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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:molybdenum coordination entity
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Accession:CHEBI:35202 term browser browse the term
Synonyms:related_synonym: molybdenum coordination compounds;   molybdenum coordination entities


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molybdate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions ISO molybdate inhibits the reaction [Potassium Chloride inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]] CTD PMID:3015922 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G CA2 carbonic anhydrase 2 decreases activity EXP molybdate results in decreased activity of CA2 protein CTD PMID:15664814 NCBI chr 8:85,464,007...85,481,493
Ensembl chr 8:85,463,968...85,481,493
JBrowse link
G CA4 carbonic anhydrase 4 decreases activity EXP molybdate results in decreased activity of CA4 protein CTD PMID:15664814 NCBI chr17:60,149,942...60,179,021
Ensembl chr17:60,149,942...60,170,899
JBrowse link
G CA5A carbonic anhydrase 5A decreases activity EXP molybdate results in decreased activity of CA5A protein CTD PMID:15664814 NCBI chr16:87,881,549...87,936,575
Ensembl chr16:87,881,546...87,936,580
JBrowse link
G CA9 carbonic anhydrase 9 decreases activity EXP molybdate results in decreased activity of CA9 protein CTD PMID:15664814 NCBI chr 9:35,673,809...35,681,159
Ensembl chr 9:35,673,918...35,681,159
JBrowse link
G INSR insulin receptor multiple interactions ISO [molybdate co-treated with INS1 protein] results in increased phosphorylation of INSR protein; [molybdate co-treated with Vanadates co-treated with INS1 protein] results in increased phosphorylation of INSR protein CTD PMID:1321133 NCBI chr19:7,112,257...7,294,414
Ensembl chr19:7,112,255...7,294,414
JBrowse link
G IRS4 insulin receptor substrate 4 multiple interactions ISO [molybdate co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein; molybdate promotes the reaction [[Vanadates co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein]; Vanadates promotes the reaction [[molybdate co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein] CTD PMID:1321133 NCBI chr  X:108,719,946...108,736,584
Ensembl chr  X:108,732,482...108,736,409
Ensembl chr  X:108,732,482...108,736,409
JBrowse link
G IVL involucrin decreases expression EXP molybdate results in decreased expression of IVL protein CTD PMID:7848924 NCBI chr 1:152,908,545...152,911,886
Ensembl chr 1:152,908,546...152,911,886
JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 increases expression ISO molybdate results in increased expression of NR3C1 protein CTD PMID:3015922 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512
JBrowse link
G PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 multiple interactions EXP PAPSS1 protein binds to and affects the metabolism of molybdate CTD PMID:15065880 NCBI chr 4:107,613,666...107,720,234
Ensembl chr 4:107,590,276...107,720,234
JBrowse link
molybdenum trichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD80 CD80 molecule increases secretion ISO molybdenum chloride results in increased secretion of CD80 protein CTD PMID:19844976 NCBI chr 3:119,524,293...119,559,614
Ensembl chr 3:119,524,293...119,559,614
JBrowse link
G IL1B interleukin 1 beta increases secretion ISO molybdenum chloride results in increased secretion of IL1B protein CTD PMID:19844976 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 increases secretion ISO molybdenum chloride results in increased secretion of IL6 protein CTD PMID:19844976 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G TNF tumor necrosis factor increases secretion ISO molybdenum chloride results in increased secretion of TNF protein CTD PMID:19844976 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
molybdenum trioxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase decreases activity
multiple interactions
ISO
EXP
molybdenum trioxide results in decreased activity of CAT protein
chromous chloride affects the reaction [molybdenum trioxide results in decreased activity of CAT protein]; molybdenum trioxide affects the reaction [chromous chloride results in decreased activity of CAT protein]
CTD PMID:30389395 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression
EXP molybdenum trioxide results in increased activity of NQO1 protein
molybdenum trioxide results in increased expression of NQO1 mRNA
CTD PMID:9029048 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
sodium molybdate (anhydrous) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions
increases activity
EXP
ISO
sodium molybdate(VI) promotes the reaction [Tetrachlorodibenzodioxin binds to AHR protein]
sodium molybdate(VI) inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]
