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Term:domoic acid
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Accession:CHEBI:34727 term browser browse the term
Definition:An L-proline derivative produced by the diatomic algal genus of Pseudo-nitzschia and other related species that is L-proline substituted by a carboxymethyl group at position 3 and a 6-carboxyhepta-2,4-dien-2-yl group at position 4. It is an analogue of kainic acid and is the neurotoxin associated with amnesic shellfish poisoning (ASP).
Synonyms:exact_synonym: (3S,4S)-4-[(2Z,4E,6R)-6-carboxyhepta-2,4-dien-2-yl]-3-(carboxymethyl)-L-proline
 related_synonym: Formula=C15H21NO6;   InChI=1S/C15H21NO6/c1-8(4-3-5-9(2)14(19)20)11-7-16-13(15(21)22)10(11)6-12(17)18/h3-5,9-11,13,16H,6-7H2,1-2H3,(H,17,18)(H,19,20)(H,21,22)/b5-3+,8-4-/t9-,10+,11-,13+/m1/s1;   InChIKey=VZFRNCSOCOPNDB-AOKDLOFSSA-N;   L-domoic acid;   SMILES=C[C@H](\\C=C\\C=C(\\C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O)C(O)=O
 xref: CAS:14277-97-5 "ChemIDplus";   CAS:14277-97-5 "KEGG COMPOUND";   HMDB:HMDB0033939;   KEGG:C13732
 xref_mesh: MESH:C012301
 xref: PDBeChem:DOQ;   PMID:10223629 "Europe PMC";   PMID:18728725 "Europe PMC";   PMID:20120452 "Europe PMC";   PMID:22406515 "Europe PMC";   PMID:24511141 "Europe PMC";   PMID:24564603 "Europe PMC";   PMID:24638960 "Europe PMC";   PMID:24663110 "Europe PMC";   PMID:28817087 "Europe PMC";   Reaxys:5126272 "Reaxys";   Wikipedia:Domoic_acid

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domoic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:6480464
G Gclm glutamate cysteine ligase, modifier subunit JBrowse link 2 225,827,504 225,847,876 RGD:6480464
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 JBrowse link 10 42,441,723 42,760,200 RGD:6480464
G Pvalb parvalbumin JBrowse link 7 119,428,657 119,443,674 RGD:6480464
G Wdr35 WD repeat domain 35 JBrowse link 6 34,094,291 34,152,048 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      biological role 19686
        hapten 2972
          domoic acid 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      carbon group element atom 19515
                        carbon atom 19508
                          organic molecular entity 19508
                            organic group 18423
                              organic divalent group 18414
                                organodiyl group 18414
                                  carbonyl group 18301
                                    carbonyl compound 18301
                                      carboxylic acid 17966
                                        amino acid 12445
                                          alpha-amino acid 7644
                                            L-alpha-amino acid 7309
                                              glutamine family amino acid 5344
                                                L-proline 242
                                                  L-proline derivative 225
                                                    domoic acid 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.