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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-nonylphenol
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Accession:CHEBI:34440 term browser browse the term
Definition:A member of the class of phenols that is phenol which is para-substituted with a nonyl group.
Synonyms:related_synonym: 4-n-Nonylphenol;   Formula=C15H24O;   InChI=1S/C15H24O/c1-2-3-4-5-6-7-8-9-14-10-12-15(16)13-11-14/h10-13,16H,2-9H2,1H3;   InChIKey=IGFHQQFPSIBGKE-UHFFFAOYSA-N;   SMILES=CCCCCCCCCc1ccc(O)cc1;   p-Nonylphenol;   p-n-Nonylphenol;   para Nonyl phenol
 xref: CAS:104-40-5;   HMDB:HMDB0038982;   KEGG:C14550;   LINCS:LSM-19987
 xref_mesh: MESH:C041594
 xref: PMID:18506497;   PMID:21823570;   PMID:22133150;   PMID:24805085;   PPDB:1543;   Reaxys:2047450


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4-nonylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 decreases expression
multiple interactions
ISO 4-nonylphenol results in decreased expression of ABCG2 protein
fulvestrant affects the reaction [4-nonylphenol results in decreased expression of ABCG2 protein]
CTD PMID:27036933 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 multiple interactions ISO ADAM10 protein affects the reaction [[ADAM17 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein]; ADAM10 protein affects the reaction [ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of HBEGF protein]]; ADAM10 protein affects the reaction [ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of TGFA protein]] CTD PMID:28703301 NCBI chr 8:77,107,355...77,237,483
Ensembl chr 8:77,107,536...77,237,483
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 affects response to substance
multiple interactions
ISO ADAM17 protein affects the susceptibility to 4-nonylphenol
[ADAM17 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein; ADAM10 protein affects the reaction [[ADAM17 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein]; ADAM10 protein affects the reaction [ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of HBEGF protein]]; ADAM10 protein affects the reaction [ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of TGFA protein]]; ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of HBEGF protein]; ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of TGFA protein]
CTD PMID:28703301 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression EXP 4-nonylphenol results in increased expression of ADIPOQ protein CTD PMID:24388992 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Afap1l2 actin filament associated protein 1-like 2 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of AFAP1L2 mRNA CTD PMID:23626723 NCBI chr 1:277,730,760...277,827,299
Ensembl chr 1:277,730,760...277,827,269
JBrowse link
G Afp alpha-fetoprotein affects binding EXP 4-nonylphenol binds to AFP protein CTD PMID:23013281, PMID:25349334 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Ahr aryl hydrocarbon receptor affects activity
increases activity
affects binding
ISO
EXP
4-nonylphenol affects the activity of AHR protein
4-nonylphenol results in increased activity of AHR protein
4-nonylphenol binds to AHR protein
CTD PMID:18294747, PMID:20436506, PMID:28728110 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
decreases expression
multiple interactions
EXP 4-nonylphenol results in decreased phosphorylation of AKT1 protein
4-nonylphenol results in decreased expression of AKT1 mRNA
[bisphenol A co-treated with 4-nonylphenol] results in increased expression of AKT1 mRNA; Acetylcysteine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of AKT1 protein]; bisphenol A inhibits the reaction [4-nonylphenol results in decreased expression of AKT1 mRNA]
CTD PMID:26804764, PMID:30228064 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 increases expression EXP 4-nonylphenol results in increased expression of AKT2 mRNA CTD PMID:30228064 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Amh anti-Mullerian hormone decreases expression ISO 4-nonylphenol analog results in decreased expression of AMH mRNA CTD PMID:27086933 NCBI chr 7:11,775,155...11,777,503
Ensembl chr 7:11,775,155...11,777,503
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 affects expression
increases expression
EXP 4-nonylphenol affects the expression of APAF1 mRNA
4-nonylphenol results in increased expression of APAF1 protein
CTD PMID:26804764, PMID:27109770 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Ar androgen receptor affects activity
decreases expression
multiple interactions
ISO 4-nonylphenol affects the activity of AR protein
4-nonylphenol analog results in decreased expression of AR mRNA
4-nonylphenol inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]
CTD PMID:16169144, PMID:18294747, PMID:27086933 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atg12 autophagy related 12 increases expression EXP 4-nonylphenol results in increased expression of ATG12 mRNA CTD PMID:28041982, PMID:30228064 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
JBrowse link
G Atg3 autophagy related 3 increases expression EXP 4-nonylphenol results in increased expression of ATG3 mRNA CTD PMID:28041982 NCBI chr11:60,585,192...60,613,706
Ensembl chr11:60,585,171...60,613,718
JBrowse link
G Atg5 autophagy related 5 increases expression EXP 4-nonylphenol results in increased expression of ATG5 mRNA CTD PMID:28041982, PMID:30228064 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Atg7 autophagy related 7 increases expression EXP 4-nonylphenol results in increased expression of ATG7 mRNA CTD PMID:28041982 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G B3gnt3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of B3GNT3 mRNA CTD PMID:23626723 NCBI chr16:20,123,948...20,133,482
