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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chloroform
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Accession:CHEBI:35255 term browser browse the term
Definition:A one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines.
Synonyms:related_synonym: 1,1,1-trichloromethane;   CHCl3;   Formula=CHCl3;   InChI=1S/CHCl3/c2-1(3)4/h1H;   InChIKey=HEDRZPFGACZZDS-UHFFFAOYSA-N;   SMILES=[H]C(Cl)(Cl)Cl;   Trichlormethan;   chloroforme;   chloroformium pro narcosi;   trichloromethane
 alt_id: CHEBI:23143;   CHEBI:34628
 xref: Beilstein:1731042;   CAS:67-66-3;   Drug_Central:4363;   Gmelin:1837;   HMDB:HMDB0029596;   KEGG:C13827;   LINCS:LSM-37229
 xref_mesh: MESH:D002725
 xref: MetaCyc:CPD-843;   PDBeChem:MCH;   PMID:10379014;   PMID:15583552;   PMID:20051454;   PMID:21850127;   PMID:23093177;   PMID:8476536;   PMID:8625290;   Reaxys:1731042;   UM-BBD_compID:c0595;   Wikipedia:Chloroform


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chloroform term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP Chloroform results in decreased expression of ABCB11 mRNA CTD PMID:17522070 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO
EXP
Chloroform results in increased expression of ABCB1 mRNA CTD PMID:15120965, PMID:17522070 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression EXP Chloroform results in increased expression of ABCB1B mRNA CTD PMID:15120965 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Chloroform results in increased expression of ABCC3 mRNA CTD PMID:17522070 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain decreases expression EXP Chloroform results in decreased expression of ACADM mRNA CTD PMID:17522070 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression EXP Chloroform results in decreased expression of ACSL1 mRNA CTD PMID:17522070 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP Chloroform results in increased expression of AKR7A3 mRNA CTD PMID:21813463 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP Chloroform results in increased expression of ALDH1A1 mRNA CTD PMID:21813463 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression EXP Chloroform results in decreased expression of ALDH3A2 mRNA CTD PMID:17522070 NCBI chr10:47,525,486...47,546,535
Ensembl chr10:47,525,493...47,546,345
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Chloroform results in increased expression of ALDOA mRNA CTD PMID:17522070 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
JBrowse link
G Anxa2 annexin A2 increases expression EXP Chloroform results in increased expression of ANXA2 mRNA CTD PMID:21813463 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression EXP Chloroform results in increased expression of APEX1 mRNA CTD PMID:17522070 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Asl argininosuccinate lyase increases expression EXP Chloroform results in increased expression of ASL mRNA CTD PMID:17522070 NCBI chr12:30,160,922...30,178,348
Ensembl chr12:30,165,694...30,178,341
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO
EXP
Chloroform results in increased expression of BTG2 mRNA CTD PMID:9397189, PMID:17522070, PMID:21813463 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Calu calumenin increases expression EXP Chloroform results in increased expression of CALU mRNA CTD PMID:17522070 NCBI chr 4:56,625,611...56,653,112
Ensembl chr 4:56,625,561...56,653,111
JBrowse link
G Cat catalase decreases expression EXP Chloroform results in decreased expression of CAT mRNA CTD PMID:17522070 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Chloroform results in increased expression of CCL2 mRNA CTD PMID:21907259 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccng1 cyclin G1 increases expression EXP Chloroform results in increased expression of CCNG1 mRNA CTD PMID:17522070 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP Chloroform results in increased expression of CDKN1A mRNA CTD PMID:21813463 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Ces2h carboxylesterase 2H increases expression EXP Chloroform results in increased expression of CES2 mRNA CTD PMID:21813463 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Clu clusterin increases expression EXP Chloroform results in increased expression of CLU mRNA CTD PMID:17522070 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Ctsl cathepsin L increases expression EXP Chloroform results in increased expression of CTSL mRNA CTD PMID:17522070 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 decreases expression EXP Chloroform results in decreased expression of CYP2D3 mRNA CTD PMID:17522070 NCBI chr 7:123,634,400...123,638,757
Ensembl chr 7:123,625,590...123,638,765
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing
increases response to substance
increases oxidation
ISO CYP2E1 protein results in increased metabolism of Chloroform
CYP2E1 gene SNP results in increased susceptibility to Chloroform
CYP2E1 protein results in increased oxidation of Chloroform
CTD PMID:1664256, PMID:15289170, PMID:18350910 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases expression EXP Chloroform results in decreased expression of CYP3A23-3A1 mRNA CTD PMID:15120965 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Chloroform results in increased expression of DDIT3 mRNA CTD PMID:17522070 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression EXP Chloroform results in decreased expression of FABP1 mRNA CTD PMID:17522070 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression EXP Chloroform results in decreased expression of FADS1 mRNA CTD PMID:17522070 NCBI chr 1:226,234,034...226,249,118
Ensembl chr 1:226,234,074...226,249,138
JBrowse link
G Fga fibrinogen alpha chain increases expression EXP Chloroform results in increased expression of FGA mRNA CTD PMID:17522070 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression EXP Chloroform results in increased expression of FHL1 mRNA CTD PMID:23558518 NCBI chr  X:159,112,516...159,172,528
Ensembl chr  X:159,112,880...159,172,524
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 decreases expression EXP Chloroform results in decreased expression of FMO1 mRNA CTD PMID:17522070 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Chloroform results in increased expression of FOS mRNA CTD PMID:8625290 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Chloroform results in increased expression of GADD45A mRNA CTD PMID:17522070 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gck glucokinase increases expression EXP Chloroform results in increased expression of GCK mRNA CTD PMID:17522070 NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659
JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression EXP Chloroform results in decreased expression of GJB1 mRNA CTD PMID:17522070 NCBI chr  X:71,272,030...71,279,973
Ensembl chr  X:71,272,042...71,279,977
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity
ISO
EXP
Anethole Trithione promotes the reaction [Chloroform results in increased activity of GPT protein]; diisopropyl 1,3-dithiol-2-ylidenemalonate inhibits the reaction [Chloroform results in increased activity of GPT protein] CTD PMID:3795300 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression EXP Chloroform results in decreased expression of GPX1 mRNA CTD PMID:17522070 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO Chloroform results in increased expression of GSR mRNA CTD PMID:15914208 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression EXP Chloroform results in decreased expression of GSTM3 mRNA CTD PMID:17522070 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression ISO Chloroform results in increased expression of HAVCR1 mRNA CTD PMID:21907259 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
JBrowse link
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 decreases activity ISO Chloroform results in decreased activity of HCN2 protein CTD PMID:22024336 NCBI chr 7:12,851,730...12,870,087
Ensembl chr 7:12,851,739...12,874,215
JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase decreases expression EXP Chloroform results in decreased expression of HIBADH mRNA CTD PMID:17522070 NCBI chr 4:82,604,369...82,702,429
Ensembl chr 4:82,604,373...82,702,429
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Chloroform results in increased expression of HMOX1 mRNA CTD PMID:15914208 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression EXP Chloroform results in increased expression of HSPA1A mRNA CTD PMID:17522070 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression EXP Chloroform results in increased expression of ICAM1 mRNA CTD PMID:17522070 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma decreases expression ISO Chloroform results in decreased expression of IFNG protein CTD PMID:16879906 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il13 interleukin 13 increases expression ISO Chloroform results in increased expression of IL13 protein CTD PMID:16879906 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il4 interleukin 4 decreases expression
multiple interactions
ISO Chloroform results in decreased expression of IL4 protein
Chloroform promotes the reaction [[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of NOS2 mRNA]
