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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gold coordination entity
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Accession:CHEBI:33971 term browser browse the term
Synonyms:related_synonym: gold coordination compounds;   gold coordination entities


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auranofin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Auranofin analog binds to ALB protein CTD PMID:16791640 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions
increases response to substance
ISO [BAX co-treated with BAK1] results in increased susceptibility to Auranofin; BAK1 mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]
BAK1 results in increased susceptibility to Auranofin
CTD PMID:18789312, PMID:21172426 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases response to substance
ISO [BAX co-treated with BAK1] results in increased susceptibility to Auranofin; BAX mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]
BAX results in increased susceptibility to Auranofin
CTD PMID:18789312, PMID:21172426 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO BCL2 protein inhibits the reaction [Auranofin results in increased activity of CASP3 protein] CTD PMID:18789312 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO
EXP
Auranofin promotes the reaction [TNF protein results in increased activity of CASP3 protein]; Auranofin results in decreased expression of and results in increased cleavage of CASP3 protein; BCL2 protein inhibits the reaction [Auranofin results in increased activity of CASP3 protein]
BAK1 mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]; BAX mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]
CTD PMID:15159275, PMID:15191400, PMID:18789312, PMID:20542334, PMID:21699084 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Auranofin results in decreased expression of and results in increased cleavage of CASP8 protein CTD PMID:20542334 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Auranofin results in decreased expression of and results in increased cleavage of CASP9 protein CTD PMID:20542334 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Auranofin results in increased expression of CDKN1A protein CTD PMID:20542334 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cebpe CCAAT/enhancer binding protein epsilon multiple interactions ISO [Auranofin co-treated with Tretinoin] results in increased expression of CEBPE protein CTD PMID:15159275 NCBI chr15:33,356,119...33,357,517
Ensembl chr15:33,355,947...33,358,138
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Auranofin inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of CHUK protein]; Auranofin inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]
Auranofin inhibits the reaction [TNF protein results in increased activity of CHUK protein]
CTD PMID:10820281 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases expression
ISO [Peptidoglycan co-treated with Lipopolysaccharides] promotes the reaction [Auranofin results in increased expression of GPX1 protein]; Auranofin promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of GPX1 protein] CTD PMID:21355852 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Auranofin results in increased expression of HMOX1 mRNA
Auranofin results in increased expression of HMOX1 mRNA; Auranofin results in increased expression of HMOX1 protein
CTD PMID:22008538, PMID:23942037 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Auranofin inhibits the reaction [IL1B protein affects the localization of RELA protein]; Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein] CTD PMID:10594346 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Auranofin co-treated with IL6 protein] results in decreased phosphorylation of IL6ST protein; [Auranofin co-treated with IL6 protein] results in decreased phosphorylation of JAK2 protein; [Auranofin co-treated with IL6 protein] results in decreased phosphorylation of STAT3 protein CTD PMID:20542334 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6st interleukin 6 signal transducer multiple interactions ISO [Auranofin co-treated with IL6 protein] results in decreased phosphorylation of IL6ST protein CTD PMID:20542334 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO Auranofin inhibits the reaction [lipopolysaccharide A results in increased degradation of IRAK1 protein] CTD PMID:17034761 NCBI chr  X:156,716,469...156,726,367
Ensembl chr  X:156,716,604...156,725,977
