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Term:3-methyl-2-oxovaleric acid
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Accession:CHEBI:35932 term browser browse the term
Definition:A 2-oxo monocarboxylic acid that is valeric acid carrying oxo- and methyl substituents at C-2 and C-3, respectively. An alpha-keto acid analogue and metabolite of isoleucine in man, animals and bacteria. Used as a clinical marker for maple syrup urine disease (MSUD).
Synonyms:related_synonym: 2-Oxo-3-methylpentanoic acid;   2-Oxo-3-methylvalerate;   2-Oxo-3-methylvaleric acid;   2-oxo-3-methyl-n-valeric acid;   2-oxoisoleucine;   2-oxokolavenic acid;   3-Methyl-2-oxopentanoic acid;   3-ethyl-3-methylpyruvic acid;   Formula=C6H10O3;   InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9);   InChIKey=JVQYSWDUAOAHFM-UHFFFAOYSA-N;   SMILES=CCC(C)C(=O)C(O)=O;   alpha-keto-beta-methyl-n-valeric acid;   alpha-keto-beta-methylvaleric acid;   alpha-oxo-beta-methyl-n-valeric acid;   alpha-oxo-beta-methylvaleric acid;   ketoisoleucine
 xref: Beilstein:1098987 "Beilstein";   CAS:1460-34-0 "ChemIDplus";   CAS:1460-34-0 "KEGG COMPOUND";   Gmelin:971983 "Gmelin";   HMDB:HMDB0000491;   KEGG:C03465
 xref_mesh: MESH:C016211
 xref: PMID:1638756 "Europe PMC";   PMID:17190852 "Europe PMC";   PMID:759179 "Europe PMC";   Reaxys:1098987 "Reaxys"
 cyclic_relationship: is_conjugate_acid_of CHEBI:28654

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3-methyl-2-oxovaleric acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      biological role 19661
        biochemical role 19179
          metabolite 19151
            eukaryotic metabolite 18770
              plant metabolite 17103
                valeric acid 14344
                  3-methyl-2-oxovaleric acid 1
                    (R)-3-methyl-2-oxovaleric acid 0
                    (S)-3-methyl-2-oxovaleric acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic group 18407
                              organic divalent group 18397
                                organodiyl group 18397
                                  carbonyl group 18285
                                    carbonyl compound 18285
                                      carboxylic acid 17940
                                        monocarboxylic acid 17260
                                          fatty acid 15814
                                            saturated fatty acid 15781
                                              straight-chain saturated fatty acid 15178
                                                valeric acid 14344
                                                  3-methyl-2-oxovaleric acid 1
                                                    (R)-3-methyl-2-oxovaleric acid 0
                                                    (S)-3-methyl-2-oxovaleric acid 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.