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ONTOLOGY REPORT - ANNOTATIONS


Term:trypanocidal drug
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Accession:CHEBI:36335 term browser browse the term
Definition:A drug used to treat or prevent infections caused by protozoal organisms belonging to the suborder Trypanosomatida.
Synonyms:related_synonym: antitrypanosomal agent;   antitrypanosomal agents;   antitrypanosomal drug;   antitrypanosomal drugs;   trypanocidal drugs;   trypanocide;   trypanosomicidal agents


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dehydrocostus lactone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hmox1 heme oxygenase 1 JBrowse link 8 75,093,618 75,100,593 RGD:6480464
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:6480464
G Nos2 nitric oxide synthase 2, inducible JBrowse link 11 78,920,787 78,960,226 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 150,100,031 150,108,234 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 JBrowse link 14 78,277,446 78,308,043 RGD:6480464
diminazene term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 JBrowse link X 164,139,342 164,188,418 RGD:6480464
G Asic5 acid-sensing (proton-gated) ion channel family member 5 JBrowse link 3 81,982,293 82,021,233 RGD:6480464
diminazene diaceturate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 JBrowse link X 164,139,342 164,188,418 RGD:6480464
G Acta2 actin, alpha 2, smooth muscle, aorta JBrowse link 19 34,240,336 34,255,585 RGD:6480464
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) JBrowse link 8 124,556,587 124,569,706 RGD:6480464
G App amyloid beta (A4) precursor protein JBrowse link 16 84,952,666 85,175,255 RGD:6480464
G Ccl2 chemokine (C-C motif) ligand 2 JBrowse link 11 82,035,577 82,037,452 RGD:6480464
G Col1a1 collagen, type I, alpha 1 JBrowse link 11 94,936,224 94,953,042 RGD:6480464
G Cybb cytochrome b-245, beta polypeptide JBrowse link X 9,435,252 9,487,766 RGD:6480464
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) JBrowse link 6 135,713,221 136,173,615 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 2 129,364,569 129,371,164 RGD:6480464
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:6480464
G Mapk1 mitogen-activated protein kinase 1 JBrowse link 16 16,983,382 17,047,453 RGD:6480464
G Mapk14 mitogen-activated protein kinase 14 JBrowse link 17 28,691,342 28,748,405 RGD:6480464
G Mapk3 mitogen-activated protein kinase 3 JBrowse link 7 126,759,626 126,765,816 RGD:6480464
G Mas1 MAS1 oncogene JBrowse link 17 12,838,841 12,868,150 RGD:6480464
G Ncf1 neutrophil cytosolic factor 1 JBrowse link 5 134,220,053 134,229,628 RGD:6480464
G Ncf2 neutrophil cytosolic factor 2 JBrowse link 1 152,800,153 152,836,990 RGD:6480464
G Nos1 nitric oxide synthase 1, neuronal JBrowse link 5 117,866,839 117,958,840 RGD:6480464
G Nox1 NADPH oxidase 1 JBrowse link X 134,086,421 134,137,711 RGD:6480464
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) JBrowse link 19 5,637,442 5,648,134 RGD:6480464
G Smad2 SMAD family member 2 JBrowse link 18 76,241,090 76,311,748 RGD:6480464
G Smad3 SMAD family member 3 JBrowse link 9 63,646,766 63,757,994 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464
ergosterol peroxide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp3 caspase 3 JBrowse link 8 46,617,291 46,639,698 RGD:6480464
kaempferol 3-O-beta-D-glucoside term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl2 chemokine (C-C motif) ligand 2 JBrowse link 11 82,035,577 82,037,452 RGD:6480464
G Ccl3 chemokine (C-C motif) ligand 3 JBrowse link 11 83,647,843 83,649,378 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 2 129,364,569 129,371,164 RGD:6480464
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:6480464
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha JBrowse link 12 55,489,409 55,492,647 RGD:6480464
