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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydrochloride
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Accession:CHEBI:36807 term browser browse the term
Definition:A salt formally resulting from the reaction of hydrochloric acid with an organic base.
Synonyms:related_synonym: Hydrochlorid;   hydrochloride salts;   hydrochlorides


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(1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd1 dopamine receptor D1 multiple interactions
affects localization
ISO A 77636 binds to and results in increased activity of DRD1 protein; SCH 23390 inhibits the reaction [A 77636 affects the localization of DRD1 protein]; SCH 23390 inhibits the reaction [A 77636 results in increased activity of DRD1 protein] CTD PMID:15985612 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
(S)-duloxetine hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Duloxetine Hydrochloride binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity
multiple interactions
ISO Duloxetine Hydrochloride results in decreased activity of CYP17A1 protein
Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone]; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione]; Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased hydroxylation of Pregnenolone]; Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased hydroxylation of Progesterone]; Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone]; Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone]
CTD PMID:29100959 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP [furafylline results in decreased activity of CYP1A2 protein] which results in decreased glutathionylation of Duloxetine Hydrochloride; CYP1A2 protein results in increased activity of and results in increased glutathionylation of Duloxetine Hydrochloride CTD PMID:20669986 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions EXP [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased glutathionylation of Duloxetine Hydrochloride; CYP2D6 protein results in increased activity of and results in increased glutathionylation of Duloxetine Hydrochloride CTD PMID:20669986 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Duloxetine Hydrochloride results in increased expression of HMOX1 mRNA CTD PMID:29134401 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Duloxetine Hydrochloride results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Duloxetine Hydrochloride results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]; Duloxetine Hydrochloride results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr 3:41,019,898...41,181,070
Ensembl chr 3:41,019,898...41,181,070
JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions ISO Duloxetine Hydrochloride results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA] CTD PMID:22164246 NCBI chr 8:33,435,493...33,463,410
Ensembl chr 8:33,433,905...33,463,467
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO Duloxetine Hydrochloride results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr11:35,011,007...35,262,362
Ensembl chr11:35,024,196...35,099,383
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization ISO Duloxetine Hydrochloride affects the localization of NFE2L2 protein CTD PMID:29134401 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Prl prolactin increases expression ISO Duloxetine Hydrochloride results in increased expression of PRL protein CTD PMID:17606668 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
4-fluoro-N-\{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl\}benzamide hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP [1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to 1-(3-chlorophenyl)piperazine; [1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine; [1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine; tertatolol inhibits the reaction [[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine]; tertatolol inhibits the reaction [[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine] CTD PMID:8539317 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
acridine orange term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases response to substance ISO BAX protein results in increased susceptibility to Acridine Orange CTD PMID:16177561 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [Acridine Orange binds to Platinum Compounds] which results in increased expression of GSTP1 mRNA; [Acridine Orange binds to Platinum] which results in increased expression of GSTP1 mRNA CTD PMID:16814760 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Acridine Orange results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
atomoxetine hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases hydroxylation ISO CYP2D6 protein results in increased hydroxylation of Atomoxetine Hydrochloride CTD PMID:17470523 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
auramine O term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions
increases expression
ISO ALDH1A1 protein promotes the reaction [Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein]
Benzophenoneidum results in increased expression of ALDH1A1 protein
CTD PMID:28722353 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Ano6 anoctamin 6 increases expression ISO Benzophenoneidum results in increased expression of ANO6 protein CTD PMID:28722353 NCBI chr 7:137,142,063...137,335,208
Ensembl chr 7:137,142,170...137,335,208
JBrowse link
G Araf A-Raf proto-oncogene, serine/threonine kinase increases expression ISO Benzophenoneidum results in increased expression of ARAF protein CTD PMID:28722353 NCBI chr  X:1,369,534...1,391,603
Ensembl chr  X:1,379,194...1,390,873
JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 increases expression ISO Benzophenoneidum results in increased expression of ATP6AP2 protein CTD PMID:28722353 NCBI chr  X:11,137,889...11,164,854
Ensembl chr  X:11,136,939...11,164,915
JBrowse link
G Ccdc22 coiled-coil domain containing 22 increases expression ISO Benzophenoneidum results in increased expression of CCDC22 protein CTD PMID:28722353 NCBI chr  X:15,742,978...15,754,925
Ensembl chr  X:15,742,978...15,754,925
JBrowse link
G Ccdc39 coiled-coil domain containing 39 increases expression ISO Benzophenoneidum results in increased expression of CCDC39 protein CTD PMID:28722353 NCBI chr 2:120,278,605...120,367,829
Ensembl chr 2:120,278,605...120,316,600
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO Benzophenoneidum results in increased expression of CD44 protein CTD PMID:28722353 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Chtf18 chromosome transmission fidelity factor 18 increases expression ISO Benzophenoneidum results in increased expression of CHTF18 protein CTD PMID:28722353 NCBI chr10:15,090,762...15,098,825
Ensembl chr10:15,090,316...15,098,791
JBrowse link
G Commd1 copper metabolism domain containing 1 increases expression ISO Benzophenoneidum results in increased expression of COMMD1 protein CTD PMID:28722353 NCBI chr14:107,664,321...107,759,974
Ensembl chr14:107,664,255...107,760,191
JBrowse link
G Cops7b COP9 signalosome subunit 7B increases expression ISO Benzophenoneidum results in increased expression of COPS7B protein CTD PMID:28722353 NCBI chr 9:93,607,199...93,633,064
Ensembl chr 9:93,607,477...93,633,064
JBrowse link
G Cul3 cullin 3 increases expression ISO Benzophenoneidum results in increased expression of CUL3 protein CTD PMID:28722353 NCBI chr 9:86,044,485...86,129,066
Ensembl chr 9:86,044,485...86,129,329
JBrowse link
G Dynlt1 dynein light chain Tctex-type 1 increases expression ISO Benzophenoneidum results in increased expression of DYNLT1 protein CTD PMID:28722353 NCBI chr 1:47,206,892...47,213,785
Ensembl chr 1:47,206,895...47,213,749
JBrowse link
G Eif4g3 eukaryotic translation initiation factor 4 gamma, 3 increases expression ISO Benzophenoneidum results in increased expression of EIF4G3 protein CTD PMID:28722353 NCBI chr 5:156,343,663...156,564,037
Ensembl chr 5:156,396,695...156,564,037
JBrowse link
G Fastkd2 FAST kinase domains 2 increases expression ISO Benzophenoneidum results in increased expression of FASTKD2 protein CTD PMID:28722353 NCBI chr 9:70,448,386...70,471,420
Ensembl chr 9:70,450,444...70,470,550
JBrowse link
G Hook3 hook microtubule-tethering protein 3 increases expression ISO Benzophenoneidum results in increased expression of HOOK3 protein CTD PMID:28722353 NCBI chr16:70,710,347...70,818,789 JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 increases expression ISO Benzophenoneidum results in increased expression of HSD17B7 protein CTD PMID:28722353 NCBI chr13:88,288,116...88,308,019
Ensembl chr13:88,288,046...88,307,988
JBrowse link
G Htt huntingtin increases expression ISO Benzophenoneidum results in increased expression of HTT protein CTD PMID:28722353 NCBI chr14:81,105,139...81,254,637
Ensembl chr14:81,105,139...81,254,637
JBrowse link
G Iqgap3 IQ motif containing GTPase activating protein 3 increases expression ISO Benzophenoneidum results in increased expression of IQGAP3 protein CTD PMID:28722353 NCBI chr 2:187,447,477...187,489,630
Ensembl chr 2:187,447,501...187,489,630
JBrowse link
G Kifap3 kinesin-associated protein 3 increases expression ISO Benzophenoneidum results in increased expression of KIFAP3 protein CTD PMID:28722353 NCBI chr13:82,072,497...82,217,256
Ensembl chr13:82,072,497...82,217,252
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO ALDH1A1 protein promotes the reaction [Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein]; Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein CTD PMID:28722353 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 increases expression ISO Benzophenoneidum results in increased expression of MAP2K4 protein CTD PMID:28722353 NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657
JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 increases expression ISO Benzophenoneidum results in increased expression of MBD3 protein CTD PMID:28722353 NCBI chr 7:12,179,046...12,186,251
Ensembl chr 7:12,179,203...12,186,656
JBrowse link
G Noa1 nitric oxide associated 1 increases expression ISO Benzophenoneidum results in increased expression of NOA1 protein CTD PMID:28722353 NCBI chr14:33,107,868...33,124,172
Ensembl chr14:33,108,024...33,124,171
JBrowse link
G Nup62 nucleoporin 62 increases expression ISO Benzophenoneidum results in increased expression of NUP62 protein CTD PMID:28722353 NCBI chr 1:100,811,140...100,827,119
Ensembl chr 1:100,811,755...100,827,111
JBrowse link
G Plcg1 phospholipase C, gamma 1 increases expression ISO Benzophenoneidum results in increased expression of PLCG1 protein CTD PMID:28722353 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
JBrowse link
G Ppp4r1 protein phosphatase 4, regulatory subunit 1 increases expression ISO Benzophenoneidum results in increased expression of PPP4R1 protein CTD PMID:28722353 NCBI chr 9:113,515,312...113,573,308
Ensembl chr 9:113,534,326...113,573,307
JBrowse link
G Prim2 DNA primase subunit 2 increases expression ISO Benzophenoneidum results in increased expression of PRIM2 protein CTD PMID:28722353 NCBI chr 9:38,535,435...38,745,058
Ensembl chr 9:38,536,920...38,745,099
JBrowse link
G Prom1 prominin 1 increases expression ISO Benzophenoneidum results in increased expression of PROM1 protein CTD PMID:28722353 NCBI chr14:71,532,321...71,637,400
Ensembl chr14:71,533,063...71,637,417
JBrowse link
G Prorp protein only RNase P catalytic subunit increases expression ISO Benzophenoneidum results in increased expression of PRORP protein CTD PMID:28722353 NCBI chr 6:76,079,880...76,171,298
Ensembl chr 6:76,079,880...76,171,296
JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 increases expression ISO Benzophenoneidum results in increased expression of SHMT1 protein CTD PMID:28722353 NCBI chr10:47,030,813...47,059,216
Ensembl chr10:47,031,050...47,059,216
JBrowse link
G Srsf11 serine and arginine rich splicing factor 11 increases expression ISO Benzophenoneidum results in increased expression of SRSF11 protein CTD PMID:28722353 NCBI chr 2:264,837,463...264,864,296
Ensembl chr 2:264,837,472...264,864,265
JBrowse link
G Tbc1d15 TBC1 domain family, member 15 increases expression ISO Benzophenoneidum results in increased expression of TBC1D15 protein CTD PMID:28722353 NCBI chr 7:58,164,190...58,219,804
Ensembl chr 7:58,164,198...58,219,790
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Benzophenoneidum results in increased expression of TFAM protein CTD PMID:28722353 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Usp24 ubiquitin specific peptidase 24 increases expression ISO Benzophenoneidum results in increased expression of USP24 protein CTD PMID:28722353 NCBI chr 5:125,896,725...126,030,411