sodium molybdate(VI) results in increased activity of AHR protein
CTD PMID:3040233, PMID:8079350, PMID:8395819 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
tetrathiomolybdate(2-) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACACA acetyl-CoA carboxylase alpha increases phosphorylation ISO tetrathiomolybdate results in increased phosphorylation of ACACA protein CTD PMID:24218578 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836
JBrowse link
G AGTR2 angiotensin II receptor type 2 decreases expression EXP tetrathiomolybdate analog results in decreased expression of AGTR2 mRNA CTD PMID:19323979 NCBI chr  X:116,170,744...116,174,974
Ensembl chr  X:116,170,744...116,174,974
JBrowse link
G ANGPT2 angiopoietin 2 increases expression EXP tetrathiomolybdate analog results in increased expression of ANGPT2 mRNA CTD PMID:19323979 NCBI chr 8:6,499,632...6,563,420
Ensembl chr 8:6,499,651...6,563,409
Ensembl chr 8:6,499,651...6,563,409
JBrowse link
G APP amyloid beta precursor protein multiple interactions
affects binding
EXP [tetrathiomolybdate binds to APP 5' UTR] which results in decreased expression of APP protein; [tetrathiomolybdate binds to APP 5' UTR] which results in decreased secretion of APP protein modified form CTD PMID:15681799 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G AQP1 aquaporin 1 (Colton blood group) decreases expression EXP tetrathiomolybdate analog results in decreased expression of AQP1 mRNA CTD PMID:19323979 NCBI chr 7:30,911,853...30,925,516
Ensembl chr 7:30,911,853...30,925,517
Ensembl chr 7:30,911,853...30,925,517
JBrowse link
G ATP7A ATPase copper transporting alpha multiple interactions ISO tetrathiomolybdate inhibits the reaction [Oxygen deficiency affects the localization of ATP7A protein] CTD PMID:19351718 NCBI chr  X:77,910,693...78,050,395
Ensembl chr  X:77,910,656...78,050,395
JBrowse link
G ATP7B ATPase copper transporting beta multiple interactions ISO tetrathiomolybdate inhibits the reaction [ATP7B gene mutant form results in increased abundance of Copper] CTD PMID:11803042 NCBI chr13:51,932,669...52,012,130
Ensembl chr13:51,930,436...52,012,125
JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression EXP tetrathiomolybdate analog results in increased expression of BCL2 mRNA; tetrathiomolybdate analog results in increased expression of BCL2 protein CTD PMID:19323979 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L11 BCL2 like 11 multiple interactions ISO [Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of BCL2L11 protein; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of BCL2L11 protein CTD PMID:22276220 NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,445
JBrowse link
G BCL2L2 BCL2 like 2 increases expression EXP tetrathiomolybdate analog results in increased expression of BCL2L2 mRNA; tetrathiomolybdate analog results in increased expression of BCL2L2 protein CTD PMID:19323979 NCBI chr14:23,306,833...23,311,751
Ensembl chr14:23,298,790...23,311,759
Ensembl chr14:23,298,790...23,311,759
JBrowse link
G CASP3 caspase 3 multiple interactions ISO [Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of CASP3 protein; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of CASP3 protein CTD PMID:22276220 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 multiple interactions ISO [Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of CASP8 protein; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of CASP8 protein CTD PMID:22276220 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP
tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CCL2 mRNA]; tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CCL2 protein]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of and results in increased expression of CCL2 protein]
tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of CCL2 mRNA]; tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of CCL2 protein]
CTD PMID:15541506, PMID:21724870, PMID:24225134 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCS copper chaperone for superoxide dismutase increases expression ISO tetrathiomolybdate results in increased expression of CCS protein CTD PMID:21784888 NCBI chr11:66,593,162...66,606,019
Ensembl chr11:66,593,153...66,606,019
JBrowse link
G CD40 CD40 molecule increases expression EXP tetrathiomolybdate analog results in increased expression of CD40 mRNA CTD PMID:19323979 NCBI chr20:46,118,242...46,129,858
Ensembl chr20:46,118,278...46,129,863
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP tetrathiomolybdate analog results in increased expression of CDKN1A protein CTD PMID:19323979 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CKM creatine kinase, M-type multiple interactions ISO tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of CKM protein] CTD PMID:16242529 NCBI chr19:45,306,413...45,322,875