G Nos2 nitric oxide synthase 2, inducible JBrowse link 11 78,920,787 78,960,226 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 150,100,031 150,108,234 RGD:6480464
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) JBrowse link 19 5,637,442 5,648,134 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464
pentamidine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ar androgen receptor JBrowse link X 98,148,757 98,323,218 RGD:6480464
G Asic5 acid-sensing (proton-gated) ion channel family member 5 JBrowse link 3 81,982,293 82,021,233 RGD:6480464
G Asns asparagine synthetase JBrowse link 6 7,675,165 7,693,209 RGD:6480464
G Atm ataxia telangiectasia mutated JBrowse link 9 53,437,122 53,536,828 RGD:6480464
G Cxcl15 chemokine (C-X-C motif) ligand 15 JBrowse link 5 90,794,534 90,803,067 RGD:6480464
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 JBrowse link 19 39,389,556 39,463,103 RGD:6480464
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 JBrowse link 19 39,061,006 39,093,948 RGD:6480464
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 JBrowse link 19 39,113,898 39,186,756 RGD:6480464
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 JBrowse link 15 82,370,527 82,380,260 RGD:6480464
G Depp1 DEPP1 autophagy regulator JBrowse link 6 116,650,684 116,652,847 RGD:6480464
G Fabp1 fatty acid binding protein 1, liver JBrowse link 6 71,199,879 71,205,034 RGD:6480464
G Fndc4 fibronectin type III domain containing 4 JBrowse link 5 31,292,242 31,295,932 RGD:6480464
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 JBrowse link 17 34,263,227 34,269,418 RGD:6480464
G H2ax H2A.X variant histone JBrowse link 9 44,334,715 44,336,077 RGD:6480464
G Hpn hepsin JBrowse link 7 31,098,725 31,115,326 RGD:6480464
G Ifng interferon gamma JBrowse link 10 118,441,046 118,445,894 RGD:6480464
G Ifngr1 interferon gamma receptor 1 JBrowse link 10 19,591,949 19,610,229 RGD:6480464
G Il10 interleukin 10 JBrowse link 1 131,019,845 131,024,970 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 2 129,364,569 129,371,164 RGD:6480464
G Il2 interleukin 2 JBrowse link 3 37,120,713 37,125,954 RGD:6480464
G Il4 interleukin 4 JBrowse link 11 53,612,460 53,618,665 RGD:6480464
G Inhbe inhibin beta-E JBrowse link 10 127,349,402 127,351,848 RGD:6480464
G Kat5 K(lysine) acetyltransferase 5 JBrowse link 19 5,603,014 5,611,556 RGD:6480464
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 JBrowse link 5 24,319,589 24,351,684 RGD:6480464
G Lss lanosterol synthase JBrowse link 10 76,531,565 76,557,139 RGD:6480464
G Mre11a MRE11A homolog A, double strand break repair nuclease JBrowse link 9 14,784,654 14,837,125 RGD:6480464
G Nbn nibrin JBrowse link 4 15,957,587 15,992,589 RGD:6480464
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 JBrowse link 4 133,553,376 133,556,686 RGD:6480464
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 10 89,454,234 89,533,645 RGD:6480464
G Nupr1 nuclear protein transcription regulator 1 JBrowse link 7 126,623,246 126,625,470 RGD:6480464
G Serpina3b serine (or cysteine) peptidase inhibitor, clade A, member 3B JBrowse link 12 104,127,986 104,139,546 RGD:6480464
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 JBrowse link 17 12,584,189 12,628,489 RGD:6480464
G Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 JBrowse link 6 122,727,809 122,802,363 RGD:6480464
G Trp53 transformation related protein 53 JBrowse link 11 69,580,348 69,591,873 RGD:6480464
G Wipi1 WD repeat domain, phosphoinositide interacting 1 JBrowse link 11 109,573,521 109,611,389 RGD:6480464
posaconazole term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 JBrowse link 2 69,238,282 69,342,616 RGD:6480464
salicylhydroxamic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tpo thyroid peroxidase JBrowse link 12 30,054,659 30,132,984 RGD:6480464