Ensembl chr16:20,123,948...20,133,322
JBrowse link
G B4galt1 beta-1,4-galactosyltransferase 1 increases expression ISO 4-nonylphenol results in increased expression of B4GALT1 mRNA CTD PMID:14605097 NCBI chr 5:57,121,768...57,168,610
Ensembl chr 5:57,121,769...57,168,610
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression EXP 4-nonylphenol results in increased expression of BAD mRNA; 4-nonylphenol results in increased expression of BAD protein CTD PMID:26804764, PMID:27087316 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases expression
EXP
ISO
3-methyladenine promotes the reaction [4-nonylphenol results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [4-nonylphenol results in increased expression of BAX protein]
4-nonylphenol results in increased expression of BAX mRNA; 4-nonylphenol results in increased expression of BAX protein
4-nonylphenol results in decreased expression of BAX mRNA; 4-nonylphenol results in decreased expression of BAX protein
CTD PMID:15461258, PMID:26804032, PMID:26804764, PMID:27087316, PMID:27109770, PMID:30228064 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
decreases expression
ISO
EXP
4-nonylphenol results in increased expression of BCL2 mRNA
[bisphenol A co-treated with 4-nonylphenol] results in decreased expression of BCL2 mRNA
4-nonylphenol results in decreased expression of BCL2 mRNA; 4-nonylphenol results in decreased expression of BCL2 protein
CTD PMID:15461258, PMID:26804764, PMID:27087316, PMID:27109770, PMID:30228064 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression EXP 4-nonylphenol results in decreased expression of BCL2L1 mRNA; 4-nonylphenol results in decreased expression of BCL2L1 protein CTD PMID:27087316, PMID:27109770 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl2l11 BCL2 like 11 increases expression EXP 4-nonylphenol results in increased expression of BCL2L11 protein CTD PMID:26804764 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
EXP 3-methyladenine inhibits the reaction [4-nonylphenol results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [4-nonylphenol results in increased expression of BECN1 protein]; AICA ribonucleotide promotes the reaction [4-nonylphenol results in increased expression of BECN1 protein]; dorsomorphin inhibits the reaction [4-nonylphenol results in increased expression of BECN1 protein]; PRKAA1 protein promotes the reaction [4-nonylphenol results in increased expression of BECN1 protein]
4-nonylphenol results in increased expression of BECN1 mRNA; 4-nonylphenol results in increased expression of BECN1 protein
CTD PMID:26804764, PMID:28041982, PMID:30228064 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO 4-nonylphenol results in increased cleavage of and results in increased activity of BID protein CTD PMID:22056370 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Btc betacellulin multiple interactions ISO [ADAM17 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein; [RHBDF2 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein; ADAM10 protein affects the reaction [[ADAM17 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein] CTD PMID:28703301 NCBI chr14:18,231,854...18,270,621
Ensembl chr14:18,231,860...18,272,484
JBrowse link
G Casp1 caspase 1 increases expression
decreases expression
EXP 4-nonylphenol results in increased expression of CASP1 mRNA
4-nonylphenol results in decreased expression of CASP1 mRNA
CTD PMID:27087316, PMID:27109770 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp2 caspase 2 increases expression EXP 4-nonylphenol results in increased expression of CASP2 mRNA CTD PMID:27087316 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 increases cleavage
increases expression
multiple interactions
affects expression
ISO
EXP
4-nonylphenol results in increased cleavage of CASP3 protein
4-nonylphenol results in increased expression of CASP3 protein modified form
4-nonylphenol results in increased expression of and results in increased activity of CASP3 protein; [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in increased expression of and results in increased activity of CASP3 protein
4-nonylphenol affects the expression of CASP3 mRNA
3-methyladenine promotes the reaction [4-nonylphenol results in increased cleavage of CASP3 protein]; 4-nonylphenol results in decreased expression of and results in increased phosphorylation of CASP3 protein; [bisphenol A co-treated with 4-nonylphenol] results in increased expression of CASP3 mRNA; Acetylcysteine inhibits the reaction [4-nonylphenol results in increased cleavage of CASP3 protein]; bisphenol A inhibits the reaction [4-nonylphenol results in increased expression of CASP3 protein modified form]
CTD PMID:22056370, PMID:26804764, PMID:27109770, PMID:29029336, PMID:30228064 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 increases expression EXP 4-nonylphenol results in increased expression of CASP4 mRNA CTD PMID:27087316 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp6 caspase 6 decreases expression EXP 4-nonylphenol results in decreased expression of CASP6 mRNA CTD PMID:27109770 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp7 caspase 7 decreases expression EXP 4-nonylphenol results in decreased expression of CASP7 mRNA CTD PMID:27109770 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions
increases expression
decreases expression
ISO
EXP
4-nonylphenol results in increased cleavage of CASP8 protein
4-nonylphenol affects the reaction [bisphenol A results in increased expression of CASP8 mRNA]; bisphenol A affects the reaction [4-nonylphenol results in increased expression of CASP8 mRNA]
4-nonylphenol results in decreased expression of CASP8 mRNA