Ensembl chr 5:125,896,725...126,030,401
JBrowse link
G Washc5 WASH complex subunit 5 increases expression ISO Benzophenoneidum results in increased expression of WASHC5 protein CTD PMID:28722353 NCBI chr 7:99,625,379...99,677,237
Ensembl chr 7:99,625,619...99,677,268
JBrowse link
colesevelam hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crp C-reactive protein decreases expression ISO Colesevelam Hydrochloride results in decreased expression of CRP protein CTD PMID:16616026 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases expression
ISO Colesevelam Hydrochloride promotes the reaction [Simvastatin results in increased expression of HMGCR mRNA]
Colesevelam Hydrochloride results in increased expression of HMGCR mRNA
CTD PMID:22120639 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO Colesevelam Hydrochloride results in increased expression of LDLR mRNA CTD PMID:22120639 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
donepezil hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity
affects binding
multiple interactions
affects activity
ISO
EXP
Donepezil results in decreased activity of ACHE protein
Donepezil binds to ACHE protein
Donepezil inhibits the reaction [Celecoxib results in increased activity of ACHE protein]; Donepezil inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
ALB protein affects the reaction [Donepezil results in decreased activity of ACHE protein]; Donepezil binds to and results in decreased activity of ACHE protein; Donepezil inhibits the reaction [asoxime chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]; Donepezil inhibits the reaction [Obidoxime Chloride metabolite results in decreased activity of ACHE protein]; Donepezil promotes the reaction [Obidoxime Chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]
Donepezil affects the activity of ACHE protein
AFDX 384 affects the reaction [Donepezil affects the activity of ACHE protein]; Donepezil inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
CTD PMID:9228650, PMID:12111444, PMID:12589378, PMID:14535624, PMID:15135892, PMID:18061284, PMID:18208924, PMID:18343489, PMID:18571635, PMID:19345205, PMID:19705549, PMID:23060470, PMID:25522658, PMID:26902639, PMID:27238725, PMID:30481507, PMID:31176713 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Alb albumin multiple interactions ISO ALB protein affects the reaction [Donepezil results in decreased activity of ACHE protein] CTD PMID:26902639 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G App amyloid beta precursor protein increases abundance
decreases response to substance
multiple interactions
ISO
EXP
Donepezil results in increased abundance of APP protein
Donepezil results in decreased susceptibility to APP protein
Donepezil inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APP protein alternative form]; Donepezil inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APP protein]; Donepezil inhibits the reaction [APP protein modified form results in increased expression of TNF protein]
Donepezil inhibits the reaction [APP protein modified form affects the localization of RELA protein]; Donepezil inhibits the reaction [APP protein modified form results in increased expression of NOS2 protein]; Donepezil inhibits the reaction [APP protein modified form results in increased expression of PTGS2 protein]; Donepezil inhibits the reaction [APP protein modified form results in increased expression of TNF protein]; Donepezil inhibits the reaction [Streptozocin results in increased expression of APP protein]
CTD PMID:18061284, PMID:18571635, PMID:24189446, PMID:28734741, PMID:30481507 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arg1 arginase 1 multiple interactions ISO Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of ARG1 mRNA]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of ARG1 protein]] CTD PMID:26114860 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Bace1 beta-secretase 1 multiple interactions ISO Donepezil inhibits the reaction [Streptozocin results in increased expression of BACE1 protein] CTD PMID:30481507 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO
EXP
Donepezil results in decreased activity of BCHE protein CTD PMID:16036213, PMID:18656440, PMID:19345205 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Donepezil inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein] CTD PMID:19345205 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO
EXP
Donepezil results in increased activity of CASP3 protein
Donepezil inhibits the reaction [Hydrogen Peroxide results in decreased expression of CASP3 protein]
CTD PMID:19345205, PMID:20522977 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO Donepezil results in increased activity of CASP8 protein CTD PMID:20522977 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity ISO Donepezil results in increased activity of CASP9 protein CTD PMID:20522977 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO Donepezil inhibits the reaction [Streptozocin results in decreased activity of CAT protein] CTD PMID:30481507 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Egr1 early growth response 1 multiple interactions
affects expression
ISO Donepezil inhibits the reaction [Scopolamine results in decreased expression of EGR1 protein]
EGR1 protein affects the reaction [Donepezil affects the expression of ICAM1 protein]
Donepezil affects the expression of EGR1 mRNA; Donepezil affects the expression of EGR1 protein
CTD PMID:29133030, PMID:32174113 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G F3 coagulation factor III, tissue factor affects expression ISO Donepezil affects the expression of F3 mRNA; Donepezil affects the expression of F3 protein CTD PMID:32174113 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fiz1 FLT3-interacting zinc finger 1 multiple interactions ISO Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of FIZ1 mRNA]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of FIZ1 protein]] CTD PMID:26114860 NCBI chr 1:72,379,705...72,387,301
Ensembl chr 1:72,380,711...72,387,301
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Donepezil inhibits the reaction [Scopolamine results in decreased expression of FOS protein] CTD PMID:29133030 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
affects expression
ISO EGR1 protein affects the reaction [Donepezil affects the expression of ICAM1 protein]
Donepezil affects the expression of ICAM1 mRNA; Donepezil affects the expression of ICAM1 protein
CTD PMID:32174113 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of IL10]] CTD PMID:26114860 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13 interleukin 13 multiple interactions ISO Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of IL13]] CTD PMID:26114860 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL1B mRNA]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL1B protein]; Donepezil inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; Donepezil inhibits the reaction [Valproic Acid results in increased expression of IL1B protein] CTD PMID:26114860, PMID:30481507, PMID:31369746 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of ARG1 mRNA]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of ARG1 protein]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of CHIL3 mRNA]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of CHIL3 protein]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of FIZ1 mRNA]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of FIZ1 protein]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of IL10]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of IL13]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of TGFB2]]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein]] CTD PMID:26114860 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions
affects expression
affects secretion
ISO Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 mRNA]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]; Donepezil inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; Donepezil inhibits the reaction [Valproic Acid results in increased expression of IL6 protein]
Donepezil affects the expression of IL6 mRNA
Donepezil affects the secretion of IL6 protein
CTD PMID:26114860, PMID:30481507, PMID:31369746, PMID:32174113 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Donepezil inhibits the reaction [Scopolamine results in decreased expression of JUN protein] CTD PMID:29133030 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Donepezil inhibits the reaction [Streptozocin results in decreased phosphorylation of MAPK1 protein] CTD PMID:23562514 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Donepezil inhibits the reaction [Streptozocin results in decreased phosphorylation of MAPK3 protein] CTD PMID:23562514 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Donepezil inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of MAPK8 protein] CTD PMID:19345205 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP Donepezil inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of MAPK9 protein] CTD PMID:19345205 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
ISO Donepezil results in decreased expression of MMP9 protein
Donepezil results in decreased expression of and results in decreased activity of MMP9 protein
CTD PMID:21750701 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Donepezil inhibits the reaction [Streptozocin results in increased activity of MPO protein] CTD PMID:23060470 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Donepezil inhibits the reaction [APP protein modified form results in increased expression of NOS2 protein]; Donepezil inhibits the reaction [Valproic Acid results in increased expression of NOS2 protein] CTD PMID:24189446, PMID:31369746 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nppb natriuretic peptide B decreases expression ISO Donepezil results in decreased expression of NPPB protein CTD PMID:19879468 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 affects expression ISO Donepezil affects the expression of OLR1 mRNA; Donepezil affects the expression of OLR1 protein CTD PMID:32174113 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression
multiple interactions
affects expression
ISO Donepezil results in decreased expression of PTGS1 mRNA
[Rivastigmine co-treated with Donepezil] results in decreased expression of PTGS1 mRNA; [Rivastigmine co-treated with Donepezil] results in decreased expression of PTGS1 protein; [Sodium Fluoride co-treated with Donepezil] results in increased expression of PTGS1 mRNA; [Sodium Fluoride co-treated with Donepezil] results in increased expression of PTGS1 protein; [Sodium Fluoride co-treated with Rivastigmine co-treated with Donepezil] results in increased expression of PTGS1 mRNA; [Sodium Fluoride co-treated with Rivastigmine co-treated with Donepezil] results in increased expression of PTGS1 protein
Donepezil affects the expression of PTGS1 protein
CTD PMID:29777723 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO [Donepezil co-treated with Rivastigmine] results in decreased expression of PTGS2 protein; [Rivastigmine co-treated with Donepezil] results in decreased expression of PTGS2 mRNA
Donepezil inhibits the reaction [APP protein modified form results in increased expression of PTGS2 protein]; Donepezil inhibits the reaction [Valproic Acid results in increased expression of PTGS2 protein]
Donepezil results in decreased expression of PTGS2 mRNA; Donepezil results in decreased expression of PTGS2 protein
CTD PMID:24189446, PMID:29777723, PMID:31369746 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Donepezil inhibits the reaction [APP protein modified form affects the localization of RELA protein]; Donepezil inhibits the reaction [Valproic Acid results in increased expression of RELA protein] CTD PMID:24189446, PMID:31369746 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Donepezil inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Donepezil inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD1 mRNA] CTD PMID:28734741 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions EXP Donepezil inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA] CTD PMID:28734741 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein]] CTD PMID:26114860 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of TGFB2]] CTD PMID:26114860 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects expression
affects secretion
ISO
EXP
Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF mRNA]; Donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]; Donepezil inhibits the reaction [APP protein modified form results in increased expression of TNF protein]; Donepezil inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Donepezil inhibits the reaction [Valproic Acid results in increased expression of TNF protein]
Donepezil affects the expression of TNF mRNA
Donepezil affects the secretion of TNF protein
CTD PMID:24189446, PMID:26114860, PMID:30481507, PMID:31369746, PMID:32174113 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Donepezil inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein] CTD PMID:19345205 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions EXP Donepezil inhibits the reaction [Hydrogen Peroxide results in decreased expression of XIAP protein] CTD PMID:19345205 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
dorzolamide hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ca3 carbonic anhydrase 3 multiple interactions ISO dorzolamide binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO dorzolamide binds to and results in decreased activity of CA2 protein CTD PMID:17826101 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
erlotinib hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [ABCG2 gene mutant form results in decreased susceptibility to Mitoxantrone]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 protein results in increased export of Methotrexate]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 results in increased export of Methotrexate] CTD PMID:18829547, PMID:19232821 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation ISO Erlotinib Hydrochloride results in increased phosphorylation of ACACA protein CTD PMID:23707608 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions ISO [Interleukin 1 Receptor Antagonist Protein co-treated with Erlotinib Hydrochloride] results in decreased expression of ADGRE1 protein CTD PMID:27738319 NCBI chr 9:9,431,888...9,585,883
Ensembl chr 9:9,431,860...9,585,865
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO Erlotinib Hydrochloride results in decreased phosphorylation of AKT1 protein
Erlotinib Hydrochloride inhibits the reaction [Derp2 allergen, Dermatophagoides pteronyssinus results in increased phosphorylation of AKT1 protein]
CTD PMID:21195724, PMID:30623574 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in increased expression of APAF1 mRNA CTD PMID:29274334 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Areg amphiregulin affects response to substance ISO AREG protein affects the susceptibility to Erlotinib Hydrochloride CTD PMID:18980991 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Arf1 ADP-ribosylation factor 1 decreases response to substance ISO ARF1 mRNA results in decreased susceptibility to Erlotinib Hydrochloride CTD PMID:23125191 NCBI chr10:45,562,700...45,579,214
Ensembl chr10:45,563,547...45,579,029
JBrowse link
G Atf4 activating transcription factor 4 increases expression EXP Erlotinib Hydrochloride results in increased expression of ATF4 protein CTD PMID:24768708 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atg5 autophagy related 5 decreases response to substance
increases expression
ISO ATG5 protein results in decreased susceptibility to Erlotinib Hydrochloride
Erlotinib Hydrochloride results in increased expression of ATG5 protein
CTD PMID:21655094, PMID:23917044 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Atg7 autophagy related 7 increases expression ISO Erlotinib Hydrochloride results in increased expression of ATG7 protein CTD PMID:21655094 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO Erlotinib Hydrochloride promotes the reaction [Arsenic Trioxide results in increased expression of ATM mRNA] CTD PMID:29274334 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atr ATR serine/threonine kinase multiple interactions
increases expression
ISO Erlotinib Hydrochloride promotes the reaction [Arsenic Trioxide results in increased expression of ATR mRNA]
Erlotinib Hydrochloride results in increased expression of ATR mRNA
CTD PMID:29274334 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
JBrowse link
G Axl Axl receptor tyrosine kinase decreases response to substance
multiple interactions
ISO AXL results in decreased susceptibility to Erlotinib Hydrochloride
[GSK 1363089 results in decreased activity of AXL protein] which results in increased susceptibility to Erlotinib Hydrochloride; [MP470 results in decreased activity of AXL protein] which results in increased susceptibility to Erlotinib Hydrochloride
CTD PMID:22751098 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO Erlotinib Hydrochloride promotes the reaction [Arsenic Trioxide results in increased expression of BAD mRNA] CTD PMID:29274334 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Erlotinib Hydrochloride promotes the reaction [Arsenic Trioxide results in increased expression of BAX mRNA] CTD PMID:29274334 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions
increases expression
ISO [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in increased expression of BBC3 mRNA; Erlotinib Hydrochloride promotes the reaction [Resveratrol results in increased expression of BBC3 protein]; Resveratrol promotes the reaction [Erlotinib Hydrochloride results in increased expression of BBC3 protein] CTD PMID:25895606, PMID:29274334 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
ISO Erlotinib Hydrochloride results in increased expression of BCL2 mRNA; Erlotinib Hydrochloride results in increased expression of BCL2 protein
[Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of BCL2 mRNA; [Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2 protein]
CTD PMID:23894143, PMID:29274334 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions
increases expression
ISO Harmine promotes the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L11 protein] CTD PMID:30171258 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bcl2l2 Bcl2-like 2 increases expression
multiple interactions
ISO Erlotinib Hydrochloride results in increased expression of BCL2L2 mRNA; Erlotinib Hydrochloride results in increased expression of BCL2L2 protein
[Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]
CTD PMID:23894143 NCBI chr15:33,543,774...33,549,165
Ensembl chr15:33,544,312...33,549,164
JBrowse link
G Becn1 beclin 1 decreases response to substance ISO BECN1 protein results in decreased susceptibility to Erlotinib Hydrochloride CTD PMID:23917044 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of BIRC5 mRNA; Erlotinib Hydrochloride inhibits the reaction [betulinic acid results in decreased expression of BIRC5 protein]; Erlotinib Hydrochloride promotes the reaction [Resveratrol results in decreased expression of BIRC5 protein]; Resveratrol promotes the reaction [Erlotinib Hydrochloride results in decreased expression of BIRC5 protein] CTD PMID:25895606, PMID:29274334, PMID:30136359 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 protein] CTD PMID:25981168 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions ISO [Erlotinib Hydrochloride results in decreased activity of EGFR protein] which results in decreased phosphorylation of BRCA1 protein CTD PMID:23548265 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases activity
ISO Erlotinib Hydrochloride results in increased cleavage of CASP3 protein
[TWIST1 protein results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased cleavage of CASP3 protein
Erlotinib Hydrochloride results in increased activity of CASP3 protein
Erlotinib Hydrochloride promotes the reaction [resveratrol results in increased activity of CASP3 protein]; resveratrol promotes the reaction [Erlotinib Hydrochloride results in increased activity of CASP3 protein]
CTD PMID:23125191, PMID:25895606, PMID:30171258 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased expression of CCL2 mRNA; [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of CCL2 mRNA CTD PMID:27738319 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of CCNB1 mRNA CTD PMID:29274334 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [sodium arsenite results in increased expression of CCND1 protein] CTD PMID:19168569 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd69 Cd69 molecule decreases expression ISO Erlotinib Hydrochloride results in decreased expression of CD69 protein CTD PMID:21195724 NCBI chr 4:163,041,147...163,049,065
Ensembl chr 4:163,041,141...163,049,084
JBrowse link
G Cdh1 cadherin 1 multiple interactions
decreases expression
ISO
EXP
Erlotinib Hydrochloride promotes the reaction [Deoxycholic Acid results in decreased glycosylation of and results in increased degradation of CDH1 protein]; Erlotinib Hydrochloride results in decreased glycosylation of and results in increased degradation of CDH1 protein
Erlotinib Hydrochloride results in decreased expression of CDH1 mRNA; Erlotinib Hydrochloride results in decreased expression of CDH1 protein
DDIT3 mutant form inhibits the reaction [Erlotinib Hydrochloride results in decreased expression of CDH1 protein]
CTD PMID:22223758, PMID:24768708 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases phosphorylation ISO Erlotinib Hydrochloride results in decreased phosphorylation of CDK4 protein CTD PMID:21195724 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions
decreases expression
ISO betulinic acid promotes the reaction [Erlotinib Hydrochloride results in decreased expression of CDK6 protein] CTD PMID:30136359 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO Erlotinib Hydrochloride results in increased expression of CDKN1A mRNA
Erlotinib Hydrochloride promotes the reaction [Arsenic Trioxide results in increased expression of CDKN1A mRNA]
CTD PMID:29274334 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Chfr checkpoint with forkhead and ring finger domains multiple interactions ISO CHFR protein affects the susceptibility to [Cisplatin co-treated with Erlotinib Hydrochloride] CTD PMID:20705357 NCBI chr12:52,562,594...52,596,162
Ensembl chr12:52,562,597...52,596,076
JBrowse link
G Chrdl2 chordin-like 2 multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of CHRDL2 protein CTD PMID:24979617 NCBI chr 1:165,008,997...165,036,431
Ensembl chr 1:165,008,912...165,036,435
JBrowse link
G Csf3 colony stimulating factor 3 increases secretion ISO Erlotinib Hydrochloride results in increased secretion of CSF3 protein CTD PMID:27738319 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
ISO [betulinic acid co-treated with Erlotinib Hydrochloride] results in decreased expression of CTNNB1 protein
Erlotinib Hydrochloride results in decreased expression of CTNNB1 protein
CTD PMID:30136359 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of CXCL11 protein CTD PMID:24979617 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Erlotinib Hydrochloride results in decreased activity of CYP19A1 protein CTD PMID:26141389 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Erlotinib Hydrochloride results in increased expression of CYP2B6 mRNA CTD PMID:30364229 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp51 cytochrome P450, family 51 increases response to substance ISO CYP51A1 mRNA results in increased susceptibility to Erlotinib Hydrochloride CTD PMID:23125191 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO
EXP
Erlotinib Hydrochloride results in increased expression of DDIT3 protein
DDIT3 mutant form inhibits the reaction [Erlotinib Hydrochloride results in decreased expression of CDH1 protein]; DDIT3 mutant form inhibits the reaction [Erlotinib Hydrochloride results in increased expression of IL6 mRNA]; DDIT3 mutant form inhibits the reaction [Erlotinib Hydrochloride results in increased secretion of IL6 protein]
CTD PMID:24768708 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dennd6b DENN domain containing 6B decreases expression ISO Erlotinib Hydrochloride results in decreased expression of DENND6B mRNA CTD PMID:27720938 NCBI chr 7:130,162,728...130,178,282
Ensembl chr 7:130,164,675...130,176,696
JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of DUSP1 mRNA CTD PMID:27738319 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Egf epidermal growth factor multiple interactions ISO
EXP
Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Cisplatin]]; Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; Erlotinib Hydrochloride inhibits the reaction [EGF protein results in decreased susceptibility to Crizotinib]; Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased activity of ELK1 protein]; Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]; Erlotinib Hydrochloride promotes the reaction [EGF protein binds to EGFR protein]
Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:21613822, PMID:21787763, PMID:22553343, PMID:25625231, PMID:27427493, PMID:30364229 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor affects response to substance
decreases expression
decreases phosphorylation
decreases activity
multiple interactions
decreases response to substance
ISO EGFR protein affects the susceptibility to Erlotinib Hydrochloride; EGFR protein mutant form affects the susceptibility to Erlotinib Hydrochloride
Erlotinib Hydrochloride results in decreased expression of EGFR protein modified form
Erlotinib Hydrochloride results in decreased phosphorylation of EGFR protein
Erlotinib Hydrochloride results in decreased activity of EGFR protein
[Erlotinib Hydrochloride results in decreased activity of EGFR protein] which results in decreased expression of RAD50 protein; [Erlotinib Hydrochloride results in decreased activity of EGFR protein] which results in decreased expression of RAD51 protein; [Erlotinib Hydrochloride results in decreased activity of EGFR protein] which results in decreased phosphorylation of BRCA1 protein; EGFR gene mutant form results in increased susceptibility to [gemcitabine co-treated with Cisplatin co-treated with Erlotinib Hydrochloride]; Erlotinib Hydrochloride inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of EGFR protein]; Erlotinib Hydrochloride inhibits the reaction [Derp2 allergen, Dermatophagoides pteronyssinus results in increased phosphorylation of EGFR protein]; Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of FOXG1 mRNA]; Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of FOXG1 protein]; Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of SOX9 mRNA]; Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of SOX9 protein]; Erlotinib Hydrochloride inhibits the reaction [Particulate Matter analog results in increased phosphorylation of EGFR protein]; Erlotinib Hydrochloride inhibits the reaction [sodium arsenite results in increased phosphorylation of EGFR protein]; Erlotinib Hydrochloride promotes the reaction [Deoxycholic Acid results in decreased glycosylation of and results in decreased expression of EGFR protein]; Erlotinib Hydrochloride promotes the reaction [EGF protein binds to EGFR protein]; Erlotinib Hydrochloride results in decreased activity of and results in decreased phosphorylation of EGFR protein; Erlotinib Hydrochloride results in decreased glycosylation of and results in decreased expression of EGFR protein
EGFR protein mutant form results in decreased susceptibility to Erlotinib Hydrochloride
CTD PMID:12907618, PMID:16407879, PMID:16891461, PMID:19168569, PMID:21080748, PMID:21541241, PMID:21787763, PMID:22223758, PMID:22751098, PMID:23099361, PMID:23440206, PMID:23548265, PMID:23894143, PMID:25625231, PMID:26455392, PMID:28101945, PMID:30136359, PMID:30364229, PMID:30623574 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases expression EXP Erlotinib Hydrochloride results in increased expression of EIF2S1 protein modified form CTD PMID:24768708 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased activity of ELK1 protein]; Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231, PMID:30364229 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 decreases response to substance ISO ERBB3 mRNA results in decreased susceptibility to Erlotinib Hydrochloride CTD PMID:23125191 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350
JBrowse link
G Foxg1 forkhead box G1 multiple interactions
decreases expression
ISO Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of FOXG1 mRNA]; Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of FOXG1 protein]
Erlotinib Hydrochloride results in decreased expression of FOXG1 protein
CTD PMID:26455392 NCBI chr 6:69,971,227...69,974,037
Ensembl chr 6:69,971,227...69,974,037
JBrowse link
G Foxo3 forkhead box O3 decreases phosphorylation ISO Erlotinib Hydrochloride results in decreased phosphorylation of FOXO3 protein CTD PMID:23099361 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of GDF15 protein CTD PMID:24979617 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gmpr guanosine monophosphate reductase decreases expression ISO Erlotinib Hydrochloride results in decreased expression of GMPR mRNA CTD PMID:27720938 NCBI chr17:19,543,274...19,580,929
Ensembl chr17:19,543,275...19,580,929
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO Erlotinib Hydrochloride results in decreased expression of GSK3B protein modified form CTD PMID:30136359 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases expression
ISO Erlotinib Hydrochloride promotes the reaction [Resveratrol results in increased expression of H2AX protein modified form]; Resveratrol promotes the reaction [Erlotinib Hydrochloride results in increased expression of H2AX protein modified form] CTD PMID:25895606 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [HBEGF protein results in decreased susceptibility to crizotinib] CTD PMID:22553343 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 decreases expression ISO Erlotinib Hydrochloride results in decreased expression of IFITM3 mRNA CTD PMID:27720938 NCBI chr 1:213,810,712...213,811,821
Ensembl chr 1:213,810,696...213,811,901
JBrowse link
G Ifng interferon gamma decreases secretion ISO Erlotinib Hydrochloride results in decreased secretion of IFNG protein CTD PMID:21195724 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il17f interleukin 17F increases expression ISO
EXP
Erlotinib Hydrochloride results in increased expression of IL17F mRNA CTD PMID:24768708 NCBI chr 9:26,885,702...26,897,219
Ensembl chr 9:26,885,708...26,897,219
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of IL1A mRNA CTD PMID:27738319 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of IL1B mRNA
Erlotinib Hydrochloride results in increased secretion of IL1B protein
CTD PMID:27738319 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased expression of IL1R1 mRNA CTD PMID:27738319 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Il1r2 interleukin 1 receptor type 2 multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which affects the expression of IL1R2 mRNA CTD PMID:27738319 NCBI chr 9:46,840,646...46,881,241
Ensembl chr 9:46,840,992...46,881,264
JBrowse link
G Il1rap interleukin 1 receptor accessory protein multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of IL1RAP mRNA CTD PMID:27738319 NCBI chr11:77,456,648...77,593,208
Ensembl chr11:77,463,954...77,593,207
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which affects the expression of IL1RN mRNA; [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased expression of IL1RN mRNA; [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased secretion of IL1RN protein CTD PMID:27738319 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il2 interleukin 2 decreases secretion ISO Erlotinib Hydrochloride results in decreased secretion of IL2 protein CTD PMID:21195724 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il25 interleukin 25 increases expression ISO
EXP
Erlotinib Hydrochloride results in increased expression of IL25 mRNA CTD PMID:24768708 NCBI chr15:33,594,852...33,599,692
Ensembl chr15:33,596,301...33,599,685
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases expression ISO Erlotinib Hydrochloride results in decreased expression of IL2RA protein CTD PMID:21195724 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Il6 interleukin 6 increases expression
increases secretion
multiple interactions
ISO
EXP
Erlotinib Hydrochloride results in increased expression of IL6 mRNA
Erlotinib Hydrochloride results in increased secretion of IL6 protein
Erlotinib Hydrochloride inhibits the reaction [Derp2 allergen, Dermatophagoides pteronyssinus results in increased expression of IL6 mRNA]; Erlotinib Hydrochloride inhibits the reaction [Derp2 allergen, Dermatophagoides pteronyssinus results in increased secretion of IL6 protein]; Interleukin 1 Receptor Antagonist Protein inhibits the reaction [Erlotinib Hydrochloride results in increased secretion of IL6 protein]
DDIT3 mutant form inhibits the reaction [Erlotinib Hydrochloride results in increased expression of IL6 mRNA]; DDIT3 mutant form inhibits the reaction [Erlotinib Hydrochloride results in increased secretion of IL6 protein]
CTD PMID:24768708, PMID:27738319, PMID:30623574 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased expression of IRAK1 mRNA CTD PMID:27738319 NCBI chr  X:156,716,469...156,726,367
Ensembl chr  X:156,716,604...156,725,977
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression EXP Erlotinib Hydrochloride results in decreased expression of ITGB1 mRNA CTD PMID:24768708 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO Erlotinib Hydrochloride results in decreased phosphorylation of JAK2 protein CTD PMID:23894143 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects activity ISO Erlotinib Hydrochloride affects the activity of KCNH2 protein CTD PMID:23707608 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kitlg KIT ligand multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of KITLG protein CTD PMID:24979617 NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054
JBrowse link
G Kras KRAS proto-oncogene, GTPase increases response to substance ISO KRAS protein results in increased susceptibility to Erlotinib Hydrochloride CTD PMID:20705357 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO Erlotinib Hydrochloride promotes the reaction [betulinic acid results in increased expression of MAP1LC3B protein modified form] CTD PMID:30136359 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
ISO
EXP
Erlotinib Hydrochloride results in decreased phosphorylation of MAPK1 protein
Erlotinib Hydrochloride inhibits the reaction [Particulate Matter analog results in increased phosphorylation of MAPK1 protein]
Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]
Erlotinib Hydrochloride inhibits the reaction [Alprenolol results in increased phosphorylation of MAPK1 protein]; Erlotinib Hydrochloride inhibits the reaction [carvedilol results in increased phosphorylation of MAPK1 protein]
CTD PMID:18787115, PMID:18980991, PMID:21195724, PMID:27427493, PMID:28101945 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO
EXP
Erlotinib Hydrochloride results in decreased phosphorylation of MAPK3 protein
Erlotinib Hydrochloride inhibits the reaction [Particulate Matter analog results in increased phosphorylation of MAPK3 protein]
Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]
Erlotinib Hydrochloride inhibits the reaction [Alprenolol results in increased phosphorylation of MAPK3 protein]; Erlotinib Hydrochloride inhibits the reaction [carvedilol results in increased phosphorylation of MAPK3 protein]
CTD PMID:18787115, PMID:18980991, PMID:21195724, PMID:27427493, PMID:28101945 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression
multiple interactions
ISO Erlotinib Hydrochloride results in decreased expression of MCL1 protein
resveratrol promotes the reaction [Erlotinib Hydrochloride results in decreased expression of MCL1 protein]
CTD PMID:25895606 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions
decreases phosphorylation
ISO [Erlotinib Hydrochloride co-treated with Dasatinib] results in decreased phosphorylation of MET protein
Erlotinib Hydrochloride results in decreased phosphorylation of MET protein
CTD PMID:21106725, PMID:23894143 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Micb MHC class I polypeptide-related sequence B increases expression ISO Erlotinib Hydrochloride results in increased expression of MICB protein CTD PMID:21951556 NCBI chr 1:79,754,587...79,772,092
Ensembl chr 1:79,754,587...79,772,092
JBrowse link
G Mmp14 matrix metallopeptidase 14 multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [Acrolein results in increased expression of MMP14 mRNA] CTD PMID:19661247 NCBI chr15:33,074,441...33,083,666
Ensembl chr15:33,074,441...33,083,655
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of MMP2 mRNA CTD PMID:29274334 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of MMP9 mRNA CTD PMID:29274334 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Msmo1 methylsterol monooxygenase 1 decreases response to substance
multiple interactions
ISO MSMO1 protein results in decreased susceptibility to Erlotinib Hydrochloride
MSMO1 protein inhibits the reaction [Erlotinib Hydrochloride results in decreased expression of RPS6 protein modified form]
CTD PMID:23125191 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation
multiple interactions
