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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-chloro-m-cresol
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Accession:CHEBI:34395 term browser browse the term
Definition:A hydroxytoluene that is 3-methylphenol which is substituted by a chlorine at position 4. A ryanodine receptor agonist.
Synonyms:related_synonym: 1-chloro-2-methyl-4-hydroxybenzene;   2-chloro-5-hydroxytoluene;   3-methyl-4-chlorophenol;   4-Chloro-3-methylphenol;   4-chloro-5-methylphenol;   6-chloro-3-hydroxytoluene;   Formula=C7H7ClO;   InChI=1S/C7H7ClO/c1-5-4-6(9)2-3-7(5)8/h2-4,9H,1H3;   InChIKey=CFKMVGJGLGKFKI-UHFFFAOYSA-N;   SMILES=C1=C(C=CC(=C1C)Cl)O;   p-chloro-m-cresol;   p-chlorocresol;   para-chloro-meta-cresol
 xref: CAS:59-50-7;   KEGG:C14331;   KEGG:D03468
 xref_mesh: MESH:C006984
 xref: PDBeChem:43M;   PMID:10360873;   PMID:10625004;   PMID:12761215;   PMID:12884985;   PMID:12944669;   PMID:15491450;   PMID:15537710;   PMID:16168959;   PMID:16530265;   PMID:16601083;   PMID:16807860;   PMID:19904006;   PMID:20818538;   PMID:23561324;   PMID:25479114;   PMID:27591377;   PMID:30655298;   PMID:30684528;   PMID:31165076;   PMID:31988840;   Wikipedia:P-Chlorocresol


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4-chloro-m-cresol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor affects activity ISO chlorocresol affects the activity of AHR protein CTD PMID:18294747 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ar androgen receptor affects activity
multiple interactions
ISO chlorocresol affects the activity of AR protein
chlorocresol inhibits the reaction [Metribolone results in increased activity of AR protein]
CTD PMID:18294747, PMID:18324785 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions
affects binding
ISO chlorocresol inhibits the reaction [afimoxifene binds to ESRRG protein]
chlorocresol binds to ESRRG protein
CTD PMID:17964775 NCBI chr13:106,063,799...106,683,353
Ensembl chr13:106,463,368...106,683,436
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]; Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]] CTD PMID:17707769 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Ryr1 ryanodine receptor 1 increases activity
multiple interactions
affects response to substance
increases response to substance
ISO chlorocresol results in increased activity of RYR1 protein
[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]; [chlorocresol results in increased activity of RYR1 protein] which affects the localization of Calcium; [chlorocresol results in increased activity of RYR1 protein] which results in increased transport of Calcium; Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]]; Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] which results in increased transport of Calcium]; RYR1 protein polymorphism affects the reaction [chlorocresol results in increased secretion of Calcium]
RYR1 protein alternative form affects the susceptibility to chlorocresol
RYR1 gene mutant form results in increased susceptibility to chlorocresol; RYR1 protein mutant form results in increased susceptibility to chlorocresol; RYR1 protein results in increased susceptibility to chlorocresol
CTD PMID:12810058, PMID:15210166, PMID:16372898, PMID:17707769, PMID:18719443, PMID:19191329, PMID:19191333, PMID:21485675 NCBI chr 1:87,959,596...88,066,252
Ensembl chr 1:87,959,712...88,066,101
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimicrobial agent 17312
          4-chloro-m-cresol 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                carbocyclic compound 18183
                                  benzenoid aromatic compound 17180
                                    benzenes 16922
                                      toluenes 6223
                                        hydroxytoluene 112
                                          4-chloro-m-cresol 5
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