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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:farnesane
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Accession:CHEBI:36756 term browser browse the term
Definition:A sesquiterpene that is dodecane substituted by methyl groups at positions 2, 6 and 10.
Synonyms:exact_synonym: 2,6,10-trimethyldodecane
 related_synonym: Farnesan;   Formula=C15H32;   InChI=1S/C15H32/c1-6-14(4)10-8-12-15(5)11-7-9-13(2)3/h13-15H,6-12H2,1-5H3;   InChIKey=YFHFHLSMISYUAQ-UHFFFAOYSA-N;   SMILES=CCC(C)CCCC(C)CCCC(C)C
 xref: Beilstein:1719672;   CAS:3891-98-3;   LIPID_MAPS_instance:LMPR0103010000;   MetaCyc:CPD-8764;   Patent:US2008098645;   Patent:US7399323;   Reaxys:1719672


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farnesal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b10 aldo-keto reductase family 1 member B10 increases reduction ISO AKR1B10 protein results in increased reduction of farnesal CTD PMID:21187079 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO farnesal results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases reduction ISO AKR1C3 protein results in increased reduction of farnesal CTD PMID:21187079 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO farnesal results in increased expression of GCLC mRNA CTD PMID:20491607 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Mt2A metallothionein 2A increases expression ISO farnesal results in increased expression of MT2A mRNA CTD PMID:20491607 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
farnesol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa1a acetyl-CoA acyltransferase 1A multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ACAA1 mRNA CTD PMID:30611723 NCBI chr 8:128,027,880...128,036,471
Ensembl chr 8:128,027,958...128,036,236
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 multiple interactions
increases expression
ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ACAA2 mRNA
Farnesol analog results in increased expression of ACAA2 mRNA
CTD PMID:30611723 NCBI chr18:70,733,872...70,762,395
Ensembl chr18:70,733,872...70,762,395
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ACADM mRNA CTD PMID:30611723 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Acads acyl-CoA dehydrogenase short chain multiple interactions
increases expression
ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ACADS mRNA
Farnesol analog results in increased expression of ACADS mRNA
CTD PMID:30611723 NCBI chr12:47,254,503...47,263,747
Ensembl chr12:47,254,484...47,263,747
JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 increases expression ISO Farnesol analog results in increased expression of ACAT1 mRNA CTD PMID:30611723 NCBI chr 8:58,166,990...58,195,884
Ensembl chr 8:58,166,990...58,195,884
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 increases expression ISO Farnesol analog results in increased expression of ACAT2 mRNA CTD PMID:30611723 NCBI chr 1:47,972,399...47,992,654
Ensembl chr 1:47,972,399...47,992,653
JBrowse link
G Acot1 acyl-CoA thioesterase 1 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ACOT1 mRNA CTD PMID:30611723 NCBI chr 6:107,485,088...107,493,082
Ensembl chr 6:107,485,249...107,493,798
JBrowse link
G Acot12 acyl-CoA thioesterase 12 increases expression
multiple interactions
ISO Farnesol analog results in increased expression of ACOT12 mRNA
[Farnesol analog co-treated with Oleic Acid] results in increased expression of ACOT12 mRNA
CTD PMID:30611723 NCBI chr 2:20,857,056...20,901,656
Ensembl chr 2:20,857,202...20,901,659
JBrowse link
G Acot6 acyl-CoA thioesterase 6 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in decreased expression of ACOT6 mRNA CTD PMID:30611723 NCBI chr 6:107,581,357...107,590,431
Ensembl chr 6:107,581,608...107,590,373
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ACOX1 mRNA CTD PMID:30611723 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acox2 acyl-CoA oxidase 2 decreases expression
increases expression
ISO Farnesol analog results in decreased expression of ACOX2 mRNA
Farnesol analog results in increased expression of ACOX2 mRNA
CTD PMID:30611723 NCBI chr15:18,449,304...18,481,472
Ensembl chr15:18,451,144...18,481,470
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ACSL4 mRNA CTD PMID:30611723 NCBI chr  X:113,596,247...113,660,024
Ensembl chr  X:113,596,239...113,659,944
JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ACSL5 mRNA CTD PMID:30611723 NCBI chr 1:276,240,703...276,290,012
Ensembl chr 1:276,240,703...276,290,008
JBrowse link
G Agpat1 1-acylglycerol-3-phosphate O-acyltransferase 1 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in decreased expression of AGPAT1 mRNA CTD PMID:30611723 NCBI chr20:4,369,399...4,378,272
Ensembl chr20:4,369,178...4,378,269
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases chemical synthesis ISO AKR1B10 protein results in increased chemical synthesis of Farnesol CTD PMID:21187079 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases chemical synthesis
multiple interactions
ISO AKR1C3 protein results in increased chemical synthesis of Farnesol
[Flurbiprofen results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol; [tolfenamic acid results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol
CTD PMID:21187079 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Apoa5 apolipoprotein A5 multiple interactions
increases expression
ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of APOA5 mRNA
Farnesol analog results in increased expression of APOA5 mRNA
CTD PMID:30611723 NCBI chr 8:50,559,079...50,561,720
Ensembl chr 8:50,559,126...50,561,736
JBrowse link
G Apoc4 apolipoprotein C4 decreases expression ISO Farnesol analog results in decreased expression of APOC4 mRNA CTD PMID:30611723 NCBI chr 1:80,595,339...80,599,525
Ensembl chr 1:80,595,326...80,599,572
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Farnesol results in increased expression of ATF3 mRNA CTD PMID:27965148 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Farnesol results in increased expression of BAK1 protein CTD PMID:12530055 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Casp3 caspase 3 increases activity
decreases activity
ISO
EXP
Farnesol results in increased activity of CASP3 protein
Farnesol results in decreased activity of CASP3 protein
CTD PMID:10733934, PMID:21453689 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase increases expression
multiple interactions
EXP Farnesol results in increased expression of CAT protein
Farnesol inhibits the reaction [Tobacco Smoke Pollution results in decreased activity of CAT protein]
CTD PMID:18793622, PMID:21453689 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases secretion ISO Farnesol results in increased secretion of CCL4 protein CTD PMID:30806763 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Farnesol results in decreased expression of CCNA2 protein CTD PMID:17138864 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Farnesol results in decreased expression of CCNB1 protein CTD PMID:17138864 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
multiple interactions
ISO Farnesol results in decreased expression of CDK2 protein
Farnesol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]; Farnesol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]
CTD PMID:17138864 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
increases response to substance
ISO Farnesol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]
Farnesol results in increased expression of CDKN1A protein
CDKN1A protein results in increased susceptibility to Farnesol
CTD PMID:17138864 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases response to substance
increases expression
multiple interactions
ISO CDKN1B protein results in increased susceptibility to Farnesol
Farnesol results in increased expression of CDKN1B protein
Farnesol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]
CTD PMID:17138864 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 decreases expression ISO Farnesol analog results in decreased expression of COX10 mRNA CTD PMID:30611723 NCBI chr10:50,439,778...50,563,920
Ensembl chr10:50,439,782...50,574,539
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of CPT1A mRNA CTD PMID:30611723 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity EXP Farnesol results in increased activity of CYP19A1 protein CTD PMID:15840382 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
increases expression
EXP
ISO
Farnesol results in increased activity of CYP1A1 protein
Farnesol results in increased expression of CYP1A1 mRNA
CTD PMID:15840382, PMID:30806763 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
multiple interactions
EXP
ISO
Farnesol results in increased activity of CYP1A2 protein
Farnesol analog inhibits the reaction [Oleic Acid results in decreased expression of CYP1A2 mRNA]
CTD PMID:15840382, PMID:30611723 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases activity EXP Farnesol results in increased activity of CYP2A1 protein CTD PMID:15840382 NCBI chr 1:83,711,223...83,725,222
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 increases activity EXP Farnesol results in increased activity of CYP2A2 protein CTD PMID:15840382 NCBI chr 1:83,744,229...83,766,490
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases activity EXP Farnesol results in increased activity of CYP2A3 protein CTD PMID:15840382 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases activity EXP Farnesol results in increased activity of CYP2B1 protein CTD PMID:15840382 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases activity EXP Farnesol results in increased activity of CYP2B2 protein CTD PMID:15840382 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression
ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of CYP2B6 mRNA; Farnesol analog inhibits the reaction [Oleic Acid results in decreased expression of CYP2B6 mRNA]
Farnesol analog results in increased expression of CYP2B6 mRNA; Farnesol results in increased expression of CYP2B6 mRNA
CTD PMID:30611723 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases activity EXP Farnesol results in increased activity of CYP2C11 protein CTD PMID:15840382 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 increases activity EXP Farnesol results in increased activity of CYP2C12 protein CTD PMID:15840382 NCBI chr 1:258,709,726...258,766,873