CTD PMID:16879906, PMID:21977998 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 increases expression ISO Chloroform results in increased expression of IL5 protein CTD PMID:16879906 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Chloroform results in decreased activity of KCNH2 protein CTD PMID:22024336 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Krt18 keratin 18 increases expression EXP Chloroform results in increased expression of KRT18 mRNA CTD PMID:17522070 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Krt8 keratin 8 increases expression EXP Chloroform results in increased expression of KRT8 mRNA CTD PMID:17522070 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP Chloroform results in increased expression of LBP mRNA CTD PMID:17522070 NCBI chr 3:154,786,232...154,812,910
Ensembl chr 3:154,786,215...154,813,464
JBrowse link
G Lgals3 galectin 3 increases expression EXP Chloroform results in increased expression of LGALS3 mRNA CTD PMID:17522070 NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
JBrowse link
G Lipc lipase C, hepatic type decreases expression EXP Chloroform results in decreased expression of LIPC mRNA CTD PMID:17522070 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248
JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP Chloroform results in increased expression of LMCD1 mRNA CTD PMID:23558518 NCBI chr 4:144,192,989...144,252,554
Ensembl chr 4:144,192,989...144,252,551
JBrowse link
G LOC100909485 spindlin-2-like decreases expression EXP Chloroform results in decreased expression of SPIN2B mRNA CTD PMID:17522070 NCBI chr  X:18,340,413...18,342,492
Ensembl chr  X:18,340,688...18,341,467
JBrowse link
G Lpl lipoprotein lipase increases expression EXP Chloroform results in increased expression of LPL mRNA CTD PMID:17522070 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Maob monoamine oxidase B decreases expression EXP Chloroform results in decreased expression of MAOB mRNA CTD PMID:17522070 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP Chloroform results in increased expression of MGMT mRNA CTD PMID:21813463 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mir100 microRNA 100 decreases expression ISO Chloroform results in decreased expression of MIR100 mRNA CTD PMID:32105654 NCBI chr 8:45,746,948...45,747,027
Ensembl chr 8:45,746,948...45,747,027
JBrowse link
G Mir125b1 microRNA 125b-1 increases expression ISO Chloroform results in increased expression of MIR125B-1 mRNA CTD PMID:32105654 NCBI chr 8:45,798,260...45,798,346
Ensembl chr 8:45,798,260...45,798,346
JBrowse link
G Mir132 microRNA 132 decreases expression ISO Chloroform results in decreased expression of MIR132 mRNA CTD PMID:32105654 NCBI chr10:62,014,995...62,015,095
Ensembl chr10:62,014,995...62,015,095
JBrowse link
G Mir141 microRNA 141 increases expression ISO Chloroform results in increased expression of MIR141 mRNA CTD PMID:32105654 NCBI chr 4:157,236,346...157,236,439
Ensembl chr 4:157,236,346...157,236,439
JBrowse link
G Mir144 microRNA 144 decreases expression ISO Chloroform results in decreased expression of MIR144 mRNA CTD PMID:32105654 NCBI chr10:65,291,365...65,291,447
Ensembl chr10:65,291,365...65,291,447
JBrowse link
G Mir16 microRNA 16 increases expression EXP Chloroform results in increased expression of MIR16 mRNA CTD PMID:17522070 NCBI chr 2:165,606,072...165,606,166
Ensembl chr 2:165,606,072...165,606,166
JBrowse link
G Mir186 microRNA 186 increases expression ISO Chloroform results in increased expression of MIR186 mRNA CTD PMID:32105654 NCBI chr 2:263,873,759...263,873,844
Ensembl chr 2:263,873,759...263,873,844
JBrowse link
G Mir196c microRNA 196c decreases expression ISO Chloroform results in decreased expression of MIR196A-1 mRNA CTD PMID:32105654 NCBI chr10:84,113,578...84,113,657
Ensembl chr10:84,113,578...84,113,657
JBrowse link
G Mir204 microRNA 204 increases expression ISO Chloroform results in increased expression of MIR204 mRNA CTD PMID:32105654 NCBI chr 1:240,403,000...240,403,109
Ensembl chr 1:240,403,000...240,403,109
JBrowse link
G Mir211 microRNA 211 increases expression ISO Chloroform results in increased expression of MIR211 mRNA CTD PMID:32105654 NCBI chr 1:125,042,119...125,042,224
Ensembl chr 1:125,042,119...125,042,224
JBrowse link
G Mir218-2 microRNA 218-2 increases expression ISO Chloroform results in increased expression of MIR218-2 mRNA CTD PMID:32105654 NCBI chr10:20,428,661...20,428,770
Ensembl chr10:20,428,661...20,428,770
JBrowse link
G Mir219a1 microRNA 219a-1 increases expression ISO Chloroform results in increased expression of MIR219A-1 mRNA CTD PMID:32105654 NCBI chr20:3,816,158...3,816,267
Ensembl chr20:3,816,158...3,816,267
JBrowse link
G Mir224 microRNA 224 decreases expression ISO Chloroform results in decreased expression of MIR224 mRNA CTD PMID:32105654 NCBI chr  X:152,223,754...152,223,835
Ensembl chr  X:152,223,754...152,223,835
JBrowse link
G Mir29b1 microRNA 29b-1 increases expression ISO Chloroform results in increased expression of MIR29B-1 mRNA CTD PMID:32105654 NCBI chr 4:58,344,310...58,344,390