ISO Erlotinib Hydrochloride results in decreased phosphorylation of MTOR protein
resveratrol promotes the reaction [Erlotinib Hydrochloride results in decreased phosphorylation of MTOR protein]
CTD PMID:21655094, PMID:25895606 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA] CTD PMID:18006877, PMID:19661247 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which affects the expression of MYD88 mRNA CTD PMID:27738319 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which affects the expression of NFKBIA mRNA CTD PMID:27738319 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nol10 nucleolar protein 10 decreases expression ISO Erlotinib Hydrochloride results in decreased expression of NOL10 mRNA CTD PMID:27720938 NCBI chr 6:42,656,661...42,745,099
Ensembl chr 6:42,656,616...42,745,098
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions
decreases response to substance
increases expression
ISO Erlotinib Hydrochloride results in increased expression of and results in increased stability of NOX4 mRNA
NOX4 protein results in decreased susceptibility to Erlotinib Hydrochloride
Erlotinib Hydrochloride results in increased expression of NOX4 protein
CTD PMID:23917044 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Erlotinib Hydrochloride binds to and results in increased activity of NR1I2 protein CTD PMID:18839173 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects localization ISO Erlotinib Hydrochloride affects the localization of NR1I3 protein mutant form CTD PMID:30364229 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like decreases response to substance ISO NSDHL protein results in decreased susceptibility to Erlotinib Hydrochloride CTD PMID:23125191 NCBI chr  X:152,933,118...152,964,399
Ensembl chr  X:152,933,069...152,964,390
JBrowse link
G Osm oncostatin M multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of OSM protein CTD PMID:24979617 NCBI chr14:84,457,487...84,469,426
Ensembl chr14:84,465,515...84,470,409
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
increases expression
ISO Erlotinib Hydrochloride results in increased cleavage of PARP1 protein
[TWIST1 protein results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased cleavage of PARP1 protein; Harmine promotes the reaction [Erlotinib Hydrochloride results in increased cleavage of PARP1 protein]; Resveratrol promotes the reaction [Erlotinib Hydrochloride results in increased expression of PARP1 protein modified form]; TWIST1 protein inhibits the reaction [Erlotinib Hydrochloride results in increased cleavage of PARP1 protein]
CTD PMID:23125191, PMID:25895606, PMID:30171258 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pml PML nuclear body scaffold increases expression
decreases response to substance
increases localization
ISO Erlotinib Hydrochloride results in increased expression of PML protein
PML protein results in decreased susceptibility to Erlotinib Hydrochloride
Erlotinib Hydrochloride results in increased localization of PML protein
CTD PMID:23440206 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of PTGS2 mRNA CTD PMID:27738319 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptpn9 protein tyrosine phosphatase, non-receptor type 9 decreases expression
decreases response to substance
ISO Erlotinib Hydrochloride results in decreased expression of PTPN9 protein
PTPN9 mutant form results in decreased susceptibility to Erlotinib Hydrochloride
CTD PMID:23894143 NCBI chr 8:61,658,851...61,739,458
Ensembl chr 8:61,659,445...61,739,434
JBrowse link
G Rad50 RAD50 double strand break repair protein multiple interactions ISO [Erlotinib Hydrochloride results in decreased activity of EGFR protein] which results in decreased expression of RAD50 protein CTD PMID:23548265 NCBI chr10:39,002,130...39,054,042
Ensembl chr10:39,001,498...39,054,142
JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO [Erlotinib Hydrochloride results in decreased activity of EGFR protein] which results in decreased expression of RAD51 protein CTD PMID:23548265 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases phosphorylation ISO Erlotinib Hydrochloride results in decreased phosphorylation of RAF1 protein CTD PMID:21195724 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation
multiple interactions
decreases expression
ISO Erlotinib Hydrochloride results in decreased phosphorylation of RB1 protein
betulinic acid promotes the reaction [Erlotinib Hydrochloride results in decreased expression of RB1 protein modified form]; Erlotinib Hydrochloride promotes the reaction [betulinic acid results in decreased expression of RB1 protein modified form]
CTD PMID:21195724, PMID:30136359 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [Particulate Matter analog results in increased acetylation of RELA protein] CTD PMID:28101945 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation
decreases expression
multiple interactions
ISO Erlotinib Hydrochloride results in decreased phosphorylation of RPS6 protein
Erlotinib Hydrochloride results in decreased expression of RPS6 protein modified form
MSMO1 protein inhibits the reaction [Erlotinib Hydrochloride results in decreased expression of RPS6 protein modified form]
CTD PMID:23125191, PMID:23440206 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation
multiple interactions
ISO Erlotinib Hydrochloride results in decreased phosphorylation of RPS6KB1 protein
resveratrol promotes the reaction [Erlotinib Hydrochloride results in decreased phosphorylation of RPS6KB1 protein]
CTD PMID:21655094, PMID:25895606 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Selenbp1 selenium binding protein 1 decreases expression ISO Erlotinib Hydrochloride results in decreased expression of SELENBP1 mRNA CTD PMID:27720938 NCBI chr 2:196,105,592...196,146,474
Ensembl chr 2:196,105,569...196,113,149
JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 decreases expression ISO Erlotinib Hydrochloride results in decreased expression of SIAH2 mRNA CTD PMID:27720938 NCBI chr 2:148,874,151...148,891,900
Ensembl chr 2:148,874,151...148,891,900
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of SNAI1 mRNA CTD PMID:29274334 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions ISO [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of SNAI2 mRNA CTD PMID:29274334 NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression EXP Erlotinib Hydrochloride results in increased expression of SOCS3 mRNA CTD PMID:24768708 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Sox9 SRY-box transcription factor 9 multiple interactions
decreases expression
ISO Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of SOX9 mRNA]; Erlotinib Hydrochloride inhibits the reaction [EGFR protein mutant form results in increased expression of SOX9 protein]
Erlotinib Hydrochloride results in decreased expression of SOX9 protein
CTD PMID:26455392 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Erlotinib Hydrochloride results in increased expression of SQSTM1 protein CTD PMID:30136359 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases phosphorylation ISO Erlotinib Hydrochloride results in decreased phosphorylation of SRC protein CTD PMID:23894143 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation
decreases expression
increases response to substance
decreases response to substance
multiple interactions
ISO Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein
Erlotinib Hydrochloride results in decreased expression of STAT3 protein modified form
STAT3 mutant form results in increased susceptibility to Erlotinib Hydrochloride
STAT3 mRNA results in decreased susceptibility to Erlotinib Hydrochloride
[betulinic acid co-treated with Erlotinib Hydrochloride] results in decreased expression of STAT3 protein modified form; [Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein]
CTD PMID:23125191, PMID:23894143, PMID:30136359 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tent5c terminal nucleotidyltransferase 5C decreases expression ISO Erlotinib Hydrochloride results in decreased expression of TENT5C mRNA CTD PMID:27720938 NCBI chr 2:202,797,766...202,816,562
Ensembl chr 2:202,798,198...202,816,562
JBrowse link
G Tfap2a transcription factor AP-2 alpha multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [TFAP2A protein binds to ULBP1 promoter]; Tetradecanoylphorbol Acetate inhibits the reaction [Erlotinib Hydrochloride inhibits the reaction [TFAP2A protein binds to ULBP1 promoter]] CTD PMID:21499124, PMID:21951556 NCBI chr17:24,653,342...24,670,457
Ensembl chr17:24,654,902...24,670,457
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [TGFA protein results in decreased susceptibility to crizotinib] CTD PMID:22553343 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Cisplatin]]; Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]] CTD PMID:21613822 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 decreases response to substance ISO TMED2 mRNA results in decreased susceptibility to Erlotinib Hydrochloride CTD PMID:23125191 NCBI chr12:37,471,259...37,480,344
Ensembl chr12:37,471,260...37,480,297
JBrowse link
G Tnfsf8 TNF superfamily member 8 multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of TNFSF8 protein CTD PMID:24979617 NCBI chr 5:79,664,779...79,691,547
Ensembl chr 5:79,664,765...79,691,258
JBrowse link
G Tollip toll interacting protein multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of TOLLIP mRNA CTD PMID:27738319 NCBI chr 1:214,823,993...214,844,861
Ensembl chr 1:214,823,978...214,844,858
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO Erlotinib Hydrochloride promotes the reaction [Arsenic Trioxide results in increased expression of TP53 mRNA]; Erlotinib Hydrochloride promotes the reaction [Resveratrol results in increased expression of TP53 protein]; Resveratrol promotes the reaction [Erlotinib Hydrochloride results in increased expression of TP53 protein] CTD PMID:25895606, PMID:29274334 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of TRAF6 mRNA CTD PMID:27738319 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
JBrowse link
G Twist1 twist family bHLH transcription factor 1 increases expression
decreases response to substance
multiple interactions
ISO Erlotinib Hydrochloride results in increased expression of TWIST1 protein
TWIST1 protein results in decreased susceptibility to Erlotinib Hydrochloride
[TWIST1 protein results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased cleavage of PARP1 protein; TWIST1 protein inhibits the reaction [Erlotinib Hydrochloride results in increased cleavage of PARP1 protein]
[TWIST1 protein results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased cleavage of CASP3 protein
CTD PMID:30171258 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214
JBrowse link
G Tyms thymidylate synthetase decreases expression
multiple interactions
ISO Erlotinib Hydrochloride results in decreased expression of TYMS protein
betulinic acid promotes the reaction [Erlotinib Hydrochloride results in decreased expression of TYMS protein]; Erlotinib Hydrochloride promotes the reaction [betulinic acid results in decreased expression of TYMS protein]
CTD PMID:30136359 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
G Ulbp1 UL16 binding protein 1 increases expression
multiple interactions
ISO Erlotinib Hydrochloride results in increased expression of ULBP1 mRNA; Erlotinib Hydrochloride results in increased expression of ULBP1 protein
Erlotinib Hydrochloride inhibits the reaction [TFAP2A protein binds to ULBP1 promoter]; Tetradecanoylphorbol Acetate inhibits the reaction [Erlotinib Hydrochloride inhibits the reaction [TFAP2A protein binds to ULBP1 promoter]]; Tetradecanoylphorbol Acetate inhibits the reaction [Erlotinib Hydrochloride results in increased expression of ULBP1 mRNA]
CTD PMID:21499124, PMID:21951556 NCBI chr 1:1,181,301...1,200,526
Ensembl chr 1:1,180,932...1,220,916
JBrowse link
G Xbp1 X-box binding protein 1 increases expression EXP Erlotinib Hydrochloride results in increased expression of XBP1 protein modified form CTD PMID:24768708 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
fingolimod hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression
ISO [Fingolimod Hydrochloride results in increased abundance of 27-hydroxycholesterol] which results in increased expression of ABCA1 mRNA; NPC1 protein affects the reaction [Fingolimod Hydrochloride results in increased expression of ABCA1 protein]; UVI 3003 inhibits the reaction [Fingolimod Hydrochloride results in increased expression of ABCA1 protein]
Fingolimod Hydrochloride results in increased expression of ABCA1 mRNA; Fingolimod Hydrochloride results in increased expression of ABCA1 protein