Ensembl chr19:45,306,413...45,322,875
JBrowse link
G COX5B cytochrome c oxidase subunit 5B increases expression EXP tetrathiomolybdate analog results in increased expression of COX5B mRNA CTD PMID:19323979 NCBI chr 2:97,646,062...97,648,383
Ensembl chr 2:97,646,062...97,648,383
JBrowse link
G CP ceruloplasmin decreases activity
decreases expression
decreases secretion
multiple interactions
ISO
EXP
tetrathiomolybdate results in decreased activity of CP protein
tetrathiomolybdate results in decreased expression of CP protein
tetrathiomolybdate results in decreased secretion of CP protein
tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CP protein]
CTD PMID:10656425, PMID:12624602, PMID:21724870, PMID:21784888, PMID:24013775 NCBI chr 3:149,162,410...149,222,008
Ensembl chr 3:149,162,410...149,221,829
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A decreases expression ISO tetrathiomolybdate results in decreased expression of CPT1A mRNA CTD PMID:21784888 NCBI chr11:68,754,620...68,844,410
Ensembl chr11:68,754,620...68,844,410
JBrowse link
G CRABP2 cellular retinoic acid binding protein 2 decreases expression EXP tetrathiomolybdate analog results in decreased expression of CRABP2 mRNA CTD PMID:19323979 NCBI chr 1:156,699,606...156,705,784
Ensembl chr 1:156,699,606...156,705,816
JBrowse link
G CREBZF CREB/ATF bZIP transcription factor increases expression EXP tetrathiomolybdate analog results in increased expression of CREBZF mRNA CTD PMID:19323979 NCBI chr11:85,657,985...85,682,863
Ensembl chr11:85,659,708...85,682,908
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 increases expression EXP tetrathiomolybdate analog results in increased expression of CXCR4 mRNA CTD PMID:19323979 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,118,149
JBrowse link
G EGF epidermal growth factor multiple interactions EXP [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; tetrathiomolybdate inhibits the reaction [EGF protein results in increased oxidation of PTPN1 protein]; tetrathiomolybdate inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:18480265 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions EXP tetrathiomolybdate inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:18480265 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G ELN elastin multiple interactions ISO [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of ELN mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of ELN protein CTD PMID:22276220 NCBI chr 7:74,027,772...74,069,907
Ensembl chr 7:74,027,789...74,069,907
JBrowse link
G EP300 E1A binding protein p300 multiple interactions ISO [Copper deficiency co-treated with tetrathiomolybdate] inhibits the reaction [EP300 protein binds to HIF1A protein]; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of EP300 protein CTD PMID:22276220 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,592...41,180,077
JBrowse link
G FBLN1 fibulin 1 multiple interactions ISO [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBLN1 mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBLN1 protein CTD PMID:22276220 NCBI chr22:45,502,883...45,601,135
Ensembl chr22:45,502,238...45,601,135
JBrowse link
G FBLN5 fibulin 5 multiple interactions ISO [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of FBLN5 mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of FBLN5 protein CTD PMID:22276220 NCBI chr14:91,869,411...91,947,694
Ensembl chr14:91,869,412...91,947,987
JBrowse link
G FBN1 fibrillin 1 multiple interactions ISO [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBN1 mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBN1 protein CTD PMID:22276220 NCBI chr15:48,408,313...48,645,709
Ensembl chr15:48,408,306...48,645,849
Ensembl chr15:48,408,306...48,645,849
JBrowse link
G FGF1 fibroblast growth factor 1 decreases secretion EXP tetrathiomolybdate results in decreased secretion of FGF1 protein CTD PMID:18400376 NCBI chr 5:142,592,178...142,698,070
Ensembl chr 5:142,592,178...142,698,070
JBrowse link
G FGF2 fibroblast growth factor 2 multiple interactions EXP [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]; Vanadates inhibits the reaction [tetrathiomolybdate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [tetrathiomolybdate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]] CTD PMID:18480265 NCBI chr 4:122,826,708...122,898,236
Ensembl chr 4:122,826,708...122,898,236
JBrowse link
G GPX3 glutathione peroxidase 3 increases expression EXP tetrathiomolybdate analog results in increased expression of GPX3 mRNA CTD PMID:19323979 NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,438...151,028,992
JBrowse link