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO Auranofin inhibits the reaction [lipopolysaccharide A results in increased activity of IRF3 protein]; Auranofin inhibits the reaction [lipopolysaccharide A results in increased phosphorylation of IRF3 protein]; Auranofin inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein]; Auranofin inhibits the reaction [TICAM1 protein results in increased activity of IRF3 protein] CTD PMID:17034761 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO [Auranofin co-treated with Tretinoin] results in increased expression of ITGAM protein CTD PMID:15159275 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO [Auranofin co-treated with IL6 protein] results in decreased phosphorylation of JAK2 protein CTD PMID:20542334 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
decreases expression
ISO [Auranofin co-treated with SN50 peptide] results in decreased expression of MCL1 protein
Auranofin results in decreased expression of MCL1 protein
CTD PMID:20542334 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Auranofin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] CTD PMID:10820281 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions ISO Auranofin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein] CTD PMID:10820281 NCBI chr 1:86,941,073...86,948,845
Ensembl chr 1:86,941,074...86,948,845
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases activity
increases cleavage
ISO Auranofin results in decreased activity of PARP1 protein
Auranofin results in increased cleavage of PARP1 protein
CTD PMID:15159275, PMID:21370912 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ppif peptidylprolyl isomerase F increases oxidation
multiple interactions
ISO
EXP
Auranofin results in increased oxidation of PPIF protein
Auranofin inhibits the reaction [[NADP co-treated with TXNRD1 protein] results in increased activity of PPIF protein]; Cyclosporine promotes the reaction [Auranofin results in increased oxidation of PPIF protein]
CTD PMID:26975474 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908
JBrowse link
G Prdx3 peroxiredoxin 3 increases oxidation
multiple interactions
ISO
EXP
Auranofin results in increased oxidation of PRDX3 protein
Cyclosporine promotes the reaction [Auranofin results in increased oxidation of PRDX3 protein]
Auranofin promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of PRDX3 protein]
CTD PMID:18789312, PMID:21355852, PMID:26975474 NCBI chr 1:282,238,774...282,251,193
Ensembl chr 1:282,238,773...282,251,257
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [lipopolysaccharide A co-treated with Auranofin] results in decreased expression of PTGS2 protein
Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]
CTD PMID:10594346, PMID:17034761 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO Auranofin results in decreased phosphorylation of RB1 protein CTD PMID:20542334 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Auranofin inhibits the reaction [IL1B protein affects the localization of RELA protein] CTD PMID:10594346 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G RT1-Ba RT1 class II, locus Ba increases response to substance ISO HLA-DQA1 gene polymorphism results in increased susceptibility to Auranofin CTD PMID:11436868 NCBI chr20:4,066,133...4,070,726
Ensembl chr20:4,066,132...4,070,721
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 increases response to substance ISO HLA-DRB1 gene polymorphism results in increased susceptibility to Auranofin CTD PMID:11436868 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Auranofin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases expression
multiple interactions
ISO Auranofin results in decreased expression of STAT3 protein modified form
[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of STAT3 protein
CTD PMID:20542334 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tbk1 TANK-binding kinase 1 multiple interactions ISO Auranofin inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein] CTD PMID:17034761 NCBI chr 7:63,655,247...63,687,978
Ensembl chr 7:63,655,247...63,687,978
JBrowse link
G Ticam1 toll-like receptor adaptor molecule 1 multiple interactions ISO Auranofin inhibits the reaction [TICAM1 protein results in increased activity of IRF3 protein] CTD PMID:17034761 NCBI chr 9:10,780,185...10,790,280 JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Auranofin inhibits the reaction [lipopolysaccharide A promotes the reaction [TLR4 protein binds to TLR4 protein]] CTD PMID:17034761 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Auranofin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Auranofin promotes the reaction [TNF protein results in increased activity of CASP3 protein]
