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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phenolphthalein
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Accession:CHEBI:34914 term browser browse the term
Definition:A phenol that has formula C20H14O4.
Synonyms:related_synonym: 3,3-Bis(4-hydroxyphenyl)phthalide;   Formula=C20H14O4;   InChI=1S/C20H14O4/c21-15-9-5-13(6-10-15)20(14-7-11-16(22)12-8-14)18-4-2-1-3-17(18)19(23)24-20/h1-12,21-22H;   InChIKey=KJFMBFZCATUALV-UHFFFAOYSA-N;   SMILES=Oc1ccc(cc1)C1(OC(=O)c2ccccc12)c1ccc(O)cc1;   euchessina;   phthalimetten;   phthalin
 xref: CAS:77-09-8;   Drug_Central:2135;   KEGG:C14286;   KEGG:D05456;   LINCS:LSM-2432
 xref_mesh: MESH:D020113


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phenolphthalein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Phenolphthalein results in decreased activity of AKR1C4 protein CTD PMID:8543560, PMID:12604236 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Phenolphthalein results in decreased activity of AKR1C2 protein CTD PMID:12604236 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity
multiple interactions
ISO Phenolphthalein results in decreased activity of AKR1C3 protein
Phenolphthalein inhibits the reaction [AKR1C3 protein affects the susceptibility to oxaliplatin]
CTD PMID:12604236, PMID:23933386 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions
increases activity
ISO Phenolphthalein binds to ESR1 protein
Phenolphthalein binds to and results in decreased activity of ESR1 protein
Phenolphthalein results in increased activity of ESR1 protein
CTD PMID:12598185, PMID:25012808 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Phenolphthalein inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Phenolphthalein binds to and results in increased activity of NR1I2 protein CTD PMID:20869355 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Phenolphthalein binds to and results in decreased activity of NR1I3 protein alternative form; Phenolphthalein binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO Phenolphthalein inhibits the reaction [POR protein affects the reaction [Benzo(a)pyrene results in increased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA]] CTD PMID:28111842 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Phenolphthalein binds to SHBG protein CTD PMID:25349334 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Tyms thymidylate synthetase decreases activity ISO Phenolphthalein results in decreased activity of TYMS protein CTD PMID:21696158 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      molecular entity 19784
        polyatomic entity 19697
          heteroatomic molecular entity 19622
            hydroxides 19068
              organic hydroxy compound 18634
                phenols 18112
                  phenolphthalein 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic ester 14077
                                        lactone 5979
                                          gamma-lactone 1214
                                            2-benzofuran-1(3H)-one 91
                                              phenolphthalein 10
paths to the root

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