G GSR glutathione-disulfide reductase increases expression EXP tetrathiomolybdate analog results in increased expression of GSR mRNA CTD PMID:19323979 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions ISO [Copper deficiency co-treated with tetrathiomolybdate] inhibits the reaction [EP300 protein binds to HIF1A protein]; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of HIF1A protein CTD PMID:22276220 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression ISO tetrathiomolybdate results in decreased expression of HMGCS2 mRNA CTD PMID:21784888 NCBI chr 1:119,747,996...119,768,932
Ensembl chr 1:119,748,002...119,768,905
Ensembl chr 1:119,748,002...119,768,905
JBrowse link
G HMMR hyaluronan mediated motility receptor decreases expression EXP tetrathiomolybdate analog results in decreased expression of RHAMM mRNA CTD PMID:19323979 NCBI chr 5:163,460,632...163,491,941
Ensembl chr 5:163,460,203...163,491,941
JBrowse link
G HMOX1 heme oxygenase 1 decreases expression
increases expression
multiple interactions
ISO
EXP
tetrathiomolybdate results in decreased expression of HMOX1 protein
tetrathiomolybdate analog results in increased expression of HMOX1 mRNA; tetrathiomolybdate analog results in increased expression of HMOX1 protein
[tetrathiomolybdate analog results in increased abundance of Superoxides] which results in increased reduction of HMOX1 protein; Acetylcysteine inhibits the reaction [tetrathiomolybdate analog results in increased expression of HMOX1 protein]; Copper inhibits the reaction [tetrathiomolybdate analog results in increased expression of HMOX1 protein]
CTD PMID:19323979, PMID:21784888 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions ISO
EXP
tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of ICAM1 mRNA]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of and results in increased expression of ICAM1 protein]
tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of ICAM1 mRNA]; tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of ICAM1 protein]
CTD PMID:21724870, PMID:24225134 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions EXP [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]; tetrathiomolybdate inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein] CTD PMID:18480265 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IGF1R insulin like growth factor 1 receptor multiple interactions EXP tetrathiomolybdate inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein] CTD PMID:18480265 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530
JBrowse link
G IL1A interleukin 1 alpha multiple interactions ISO tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1A protein] CTD PMID:21724870 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of IL1B protein] CTD PMID:16242529 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL2 interleukin 2 multiple interactions ISO tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of IL2 protein] CTD PMID:16242529 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL2RA interleukin 2 receptor subunit alpha decreases expression
multiple interactions
EXP
ISO
tetrathiomolybdate analog results in decreased expression of IL2RA mRNA
tetrathiomolybdate inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]]
CTD PMID:19323979, PMID:23134680 NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370
JBrowse link
G IL6 interleukin 6 multiple interactions ISO tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA] CTD PMID:21724870 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G ITGB4 integrin subunit beta 4 decreases expression EXP tetrathiomolybdate analog results in decreased expression of ITGB4 mRNA CTD PMID:19323979 NCBI chr17:75,721,339...75,757,819
Ensembl chr17:75,721,328...75,757,818
JBrowse link
G ITGB6 integrin subunit beta 6 multiple interactions ISO [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of ITGB6 mRNA CTD PMID:22276220 NCBI chr 2:160,099,671...160,200,272
Ensembl chr 2:160,099,667...160,200,313
JBrowse link
G JAG1 jagged canonical Notch ligand 1 increases expression EXP tetrathiomolybdate analog results in increased expression of JAG1 mRNA CTD PMID:19323979 NCBI chr20:10,637,684...10,673,999
Ensembl chr20:10,637,684...10,673,999
JBrowse link
G KLF2 Kruppel like factor 2 decreases expression EXP tetrathiomolybdate analog results in decreased expression of KLF2 mRNA CTD PMID:19323979 NCBI chr19:16,324,826...16,328,685
Ensembl chr19:16,324,817...16,327,874
Ensembl chr19:16,324,817...16,327,874
JBrowse link
G LOX lysyl oxidase multiple interactions ISO [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of LOX mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of LOX protein CTD PMID:22276220 NCBI chr 5:122,063,195...122,078,259
Ensembl chr 5:122,063,195...122,078,360
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
ISO
EXP