CTD PMID:20056921 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of ACTA2 mRNA]; Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of ACTA2 protein] CTD PMID:24893116 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Adm adrenomedullin multiple interactions EXP Fingolimod Hydrochloride promotes the reaction [Mercuric Chloride results in increased expression of ADM mRNA]; Fingolimod Hydrochloride promotes the reaction [Mercuric Chloride results in increased expression of ADM protein] CTD PMID:15680492 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO Acetylcysteine inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein]; pifithrin inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein] CTD PMID:25939952 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO Fingolimod Hydrochloride promotes the reaction [APOA1 protein results in increased secretion of Cholesterol] CTD PMID:20056921 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Atg12 autophagy related 12 increases expression ISO Fingolimod Hydrochloride results in increased expression of ATG12 protein CTD PMID:25939952 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
JBrowse link
G Atg3 autophagy related 3 increases expression ISO Fingolimod Hydrochloride results in increased expression of ATG3 protein CTD PMID:25939952 NCBI chr11:60,585,192...60,613,706
Ensembl chr11:60,585,171...60,613,718
JBrowse link
G Atg5 autophagy related 5 increases expression ISO Fingolimod Hydrochloride results in increased expression of ATG5 protein CTD PMID:25939952 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Atg7 autophagy related 7 increases expression ISO Fingolimod Hydrochloride results in increased expression of ATG7 protein CTD PMID:25939952 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression ISO Fingolimod Hydrochloride results in increased expression of BDNF mRNA CTD PMID:24859201 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Becn1 beclin 1 multiple interactions ISO BECN1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of BECN1 protein]; Fingolimod Hydrochloride results in increased expression of and results in increased cleavage of BECN1 protein CTD PMID:25939952 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage
ISO 3-methyladenine inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP3 protein]
Fingolimod Hydrochloride results in increased activity of CASP3 protein
CTD PMID:25939952, PMID:29654831 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions
ISO Fingolimod Hydrochloride results in increased cleavage of CASP8 protein
SQSTM1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP8 protein]
CTD PMID:25939952 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases response to substance
increases expression
ISO 3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid inhibits the reaction [Fingolimod Hydrochloride results in increased expression of CCL2 protein]
CCL2 results in increased susceptibility to Fingolimod Hydrochloride
CTD PMID:23043544 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO Fingolimod Hydrochloride results in decreased expression of CCND1 mRNA
Estradiol inhibits the reaction [Fingolimod Hydrochloride results in decreased expression of CCND1 mRNA]; Fingolimod Hydrochloride inhibits the reaction [Estradiol results in decreased expression of CCND1 mRNA]
CTD PMID:29654831 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Fingolimod Hydrochloride results in increased expression of CCNG2 mRNA CTD PMID:24356939 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA] CTD PMID:24893116 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA] CTD PMID:24893116 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Comt catechol-O-methyltransferase increases expression ISO Fingolimod Hydrochloride results in increased expression of COMT mRNA CTD PMID:29654831 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions
decreases expression
ISO Fingolimod Hydrochloride inhibits the reaction [Estradiol results in increased expression of CXCR4 mRNA]
Fingolimod Hydrochloride results in decreased expression of CXCR4 mRNA
CTD PMID:29654831 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CYP19A1 mRNA CTD PMID:29654831 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CYP1A1 mRNA CTD PMID:29654831 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CYP1B1 mRNA CTD PMID:29654831 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Estradiol results in increased expression of ESR1 protein] CTD PMID:29654831 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
decreases expression
ISO Fingolimod Hydrochloride inhibits the reaction [Estradiol results in increased expression of ESR2 protein]
Fingolimod Hydrochloride results in decreased expression of ESR2 protein
CTD PMID:29654831 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Fingolimod Hydrochloride results in increased expression of FOS mRNA CTD PMID:24859201 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gnaq G protein subunit alpha q multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein] CTD PMID:25980589 NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786
JBrowse link
G Hdac1 histone deacetylase 1 affects binding
multiple interactions
ISO Fingolimod Hydrochloride metabolite binds to HDAC1 protein
Fingolimod Hydrochloride metabolite inhibits the reaction [S1PR1 protein binds to HDAC1 protein]; SPHK2 protein promotes the reaction [Fingolimod Hydrochloride metabolite binds to HDAC1 protein]
CTD PMID:24859201 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO Fingolimod Hydrochloride results in increased expression of HMGCR mRNA CTD PMID:24356939 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Fingolimod Hydrochloride results in increased expression of HMGCS1 mRNA CTD PMID:24356939 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression ISO Fingolimod Hydrochloride results in increased expression of IDI1 mRNA CTD PMID:24356939 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of IL1B protein] CTD PMID:24893116 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of IL6 protein] CTD PMID:24893116 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Fingolimod Hydrochloride results in decreased activity of KCNH2 protein CTD PMID:25223691 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Klhl24 kelch-like family member 24 increases expression ISO Fingolimod Hydrochloride results in increased expression of KLHL24 mRNA CTD PMID:24356939 NCBI chr11:84,613,101...84,643,674
Ensembl chr11:84,615,760...84,633,504
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Fingolimod Hydrochloride results in increased phosphorylation of MAPK1 protein CTD PMID:25939952 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Fingolimod Hydrochloride results in increased phosphorylation of MAPK3 protein CTD PMID:25939952 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein] CTD PMID:25980589 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Fingolimod Hydrochloride results in decreased phosphorylation of MTOR protein CTD PMID:25939952 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 multiple interactions
increases expression
ISO NPC1 protein affects the reaction [Fingolimod Hydrochloride results in increased expression of ABCA1 protein]
Fingolimod Hydrochloride results in increased expression of NPC1 protein
CTD PMID:20056921 NCBI chr18:3,616,878...3,662,656
Ensembl chr18:3,616,878...3,662,683
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO 3-methyladenine inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; BECN1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; necrostatin-1 inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; RIPK3 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; SQSTM1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein] CTD PMID:25939952 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdcd4 programmed cell death 4 increases expression ISO Fingolimod Hydrochloride results in increased expression of PDCD4 mRNA CTD PMID:24356939 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Plcb4 phospholipase C, beta 4 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein] CTD PMID:25980589 NCBI chr 3:128,601,163...128,971,720
Ensembl chr 3:128,756,799...128,971,746
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions
increases expression
ISO necrostatin-1 inhibits the reaction [Fingolimod Hydrochloride results in increased expression of RIPK1 protein] CTD PMID:25939952 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 increases expression
multiple interactions
ISO Fingolimod Hydrochloride results in increased expression of RIPK3 protein
RIPK3 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; RIPK3 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein]
CTD PMID:25939952 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO Fingolimod Hydrochloride results in decreased phosphorylation of RPS6KB1 protein CTD PMID:25939952 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 multiple interactions
decreases activity
decreases expression
ISO Fingolimod Hydrochloride inhibits the reaction [SPHK2 protein results in increased expression of S1PR1 protein]; Fingolimod Hydrochloride metabolite inhibits the reaction [S1PR1 protein binds to HDAC1 protein]
Fingolimod Hydrochloride analog results in decreased activity of S1PR1 protein
Fingolimod Hydrochloride results in decreased expression of S1PR1 protein
[3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid results in decreased activity of S1PR1 protein] which results in decreased susceptibility to Fingolimod Hydrochloride
CTD PMID:23043544, PMID:24420784, PMID:24859201 NCBI chr 2:218,654,406...218,658,761
Ensembl chr 2:218,654,554...218,658,761
JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein] CTD PMID:25980589 NCBI chr17:13,799,383...13,812,877
Ensembl chr17:13,799,383...13,812,704
JBrowse link
G Sphk2 sphingosine kinase 2 multiple interactions
increases response to substance
increases phosphorylation
ISO Fingolimod Hydrochloride inhibits the reaction [SPHK2 protein results in increased expression of S1PR1 protein]; SPHK2 protein promotes the reaction [Fingolimod Hydrochloride metabolite binds to HDAC1 protein]
SPHK2 results in increased susceptibility to Fingolimod Hydrochloride
SPHK2 protein results in increased phosphorylation of Fingolimod Hydrochloride
CTD PMID:23043544, PMID:24859201 NCBI chr 1:101,692,972...101,700,604
Ensembl chr 1:101,692,973...101,697,277
JBrowse link
G Sqle squalene epoxidase increases expression ISO Fingolimod Hydrochloride results in increased expression of SQLE mRNA CTD PMID:24356939 NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression
ISO Fingolimod Hydrochloride affects the reaction [bafilomycin A1 results in increased expression of SQSTM1 protein]; SQSTM1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP8 protein]; SQSTM1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]
Fingolimod Hydrochloride results in decreased expression of SQSTM1 protein
CTD PMID:25939952 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tfe3 transcription factor binding to IGHM enhancer 3 decreases phosphorylation ISO Fingolimod Hydrochloride results in decreased phosphorylation of TFE3 protein CTD PMID:29945972 NCBI chr  X:15,574,579...15,587,826
Ensembl chr  X:15,575,934...15,587,419
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA] CTD PMID:24893116 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of TNF protein] CTD PMID:24893116 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases phosphorylation
ISO Acetylcysteine inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein]; necrostatin-1 inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein]; RIPK3 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein] CTD PMID:25939952 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of VEGFA mRNA] CTD PMID:24893116 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vegfd vascular endothelial growth factor D increases expression ISO Fingolimod Hydrochloride results in increased expression of VEGFD mRNA CTD PMID:24859201 NCBI chr  X:31,816,480...31,852,239
Ensembl chr  X:31,816,436...31,851,715
JBrowse link
fluoxetine hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a4 solute carrier family 6 member 4 decreases expression EXP fluoxetine decreases expression of Slc6a4 mRNA in the dorsal raphe nucleus RGD PMID:15936043 RGD:38549581 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
