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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3-Hydroxybenzo[a]pyrene
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Accession:CHEBI:34337 term browser browse the term
Definition:An ortho- and peri-fused polycyclic arene that has formula C20H12O.
Synonyms:related_synonym: Formula=C20H12O;   InChI=1S/C20H12O/c21-18-10-7-12-5-8-16-15-4-2-1-3-13(15)11-14-6-9-17(18)19(12)20(14)16/h1-11,21H;   InChIKey=SPUUWWRWIAEPDB-UHFFFAOYSA-N;   SMILES=Oc1ccc2ccc3c4ccccc4cc4ccc1c2c34
 xref: CAS:13345-21-6;   KEGG:C14461
 xref_mesh: MESH:C021338


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3-Hydroxybenzo[a]pyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO 3-hydroxybenzo(a)pyrene results in increased expression of AKR1B10 mRNA CTD PMID:26238291 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Areg amphiregulin increases expression ISO 3-hydroxybenzo(a)pyrene results in increased expression of AREG mRNA CTD PMID:26238291 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Aspm assembly factor for spindle microtubules decreases expression ISO 3-hydroxybenzo(a)pyrene results in decreased expression of ASPM mRNA CTD PMID:26238291 NCBI chr13:56,546,021...56,591,793
Ensembl chr13:56,546,021...56,591,793
JBrowse link
G Fst follistatin multiple interactions ISO [Polycyclic Aromatic Hydrocarbons results in increased abundance of 3-hydroxybenzo(a)pyrene] which results in increased expression of FST protein CTD PMID:31228248 NCBI chr 2:46,537,589...46,544,813
Ensembl chr 2:46,538,700...46,544,457
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO 3-hydroxybenzo(a)pyrene results in increased expression of GCLM mRNA CTD PMID:26238291 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions ISO [Polycyclic Aromatic Hydrocarbons results in increased abundance of 3-hydroxybenzo(a)pyrene] which results in increased expression of HSPB1 protein CTD PMID:31228248 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Il16 interleukin 16 multiple interactions ISO [Polycyclic Aromatic Hydrocarbons results in increased abundance of 3-hydroxybenzo(a)pyrene] which results in increased expression of IL16 protein CTD PMID:31228248 NCBI chr 1:145,781,923...145,881,538
Ensembl chr 1:145,781,928...145,870,912
JBrowse link
G Klk13 kallikrein related-peptidase 13 multiple interactions ISO [Polycyclic Aromatic Hydrocarbons results in increased abundance of 3-hydroxybenzo(a)pyrene] which affects the expression of KLK13 protein CTD PMID:30753342 NCBI chr 1:99,648,658...99,661,025
Ensembl chr 1:99,648,658...99,660,277
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO 3-hydroxybenzo(a)pyrene results in increased expression of SRXN1 mRNA CTD PMID:26238291 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO Polychlorinated Biphenyls metabolite inhibits the reaction [SULT1A1 protein polymorphism results in increased sulfation of 3-hydroxybenzo(a)pyrene] CTD PMID:15929889 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions ISO Polychlorinated Biphenyls metabolite inhibits the reaction [SULT1E1 protein results in increased sulfation of 3-hydroxybenzo(a)pyrene] CTD PMID:15929889 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation EXP UGT1A1 protein results in increased glucuronidation of 3-hydroxybenzo(a)pyrene CTD PMID:1435739 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 increases glucuronidation ISO UGT2A1 protein results in increased glucuronidation of 3-hydroxybenzo(a)pyrene CTD PMID:21164388 NCBI chr14:22,192,970...22,217,094 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        aetiopathogenetic role 18960
          carcinogenic agent 18331
            polycyclic arene 16889
              ortho- and peri-fused polycyclic arene 16155
                3-Hydroxybenzo[a]pyrene 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            organic hydride 18269
                              organic fundamental parent 18269
                                hydrocarbon 17988
                                  cyclic hydrocarbon 17075
                                    arene 17071
                                      polycyclic arene 16889
                                        ortho- and peri-fused polycyclic arene 16155
                                          3-Hydroxybenzo[a]pyrene 13
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