[Copper deficiency co-treated with tetrathiomolybdate] results in decreased phosphorylation of MAPK1 protein
tetrathiomolybdate results in decreased phosphorylation of MAPK1 protein
[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]; Hydrogen Peroxide inhibits the reaction [tetrathiomolybdate results in decreased phosphorylation of MAPK1 protein]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [tetrathiomolybdate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]
tetrathiomolybdate analog results in increased phosphorylation of MAPK1 protein
CTD PMID:18480265, PMID:19323979, PMID:22276220 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation
ISO
EXP
[Copper deficiency co-treated with tetrathiomolybdate] results in decreased phosphorylation of MAPK3 protein
tetrathiomolybdate results in decreased phosphorylation of MAPK3 protein
tetrathiomolybdate analog results in increased phosphorylation of MAPK3 protein
[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]; Hydrogen Peroxide inhibits the reaction [tetrathiomolybdate results in decreased phosphorylation of MAPK3 protein]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]; Vanadates inhibits the reaction [tetrathiomolybdate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]
CTD PMID:18480265, PMID:19323979, PMID:22276220 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPT microtubule associated protein tau multiple interactions EXP tetrathiomolybdate inhibits the reaction [Copper results in increased phosphorylation of MAPT protein] CTD PMID:25671100 NCBI chr17:45,894,538...46,028,334
Ensembl chr17:45,894,551...46,028,334
Ensembl chr17:45,894,551...46,028,334
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions EXP tetrathiomolybdate analog affects the localization of and results in increased activity of NFE2L2 protein CTD PMID:19323979 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP tetrathiomolybdate results in decreased phosphorylation of and results in decreased degradation of NFKBIA protein CTD PMID:24225134 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G PCNA proliferating cell nuclear antigen decreases expression EXP tetrathiomolybdate results in decreased expression of PCNA protein CTD PMID:24614111 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PDGFRB platelet derived growth factor receptor beta decreases expression EXP tetrathiomolybdate results in decreased expression of PDGFRB protein CTD PMID:18480265 NCBI chr 5:150,113,839...150,155,845
Ensembl chr 5:150,113,839...150,155,872
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha decreases expression ISO tetrathiomolybdate results in decreased expression of PPARA mRNA CTD PMID:21784888 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression EXP tetrathiomolybdate analog results in increased expression of PTGS2 mRNA CTD PMID:19323979 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G PTK2 protein tyrosine kinase 2 multiple interactions ISO [Copper deficiency co-treated with tetrathiomolybdate] results in decreased phosphorylation of PTK2 protein CTD PMID:22276220 NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216
JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 multiple interactions EXP tetrathiomolybdate inhibits the reaction [EGF protein results in increased oxidation of PTPN1 protein] CTD PMID:18480265 NCBI chr20:50,510,383...50,585,241
Ensembl chr20:50,510,321...50,585,241
JBrowse link
G SLC31A1 solute carrier family 31 member 1 multiple interactions
increases expression
EXP [tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to oxaliplatin; [tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Cisplatin; tetrathiomolybdate promotes the reaction [SP1 protein binds to SLC31A1 promoter] CTD PMID:22172574, PMID:22914438 NCBI chr 9:113,221,544...113,264,492
Ensembl chr 9:113,221,544...113,264,492
JBrowse link
G SLC31A2 solute carrier family 31 member 2 decreases response to substance EXP SLC31A2 mRNA results in decreased susceptibility to tetrathiomolybdate CTD PMID:24522273 NCBI chr 9:113,150,976...113,164,140
Ensembl chr 9:113,150,976...113,164,140
JBrowse link
G SLC7A11 solute carrier family 7 member 11 increases expression EXP tetrathiomolybdate analog results in increased expression of SLC7A11 mRNA CTD PMID:19323979 NCBI chr 4:138,164,097...138,242,349
Ensembl chr 4:138,164,097...138,242,349
JBrowse link
G SOD1 superoxide dismutase 1 decreases expression
affects localization
decreases activity
multiple interactions
ISO
EXP
tetrathiomolybdate results in decreased expression of SOD1 protein
tetrathiomolybdate analog affects the localization of SOD1 protein
tetrathiomolybdate results in decreased activity of SOD1 protein