Auranofin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD PMID:10820281, PMID:18789312 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Txn1 thioredoxin 1 increases oxidation ISO Auranofin results in increased oxidation of TXN protein CTD PMID:26975474 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Txn2 thioredoxin 2 increases oxidation
multiple interactions
ISO
EXP
Auranofin results in increased oxidation of TXN2 protein
Cyclosporine promotes the reaction [Auranofin results in increased oxidation of TXN2 protein]
CTD PMID:26975474 NCBI chr 7:119,144,350...119,158,173
Ensembl chr 7:119,144,351...119,158,201
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions
decreases activity
increases oxidation
increases expression
ISO
EXP
Auranofin inhibits the reaction [Sodium Selenite results in increased activity of TXNRD1 protein]; Auranofin promotes the reaction [Sodium Selenite results in increased expression of TXNRD1 mRNA]; potassium tellurate(IV) promotes the reaction [Auranofin results in increased oxidation of TXNRD1 protein]; Sodium Selenite promotes the reaction [Auranofin results in increased oxidation of TXNRD1 protein]
Auranofin inhibits the reaction [[NADP co-treated with TXNRD1 protein] results in increased activity of PPIF protein]; Auranofin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]
Auranofin results in decreased activity of TXNRD1 protein
Auranofin results in increased expression of TXNRD1 mRNA
CTD PMID:16510263, PMID:18405881, PMID:18789312, PMID:19486940, PMID:20457604, PMID:21172426, PMID:26975474 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Txnrd2 thioredoxin reductase 2 multiple interactions
decreases activity
ISO
EXP
Auranofin inhibits the reaction [Sodium Selenite results in increased activity of TXNRD2 protein]; Auranofin promotes the reaction [Sodium Selenite results in decreased expression of TXNRD2 mRNA]
Auranofin results in decreased activity of TXNRD2 protein
CTD PMID:15458826, PMID:19486940, PMID:21172426, PMID:21355852 NCBI chr11:86,667,994...86,716,063
Ensembl chr11:86,667,997...86,716,254
JBrowse link
sodium aurothiomalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ackr3 atypical chemokine receptor 3 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of ACKR3 mRNA CTD PMID:19192274 NCBI chr 9:97,355,881...97,367,455
Ensembl chr 9:97,355,924...97,367,445
JBrowse link
G Adora2a adenosine A2a receptor decreases expression ISO Gold Sodium Thiomalate results in decreased expression of ADORA2A mRNA CTD PMID:19192274 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Amigo2 adhesion molecule with Ig like domain 2 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of AMIGO2 mRNA CTD PMID:19192274 NCBI chr 7:138,704,124...138,707,221
Ensembl chr 7:138,704,126...138,707,221
JBrowse link
G Antxr1 ANTXR cell adhesion molecule 1 increases expression ISO Gold Sodium Thiomalate results in increased expression of ANTXR1 mRNA CTD PMID:19192274 NCBI chr 4:118,946,267...119,131,202
Ensembl chr 4:118,946,268...119,131,202
JBrowse link
G Aox1 aldehyde oxidase 1 increases expression ISO Gold Sodium Thiomalate results in increased expression of AOX1 mRNA CTD PMID:19192274 NCBI chr 9:64,929,682...65,007,872
Ensembl chr 9:64,929,721...65,007,870
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of BCL2A1 mRNA CTD PMID:19192274 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of BST2 mRNA CTD PMID:19192274 NCBI chr16:19,938,781...19,942,353
Ensembl chr16:19,938,784...19,942,353
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of CCL20 mRNA; Gold Sodium Thiomalate results in decreased expression of CCL20 protein CTD PMID:19192274 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO Gold Sodium Thiomalate results in increased expression of CCN1 mRNA CTD PMID:19192274 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Ccn5 cellular communication network factor 5 increases expression ISO Gold Sodium Thiomalate results in increased expression of CCN5 mRNA CTD PMID:19192274 NCBI chr 3:160,207,969...160,219,316
Ensembl chr 3:160,207,913...160,219,331
JBrowse link
G Cd28 Cd28 molecule multiple interactions
affects response to substance
ISO CD28 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]
CD28 protein affects the susceptibility to Gold Sodium Thiomalate