CTD PMID:22056370, PMID:27087316, PMID:30228064 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases cleavage
decreases expression
increases expression
ISO
EXP
4-nonylphenol results in increased cleavage of CASP9 protein
4-nonylphenol results in decreased expression of CASP9 mRNA
4-nonylphenol results in increased expression of CASP9 mRNA
CTD PMID:22056370, PMID:27087316, PMID:27109770 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase decreases expression EXP 4-nonylphenol results in decreased expression of CAT mRNA CTD PMID:27087316, PMID:27109770 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccbe1 collagen and calcium binding EGF domains 1 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of CCBE1 mRNA CTD PMID:23626723 NCBI chr18:61,758,754...62,013,194
Ensembl chr18:61,759,289...61,788,863
JBrowse link
G Ccn5 cellular communication network factor 5 increases expression
multiple interactions
ISO 4-nonylphenol results in increased expression of CCN5 mRNA
ESR1 protein inhibits the reaction [4-nonylphenol results in increased expression of CCN5 mRNA]
CTD PMID:23384675 NCBI chr 3:160,207,969...160,219,316
Ensembl chr 3:160,207,913...160,219,331
JBrowse link
G Ccna2 cyclin A2 decreases expression EXP 4-nonylphenol results in decreased expression of CCNA2 protein CTD PMID:26804764 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 increases expression EXP 4-nonylphenol results in increased expression of CCNB1 protein CTD PMID:26804764 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 decreases expression
increases expression
EXP
ISO
4-nonylphenol results in decreased expression of CCND1 protein
4-nonylphenol results in increased expression of CCND1 mRNA; 4-nonylphenol results in increased expression of CCND1 protein
CTD PMID:26804032, PMID:26804764 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO 4-nonylphenol results in decreased expression of CCNE1 mRNA CTD PMID:26804032 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
decreases expression
EXP
ISO
4-nonylphenol results in increased expression of CDKN1A protein
4-nonylphenol results in decreased expression of CDKN1A protein
CTD PMID:26804032, PMID:26804764 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
decreases expression
EXP
ISO
4-nonylphenol results in increased expression of CDKN1B protein
4-nonylphenol results in decreased expression of CDKN1B mRNA
CTD PMID:26804032, PMID:26804764 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C increases expression ISO 4-nonylphenol results in increased expression of CDKN1C protein CTD PMID:26027920 NCBI chr 1:216,661,067...216,663,791
Ensembl chr 1:216,661,080...216,663,721
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions ISO 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; 4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]] CTD PMID:11711029 NCBI chr 8:59,594,007...59,607,122
Ensembl chr 8:59,592,403...59,607,275
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:11711029 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:11711029 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions ISO 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; 4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]] CTD PMID:11711029 NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133
JBrowse link
G Col14a1 collagen type XIV alpha 1 chain multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of COL14A1 mRNA CTD PMID:23626723 NCBI chr 7:95,054,877...95,274,073
Ensembl chr 7:95,074,236...95,273,298
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased phosphorylation of CREB1 protein; wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in increased phosphorylation of CREB1 protein] CTD PMID:23626723 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of CSF1R mRNA CTD PMID:23626723 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300
JBrowse link
G Csf2 colony stimulating factor 2 increases secretion ISO 4-nonylphenol results in increased secretion of CSF2 protein CTD PMID:20194071 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Ctsd cathepsin D increases expression ISO 4-nonylphenol results in increased expression of CTSD protein CTD PMID:26804032 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of CYP11A1 mRNA CTD PMID:29029336 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions
decreases expression
ISO [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in increased expression of CYP17A1 mRNA
4-nonylphenol results in decreased expression of CYP17A1 mRNA
CTD PMID:29029336 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
decreases expression
ISO [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of CYP19A1 mRNA; [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of CYP19A1 protein
4-nonylphenol results in decreased expression of CYP19A1 mRNA; 4-nonylphenol results in decreased expression of CYP19A1 protein
CTD PMID:29029336 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression EXP 4-nonylphenol results in decreased expression of CYP1B1 mRNA CTD PMID:27087316, PMID:27109770 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression
multiple interactions
ISO 4-nonylphenol results in increased expression of CYP2B10 mRNA
4-nonylphenol promotes the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]; [4-nonylphenol inhibits the reaction [androstan-3-ol binds to and results in decreased activity of NR1I3 protein]] which results in increased expression of CYP2B6 mRNA; NR1I3 protein promotes the reaction [4-nonylphenol results in increased expression of CYP2B10 mRNA]
CTD PMID:17483497 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression
ISO 4-nonylphenol promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]