Ensembl chr 1:258,709,721...258,766,881
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases activity
multiple interactions
decreases expression
EXP
ISO
Farnesol results in increased activity of CYP2E1 protein
[Farnesol analog co-treated with Oleic Acid] results in increased expression of CYP2E1 mRNA; Farnesol analog inhibits the reaction [Oleic Acid results in increased expression of CYP2E1 mRNA]
Farnesol analog results in decreased expression of CYP2E1 mRNA; Farnesol results in decreased expression of CYP2E1 mRNA
CTD PMID:15840382, PMID:30611723 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases activity EXP Farnesol results in increased activity of CYP3A2 protein CTD PMID:15840382 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases activity EXP Farnesol results in increased activity of CYP3A23-3A1 protein CTD PMID:15840382 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases activity EXP Farnesol results in increased activity of CYP4A1 protein CTD PMID:15840382 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 increases activity EXP Farnesol results in increased activity of CYP4A2 protein CTD PMID:15840382 NCBI chr 5:134,196,910...134,207,888
Ensembl chr 5:134,196,912...134,207,863
JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 increases activity EXP Farnesol results in increased activity of CYP4A3 protein CTD PMID:15840382 NCBI chr 5:134,468,666...134,484,851
Ensembl chr 5:134,469,270...134,484,839
JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in decreased expression of DECR1 mRNA CTD PMID:30611723 NCBI chr 5:29,573,893...29,601,731
Ensembl chr 5:29,573,898...29,601,748
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 decreases expression ISO Farnesol analog results in decreased expression of DGAT1 mRNA CTD PMID:30611723 NCBI chr 7:117,566,363...117,576,735
Ensembl chr 7:117,566,368...117,576,737
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of DGAT2 mRNA CTD PMID:30611723 NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Farnesol results in increased expression of DNAJB4 mRNA CTD PMID:27965148 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression ISO Farnesol analog results in increased expression of ECH1 mRNA CTD PMID:30611723 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
JBrowse link
G Egf epidermal growth factor multiple interactions ISO Farnesol analog inhibits the reaction [EGF protein results in increased activity of RHOA protein]; Farnesol analog results in decreased susceptibility to [INS protein co-treated with EGF protein] CTD PMID:24587105 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ELOVL6 mRNA CTD PMID:30611723 NCBI chr 2:234,187,490...234,296,124
Ensembl chr 2:234,189,105...234,296,145
Ensembl chr 2:234,189,105...234,296,145
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Farnesol analog results in increased expression of FABP1 mRNA CTD PMID:30611723 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO Farnesol results in increased expression of FABP4 mRNA CTD PMID:30806763 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of FASN mRNA CTD PMID:30611723 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression ISO Farnesol analog results in increased expression of FDFT1 mRNA CTD PMID:30611723 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302
JBrowse link
G Fnta farnesyltransferase, CAAX box, alpha multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of FNTA mRNA CTD PMID:30611723 NCBI chr16:70,834,957...70,854,724
Ensembl chr16:70,834,957...70,854,724
JBrowse link
G Fntb farnesyltransferase, CAAX box, beta decreases expression ISO Farnesol analog results in decreased expression of FNTB mRNA CTD PMID:30611723 NCBI chr 6:99,883,959...99,966,988
Ensembl chr 6:99,883,959...99,966,988
JBrowse link
G Gpat4 glycerol-3-phosphate acyltransferase 4 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of GPAT4 mRNA CTD PMID:30611723 NCBI chr16:73,615,949...73,649,769
Ensembl chr16:73,615,949...73,649,767
JBrowse link
G Gsr glutathione-disulfide reductase increases activity
increases expression
EXP Farnesol results in increased activity of GSR protein
Farnesol results in increased expression of GSR protein
CTD PMID:15840382, PMID:21453689 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha increases expression
multiple interactions
ISO Farnesol analog results in increased expression of HADHA mRNA
[Farnesol analog co-treated with Oleic Acid] results in increased expression of HADHA mRNA
CTD PMID:30611723 NCBI chr 6:27,589,840...27,628,921
Ensembl chr 6:27,589,657...27,629,175
JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta increases expression
multiple interactions
ISO Farnesol analog results in increased expression of HADHB mRNA
[Farnesol analog co-treated with Oleic Acid] results in increased expression of HADHB mRNA
CTD PMID:30611723 NCBI chr 6:27,555,408...27,589,539
Ensembl chr 6:27,555,412...27,582,995
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases expression
decreases activity
ISO
EXP
[Farnesol analog co-treated with Oleic Acid] results in increased expression of HMGCR mRNA
Farnesol results in increased expression of HMGCR protein