CTD PMID:19077085 NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Gold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein] CTD PMID:10820281 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Clgn calmegin decreases expression ISO Gold Sodium Thiomalate results in decreased expression of CLGN mRNA CTD PMID:19192274 NCBI chr19:24,545,257...24,578,527
Ensembl chr19:24,545,318...24,576,798
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Gold Sodium Thiomalate results in increased expression of COL1A1 mRNA CTD PMID:19192274 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Colec12 collectin sub-family member 12 increases expression ISO Gold Sodium Thiomalate results in increased expression of COLEC12 mRNA CTD PMID:19192274 NCBI chr18:867,048...1,054,047
Ensembl chr18:867,048...1,052,606
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of CXCL1 mRNA CTD PMID:19192274 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of CXCL2 mRNA CTD PMID:19192274 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of CXCL1 mRNA CTD PMID:19192274 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of CXCR4 mRNA CTD PMID:19192274 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Ddx10 DEAD-box helicase 10 increases expression ISO Gold Sodium Thiomalate results in increased expression of DDX10 mRNA CTD PMID:19192274 NCBI chr 8:57,667,472...57,830,504
Ensembl chr 8:57,667,472...57,830,504
JBrowse link
G Ddx58 DEXD/H-box helicase 58 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of DDX58 mRNA CTD PMID:19192274 NCBI chr 5:56,486,584...56,536,898
Ensembl chr 5:56,500,734...56,536,772
JBrowse link
G Efemp1 EGF containing fibulin extracellular matrix protein 1 increases expression ISO Gold Sodium Thiomalate results in increased expression of EFEMP1 mRNA CTD PMID:19192274 NCBI chr14:113,202,382...113,294,993
Ensembl chr14:113,202,419...113,295,014
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 increases expression ISO Gold Sodium Thiomalate results in increased expression of ENPP2 mRNA CTD PMID:19192274 NCBI chr 7:94,479,931...94,563,086
Ensembl chr 7:94,480,396...94,563,001
JBrowse link
G Entpd3 ectonucleoside triphosphate diphosphohydrolase 3 increases expression ISO Gold Sodium Thiomalate results in increased expression of ENTPD3 mRNA CTD PMID:19192274 NCBI chr 8:129,201,000...129,232,436
Ensembl chr 8:129,201,669...129,232,677
JBrowse link
G Fbl fibrillarin affects localization
decreases activity
multiple interactions
ISO Gold Sodium Thiomalate affects the localization of FBL protein
Gold Sodium Thiomalate results in decreased activity of FBL protein
CD28 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]; IFNG protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]; IL4 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]; IL6 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]
CTD PMID:10942594, PMID:19077085 NCBI chr 1:85,103,519...85,112,619
Ensembl chr 1:85,103,519...85,112,619
JBrowse link
G Fbln1 fibulin 1 increases expression ISO Gold Sodium Thiomalate results in increased expression of FBLN1 mRNA CTD PMID:19192274 NCBI chr 7:126,096,793...126,176,468
Ensembl chr 7:126,096,793...126,176,468
JBrowse link
G Fgf7 fibroblast growth factor 7 increases expression ISO Gold Sodium Thiomalate results in increased expression of FGF7 mRNA CTD PMID:19192274 NCBI chr 3:118,315,859...118,368,464
Ensembl chr 3:118,317,761...118,366,872
JBrowse link
G Gbp1 guanylate binding protein 1 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of GBP1 mRNA CTD PMID:19192274 NCBI chr 2:248,343,334...248,423,402
Ensembl chr 2:248,398,917...248,409,570
JBrowse link
G Gpm6b glycoprotein m6b increases expression ISO Gold Sodium Thiomalate results in increased expression of GPM6B mRNA CTD PMID:19192274 NCBI chr  X:29,604,607...29,751,174
Ensembl chr  X:29,607,075...29,648,403
JBrowse link
G Gsdme gasdermin E decreases expression ISO Gold Sodium Thiomalate results in decreased expression of GSDME mRNA CTD PMID:19192274 NCBI chr 4:79,934,075...79,999,678
Ensembl chr 4:79,934,887...79,989,572
JBrowse link
G Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of HERC6 mRNA CTD PMID:19192274 NCBI chr 4:88,606,851...88,649,424
Ensembl chr 4:88,607,518...88,649,216
JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated decreases expression ISO Gold Sodium Thiomalate results in decreased expression of HILPDA mRNA CTD PMID:19192274 NCBI chr 4:56,547,600...56,550,584
Ensembl chr 4:56,549,739...56,549,993
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of HSD11B1 mRNA CTD PMID:19192274 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of IFI27 mRNA CTD PMID:19192274 NCBI chr 6:127,327,959...127,334,430