4-nonylphenol results in increased expression of CYP2B6 mRNA
CTD PMID:17483497 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP 4-nonylphenol promotes the reaction [NR1I2 protein results in increased expression of CYP3A23-3A1 mRNA] CTD PMID:17483497 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DIO2 mRNA CTD PMID:23626723 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A mRNA; [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A protein; wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A protein] CTD PMID:23626723 NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3B mRNA; [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3B protein; wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3B protein] CTD PMID:23626723 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
JBrowse link
G Dnmt3l DNA methyltransferase 3 like multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3L mRNA; [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3L protein; wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3L protein] CTD PMID:23626723 NCBI chr20:11,344,513...11,359,090
Ensembl chr20:11,344,514...11,359,090
JBrowse link
G Ebf2 EBF transcription factor 2 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of EBF2 mRNA CTD PMID:23626723 NCBI chr15:43,905,099...44,103,742
Ensembl chr15:43,905,099...44,103,742
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation
multiple interactions
EXP 4-nonylphenol results in decreased phosphorylation of EIF4EBP1 protein
Acetylcysteine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of EIF4EBP1 protein]; dorsomorphin inhibits the reaction [4-nonylphenol results in decreased phosphorylation of EIF4EBP1 protein]; PRKAA1 protein promotes the reaction [4-nonylphenol results in decreased phosphorylation of EIF4EBP1 protein]
CTD PMID:26804764, PMID:28041982, PMID:30228064 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression ISO 4-nonylphenol results in decreased expression of ERBB2 mRNA CTD PMID:16393665 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
affects binding
affects localization
increases activity
ISO
EXP
4-nonylphenol binds to and results in increased activity of ESR1 protein; 4-nonylphenol inhibits the reaction [Estradiol binds to ESR1 protein]; [4-nonylphenol co-treated with ESR1 protein] results in increased expression of LTF mRNA; ESR1 protein inhibits the reaction [4-nonylphenol results in increased expression of CCN5 mRNA]
4-nonylphenol analog results in decreased expression of ESR1 mRNA; 4-nonylphenol analog results in decreased expression of ESR1 protein
4-nonylphenol results in decreased expression of ESR1 mRNA; 4-nonylphenol results in decreased expression of ESR1 protein
4-nonylphenol binds to ESR1 protein
4-nonylphenol inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]
4-nonylphenol affects the localization of ESR1 protein
4-nonylphenol results in increased activity of ESR1 protein; 4-nonylphenol results in increased activity of ESR1 protein mutant form
CTD PMID:11518614, PMID:11530281, PMID:12127041, PMID:12598185, PMID:16393665, PMID:17141713, PMID:17174995, PMID:19720131, PMID:19913605, PMID:20353888, PMID:20950447, PMID:21783566, PMID:22056370, PMID:23384675, PMID:24388992, PMID:25012808, PMID:27086933, PMID:27633901, PMID:28728110, PMID:29066353, PMID:29162470 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 affects localization
decreases expression
affects binding
multiple interactions
ISO 4-nonylphenol affects the localization of ESR2 protein
4-nonylphenol analog results in decreased expression of ESR2 mRNA; 4-nonylphenol analog results in decreased expression of ESR2 protein
4-nonylphenol binds to ESR2 protein
4-nonylphenol binds to and results in increased activity of ESR2 protein; [4-nonylphenol co-treated with ESR2 protein] results in increased expression of LTF mRNA
4-nonylphenol inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]
CTD PMID:11518614, PMID:12224631, PMID:19913605, PMID:20950447, PMID:21783566, PMID:22056370, PMID:27086933, PMID:27633901 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fam102a family with sequence similarity 102, member A increases expression ISO 4-nonylphenol results in increased expression of FAM102A mRNA CTD PMID:14605097 NCBI chr 3:11,554,084...11,586,315
Ensembl chr 3:11,554,457...11,586,303
JBrowse link
G Fas Fas cell surface death receptor increases expression EXP 4-nonylphenol results in increased expression of FAS mRNA; 4-nonylphenol results in increased expression of FAS protein CTD PMID:27087316, PMID:27109770 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand increases expression EXP 4-nonylphenol results in increased expression of FASLG mRNA; 4-nonylphenol results in increased expression of FASLG protein CTD PMID:27087316, PMID:27109770 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fasn fatty acid synthase increases expression EXP 4-nonylphenol results in increased expression of FASN mRNA CTD PMID:24388992 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fcgr3a Fc fragment of IgG receptor IIIa multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of FCGR3A mRNA CTD PMID:23626723 NCBI chr13:89,385,775...89,396,047
Ensembl chr13:89,385,859...89,396,051
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO 4-nonylphenol results in increased expression of FOS mRNA; 4-nonylphenol results in increased expression of FOS protein CTD PMID:24308608 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression
multiple interactions
EXP 4-nonylphenol results in decreased expression of FSHB protein
[4-nonylphenol results in increased susceptibility to bisphenol A] which results in increased secretion of FSHB protein