Farnesol results in decreased activity of HMGCR protein
CTD PMID:12477733, PMID:16332721, PMID:30611723 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Farnesol results in increased expression of HMOX1 mRNA CTD PMID:30806763 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO Farnesol inhibits the reaction [Simvastatin results in decreased farnesylation of and affects the localization of HRAS protein] CTD PMID:12477733 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Farnesol results in increased expression of ICAM1 mRNA CTD PMID:30806763 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il16 interleukin 16 increases secretion ISO Farnesol results in increased secretion of IL16 protein CTD PMID:30806763 NCBI chr 1:145,781,923...145,881,538
Ensembl chr 1:145,781,928...145,870,912
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Farnesol results in increased expression of IL1A mRNA CTD PMID:30806763 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Farnesol inhibits the reaction [[MVK gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL1B protein]
Farnesol inhibits the reaction [[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]
CTD PMID:20304105 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1r2 interleukin 1 receptor type 2 increases expression ISO Farnesol results in increased expression of IL1R2 mRNA CTD PMID:30806763 NCBI chr 9:46,840,646...46,881,241
Ensembl chr 9:46,840,992...46,881,264
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Farnesol analog results in decreased susceptibility to [INS protein co-treated with EGF protein] CTD PMID:24587105 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Lipc lipase C, hepatic type increases expression ISO Farnesol analog results in increased expression of LIPC mRNA CTD PMID:30611723 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248
JBrowse link
G Lpin1 lipin 1 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of LPIN1 mRNA CTD PMID:30611723 NCBI chr 6:41,796,214...41,905,149
Ensembl chr 6:41,799,749...41,870,046
JBrowse link
G Lpin3 lipin 3 decreases expression ISO Farnesol analog results in decreased expression of LPIN3 mRNA CTD PMID:30611723 NCBI chr 3:156,874,805...156,899,601
Ensembl chr 3:156,886,454...156,899,436
JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in decreased expression of MLXIPL mRNA CTD PMID:30611723 NCBI chr12:24,590,645...24,619,639 JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO Farnesol results in increased expression of MMP3 mRNA CTD PMID:30806763 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mvk mevalonate kinase decreases activity
multiple interactions
ISO Farnesol results in decreased activity of MVK protein
Farnesol inhibits the reaction [[MVK gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL1B protein]; Farnesol inhibits the reaction [MVK gene mutant form results in increased susceptibility to Lipopolysaccharides]; Farnesol inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; Farnesol inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]
CTD PMID:9392419, PMID:20304105 NCBI chr12:47,904,266...47,920,457
Ensembl chr12:47,904,719...47,919,400
JBrowse link
G Myl9 myosin light chain 9 multiple interactions ISO Farnesol analog inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of MYL9 protein] CTD PMID:24587105 NCBI chr 3:152,857,573...152,863,961
Ensembl chr 3:152,857,592...152,863,960
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity EXP Farnesol results in increased activity of NQO1 protein CTD PMID:15840382 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression
multiple interactions
ISO Farnesol analog results in decreased expression of NR0B2 mRNA
[Farnesol analog co-treated with Oleic Acid] results in decreased expression of NR0B2 mRNA
CTD PMID:30611723 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
decreases expression
ISO Farnesol binds to and results in increased activity of NR1H4 protein
Farnesol analog results in decreased expression of NR1H4 mRNA
CTD PMID:15491415, PMID:30611723 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions
decreases expression
ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of PCK1 mRNA
Farnesol analog results in decreased expression of PCK1 mRNA
CTD PMID:30611723 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pdss1 decaprenyl diphosphate synthase subunit 1 increases expression ISO Farnesol analog results in increased expression of PDSS1 mRNA CTD PMID:30611723 NCBI chr17:90,033,432...90,072,506
Ensembl chr17:90,033,539...90,071,408
JBrowse link
G Plin2 perilipin 2 increases expression
multiple interactions
ISO Farnesol analog results in increased expression of PLIN2 mRNA
[Farnesol analog co-treated with Oleic Acid] results in increased expression of PLIN2 mRNA
CTD PMID:30611723 NCBI chr 5:104,984,413...105,010,863
Ensembl chr 5:104,984,414...105,010,857
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of PPARA mRNA; Farnesol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] CTD PMID:11779144, PMID:30611723 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of PPARG mRNA
Farnesol analog results in increased expression of PPARG mRNA