[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] which results in decreased abundance of Hydrogen Peroxide; [tetrathiomolybdate results in decreased activity of SOD1 protein] which results in increased abundance of Superoxides; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]
tetrathiomolybdate analog results in decreased expression of SOD1 mRNA
CTD PMID:18480265, PMID:19323979, PMID:21784888 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 increases expression EXP tetrathiomolybdate analog results in increased expression of SOD2 mRNA; tetrathiomolybdate analog results in increased expression of SOD2 protein CTD PMID:19323979 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SP1 Sp1 transcription factor multiple interactions
increases expression
increases activity
EXP [tetrathiomolybdate results in decreased abundance of Copper] which results in increased expression of SP1 protein; tetrathiomolybdate promotes the reaction [SP1 protein binds to SLC31A1 promoter]; tetrathiomolybdate promotes the reaction [SP1 protein binds to SP1 promoter]
tetrathiomolybdate results in increased expression of SP1; tetrathiomolybdate results in increased expression of SP1 mRNA
tetrathiomolybdate results in increased activity of SP1 protein
CTD PMID:22172574, PMID:22914438 NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446
JBrowse link
G SP3 Sp3 transcription factor decreases expression EXP tetrathiomolybdate results in decreased expression of SP3 CTD PMID:22172574 NCBI chr 2:173,900,775...173,965,702
Ensembl chr 2:173,880,850...173,965,702
JBrowse link
G TFB1M transcription factor B1, mitochondrial decreases expression ISO tetrathiomolybdate results in decreased expression of TFB1M mRNA CTD PMID:21784888 NCBI chr 6:155,229,871...155,314,497
Ensembl chr 6:155,256,134...155,314,493
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein] CTD PMID:15541506 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein] CTD PMID:15541506, PMID:16242529, PMID:21724870 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNNI3 troponin I3, cardiac type multiple interactions ISO tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of TNNI3 protein] CTD PMID:16242529 NCBI chr19:55,151,767...55,157,732
Ensembl chr19:55,151,767...55,157,773
JBrowse link
G TP53 tumor protein p53 multiple interactions ISO [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of TP53 protein CTD PMID:22276220 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression EXP tetrathiomolybdate analog results in increased expression of TXNRD1 mRNA CTD PMID:19323979 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions ISO
EXP
tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of VCAM1 mRNA]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of and results in increased expression of VCAM1 protein]
tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 mRNA]; tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 protein]
CTD PMID:21724870, PMID:24225134 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions
decreases expression
ISO [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of VEGFA mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of VEGFA protein
tetrathiomolybdate results in decreased expression of VEGFA protein
CTD PMID:16277669, PMID:22276220 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24216
    chemical entity 24181
      molecular entity 24130
        transition element molecular entity 17792
          transition element coordination entity 11945
            molybdenum coordination entity 90
              Cu(I)-S-Mo(IV)(=O)O-NBIC Cluster 0
              Mo(V)-molybdopterin cytosine dinucleotide 0
              Mo-molybdopterin cofactor + 0
              aquapentachloromolybdate(2-) 0
              bis[tricarbonyl(eta(5)-cyclopentadienyl)molybdenum](Mo--Mo) 0
              bromidotricarbonyl[benzene-1,2-diylbis(dimethylarsane)]molybdenum(1+) 0
              carbonylbis(eta(5)-cyclopentadienyl)molybdenum 0
              cis-tetrakis[dimethyl(phenyl)phosphane]bis(dinitrogen)molybdenum 0
              dioxo(sulfanyl)molybdenum 0
              heptacyanomolybdate(4-) 0
              heptacyanomolybdate(5-) 0
              hexaammonium heptamolybdate tetrahydrate 0
              hexaaquamolybdenum(3+) 0
              hexacarbonylmolybdenum 0
              hexachloromolybdate(3-) 0
              hexacyanomolybdate(3-) 0
              hexacyanomolybdate(4-) 0
              hexafluoromolybdate(1-) 0
              hexafluoromolybdate(2-) 0
              hexafluoromolybdate(3-) 0
              iron-sulfur-molybdenum cofactor 0
              molybdenum halide + 4
              molybdenum oxide + 2
              molybdenum oxoacid + 0
              molybdenum oxoanion + 10
              octacyanomolybdate(3-) 0
              octacyanomolybdate(4-) 0
              octafluoromolybdate(2-) 0
              octafluoromolybdate(4-) 0