CTD PMID:27087316, PMID:27109770, PMID:30228064 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gcnt4 glucosaminyl (N-acetyl) transferase 4 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of GCNT4 mRNA CTD PMID:23626723 Ensembl chr 2:27,713,880...27,780,119 JBrowse link
G Gh1 growth hormone 1 increases secretion
multiple interactions
increases expression
EXP 4-nonylphenol results in increased secretion of GH1 protein
fulvestrant inhibits the reaction [4-nonylphenol results in increased expression of GH1 mRNA]; fulvestrant inhibits the reaction [4-nonylphenol results in increased expression of GH1 protein]; fulvestrant inhibits the reaction [4-nonylphenol results in increased secretion of GH1 protein]
4-nonylphenol results in increased expression of GH1 mRNA; 4-nonylphenol results in increased expression of GH1 protein
CTD PMID:19145065, PMID:19463694 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 increases expression ISO 4-nonylphenol results in increased expression of GPER1 mRNA CTD PMID:29783106 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression EXP 4-nonylphenol results in decreased expression of GPX1 mRNA CTD PMID:27109770 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Has2 hyaluronan synthase 2 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of HAS2 mRNA CTD PMID:23626723 NCBI chr 7:96,438,046...96,464,049
Ensembl chr 7:96,438,046...96,464,049
JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases secretion
multiple interactions
ISO 4-nonylphenol results in increased secretion of HBEGF protein
3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2,2-dimethyl-1-methylcarbamoyl-1-propyl)amide inhibits the reaction [4-nonylphenol results in increased secretion of HBEGF protein]; ADAM10 protein affects the reaction [ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of HBEGF protein]]; ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of HBEGF protein]; GW280264X inhibits the reaction [4-nonylphenol results in increased secretion of HBEGF protein]
CTD PMID:28703301 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Hoxa1 homeobox A1 multiple interactions ISO 4-nonylphenol inhibits the reaction [Vitamin A results in increased expression of HOXA1 mRNA] CTD PMID:23696197 NCBI chr 4:82,124,358...82,127,182
Ensembl chr 4:82,125,406...82,127,066
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases activity ISO 4-nonylphenol results in decreased activity of HSD11B1 protein CTD PMID:16184081 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity ISO 4-nonylphenol results in decreased activity of HSD11B2 protein CTD PMID:16184081 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO 4-nonylphenol results in decreased expression of HSD3B1 mRNA CTD PMID:29029336
G Ifng interferon gamma affects secretion
decreases expression
ISO
EXP
4-nonylphenol affects the secretion of IFNG protein
4-nonylphenol results in decreased expression of IFNG mRNA
CTD PMID:20194071, PMID:27109770 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 increases secretion ISO 4-nonylphenol results in increased secretion of IL10 protein CTD PMID:20194071 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta affects secretion
affects expression
ISO
EXP
4-nonylphenol affects the secretion of IL1B protein
4-nonylphenol affects the expression of IL1B mRNA
CTD PMID:20194071, PMID:27109770 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 affects secretion ISO 4-nonylphenol affects the secretion of IL4 protein CTD PMID:20194071 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Kcnb2 potassium voltage-gated channel subfamily B member 2 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of KCNB2 mRNA CTD PMID:23626723 NCBI chr 5:2,975,934...3,430,837 JBrowse link
G Kcnv1 potassium voltage-gated channel modifier subfamily V member 1 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of KCNV1 mRNA CTD PMID:23626723 NCBI chr 7:84,016,864...84,023,205
Ensembl chr 7:84,015,207...84,023,316
JBrowse link
G Klk6 kallikrein related-peptidase 6 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of KLK6 mRNA CTD PMID:23626723 NCBI chr 1:99,762,195...99,769,486
Ensembl chr 1:99,762,253...99,769,488
JBrowse link
G Lamp3 lysosomal-associated membrane protein 3 decreases expression ISO 4-nonylphenol results in decreased expression of LAMP3 mRNA CTD PMID:20678512 NCBI chr11:84,930,965...85,000,694
Ensembl chr11:84,972,132...85,000,681
JBrowse link
G Lep leptin increases expression EXP 4-nonylphenol results in increased expression of LEP protein CTD PMID:24388992 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions
increases secretion
decreases expression
affects expression
EXP 4-nonylphenol inhibits the reaction [bisphenol A results in increased secretion of LHB protein]; 4-nonylphenol results in decreased expression of and results in decreased secretion of LHB protein; bisphenol A inhibits the reaction [4-nonylphenol results in increased secretion of LHB protein]
4-nonylphenol results in decreased expression of LHB protein
4-nonylphenol affects the expression of LHB protein
CTD PMID:15888928, PMID:17033158, PMID:27087316, PMID:27109770, PMID:30228064 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Lpar3 lysophosphatidic acid receptor 3 increases expression EXP 4-nonylphenol results in increased expression of LPAR3 mRNA CTD PMID:24460192 NCBI chr 2:252,090,634...252,159,221
Ensembl chr 2:252,090,669...252,159,903
JBrowse link
G Lpl lipoprotein lipase increases expression EXP 4-nonylphenol results in increased expression of LPL mRNA CTD PMID:24388992 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Ltf lactotransferrin multiple interactions ISO [4-nonylphenol co-treated with ESR1 protein] results in increased expression of LTF mRNA; [4-nonylphenol co-treated with ESR2 protein] results in increased expression of LTF mRNA CTD PMID:21783566 NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases expression EXP 4-nonylphenol results in increased expression of MAP1LC3A mRNA CTD PMID:30228064 NCBI chr 3:150,801,289...150,802,935