Ensembl chr 4:58,344,310...58,344,390
JBrowse link
G Mir33 microRNA 33 decreases expression ISO Chloroform results in decreased expression of MIR33 mRNA CTD PMID:32105654 NCBI chr 7:123,431,612...123,431,680
Ensembl chr 7:123,431,612...123,431,680
JBrowse link
G Mir331 microRNA 331 increases expression ISO Chloroform results in increased expression of MIR331 mRNA CTD PMID:32105654 NCBI chr 7:34,881,095...34,881,190
Ensembl chr 7:34,881,095...34,881,190
JBrowse link
G Mir409 microRNA 409 decreases expression ISO Chloroform results in decreased expression of MIR409 mRNA CTD PMID:32105654 NCBI chr 6:133,893,419...133,893,495 JBrowse link
G Mir410 microRNA 410 increases expression ISO Chloroform results in increased expression of MIR410 mRNA CTD PMID:32105654 NCBI chr 6:133,893,997...133,894,072
Ensembl chr 6:133,893,993...133,894,073
JBrowse link
G Mir429 microRNA 429 increases expression ISO Chloroform results in increased expression of MIR429 mRNA CTD PMID:32105654 NCBI chr 5:173,488,331...173,488,415
Ensembl chr 5:173,488,331...173,488,415
JBrowse link
G Mir451a microRNA 451a increases expression ISO Chloroform results in increased expression of MIR451A mRNA CTD PMID:32105654 NCBI chr10:65,291,204...65,291,275
Ensembl chr10:65,291,204...65,291,275
JBrowse link
G Mir496 microRNA 496 decreases expression ISO Chloroform results in decreased expression of MIR496A mRNA CTD PMID:32105654 NCBI chr 6:133,889,283...133,889,361
Ensembl chr 6:133,889,283...133,889,361
JBrowse link
G Mir541 microRNA 541 increases expression ISO Chloroform results in increased expression of MIR541 mRNA CTD PMID:32105654 NCBI chr 6:133,892,655...133,892,744
Ensembl chr 6:133,892,655...133,892,744
JBrowse link
G Mir582 microRNA 582 decreases expression ISO Chloroform results in decreased expression of MIR582 mRNA CTD PMID:32105654 NCBI chr 2:40,863,750...40,863,830
Ensembl chr 2:40,863,750...40,863,830
JBrowse link
G Mir671 microRNA 671 decreases expression ISO Chloroform results in decreased expression of MIR671 mRNA CTD PMID:32105654 NCBI chr 4:7,108,747...7,108,827
Ensembl chr 4:7,108,738...7,108,835
JBrowse link
G Mir98 microRNA 98 decreases expression ISO Chloroform results in decreased expression of MIR98 mRNA CTD PMID:32105654 NCBI chr  X:21,583,875...21,583,982
Ensembl chr  X:21,583,875...21,583,982
JBrowse link
G Mug1 murinoglobulin 1 decreases expression EXP Chloroform results in decreased expression of MUG1 mRNA CTD PMID:17522070 NCBI chr 4:154,676,382...154,729,288
Ensembl chr 4:154,391,647...154,729,310
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression
decreases methylation
ISO
EXP
Chloroform inhibits the reaction [Dichloroacetic Acid results in decreased expression of MYC mRNA]; Chloroform inhibits the reaction [Dichloroacetic Acid results in decreased methylation of MYC gene]; Chloroform inhibits the reaction [Dichloroacetic Acid results in increased expression of MYC mRNA]; Chloroform promotes the reaction [Dichloroacetic Acid results in decreased methylation of MYC promoter]
Chloroform results in increased expression of MYC mRNA
Chloroform results in decreased methylation of MYC promoter
CTD PMID:8625290, PMID:11099637, PMID:11532874, PMID:16014735 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Chloroform results in increased localization of and results in increased activity of NFKB1 protein CTD PMID:11306435 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbib NFKB inhibitor beta increases expression EXP Chloroform results in increased expression of NFKBIB mRNA CTD PMID:17522070 NCBI chr 1:86,941,073...86,948,845
Ensembl chr 1:86,941,074...86,948,845
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Chloroform promotes the reaction [[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of NOS2 mRNA] CTD PMID:21977998 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression EXP Chloroform results in increased expression of ODC1 mRNA CTD PMID:17522070 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Otc ornithine transcarbamylase decreases expression EXP Chloroform results in decreased expression of OTC mRNA CTD PMID:17522070 NCBI chr  X:13,524,804...13,601,074
Ensembl chr  X:13,524,607...13,601,069
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Chloroform results in increased expression of PCNA protein CTD PMID:11099637 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Por cytochrome p450 oxidoreductase decreases response to substance
affects response to substance
ISO POR results in decreased susceptibility to Chloroform
POR protein affects the susceptibility to Chloroform
CTD PMID:18031782, PMID:23732084 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ptma prothymosin alpha increases expression EXP Chloroform results in increased expression of PTMA mRNA CTD PMID:17522070 NCBI chr 9:93,545,396...93,549,436