suramin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Calca calcitonin/calcitonin-related polypeptide, alpha JBrowse link 7 114,625,981 114,636,910 RGD:6480464
G Casp1 caspase 1 JBrowse link 9 5,298,517 5,307,281 RGD:6480464
G Casp3 caspase 3 JBrowse link 8 46,617,291 46,639,698 RGD:6480464
G Chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 JBrowse link 7 63,098,692 63,212,526 RGD:6480464
G Creb1 cAMP responsive element binding protein 1 JBrowse link 1 64,532,794 64,604,548 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 9 57,676,937 57,683,655 RGD:6480464
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 17 79,706,940 79,715,061 RGD:6480464
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 JBrowse link 19 39,389,556 39,463,103 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 11 16,752,203 16,913,907 RGD:6480464
G Fgf2 fibroblast growth factor 2 JBrowse link 3 37,348,477 37,410,106 RGD:6480464
G Fgf5 fibroblast growth factor 5 JBrowse link 5 98,254,184 98,277,033 RGD:6480464
G Fgf7 fibroblast growth factor 7 JBrowse link 2 126,034,658 126,091,185 RGD:6480464
G Fgfr2 fibroblast growth factor receptor 2 JBrowse link 7 130,162,451 130,266,808 RGD:6480464
G Fmr1 FMRP translational regulator 1 JBrowse link X 68,678,536 68,717,963 RGD:6480464
G Hpgds hematopoietic prostaglandin D synthase JBrowse link 6 65,117,293 65,144,981 RGD:6480464
G Il10 interleukin 10 JBrowse link 1 131,019,845 131,024,970 RGD:6480464
G Il12b interleukin 12b JBrowse link 11 44,400,063 44,414,677 RGD:6480464
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:6480464
G Lmna lamin A JBrowse link 3 88,481,148 88,509,932 RGD:6480464
G Mapk1 mitogen-activated protein kinase 1 JBrowse link 16 16,983,382 17,047,453 RGD:6480464
G Mapk3 mitogen-activated protein kinase 3 JBrowse link 7 126,759,626 126,765,816 RGD:6480464
G P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 JBrowse link 2 84,996,549 85,037,108 RGD:6480464
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 JBrowse link 5 122,643,927 122,692,336 RGD:6480464
G P2ry2 purinergic receptor P2Y, G-protein coupled 2 JBrowse link 7 100,996,568 101,012,053 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 150,100,031 150,108,234 RGD:6480464
G Shc1 src homology 2 domain-containing transforming protein C1 JBrowse link 3 89,418,551 89,430,029 RGD:6480464
G Sirt1 sirtuin 1 JBrowse link 10 63,319,005 63,339,035 RGD:6480464
G Tacr1 tachykinin receptor 1 JBrowse link 6 82,402,003 82,560,104 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464
G Trp53 transformation related protein 53 JBrowse link 11 69,580,348 69,591,873 RGD:6480464
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor JBrowse link 15 97,854,427 97,908,296 RGD:6480464
tropisetron term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl3 chemokine (C-C motif) ligand 3 JBrowse link 11 83,647,843 83,649,378 RGD:6480464
G Cxcl1 chemokine (C-X-C motif) ligand 1 JBrowse link 5 90,891,245 90,893,121 RGD:6480464
G Cxcl2 chemokine (C-X-C motif) ligand 2 JBrowse link 5 90,903,899 90,905,938 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 8 75,093,618 75,100,593 RGD:6480464
G Icam1 intercellular adhesion molecule 1 JBrowse link 9 21,015,940 21,028,814 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 2 129,364,569 129,371,164 RGD:6480464
G Il2 interleukin 2 JBrowse link 3 37,120,713 37,125,954 RGD:6480464
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:6480464
G Mpo myeloperoxidase JBrowse link 11 87,793,784 87,804,412 RGD:6480464
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 JBrowse link 17 12,584,189 12,628,489 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21269
    role 21253
      biological role 21251
        antimicrobial agent 18131
          antimicrobial drug 6276
            antiprotozoal drug 3860
              trypanocidal drug 91