Ensembl chr 3:150,801,289...150,802,935
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
EXP
ISO
4-nonylphenol results in increased phosphorylation of MAPK1 protein
4-nonylphenol analog affects the reaction [Estradiol affects the phosphorylation of MAPK1 protein]; 4-nonylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; 4-nonylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK1 protein]
4-nonylphenol inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; 4-nonylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; 4-nonylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; fulvestrant inhibits the reaction [4-nonylphenol results in increased phosphorylation of MAPK1 protein]
CTD PMID:17174995, PMID:19463694, PMID:20870566, PMID:20950447, PMID:28849599 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
EXP
ISO
4-nonylphenol results in increased phosphorylation of MAPK3 protein
4-nonylphenol analog affects the reaction [Estradiol affects the phosphorylation of MAPK3 protein]; 4-nonylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; 4-nonylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK3 protein]
4-nonylphenol inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; 4-nonylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; 4-nonylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]; fulvestrant inhibits the reaction [4-nonylphenol results in increased phosphorylation of MAPK3 protein]
CTD PMID:19463694, PMID:20870566, PMID:20950447, PMID:28849599 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO 4-nonylphenol analog results in increased phosphorylation of MAPK8 protein CTD PMID:27086933 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO 4-nonylphenol analog results in increased phosphorylation of MAPK9 protein CTD PMID:27086933 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression EXP 4-nonylphenol results in decreased expression of MCL1 protein CTD PMID:26804764 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation
increases phosphorylation
multiple interactions
EXP 4-nonylphenol results in decreased phosphorylation of MTOR protein
4-nonylphenol results in increased phosphorylation of MTOR protein
4-nonylphenol inhibits the reaction [bisphenol A results in decreased expression of MTOR mRNA]; 4-nonylphenol inhibits the reaction [bisphenol A results in increased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]; AICA ribonucleotide promotes the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]; bisphenol A inhibits the reaction [4-nonylphenol results in increased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]; PRKAA1 protein promotes the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]
CTD PMID:26804764, PMID:28041982, PMID:30228064 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Naalad2 N-acetylated alpha-linked acidic dipeptidase 2 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of NAALAD2 mRNA CTD PMID:23626723 NCBI chr 8:17,453,198...17,525,906
Ensembl chr 8:17,454,122...17,525,906
JBrowse link
G Nid1 nidogen 1 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of NID1 mRNA CTD PMID:23626723 NCBI chr17:90,553,161...90,627,133
Ensembl chr17:90,553,394...90,627,101
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects binding
increases activity
multiple interactions
ISO
EXP
4-nonylphenol binds to NR1I2 protein
4-nonylphenol results in increased activity of NR1I2 protein
4-nonylphenol promotes the reaction [NR1I2 protein results in increased expression of CYP3A23-3A1 mRNA]
4-nonylphenol binds to and results in increased activity of NR1I2 protein
CTD PMID:15792627, PMID:17483497, PMID:20869355, PMID:25680588 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity
increases response to substance
multiple interactions
affects localization
ISO 4-nonylphenol results in increased activity of NR1I3 protein; 4-nonylphenol results in increased activity of NR1I3 protein alternative form
NR1I3 protein results in increased susceptibility to 4-nonylphenol
4-nonylphenol inhibits the reaction [androstan-3-ol binds to and results in decreased activity of NR1I3 protein]; 4-nonylphenol promotes the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]; [4-nonylphenol inhibits the reaction [androstan-3-ol binds to and results in decreased activity of NR1I3 protein]] which results in increased expression of CYP2B6 mRNA; NR1I3 protein promotes the reaction [4-nonylphenol results in increased expression of CYP2B10 mRNA]
4-nonylphenol affects the localization of NR1I3 protein
1,5-benzothiazepine analog inhibits the reaction [4-nonylphenol results in increased activity of NR1I3 protein]; 4-nonylphenol binds to and results in increased activity of NR1I3 protein; 4-nonylphenol binds to and results in increased activity of NR1I3 protein alternative form; 4-nonylphenol inhibits the reaction [PK 11195 results in decreased activity of NR1I3 protein]; 4-nonylphenol promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]; 7-acetoxy-6,7-dihydro-6-(4-methoxyphenyl)pyrrolo(2,1-d)(1,5)benzothiazepine inhibits the reaction [4-nonylphenol results in increased activity of NR1I3 protein]; Clotrimazole inhibits the reaction [4-nonylphenol results in increased activity of NR1I3 protein]; PK 11195 results in decreased susceptibility to [4-nonylphenol binds to and results in increased activity of NR1I3 protein alternative form]