Ensembl chr 9:93,545,396...93,549,436
JBrowse link
G Pvr PVR cell adhesion molecule increases expression EXP Chloroform results in increased expression of PVR mRNA CTD PMID:17522070 NCBI chr 1:80,820,306...80,835,712
Ensembl chr 1:80,820,050...80,835,701
JBrowse link
G Pygl glycogen phosphorylase L decreases expression EXP Chloroform results in decreased expression of PYGL mRNA CTD PMID:17522070 NCBI chr 6:92,597,759...92,643,734
Ensembl chr 6:92,597,706...92,643,847
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Chloroform results in increased localization of and results in increased activity of RELA protein CTD PMID:11306435 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rnd1 Rho family GTPase 1 increases expression EXP Chloroform results in increased expression of RND1 mRNA CTD PMID:23558518 NCBI chr 7:140,349,138...140,356,209
Ensembl chr 7:140,349,138...140,356,209
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP Chloroform results in increased expression of S100A8 mRNA CTD PMID:17522070 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression EXP Chloroform results in increased expression of S100A9 mRNA CTD PMID:17522070 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity ISO Chloroform results in decreased activity of SCN5A protein CTD PMID:22024336 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
G Serpine1 serpin family E member 1 increases expression EXP Chloroform results in increased expression of SERPINE1 mRNA CTD PMID:23558518 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression EXP Chloroform results in increased expression of SLC2A1 mRNA CTD PMID:17522070 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Snora58 small nucleolar RNA, H/ACA box 58 decreases expression ISO Chloroform results in decreased expression of MIR3068 mRNA CTD PMID:32105654 NCBI chr 6:111,468,732...111,468,807
Ensembl chr 6:111,468,732...111,468,807
JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member increases expression EXP Chloroform results in increased expression of TAP1 mRNA CTD PMID:21813463 NCBI chr20:3,979,302...3,989,669
Ensembl chr20:3,979,035...3,989,669
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP Chloroform results in increased expression of TGFB2 mRNA CTD PMID:23558518 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP Chloroform results in decreased expression of THRSP mRNA CTD PMID:17522070 NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Chloroform results in increased expression of TIMP1 mRNA CTD PMID:17522070, PMID:23558518 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression EXP Chloroform results in increased expression of TNFRSF1A mRNA CTD PMID:17522070 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tp53 tumor protein p53 increases expression
increases phosphorylation
EXP
ISO
Chloroform results in increased expression of TP53 mRNA
Chloroform results in increased phosphorylation of TP53 protein
CTD PMID:8076368, PMID:17522070 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ttr transthyretin decreases expression EXP Chloroform results in decreased expression of TTR mRNA CTD PMID:17522070 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link
G Txn1 thioredoxin 1 increases expression EXP Chloroform results in increased expression of TXN mRNA CTD PMID:17522070 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases expression EXP Chloroform results in decreased expression of TXNRD1 mRNA CTD PMID:17522070 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Vnn1 vanin 1 increases expression ISO Chloroform results in increased expression of VNN1 mRNA CTD PMID:21907259 NCBI chr 1:22,614,832...22,625,134
Ensembl chr 1:22,614,783...22,625,204
JBrowse link
G Zfand5 zinc finger AN1-type containing 5 increases expression ISO Chloroform results in increased expression of ZFAND5 mRNA CTD PMID:9397189 NCBI chr 1:238,842,506...238,854,030
Ensembl chr 1:238,843,338...238,852,566
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        refrigerant 17439
          chloroform 116
            trichloromethyl group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            organic hydride 18269
                              organic fundamental parent 18269
                                hydrocarbon 17988
                                  halohydrocarbon 13956
                                    haloalkane 11674
                                      chloroalkane 9140
                                        chloromethanes 7273
                                          chloroform 116
                                            trichloromethyl group 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.