CTD PMID:30611723 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP Farnesol inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PPARGC1A protein]] CTD PMID:22343369 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Rabggta Rab geranylgeranyltransferase subunit alpha multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in decreased expression of RABGGTA mRNA CTD PMID:30611723 NCBI chr15:34,393,419...34,400,466
Ensembl chr15:34,393,233...34,400,449
JBrowse link
G Rabggtb Rab geranylgeranyltransferase subunit beta multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in decreased expression of RABGGTB mRNA CTD PMID:30611723 NCBI chr 2:260,110,309...260,115,574
Ensembl chr 2:260,110,309...260,115,577
JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP
ISO
Farnesol inhibits the reaction [Lovastatin affects the localization of RHOA protein]
Farnesol analog inhibits the reaction [EGF protein results in increased activity of RHOA protein]; Farnesol analog inhibits the reaction [lysophosphatidic acid results in increased activity of RHOA protein]
CTD PMID:9398081, PMID:24587105 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rhoc ras homolog family member C multiple interactions ISO Farnesol analog inhibits the reaction [lysophosphatidic acid results in increased activity of RHOC protein] CTD PMID:24587105 NCBI chr 2:207,271,692...207,278,010
Ensembl chr 2:207,271,853...207,279,314
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO Farnesol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] CTD PMID:11779144 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in decreased expression of SCD mRNA CTD PMID:30611723 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Serpinb3 serpin family B member 3 increases expression ISO Farnesol results in increased expression of SERPINB3 mRNA CTD PMID:30806763 NCBI chr13:27,186,701...27,193,211
Ensembl chr13:27,187,130...27,192,592
JBrowse link
G Slc25a20 solute carrier family 25 member 20 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of SLC25A20 mRNA CTD PMID:30611723 NCBI chr 8:117,455,308...117,476,762
Ensembl chr 8:117,455,262...117,476,734
JBrowse link
G Slc27a1 solute carrier family 27 member 1 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of SLC27A1 mRNA CTD PMID:30611723 NCBI chr16:19,997,823...20,016,193
Ensembl chr16:19,999,112...20,016,190
JBrowse link
G Slc27a2 solute carrier family 27 member 2 increases expression ISO Farnesol analog results in increased expression of SLC27A2 mRNA CTD PMID:30611723 NCBI chr 3:119,014,620...119,052,531
Ensembl chr 3:119,014,620...119,052,531
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Farnesol results in increased expression of SLC7A11 mRNA CTD PMID:30806763 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP
ISO
Farnesol inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PPARGC1A protein]]
Farnesol results in increased expression of TNF mRNA
CTD PMID:22343369, PMID:30806763 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Farnesol CTD PMID:15320866 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Farnesol CTD PMID:15320866 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of Farnesol CTD PMID:15320866 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases glucuronidation ISO UGT1A6 protein results in increased glucuronidation of Farnesol CTD PMID:15320866 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Farnesol CTD PMID:15320866 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of Farnesol CTD PMID:15320866 NCBI chr14:22,597,103...22,619,968 JBrowse link
juvenile hormone III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO juvenile hormone III binds to and results in increased activity of NR1H4 protein CTD PMID:15491415 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
methoprene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rxra retinoid X receptor alpha multiple interactions ISO
EXP
Methoprene binds to and results in increased activity of RXRA protein CTD PMID:16731579 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Rxrb retinoid X receptor beta multiple interactions ISO Methoprene binds to and results in increased activity of RXRB protein CTD PMID:12970175 NCBI chr20:3,822,673...3,829,138
Ensembl chr20:3,823,042...3,829,140
JBrowse link
G Ucp1 uncoupling protein 1 increases expression ISO Methoprene results in increased expression of UCP1 mRNA CTD PMID:10600643 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          metabolite 19294
            eukaryotic metabolite 18943
              plant metabolite 17424
                farnesane 112
                  2,6,10-trimethyldodeca-2,6,10-triene + 0
                  farnesane sesquiterpenoid + 112
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            organic hydride 18269
                              organic fundamental parent 18269
                                hydrocarbon 17988
                                  terpene 9607
                                    sesquiterpene 2692
                                      farnesane 112
                                        2,6,10-trimethyldodeca-2,6,10-triene + 0
                                        farnesane sesquiterpenoid + 112
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.