CTD PMID:17483497, PMID:20869355, PMID:21227907, PMID:21315811, PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Olr1095 olfactory receptor 1095 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of OR10H1 mRNA CTD PMID:23626723 NCBI chr 7:15,621,989...15,622,945
Ensembl chr 7:15,621,989...15,622,945
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta multiple interactions
decreases activity
EXP 4-nonylphenol inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]
4-nonylphenol results in decreased activity of P4HB protein
CTD PMID:16617682 NCBI chr10:109,736,459...109,748,070
Ensembl chr10:109,736,458...109,747,987
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
decreases expression
affects expression
ISO
EXP
4-nonylphenol results in increased expression of PCNA mRNA
4-nonylphenol results in decreased expression of PCNA mRNA; 4-nonylphenol results in decreased expression of PCNA protein
4-nonylphenol affects the expression of PCNA mRNA
4-nonylphenol results in increased expression of PCNA protein
CTD PMID:15461258, PMID:18839522, PMID:27087316, PMID:27109770 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdzk1 PDZ domain containing 1 increases expression ISO 4-nonylphenol results in increased expression of PDZK1 mRNA CTD PMID:14605097, PMID:16393665 NCBI chr 2:198,965,685...198,999,323
Ensembl chr 2:198,965,685...198,999,323
JBrowse link
G Pgr progesterone receptor increases expression
decreases expression
ISO
EXP
4-nonylphenol results in increased expression of PGR mRNA
4-nonylphenol analog results in decreased expression of PGR mRNA
CTD PMID:16393665, PMID:17033158, PMID:27086933 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma increases expression
multiple interactions
EXP 4-nonylphenol results in increased expression of PIK3CG mRNA
4-nonylphenol promotes the reaction [bisphenol A results in increased expression of PIK3CG mRNA]; bisphenol A promotes the reaction [4-nonylphenol results in increased expression of PIK3CG mRNA]
CTD PMID:30228064 NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
JBrowse link
G Pou5f1 POU class 5 homeobox 1 increases expression ISO 4-nonylphenol results in increased expression of POU5F1 mRNA CTD PMID:20615461 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression EXP 4-nonylphenol results in increased expression of PPARG mRNA CTD PMID:24388992 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppfia4 PTPRF interacting protein alpha 4 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of PPFIA4 mRNA CTD PMID:23626723 NCBI chr13:51,134,831...51,183,321
Ensembl chr13:51,134,525...51,183,269
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP PRKAA1 protein promotes the reaction [4-nonylphenol results in decreased phosphorylation of EIF4EBP1 protein]; PRKAA1 protein promotes the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]; PRKAA1 protein promotes the reaction [4-nonylphenol results in decreased phosphorylation of RPS6KB1 protein]; PRKAA1 protein promotes the reaction [4-nonylphenol results in increased expression of BECN1 protein] CTD PMID:28041982 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions EXP [4-nonylphenol results in increased susceptibility to bisphenol A] which results in decreased expression of PRKAA2 mRNA; [bisphenol A co-treated with 4-nonylphenol] results in decreased expression of PRKAA2 mRNA CTD PMID:30228064 NCBI chr 5:124,568,845...124,642,569
Ensembl chr 5:124,574,079...124,642,569
JBrowse link
G Prl prolactin increases expression
increases secretion
multiple interactions
EXP
ISO
4-nonylphenol results in increased expression of PRL mRNA
4-nonylphenol results in increased secretion of PRL protein
4-nonylphenol affects the reaction [Estriol results in increased secretion of PRL protein]; 4-nonylphenol inhibits the reaction [Estradiol results in increased secretion of PRL protein]; 4-nonylphenol inhibits the reaction [Estrone results in increased secretion of PRL protein]
fulvestrant inhibits the reaction [4-nonylphenol results in increased expression of PRL mRNA]; fulvestrant inhibits the reaction [4-nonylphenol results in increased secretion of PRL protein]
CTD PMID:17174995, PMID:19463694, PMID:20950447 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Pten phosphatase and tensin homolog decreases phosphorylation
multiple interactions
increases expression
EXP 4-nonylphenol results in decreased phosphorylation of PTEN protein
4-nonylphenol promotes the reaction [bisphenol A results in decreased phosphorylation of PTEN protein]; bisphenol A inhibits the reaction [4-nonylphenol results in decreased phosphorylation of PTEN protein]
4-nonylphenol results in increased expression of PTEN mRNA
CTD PMID:30228064 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Rhbdf2 rhomboid 5 homolog 2 multiple interactions
affects response to substance
ISO [RHBDF2 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein CTD PMID:28703301 NCBI chr10:105,573,759...105,600,885
Ensembl chr10:105,573,752...105,600,913
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
decreases phosphorylation
EXP Acetylcysteine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of RPS6KB1 protein]; dorsomorphin inhibits the reaction [4-nonylphenol results in decreased phosphorylation of RPS6KB1 protein]; PRKAA1 protein promotes the reaction [4-nonylphenol results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:26804764, PMID:28041982 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Rxra retinoid X receptor alpha decreases expression ISO 4-nonylphenol results in decreased expression of RXRA mRNA CTD PMID:16013040 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G S100g S100 calcium binding protein G increases expression EXP 4-nonylphenol results in increased expression of S100G mRNA; 4-nonylphenol results in increased expression of S100G protein CTD PMID:17365578 NCBI chr  X:33,442,820...33,445,714
