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ONTOLOGY REPORT - ANNOTATIONS


Term:EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
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Accession:CHEBI:35544 term browser browse the term
Definition:A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.
Synonyms:related_synonym: (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase inhibitor;   (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase inhibitors;   (PG)H synthase inhibitor;   (PG)H synthase inhibitors;   COX inhibitor;   EC 1.14.99.1 (cyclooxygenase) inhibitors;   EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitors;   EC 1.14.99.1 inhibitor;   EC 1.14.99.1 inhibitors;   PG synthetase inhibitor;   PG synthetase inhibitors;   cyclooxygenase (EC 1.14.99.1) inhibitor;   cyclooxygenase inhibitor;   cyclooxygenase inhibitors;   fatty acid cyclooxygenase inhibitor;   fatty acid cyclooxygenase inhibitors;   prostaglandin G/H synthase inhibitor;   prostaglandin G/H synthase inhibitors;   prostaglandin endoperoxide synthetase inhibitor;   prostaglandin endoperoxide synthetase inhibitors;   prostaglandin synthase inhibitor;   prostaglandin synthase inhibitors;   prostaglandin synthetase inhibitor;   prostaglandin synthetase inhibitors


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  CHEBI ontology 19728
    role 19675
      biological role 19673
        biochemical role 19178
          enzyme inhibitor 18079
            EC 1.* (oxidoreductase) inhibitor 16466
              EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor 14187
                EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor 12496
                  EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor 12496
                    (2S)-2-(4-\{[(1R,2S)-2-hydroxycyclopentyl]methyl\}phenyl)propanoic acid 0
                    (6-methoxy-2-naphthyl)acetic acid 0
                    3',5'-di-O-methyltricetin + 1
                    4-(methylamino)antipyrine 0
                    4-aminoantipyrine 0
                    aceclofenac 4
                    acemetacin 1
                    aiphanol 0
                    ampiroxicam 0
                    carprofen + 0
                    clonixin 0
                    clonixin lysine salt 0
                    cudratricusxanthone A 0
                    cyclooxygenase 1 inhibitor + 10907
                    cyclooxygenase 2 inhibitor + 11603
                    cyclooxygenase 3 inhibitor + 10647
                    diclofenac + 994
                    flufenamic acid 42
                    flunixin 1
                    flunixin meglumine 0
                    flurbiprofen + 108
                    ibufenac 0
                    indometacin + 3158
                    indoprofen 3
                    ketoprofen 27
                    lonazolac 0
                    lonazolac calcium 0
                    loxoprofen + 3
                    loxoprofen sodium + 0
                    loxoprofen sodium hydrate 0
                    meclofenamic acid 11
                    mefenamic acid 33
                    naproxcinod 0
                    nitrosulindac 0
                    oxametacin 0
                    piroxicam + 587
                    proglumetacin + 0
                    proglumetacin dimaleate 0
                    salicin + 2
                    sodium meclofenamate monohydrate 0
                    sulindac + 771
                    suprofen 3
                    tenidap 2
                    tenoxicam 1
                    tepoxalin 5
                    tolfenamic acid 18
                    tolmetin 6
                    tolmetin sodium + 0
                    tolmetin sodium dihydrate 0
                    vedaprofen 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.