lurasidone hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 multiple interactions ISO Lurasidone Hydrochloride binds to and results in decreased activity of DRD2 protein CTD PMID:20404009 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions ISO Lurasidone Hydrochloride binds to and results in increased activity of HTR1A protein CTD PMID:20404009 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 multiple interactions ISO Lurasidone Hydrochloride binds to and results in decreased activity of HTR7 protein CTD PMID:20404009 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778
JBrowse link
methoctramine tetrahydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO methoctramine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein] CTD PMID:11306684 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO methoctramine inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein] CTD PMID:9846649 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions ISO methoctramine inhibits the reaction [Scopolamine Derivatives binds to CHRM4 protein] CTD PMID:11306684 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 multiple interactions ISO methoctramine inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein] CTD PMID:9846649 NCBI chr 3:103,966,451...104,018,815
Ensembl chr 3:103,966,451...104,018,861
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP methoctramine analog results in increased phosphorylation of MAPK1 protein CTD PMID:19576191 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation EXP methoctramine analog results in increased phosphorylation of MAPK3 protein CTD PMID:19576191 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP methoctramine inhibits the reaction [Mevinphos affects the localization of and affects the activity of NFKB1 protein] CTD PMID:17395621 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS1 protein] CTD PMID:17395621 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS2 protein] CTD PMID:17395621 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Odc1 ornithine decarboxylase 1 decreases activity ISO methoctramine analog results in decreased activity of ODC1 protein; methoctramine results in decreased activity of ODC1 protein CTD PMID:19576191 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP methoctramine inhibits the reaction [Mevinphos affects the localization of and affects the activity of RELA protein] CTD PMID:17395621 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases activity ISO methoctramine analog results in increased activity of SAT1 protein; methoctramine results in increased activity of SAT1 protein CTD PMID:19576191 NCBI chr  X:43,626,480...43,629,767
Ensembl chr  X:43,625,169...43,629,765
JBrowse link
G Tp53 tumor protein p53 increases expression EXP methoctramine analog results in increased expression of TP53 protein CTD PMID:19576191 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
N-\{2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethyl\}-N-propylpropan-1-amine hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sigmar1 sigma non-opioid intracellular receptor 1 multiple interactions EXP [N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride binds to and results in decreased activity of SIGMAR1 protein] inhibits the reaction [1-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-3,4-dihydro-5-methoxy-2(1H)-quinolinone results in increased secretion of Acetylcholine] CTD PMID:11907181 NCBI chr 5:58,121,824...58,124,687
Ensembl chr 5:58,121,786...58,124,681
JBrowse link
PF-670462 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tardbp TAR DNA binding protein multiple interactions ISO PF-670462 inhibits the reaction [arsenite results in increased phosphorylation of TARDBP protein] CTD PMID:29109149 NCBI chr 5:165,432,089...165,442,232
Ensembl chr 5:165,432,095...165,442,048
JBrowse link
prasugrel hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2ry12 purinergic receptor P2Y12 multiple interactions ISO Prasugrel Hydrochloride binds to and results in decreased activity of P2RY12 protein CTD PMID:17681285 NCBI chr 2:149,440,807...149,482,592
Ensembl chr 2:149,441,598...149,444,548
JBrowse link
quinapril hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity EXP
ISO
Quinapril results in decreased activity of ACE protein CTD PMID:8227822, PMID:15728788 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Adm adrenomedullin decreases expression EXP Quinapril results in decreased expression of ADM protein CTD PMID:10334802 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Agt angiotensinogen decreases activity
multiple interactions
EXP Quinapril results in decreased activity of AGT protein
Quinapril inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Quinapril promotes the reaction [Isoproterenol results in increased expression of AGT protein]
CTD PMID:11709406, PMID:15728788 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression EXP Quinapril results in decreased expression of CXCL10 CTD PMID:15831368 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO Quinapril results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Edn1 endothelin 1 decreases expression ISO Quinapril results in decreased expression of EDN1; Quinapril results in decreased expression of EDN1 protein CTD PMID:12149661, PMID:12425201 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G F2 coagulation factor II decreases activity ISO Quinapril results in decreased activity of F2 protein CTD PMID:16907931 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G F5 coagulation factor V decreases activity ISO Quinapril results in decreased activity of F5 protein CTD PMID:16907931 NCBI chr13:82,479,997...82,535,540
Ensembl chr13:82,479,998...82,535,534
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Quinapril results in increased expression of FOS mRNA CTD PMID:8539265 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Tacrolimus co-treated with Quinapril] results in decreased expression of IL6 protein; [Tacrolimus co-treated with Quinapril] results in increased expression of IL6 protein CTD PMID:16549154 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP Quinapril results in increased expression of MYC mRNA CTD PMID:8539265 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nos3 nitric oxide synthase 3 affects expression EXP Quinapril affects the expression of NOS3 mRNA CTD PMID:12176110 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nppa natriuretic peptide A increases expression
increases secretion
EXP Quinapril results in increased expression of NPPA mRNA; Quinapril results in increased expression of NPPA protein
Quinapril results in increased secretion of NPPA protein
CTD PMID:14639023 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions EXP Quinapril inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA]; Quinapril inhibits the reaction [Folic Acid results in increased expression of PTHLH protein] CTD PMID:15728788 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Ren renin multiple interactions
increases expression
EXP Quinapril promotes the reaction [Isoproterenol results in increased expression of REN protein]
Quinapril results in increased expression of REN protein
CTD PMID:10334802, PMID:11709406 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO Quinapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:106,800,081...106,844,668
Ensembl chr15:106,800,081...106,844,426
JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions EXP
ISO
Quinapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:66,932,664...66,961,708
Ensembl chr11:66,932,614...66,961,713
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [Tacrolimus co-treated with Quinapril] results in increased expression of TGFB1 protein CTD PMID:16549154 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
SKF-96365 hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor multiple interactions ISO 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Oxygen deficiency results in increased secretion of BDNF protein] CTD PMID:16553631 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Casr calcium-sensing receptor multiple interactions ISO 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [CASR protein results in increased uptake of Calcium] CTD PMID:21562303 NCBI chr11:67,188,204...67,262,261
Ensembl chr11:67,188,630...67,258,771
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Doxorubicin results in increased expression of DDIT3 protein] CTD PMID:28495616 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Grm1 glutamate metabotropic receptor 1 multiple interactions EXP 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium] CTD PMID:14622174 NCBI chr 1:4,753,141...5,165,859
Ensembl chr 1:4,753,144...5,165,859
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Doxorubicin results in increased expression of HSPA5 protein] CTD PMID:28495616 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Ins2 insulin 2 decreases response to substance ISO 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole results in decreased susceptibility to INS protein CTD PMID:22031853 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Lep leptin multiple interactions ISO 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Aflatoxin B1 results in increased phosphorylation of MAPK1 protein] CTD PMID:27818125 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Aflatoxin B1 results in increased phosphorylation of MAPK3 protein] CTD PMID:27818125 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Myl9 myosin light chain 9 multiple interactions ISO 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MYL9 protein] CTD PMID:20164382 NCBI chr 3:152,857,573...152,863,961
Ensembl chr 3:152,857,592...152,863,960
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [fluoranthene results in increased expression of NOS3 protein]; 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [fluorene results in increased expression of NOS3 protein]; 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [naphthalene results in increased expression of NOS3 protein] CTD PMID:15183461 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[Particulate Matter co-treated with Methylene Chloride] results in increased expression of PTGS2 mRNA] CTD PMID:30503853 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 multiple interactions EXP 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[Phenylephrine results in increased expression of TRPC3 protein] which results in increased transport of Calcium] CTD PMID:19244478 NCBI chr 2:123,329,954...123,467,574
Ensembl chr 2:123,329,875...123,407,496
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions
decreases activity
EXP
ISO
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [1-oleoyl-2-acetoyl-sn-glycerol promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]; 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Acetylcholine promotes the reaction [TRPC6 protein results in increased uptake of Calcium]]
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole results in decreased activity of TRPC6 protein
CTD PMID:11179201, PMID:11535132 NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535
JBrowse link
vanoxerine dihydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO [Mephenytoin results in decreased activity of CYP2C19 protein] which results in decreased degradation of vanoxerine CTD PMID:11502731 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases degradation
multiple interactions
ISO CYP2C8 protein results in decreased degradation of vanoxerine
[Quercetin results in decreased activity of CYP2C8 protein] which results in decreased degradation of vanoxerine
CTD PMID:11502731 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases degradation
multiple interactions
ISO CYP2E1 protein results in decreased degradation of vanoxerine
[Chlorzoxazone results in decreased activity of CYP2E1 protein] which results in decreased degradation of vanoxerine
CTD PMID:11502731 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP vanoxerine results in increased expression of FOS protein CTD PMID:10904129 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions ISO vanoxerine inhibits the reaction [[GDNF protein co-treated with Cyclic AMP] results in increased susceptibility to 1-Methyl-4-phenylpyridinium] CTD PMID:19647008 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO vanoxerine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:19583963 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Pdyn prodynorphin affects expression EXP vanoxerine affects the expression of PDYN protein CTD PMID:14997015 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
JBrowse link
G Slc18a2 solute carrier family 18 member A2 affects binding ISO vanoxerine binds to SLC18A2 protein CTD PMID:7912402 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148
