 cytochrome P450 19A2 multiple interactions EXP deoxynivalenol inhibits the reaction [[FSHB protein co-treated with IGF1 protein] results in increased expression of CYP19A1 mRNA] CTD PMID:17656051 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G DEFB1 defensin beta 1 decreases expression EXP deoxynivalenol results in decreased expression of DEFB1 mRNA CTD PMID:25701311
G DNMT3A DNA methyltransferase 3 alpha increases expression EXP deoxynivalenol results in increased expression of DNMT3A mRNA CTD PMID:26988607 NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,609,139
JBrowse link
G EIF4E eukaryotic translation initiation factor 4E decreases phosphorylation EXP deoxynivalenol results in decreased phosphorylation of EIF4E protein CTD PMID:16099139 NCBI chr 8:121,409,633...121,464,467
Ensembl chr 8:121,409,731...121,466,899
JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 decreases expression EXP deoxynivalenol results in decreased expression of EIF4EBP1 protein modified form CTD PMID:16099139 NCBI chr15:48,423,001...48,443,373
Ensembl chr15:48,422,816...48,443,399
JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit increases expression EXP deoxynivalenol results in increased expression of EZH2 mRNA CTD PMID:26988607 NCBI chr 9:109,384,976...109,450,943
Ensembl chr 9:109,384,995...109,450,941
JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions EXP deoxynivalenol affects the reaction [[FSHB protein co-treated with IGF1 protein] results in increased abundance of Estradiol]; deoxynivalenol inhibits the reaction [[FSHB protein co-treated with IGF1 protein] results in increased abundance of Progesterone]; deoxynivalenol inhibits the reaction [[FSHB protein co-treated with IGF1 protein] results in increased expression of CYP11A1 mRNA]; deoxynivalenol inhibits the reaction [[FSHB protein co-treated with IGF1 protein] results in increased expression of CYP19A1 mRNA] CTD PMID:17656051 NCBI chr 2:30,395,769...30,399,282
Ensembl chr 2:30,395,018...30,399,274
JBrowse link
G GPX2 glutathione peroxidase 2 increases expression EXP deoxynivalenol results in increased expression of GPX2 mRNA CTD PMID:25701311 NCBI chr 7:89,007,636...89,011,620
Ensembl chr 7:89,007,369...89,011,620
JBrowse link
G GPX3 glutathione peroxidase 3 decreases expression EXP deoxynivalenol results in decreased expression of GPX3 mRNA CTD PMID:25701311 NCBI chr16:71,980,467...71,989,011
Ensembl chr16:71,980,475...71,989,026
JBrowse link
G GPX4 glutathione peroxidase 4 decreases expression EXP deoxynivalenol results in decreased expression of GPX4 mRNA CTD PMID:25701311 NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,886
JBrowse link
G GSK3B glycogen synthase kinase 3 beta increases expression EXP deoxynivalenol results in increased expression of GSK3B protein CTD PMID:30690062 NCBI chr13:140,136,109...140,370,197
Ensembl chr13:140,136,158...140,369,574
JBrowse link
G GSR glutathione-disulfide reductase decreases activity
multiple interactions
EXP deoxynivalenol results in decreased activity of GSR protein
Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]]; fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]; fumonisin B1 promotes the reaction [Zearalenone promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]; Zearalenone promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]; Zearalenone promotes the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]
CTD PMID:29109043 NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,989
JBrowse link
G IFNB1 interferon beta 1 increases expression EXP deoxynivalenol results in increased expression of IFNB1 mRNA CTD PMID:24394488 NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495
JBrowse link
G IFNG interferon gamma increases expression
decreases expression
multiple interactions
EXP deoxynivalenol results in increased expression of IFNG mRNA
deoxynivalenol results in decreased expression of IFNG mRNA
[Zearalenone co-treated with deoxynivalenol] results in decreased expression of IFNG mRNA
CTD PMID:18296887, PMID:18329193, PMID:25701311 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,848...32,482,752
JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions EXP deoxynivalenol affects the reaction [[FSHB protein co-treated with IGF1 protein] results in increased abundance of Estradiol]; deoxynivalenol affects the reaction [IGF1 protein results in increased abundance of Estradiol]; deoxynivalenol inhibits the reaction [[FSHB protein co-treated with IGF1 protein] results in increased abundance of Progesterone]; deoxynivalenol inhibits the reaction [[FSHB protein co-treated with IGF1 protein] results in increased expression of CYP11A1 mRNA]; deoxynivalenol inhibits the reaction [[FSHB protein co-treated with IGF1 protein] results in increased expression of CYP19A1 mRNA] CTD PMID:17656051 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,037
JBrowse link
G IL10 interleukin 10 increases expression
multiple interactions
EXP deoxynivalenol results in increased expression of IL10 mRNA
deoxynivalenol promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL10 mRNA]
CTD PMID:19027837, PMID:19607891 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,727...67,405,711
JBrowse link
G IL17A interleukin 17A multiple interactions
increases expression
EXP [deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of IL17A protein; deoxynivalenol promotes the reaction [nivalenol results in increased expression of IL17A mRNA]; fumonisin B1 inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of IL17A protein]; fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of IL17A protein]
deoxynivalenol results in increased expression of IL17A mRNA; deoxynivalenol results in increased expression of IL17A protein
CTD PMID:23326479, PMID:27915442, PMID:30708112 NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153
JBrowse link
G IL1A interleukin 1 alpha increases expression
multiple interactions
decreases expression
EXP deoxynivalenol results in increased expression of IL1A mRNA; deoxynivalenol results in increased expression of IL1A protein
[deoxynivalenol co-treated with fumonisin B1] results in decreased expression of IL1A mRNA; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of IL1A mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1A mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone] results in increased expression of IL1A mRNA; [deoxynivalenol co-treated with nivalenol] results in increased expression of IL1A mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1A mRNA; [deoxynivalenol co-treated with Zearalenone] results in decreased expression of IL1A mRNA; [deoxynivalenol co-treated with Zearalenone] results in increased expression of IL1A mRNA; deoxynivalenol promotes the reaction [nivalenol results in increased expression of IL1A mRNA]; nivalenol promotes the reaction [deoxynivalenol results in increased expression of IL1A mRNA]
deoxynivalenol results in decreased expression of IL1A mRNA
CTD PMID:23326479, PMID:23688591, PMID:27915442 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119
JBrowse link
G IL1B2 interleukin 1, beta 2 increases expression
multiple interactions
EXP deoxynivalenol results in increased expression of IL1B2 mRNA
deoxynivalenol promotes the reaction [nivalenol results in increased expression of IL1B2 mRNA]; nivalenol promotes the reaction [deoxynivalenol results in increased expression of IL1B2 mRNA]
CTD PMID:27915442
G IL2 interleukin 2 multiple interactions EXP [Zearalenone co-treated with deoxynivalenol] results in decreased expression of IL2 mRNA CTD PMID:18296887 NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609
JBrowse link
G IL21 interleukin 21 increases expression EXP deoxynivalenol results in increased expression of IL21 mRNA CTD PMID:23326479 NCBI chr 8:101,532,742...101,540,712
Ensembl chr 8:101,530,949...101,540,738
JBrowse link
G IL22 interleukin 22 multiple interactions
increases expression
EXP deoxynivalenol promotes the reaction [nivalenol results in increased expression of IL22 mRNA]
deoxynivalenol results in increased expression of IL22 mRNA
CTD PMID:23326479, PMID:27915442 NCBI chr 5:32,599,522...32,604,507
Ensembl chr 5:32,599,301...32,604,736
JBrowse link
G IL23A interleukin 23 subunit alpha increases expression EXP deoxynivalenol results in increased expression of IL23A mRNA CTD PMID:23326479 NCBI chr 5:21,732,416...21,733,981
Ensembl chr 5:21,732,165...21,734,267
JBrowse link
G IL4 interleukin 4 increases expression EXP deoxynivalenol results in increased expression of IL4 mRNA CTD PMID:25701311 NCBI chr 2:134,986,817...1