Ensembl chr 6:127,327,959...127,334,428
JBrowse link
G Ifi35 interferon-induced protein 35 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of IFI35 mRNA CTD PMID:19192274 NCBI chr10:89,358,376...89,366,628
Ensembl chr10:89,358,376...89,366,626
JBrowse link
G Ifi44 interferon-induced protein 44 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of IFI44 mRNA CTD PMID:19192274 NCBI chr 2:256,897,765...256,915,591
Ensembl chr 2:256,897,772...256,915,569
JBrowse link
G Ifi44l interferon-induced protein 44-like decreases expression ISO Gold Sodium Thiomalate results in decreased expression of IFI44L mRNA CTD PMID:19192274 NCBI chr 2:256,948,722...256,979,573
Ensembl chr 2:256,964,860...256,978,668
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of IFIH1 mRNA CTD PMID:19192274 NCBI chr 3:48,557,696...48,604,097
Ensembl chr 3:48,557,696...48,604,097
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of IFIT3 mRNA CTD PMID:19192274 NCBI chr 1:252,906,234...252,911,377
Ensembl chr 1:252,906,234...252,911,382
JBrowse link
G Ifng interferon gamma multiple interactions
affects response to substance
ISO IFNG protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]
IFNG protein affects the susceptibility to Gold Sodium Thiomalate
CTD PMID:19077085 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO Gold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein] CTD PMID:10820281 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Gold Sodium Thiomalate co-treated with mercury nitrate analog] results in increased expression of IL10 protein CTD PMID:11824965 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Gold Sodium Thiomalate inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Gold Sodium Thiomalate inhibits the reaction [IL1B protein results in increased expression of PTGES] CTD PMID:16393772, PMID:25314295 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression ISO Gold Sodium Thiomalate results in decreased expression of IL1RN mRNA CTD PMID:19192274 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il23a interleukin 23 subunit alpha decreases expression ISO Gold Sodium Thiomalate results in decreased expression of IL23A mRNA CTD PMID:19192274 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G Il4 interleukin 4 multiple interactions
affects response to substance
ISO IL4 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]
IL4 protein affects the susceptibility to Gold Sodium Thiomalate
CTD PMID:19077085 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
affects response to substance
ISO [Gold Sodium Thiomalate co-treated with mercury nitrate analog] results in increased expression of IL6 protein
Gold Sodium Thiomalate results in decreased expression of IL6 mRNA; Gold Sodium Thiomalate results in decreased expression of IL6 protein
IL6 protein affects the susceptibility to Gold Sodium Thiomalate
IL6 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]
CTD PMID:11824965, PMID:19077085, PMID:19192274 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of IRF7 mRNA CTD PMID:19192274 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression ISO Gold Sodium Thiomalate results in decreased expression of ISG15 mRNA CTD PMID:19192274 NCBI chr 5:173,624,862...173,629,124
Ensembl chr 5:173,624,310...173,626,248
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of ISG20 mRNA CTD PMID:19192274 NCBI chr 1:140,602,553...140,608,892
Ensembl chr 1:140,601,791...140,608,946
JBrowse link
G Lamb3 laminin subunit beta 3 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of LAMB3 mRNA CTD PMID:19192274 NCBI chr13:112,031,614...112,073,187
Ensembl chr13:112,031,594...112,073,186
JBrowse link
G Lxn latexin increases expression ISO Gold Sodium Thiomalate results in increased expression of LXN mRNA CTD PMID:19192274 NCBI chr 2:164,628,565...164,634,434
Ensembl chr 2:164,628,566...164,634,434
JBrowse link
G Ly6e lymphocyte antigen 6 family member E decreases expression ISO Gold Sodium Thiomalate results in decreased expression of LY6E mRNA CTD PMID:19192274 NCBI chr 7:116,355,426...116,359,862
Ensembl chr 7:116,355,698...116,359,862
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate decreases expression ISO Gold Sodium Thiomalate results in decreased expression of MARCKS mRNA CTD PMID:19192274 NCBI chr20:42,966,140...42,971,838
Ensembl chr20:42,966,140...42,971,838
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO Gold Sodium Thiomalate results in decreased expression of MET mRNA CTD PMID:19192274 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of MMP10 mRNA CTD PMID:19192274 NCBI chr 8:5,734,348...5,742,243