Ensembl chr  X:33,443,186...33,445,709
JBrowse link
G Sbspon somatomedin B and thrombospondin, type 1 domain containing multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of SBSPON mRNA CTD PMID:23626723 NCBI chr 5:2,813,004...2,847,697
Ensembl chr 5:2,813,131...2,843,483
JBrowse link
G Sdr16c5 short chain dehydrogenase/reductase family 16C, member 5 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of SDR16C5 mRNA CTD PMID:23626723 NCBI chr 5:16,904,926...16,930,111
Ensembl chr 5:16,904,926...16,930,075
JBrowse link
G Serf1 small EDRK-rich factor 1 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of SERF1A mRNA CTD PMID:23626723 NCBI chr 2:30,345,861...30,352,114
Ensembl chr 2:30,346,069...30,352,099
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO 4-nonylphenol binds to SHBG protein CTD PMID:25349334 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Skil SKI-like proto-oncogene increases expression ISO 4-nonylphenol results in increased expression of SKIL protein CTD PMID:24308608 NCBI chr 2:115,862,932...115,891,304
Ensembl chr 2:115,866,701...115,891,097
JBrowse link
G Slc7a7 solute carrier family 7 member 7 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of SLC7A7 mRNA CTD PMID:23626723 NCBI chr15:33,013,346...33,059,733
Ensembl chr15:33,013,504...33,051,129
JBrowse link
G Smad3 SMAD family member 3 multiple interactions
decreases phosphorylation
ISO fulvestrant inhibits the reaction [4-nonylphenol results in decreased phosphorylation of SMAD3 protein] CTD PMID:24308608 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression EXP 4-nonylphenol results in decreased expression of SOD1 mRNA CTD PMID:27087316, PMID:27109770 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of SP1 mRNA CTD PMID:29029336 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression EXP 4-nonylphenol results in increased expression of SREBF1 mRNA CTD PMID:24388992 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in increased expression of STAR mRNA CTD PMID:29029336 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases metabolic processing ISO SULT1A1 protein results in increased metabolism of 4-nonylphenol CTD PMID:10623578 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 increases metabolic processing ISO SULT1B1 protein results in increased metabolism of 4-nonylphenol CTD PMID:10623578 NCBI chr14:22,142,412...22,155,246
Ensembl chr14:22,142,364...22,155,231
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions ISO 4-nonylphenol inhibits the reaction [Progesterone results in increased expression of SULT1E1 mRNA] CTD PMID:22414680 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases metabolic processing ISO SULT2A1 protein results in increased metabolism of 4-nonylphenol CTD PMID:10623578 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Tf transferrin increases expression ISO 4-nonylphenol analog results in increased expression of TRF mRNA CTD PMID:27086933 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO 4-nonylphenol results in increased expression of TFF1 mRNA CTD PMID:16393665 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions
increases secretion
ISO ADAM10 protein affects the reaction [ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of TGFA protein]]; ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of TGFA protein]; GW280264X inhibits the reaction [4-nonylphenol results in increased secretion of TGFA protein] CTD PMID:28703301 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO 4-nonylphenol inhibits the reaction [Triiodothyronine results in increased activity of THRB protein] CTD PMID:31077750 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tnf tumor necrosis factor affects secretion
decreases expression
increases expression
ISO
EXP
4-nonylphenol affects the secretion of TNF protein
4-nonylphenol results in decreased expression of TNF protein
4-nonylphenol results in increased expression of TNF mRNA; 4-nonylphenol results in increased expression of TNF protein
CTD PMID:20194071, PMID:27109770, PMID:28490175 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression EXP 4-nonylphenol results in increased expression of TP53 mRNA; 4-nonylphenol results in increased expression of TP53 protein CTD PMID:27087316, PMID:27109770 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trmt9b tRNA methyltransferase 9B (putative) multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of TRMT9B mRNA CTD PMID:23626723 NCBI chr16:59,316,145...59,368,559
Ensembl chr16:59,317,699...59,366,824
JBrowse link
G Tsc2 TSC complex subunit 2 decreases phosphorylation
multiple interactions
EXP 4-nonylphenol results in decreased phosphorylation of TSC2 protein
dorsomorphin inhibits the reaction [4-nonylphenol results in decreased phosphorylation of TSC2 protein]
CTD PMID:26804764, PMID:28041982 NCBI chr10:13,962,006...13,996,684
Ensembl chr10:13,961,947...13,996,584
JBrowse link
G Ttr transthyretin multiple interactions ISO 4-nonylphenol inhibits the reaction [Thyroxine binds to TTR protein] CTD PMID:31077750 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link
G Vipr1 vasoactive intestinal peptide receptor 1 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of VIPR1 mRNA CTD PMID:23626723 NCBI chr 8:130,283,453...130,313,431 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      chemical role 19288
        environmental contaminant 18613
          4-nonylphenol 152
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic aromatic compound 19154
                                  phenols 18145
                                    4-nonylphenol 152
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.