Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


Term:NS 1619
go back to main search page
Accession:CHEBI:34879 term browser browse the term
Definition:A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It is an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).
Synonyms:related_synonym: 1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one;   1-(2'-hydroxy-5'-trifluoromethylphenyl)-5-trifluoromethyl-2(3H)-benzimidazolone;   5-trifluoromethyl-2,3-dihydro-1-(5-trifluoromethyl-2-hydroxyphenyl)-1H-2-oxo-benzimidazole;   Formula=C15H8F6N2O2;   InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25);   InChIKey=YLFMCMWKHSDUCT-UHFFFAOYSA-N;   NS1619;   SMILES=Oc1ccc(cc1-n1c2ccc(cc2[nH]c1=O)C(F)(F)F)C(F)(F)F
 xref: CAS:153587-01-0 "ChemIDplus";   CAS:153587-01-0 "KEGG COMPOUND";   KEGG:C13833;   LINCS:LSM-3206
 xref_mesh: MESH:C086491
 xref: PMID:15543339 "Europe PMC";   PMID:18706395 "Europe PMC";   PMID:21415309 "Europe PMC";   PMID:21441626 "Europe PMC";   PMID:24398773 "Europe PMC";   PMID:24497961 "Europe PMC";   PMID:24813114 "Europe PMC";   PMID:7534190 "Europe PMC";   PMID:7589189 "Europe PMC";   PMID:9151934 "Europe PMC";   Reaxys:8165035 "Reaxys"

show annotations for term's descendants       view all columns           Sort by:
NS 1619 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Flt1 Fms related receptor tyrosine kinase 1 JBrowse link 12 9,033,993 9,205,886 RGD:6480464
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 JBrowse link 15 344,204 1,048,849 RGD:6480464
G Kcnmb1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 JBrowse link 10 18,910,586 18,922,856 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      biological role 19686
        biophysical role 12244
          membrane transport modulator 12021
            potassium channel modulator 350
              potassium channel opener 25
                NS 1619 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    main group molecular entity 19622
                      s-block molecular entity 19388
                        hydrogen molecular entity 19377
                          hydrides 18283
                            organic hydride 17547
                              organic fundamental parent 17547
                                hydrocarbon 16958
                                  alkane 12514
                                    methane 9394
                                      halomethane 9394
                                        fluoromethanes 6265
                                          fluoroform 6265
                                            trifluoromethyl group 6265
                                              (trifluoromethyl)benzenes 6265
                                                NS 1619 4
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.