              pentabromo(oxo)molybdate(2-) 0
              tetrabromo(dioxo)molybdate(2-) 0
              tetracarbonylbis(hexamethylphosphorous triamide)molybdenum 0
              tetrachloridobis(pyridine)molybdenum 0
              tetrachloro(dioxo)molybdate(2-) 0
              tetrachloro(oxo)molybdenum 0
              tetrafluoro(oxo)molybdenum 0
              tetrafluoro(oxo)peroxomolybdate(2-) 0
              tetrafluoro(selenoxo)molybdenum 0
              tetrafluoro(thioxo)molybdenum 0
              tetraiodo(oxo)molybdate(1-) 0
              tetraperoxidomolybdate(2-) 0
              tetrathiomolybdate(2-) 77
              trans-bis(dinitrogen)bis(dppe)molybdenum 0
              trans-tetrakis[dimethyl(phenyl)phosphane]bis(dinitrogen)molybdenum 0
              tricarbonyl(diethylenetriamine)molybdenum 0
              trichloridonitridomolybdenum 0
              trichloridooxidomolybdenum 0
              trichloridoselenidomolybdenum 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 24216
    subatomic particle 24167
      composite particle 24167
        hadron 24167
          baryon 24167
            nucleon 24167
              atomic nucleus 24167
                atom 24167
                  metal atom 19283
                    transition element atom 18311
                      d-block element atom 18299
                        chromium group element atom 7722
                          molybdenum atom 95
                            molybdenum molecular entity 90
                              molybdenum coordination entity 90
                                Cu(I)-S-Mo(IV)(=O)O-NBIC Cluster 0
                                Mo(V)-molybdopterin cytosine dinucleotide 0
                                Mo-molybdopterin cofactor + 0
                                aquapentachloromolybdate(2-) 0
                                bis[tricarbonyl(eta(5)-cyclopentadienyl)molybdenum](Mo--Mo) 0
                                bromidotricarbonyl[benzene-1,2-diylbis(dimethylarsane)]molybdenum(1+) 0
                                carbonylbis(eta(5)-cyclopentadienyl)molybdenum 0
                                cis-tetrakis[dimethyl(phenyl)phosphane]bis(dinitrogen)molybdenum 0
                                dioxo(sulfanyl)molybdenum 0
                                heptacyanomolybdate(4-) 0
                                heptacyanomolybdate(5-) 0
                                hexaammonium heptamolybdate tetrahydrate 0
                                hexaaquamolybdenum(3+) 0
                                hexacarbonylmolybdenum 0
                                hexachloromolybdate(3-) 0
                                hexacyanomolybdate(3-) 0
                                hexacyanomolybdate(4-) 0
                                hexafluoromolybdate(1-) 0
                                hexafluoromolybdate(2-) 0
                                hexafluoromolybdate(3-) 0
                                iron-sulfur-molybdenum cofactor 0
                                molybdenum halide + 4
                                molybdenum oxide + 2
                                molybdenum oxoacid + 0
                                molybdenum oxoanion + 10
                                octacyanomolybdate(3-) 0
                                octacyanomolybdate(4-) 0
                                octafluoromolybdate(2-) 0
                                octafluoromolybdate(4-) 0
                                pentabromo(oxo)molybdate(2-) 0
                                tetrabromo(dioxo)molybdate(2-) 0
                                tetracarbonylbis(hexamethylphosphorous triamide)molybdenum 0
                                tetrachloridobis(pyridine)molybdenum 0
                                tetrachloro(dioxo)molybdate(2-) 0
                                tetrachloro(oxo)molybdenum 0
                                tetrafluoro(oxo)molybdenum 0
                                tetrafluoro(oxo)peroxomolybdate(2-) 0
                                tetrafluoro(selenoxo)molybdenum 0
                                tetrafluoro(thioxo)molybdenum 0
                                tetraiodo(oxo)molybdate(1-) 0
                                tetraperoxidomolybdate(2-) 0
                                tetrathiomolybdate(2-) 77
                                trans-bis(dinitrogen)bis(dppe)molybdenum 0
                                trans-tetrakis[dimethyl(phenyl)phosphane]bis(dinitrogen)molybdenum 0
                                tricarbonyl(diethylenetriamine)molybdenum 0
                                trichloridonitridomolybdenum 0
                                trichloridooxidomolybdenum 0
                                trichloridoselenidomolybdenum 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.