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Accession:CHEBI:35852 term browser browse the term
Definition:A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a trans planar configuration around the central platinum ion. Unlike its cis-isomer, cisplatin, it does not exhibit any useful pharmacological effect and is toxic.
Synonyms:exact_synonym: (SP-4-1)-diamminedichloridoplatinum;   (SP-4-1)-diamminedichloroplatinum;   trans-diamminedichloridoplatinum(II);   trans-diamminedichloroplatinum(II)
 related_synonym: Formula=Cl2H6N2Pt;   InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2;   InChIKey=LXZZYRPGZAFOLE-UHFFFAOYSA-L;   SMILES=[H][N]([H])([H])[Pt](Cl)(Cl)[N]([H])([H])[H];   trans-DDP;   trans-Diamminedichloroplatinum;   trans-Dichlorodiammine platinum;   trans-Platinum(II) ammonium chloride;   trans-Platinum(II) diamminedichloride;   trans-Platinumdiammine dichloride;   trans-platin
 xref: CAS:14913-33-8 "ChemIDplus";   Gmelin:2520 "Gmelin"
 xref_mesh: MESH:C034697
 xref: PMID:1855275 "Europe PMC";   PMID:19945168 "Europe PMC";   PMID:20459174 "Europe PMC";   PMID:23584074 "Europe PMC";   PMID:23664917 "Europe PMC";   PMID:23770803 "Europe PMC";   Reaxys:11334149 "Reaxys"

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transplatin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 JBrowse link 1 238,222,689 238,264,381 RGD:6480464
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 JBrowse link 15 27,849,943 27,852,083 RGD:6480464
G Apoc3 apolipoprotein C3 JBrowse link 8 50,529,318 50,531,498 RGD:6480464
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Ltf lactotransferrin JBrowse link 8 119,290,416 119,313,261 RGD:6480464
G Pcna proliferating cell nuclear antigen JBrowse link 3 124,880,698 124,884,570 RGD:6480464
G Pdia4 protein disulfide isomerase family A, member 4 JBrowse link 4 77,470,636 77,489,535 RGD:6480464
G Polb DNA polymerase beta JBrowse link 16 74,237,001 74,260,272 RGD:6480464
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:6480464
G Ung uracil-DNA glycosylase JBrowse link 12 48,246,593 48,255,547 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19754
    chemical entity 19753
      molecular entity 19751
        transition element molecular entity 16410
          transition element coordination entity 11067
            platinum coordination entity 8403
              diamminedichloroplatinum 7300
                transplatin 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19754
    subatomic particle 19752
      composite particle 19752
        hadron 19752
          baryon 19752
            nucleon 19752
              atomic nucleus 19752
                atom 19752
                  metal atom 17249
                    transition element atom 16725
                      d-block element atom 16715
                        nickel group element atom 10124
                          platinum 8403
                            platinum molecular entity 8403
                              platinum coordination entity 8403
                                diamminedichloroplatinum 7300
                                  transplatin 15
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.