Ensembl chr 8:5,734,348...5,742,243
JBrowse link
G Mx2 MX dynamin like GTPase 2 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of MX1 mRNA CTD PMID:19192274 NCBI chr11:38,035,306...38,066,185
Ensembl chr11:38,035,450...38,059,950
JBrowse link
G Ndufa4l2 NDUFA4, mitochondrial complex associated like 2 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of NDUFA4L2 mRNA CTD PMID:19192274 NCBI chr 7:70,821,904...70,824,085
Ensembl chr 7:70,821,957...70,824,085
JBrowse link
G Nmb neuromedin B decreases expression ISO Gold Sodium Thiomalate results in decreased expression of NMB mRNA CTD PMID:19192274 NCBI chr 1:142,721,263...142,724,646
Ensembl chr 1:142,721,002...142,724,511
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Gold Sodium Thiomalate inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide] CTD PMID:16393772 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of NR4A3 mRNA CTD PMID:19192274 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A decreases expression ISO Gold Sodium Thiomalate results in decreased expression of OAS1 mRNA CTD PMID:19192274 NCBI chr12:41,200,680...41,211,393
Ensembl chr12:41,200,718...41,211,909
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like decreases expression ISO Gold Sodium Thiomalate results in decreased expression of OASL mRNA CTD PMID:19192274 NCBI chr12:47,444,138...47,456,680
Ensembl chr12:47,444,104...47,456,894
JBrowse link
G Olfml2b olfactomedin-like 2B increases expression ISO Gold Sodium Thiomalate results in increased expression of OLFML2B mRNA CTD PMID:19192274 NCBI chr13:88,995,301...89,032,487
Ensembl chr13:88,995,316...89,032,487
JBrowse link
G Phgdh phosphoglycerate dehydrogenase decreases expression ISO Gold Sodium Thiomalate results in decreased expression of PHGDH mRNA CTD PMID:19192274 NCBI chr 2:200,484,245...200,513,564
Ensembl chr 2:200,484,246...200,513,564
JBrowse link
G Plpp3 phospholipid phosphatase 3 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of PLPP3 mRNA CTD PMID:19192274 NCBI chr 5:124,690,214...124,765,499
Ensembl chr 5:124,690,214...124,765,498
JBrowse link
G Ppp4r2 protein phosphatase 4, regulatory subunit 2 increases expression ISO Gold Sodium Thiomalate results in increased expression of PPP4R2 mRNA CTD PMID:19192274 NCBI chr 4:133,285,552...133,323,755
Ensembl chr 4:133,285,552...133,323,755
JBrowse link
G Ptges prostaglandin E synthase multiple interactions ISO Gold Sodium Thiomalate inhibits the reaction [IL1B protein results in increased expression of PTGES] CTD PMID:25314295 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of PTGS2 mRNA CTD PMID:19192274 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rarres1 retinoic acid receptor responder 1 increases expression ISO Gold Sodium Thiomalate results in increased expression of RARRES1 mRNA CTD PMID:19192274 NCBI chr 2:164,650,722...164,684,982
Ensembl chr 2:164,650,722...164,684,985
JBrowse link
G Rgs4 regulator of G-protein signaling 4 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of RGS4 mRNA CTD PMID:19192274 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of RIPK2 mRNA CTD PMID:19192274 NCBI chr 5:29,838,713...29,870,390
Ensembl chr 5:29,838,747...29,870,735
JBrowse link
G Rnf19b ring finger protein 19B decreases expression ISO Gold Sodium Thiomalate results in decreased expression of RNF19B mRNA CTD PMID:19192274 NCBI chr 5:147,246,032...147,270,892
Ensembl chr 5:147,246,037...147,270,957
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of RSAD2 mRNA CTD PMID:19192274 NCBI chr 6:45,655,947...45,669,083
Ensembl chr 6:45,655,954...45,669,148
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of SLC7A11 mRNA CTD PMID:19192274 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Sms spermine synthase decreases expression ISO Gold Sodium Thiomalate results in decreased expression of SMS mRNA CTD PMID:19192274 NCBI chr  X:40,363,646...40,415,110
Ensembl chr  X:40,363,646...40,415,109
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of SOD2 mRNA CTD PMID:19192274 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Spon1 spondin 1 increases expression ISO Gold Sodium Thiomalate results in increased expression of SPON1 mRNA CTD PMID:19192274 NCBI chr 1:178,568,777...178,935,715
Ensembl chr 1:178,636,544...178,935,051
JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of STAT1 mRNA CTD PMID:19192274 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Sts steroid sulfatase increases expression ISO Gold Sodium Thiomalate results in increased expression of STS mRNA CTD PMID:19192274 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO Gold Sodium Thiomalate results in increased expression of THBS1 mRNA CTD PMID:19192274 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Thbs2 thrombospondin 2 increases expression ISO Gold Sodium Thiomalate results in increased expression of THBS2 mRNA CTD PMID:19192274 NCBI chr 1:56,653,929...56,683,571
Ensembl chr 1:56,653,938...56,683,731
JBrowse link
G Tlr2 toll-like receptor 2 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of TLR2 mRNA CTD PMID:19192274 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tnfaip2 TNF alpha induced protein 2 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of TNFAIP2 mRNA CTD PMID:19192274 NCBI chr 6:135,890,869...135,903,647
Ensembl chr 6:135,890,931...135,903,647
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO Gold Sodium Thiomalate results in increased expression of TXNIP mRNA CTD PMID:19192274 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions
decreases activity
ISO
EXP
Gold Sodium Thiomalate inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]
Gold Sodium Thiomalate results in decreased activity of TXNRD1 protein
CTD PMID:16510263, PMID:17229725 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Txnrd2 thioredoxin reductase 2 decreases activity EXP Gold Sodium Thiomalate results in decreased activity of TXNRD2 protein CTD PMID:15458826 NCBI chr11:86,667,994...86,716,063
Ensembl chr11:86,667,997...86,716,254
JBrowse link
sodium aurothiosulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Gold Sodium Thiosulfate binds to ALB protein CTD PMID:16791640 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Cd40 CD40 molecule increases expression ISO Gold Sodium Thiosulfate results in increased expression of CD40 protein CTD PMID:25458486 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Il6 interleukin 6 increases secretion ISO Gold Sodium Thiosulfate results in increased secretion of IL6 protein CTD PMID:25458486 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO TLR3 protein affects the reaction [Gold Sodium Thiosulfate results in increased secretion of CXCL8 protein] CTD PMID:25458486 NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    chemical entity 19791
      molecular entity 19787
        transition element molecular entity 16418
          transition element coordination entity 11076
            gold coordination entity 123
              auranofin 40
              aurothiomalic acid + 0
              aurothiosulfate(3-) + 4
              dicyanoaurate(1-) + 0
              digold hexachloride 0
              gold pentafluoride 0
              gold tribromide 0
              gold trichloride 0
              gold trifluoride 0
              hexafluoroaurate(1-) 0
              monosodium aurothiomalate + 87
              tetraamminegold(3+) 0
              tetrabromoaurate(1-) + 0
              tetrachloroaurate(1-) + 0
              tetracyanoaurate(1-) 0
              tetrafluoroaurate(1-) 0
              tetranitratoaurate(1-) 0
              tetraxenonogold(2+) + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  metal atom 17279
                    transition element atom 16730
                      d-block element atom 16720
                        copper group element atom 9360
                          gold atom 547
                            gold molecular entity 547
                              gold coordination entity 123
                                auranofin 40
                                aurothiomalic acid + 0
                                aurothiosulfate(3-) + 4
                                dicyanoaurate(1-) + 0
                                digold hexachloride 0
                                gold pentafluoride 0
                                gold tribromide 0
                                gold trichloride 0
                                gold trifluoride 0
                                hexafluoroaurate(1-) 0
                                monosodium aurothiomalate + 87
                                tetraamminegold(3+) 0
                                tetrabromoaurate(1-) + 0
                                tetrachloroaurate(1-) + 0
                                tetracyanoaurate(1-) 0
                                tetrafluoroaurate(1-) 0
                                tetranitratoaurate(1-) 0
                                tetraxenonogold(2+) + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.