                (-)-annonaine + 0
                (-)-cubebin 0
                (1R,4S)-1-hydroperoxy-p-menth-2-en-8-ol acetate 0
                10alpha-hydroperoxy-guaia-1,11-diene 0
                15alpha-hydroperoxy-guaia-1(10),11-diene 0
                1alpha-hydroperoxy-guaia-10(15),11-diene 0
                2''-acetylastragalin 0
                2''-acetylpaeonoside 0
                2''-acetylpetiolaroside 0
                2,2',4'-trihydroxy-6'-methoxy-3',5'-dimethylchalcone 0
                4'-O-demethylknipholone-4'-O-beta-D-glucopyranoside 0
                7-epiclusianone 0
                ancistrotanzanine A 0
                ancistrotanzanine B 0
                astragalin heptaacetate 0
                burchellin 0
                dehydrocostus lactone 6
                diminazene 2
                diminazene diaceturate 22
                diminazene(2+) + 22
                eflornithine + 0
                ergosterol peroxide 1
                ethidium bromide 0
                gaboroquinone A 0
                hinokinin 0
                kaempferol 3-O-beta-D-glucoside + 9
                kaempferol-3-O-beta-D-glucopyranosyl-7-O-beta-D-glucopyranoside + 0
                komaroviquinone 0
                paeonoside decaacetate 0
                pentamidine 35
                pentamidine isethionate 0
                petiolaroside + 0
                petiolaroside decaacetate 0
                posaconazole 1
                salicylhydroxamic acid 1
                suramin 31
                tafenoquine 0
                tropisetron 11
                tropisetron hydrochloride 0
                zaluzanin D 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21269
    role 21253
      application 20687
        pharmaceutical 20070
          drug 20070
            antiinfective agent 13504
              antiparasitic agent 6150
                antiprotozoal drug 3860
                  trypanocidal drug 91
                    (-)-annonaine + 0
                    (-)-cubebin 0
                    (1R,4S)-1-hydroperoxy-p-menth-2-en-8-ol acetate 0
                    10alpha-hydroperoxy-guaia-1,11-diene 0
                    15alpha-hydroperoxy-guaia-1(10),11-diene 0
                    1alpha-hydroperoxy-guaia-10(15),11-diene 0
                    2''-acetylastragalin 0
                    2''-acetylpaeonoside 0
                    2''-acetylpetiolaroside 0
                    2,2',4'-trihydroxy-6'-methoxy-3',5'-dimethylchalcone 0
                    4'-O-demethylknipholone-4'-O-beta-D-glucopyranoside 0
                    7-epiclusianone 0
                    ancistrotanzanine A 0
                    ancistrotanzanine B 0
                    astragalin heptaacetate 0
                    burchellin 0
                    dehydrocostus lactone 6
                    diminazene 2
                    diminazene diaceturate 22
                    diminazene(2+) + 22
                    eflornithine + 0
                    ergosterol peroxide 1
                    ethidium bromide 0
                    gaboroquinone A 0
                    hinokinin 0
                    kaempferol 3-O-beta-D-glucoside + 9
                    kaempferol-3-O-beta-D-glucopyranosyl-7-O-beta-D-glucopyranoside + 0
                    komaroviquinone 0
                    paeonoside decaacetate 0
                    pentamidine 35
                    pentamidine isethionate 0
                    petiolaroside + 0
                    petiolaroside decaacetate 0
                    posaconazole 1
                    salicylhydroxamic acid 1
                    suramin 31
                    tafenoquine 0
                    tropisetron 11
                    tropisetron hydrochloride 0
                    zaluzanin D 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.