JBrowse link
G Slc6a3 solute carrier family 6 member 3 affects binding
decreases activity
multiple interactions
affects response to substance
decreases response to substance
ISO
EXP
vanoxerine binds to SLC6A3 protein
vanoxerine results in decreased activity of SLC6A3 protein
vanoxerine affects the reaction [Cocaine affects the expression of SLC6A3 protein]
SLC6A3 protein affects the susceptibility to vanoxerine
vanoxerine inhibits the reaction [SLC6A3 protein promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of Dopamine]]
SLC6A3 gene mutant form results in decreased susceptibility to vanoxerine
[vanoxerine results in decreased activity of SLC6A3 protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium; vanoxerine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]
CTD PMID:11222668, PMID:11249581, PMID:11312315, PMID:17250655, PMID:18206288, PMID:18561912, PMID:19616025, PMID:22342763 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO vanoxerine inhibits the reaction [Dopamine analog results in increased expression of TNF protein] CTD PMID:27026709 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
venlafaxine hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
increases export
ISO Venlafaxine Hydrochloride results in increased expression of ABCB1 mRNA
ABCB1 protein results in increased export of Venlafaxine Hydrochloride
CTD PMID:14550684, PMID:17191263 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO Venlafaxine Hydrochloride results in increased expression of ABCC1 mRNA CTD PMID:17191263 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Ace angiotensin I converting enzyme increases expression EXP Venlafaxine Hydrochloride results in increased expression of ACE mRNA CTD PMID:25423262 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant decreases expression ISO Venlafaxine Hydrochloride results in decreased expression of ACP5 mRNA CTD PMID:16341940 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
JBrowse link
G Acvr1c activin A receptor type 1C increases expression EXP Venlafaxine Hydrochloride results in increased expression of ACVR1C mRNA CTD PMID:25423262 NCBI chr 3:44,272,859...44,342,501
Ensembl chr 3:44,270,653...44,342,355
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 increases expression EXP Venlafaxine Hydrochloride results in increased expression of ADAM10 mRNA CTD PMID:25423262 NCBI chr 8:77,107,355...77,237,483
Ensembl chr 8:77,107,536...77,237,483
JBrowse link
G Adgrl1 adhesion G protein-coupled receptor L1 affects expression EXP Venlafaxine Hydrochloride affects the expression of ADGRL1 mRNA CTD PMID:25423262 NCBI chr19:25,029,037...25,069,146
Ensembl chr19:25,029,037...25,069,142
JBrowse link
G Ago2 argonaute RISC catalytic component 2 increases expression EXP Venlafaxine Hydrochloride results in increased expression of AGO2 mRNA CTD PMID:25423262 NCBI chr 7:114,339,607...114,377,277
Ensembl chr 7:114,339,434...114,380,613
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression EXP Venlafaxine Hydrochloride results in increased expression of AHR mRNA CTD PMID:25423262 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akap5 A-kinase anchoring protein 5 increases expression EXP Venlafaxine Hydrochloride results in increased expression of AKAP5 mRNA CTD PMID:25423262 NCBI chr 6:99,356,509...99,361,909
Ensembl chr 6:99,356,509...99,361,909
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression EXP Venlafaxine Hydrochloride results in increased expression of AKT1 protein CTD PMID:18511088 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin multiple interactions EXP Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in decreased expression of ALB protein] CTD PMID:29852128 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Alcam activated leukocyte cell adhesion molecule increases expression EXP Venlafaxine Hydrochloride results in increased expression of ALCAM mRNA CTD PMID:25423262 NCBI chr11:50,780,735...50,985,083
Ensembl chr11:50,781,127...50,985,083
JBrowse link
G Ankrd55 ankyrin repeat domain 55 increases expression ISO Venlafaxine Hydrochloride results in increased expression of ANKRD55 mRNA CTD PMID:16341940 NCBI chr 2:43,819,234...44,196,602
Ensembl chr 2:44,096,061...44,196,605
JBrowse link
G Ap2b1 adaptor related protein complex 2 subunit beta 1 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of AP2B1 mRNA CTD PMID:25423262 NCBI chr10:70,516,462...70,621,973
Ensembl chr10:70,520,206...70,621,977
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein increases expression EXP Venlafaxine Hydrochloride results in increased expression of ARC mRNA; Venlafaxine Hydrochloride results in increased expression of ARC protein CTD PMID:14580947, PMID:15087240, PMID:15838995 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541
JBrowse link
G Arf3 ADP-ribosylation factor 3 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of ARF3 mRNA CTD PMID:25423262 NCBI chr 7:140,412,463...140,438,751
Ensembl chr 7:140,398,199...140,437,467
JBrowse link
G Arhgap10 Rho GTPase activating protein 10 increases expression ISO Venlafaxine Hydrochloride results in increased expression of ARHGAP10 mRNA CTD PMID:16341940 NCBI chr19:34,138,978...34,406,593
Ensembl chr19:34,139,997...34,402,436
JBrowse link
G Arhgef9 Cdc42 guanine nucleotide exchange factor 9 increases expression EXP Venlafaxine Hydrochloride results in increased expression of ARHGEF9 mRNA CTD PMID:25423262 NCBI chr  X:64,249,576...64,428,444
Ensembl chr  X:64,248,278...64,428,592
JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 decreases expression
increases expression
EXP Venlafaxine Hydrochloride results in decreased expression of ASCL1 mRNA
Venlafaxine Hydrochloride results in increased expression of ASCL1 mRNA
CTD PMID:25423262 NCBI chr 7:28,038,662...28,040,504
Ensembl chr 7:28,038,662...28,040,510
JBrowse link
G Atp2b3 ATPase plasma membrane Ca2+ transporting 3 increases expression EXP Venlafaxine Hydrochloride results in increased expression of ATP2B3 mRNA CTD PMID:25423262 NCBI chr  X:157,236,400...157,312,028
Ensembl chr  X:157,239,306...157,312,028
JBrowse link
G Atrx ATRX, chromatin remodeler increases expression EXP Venlafaxine Hydrochloride results in increased expression of ATRX mRNA CTD PMID:25423262 NCBI chr  X:76,820,110...76,979,155
Ensembl chr  X:76,692,970...76,708,878
Ensembl chr  X:76,692,970...76,708,878
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in increased expression of BAX protein] CTD PMID:29852128 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
EXP Venlafaxine Hydrochloride results in decreased expression of BCL2 mRNA
Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]
CTD PMID:25423262, PMID:29852128 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Venlafaxine Hydrochloride results in increased expression of BDNF mRNA CTD PMID:17950272 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Brinp3 BMP/retinoic acid inducible neural specific 3 increases expression ISO Venlafaxine Hydrochloride results in increased expression of BRINP3 mRNA CTD PMID:16341940 NCBI chr13:63,526,486...63,959,390
Ensembl chr13:63,526,486...63,959,332
JBrowse link
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 increases expression EXP Venlafaxine Hydrochloride results in increased expression of CACNB4 mRNA CTD PMID:25423262 NCBI chr 3:37,950,846...38,211,478
Ensembl chr 3:37,955,069...38,090,526
JBrowse link
G Calm3 calmodulin 3 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of CALM3 mRNA CTD PMID:25423262 NCBI chr 1:78,844,520...78,851,628
Ensembl chr 1:78,843,080...78,851,719
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha increases expression EXP Venlafaxine Hydrochloride results in increased expression of CAMK2A mRNA CTD PMID:25423262 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta affects expression EXP Venlafaxine Hydrochloride affects the expression of CAMK2B mRNA CTD PMID:25423262 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652
JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma affects expression EXP Venlafaxine Hydrochloride affects the expression of CAMK2G mRNA CTD PMID:25423262 NCBI chr15:3,936,721...3,995,740
Ensembl chr15:3,936,786...3,995,915
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein] CTD PMID:29852128 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions EXP Nitric Oxide promotes the reaction [Venlafaxine Hydrochloride inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]]; Venlafaxine Hydrochloride inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in decreased activity of CAT protein] CTD PMID:20305041, PMID:29852128 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cd47 Cd47 molecule decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of CD47 mRNA CTD PMID:25423262 NCBI chr11:53,511,485...53,575,754
Ensembl chr11:53,514,595...53,575,175
JBrowse link
G Cdh22 cadherin 22 affects expression EXP Venlafaxine Hydrochloride affects the expression of CDH22 mRNA CTD PMID:25423262 NCBI chr 3:161,574,993...161,971,102
Ensembl chr 3:161,575,631...161,917,285
JBrowse link
G Celf2 CUGBP, Elav-like family member 2 increases expression EXP Venlafaxine Hydrochloride results in increased expression of CELF2 mRNA CTD PMID:25423262 NCBI chr17:75,259,269...75,660,154
Ensembl chr17:75,352,389...75,654,951
JBrowse link
G Clns1a chloride nucleotide-sensitive channel 1A decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of CLNS1A mRNA CTD PMID:25423262 NCBI chr 1:162,676,246...162,696,549
Ensembl chr 1:162,676,269...162,696,544
JBrowse link
G Clstn2 calsyntenin 2 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of CLSTN2 mRNA CTD PMID:25423262 NCBI chr 8:105,322,577...106,036,821
Ensembl chr 8:105,323,837...105,462,168
JBrowse link
G Cnbp CCHC-type zinc finger, nucleic acid binding protein increases expression EXP Venlafaxine Hydrochloride results in increased expression of CNBP mRNA CTD PMID:25423262 NCBI chr 4:119,747,890...119,756,787
Ensembl chr 4:119,747,911...119,756,765
JBrowse link
G Cnr1 cannabinoid receptor 1 increases expression EXP Venlafaxine Hydrochloride results in increased expression of CNR1 mRNA CTD PMID:25423262 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Cntn2 contactin 2 increases expression EXP Venlafaxine Hydrochloride results in increased expression of CNTN2 mRNA CTD PMID:25423262 NCBI chr13:49,280,913...49,314,061
Ensembl chr13:49,285,310...49,313,940
JBrowse link
G Cox17 cytochrome c oxidase copper chaperone COX17 increases expression EXP Venlafaxine Hydrochloride results in increased expression of COX17 mRNA CTD PMID:25423262 NCBI chr11:64,962,663...64,968,437
Ensembl chr11:64,962,666...64,968,437
JBrowse link
G Cpd carboxypeptidase D increases expression EXP Venlafaxine Hydrochloride results in increased expression of CPD mRNA CTD PMID:25423262 NCBI chr10:63,325,764...63,389,811
Ensembl chr10:63,325,199...63,389,817
JBrowse link
G Ctnnb1 catenin beta 1 increases expression EXP Venlafaxine Hydrochloride results in increased expression of CTNNB1 protein CTD PMID:18511088 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxxc4 CXXC finger protein 4 increases expression EXP Venlafaxine Hydrochloride results in increased expression of CXXC4 mRNA CTD PMID:25423262 NCBI chr 2:239,414,882...239,439,640
Ensembl chr 2:239,415,046...239,439,568
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions
decreases activity
ISO Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased hydroxylation of Pregnenolone]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased hydroxylation of Progesterone]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone]
Venlafaxine Hydrochloride results in decreased activity of CYP17A1 protein
CTD PMID:29100959 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects methylation
decreases methylation
ISO CYP2C19 gene polymorphism affects the methylation of Venlafaxine Hydrochloride
CYP2C19 protein results in decreased methylation of Venlafaxine Hydrochloride
CTD PMID:10877013 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
decreases activity
increases metabolic processing
decreases methylation
affects response to substance
affects methylation
ISO CYP2D6 gene mutant form affects the metabolism of Venlafaxine Hydrochloride; CYP2D6 gene polymorphism affects the metabolism of Venlafaxine Hydrochloride
Venlafaxine Hydrochloride results in decreased activity of CYP2D6 protein
CYP2D6 protein results in increased metabolism of Venlafaxine Hydrochloride
CYP2D6 protein results in decreased methylation of Venlafaxine Hydrochloride
CYP2D6 protein affects the susceptibility to Venlafaxine Hydrochloride
CYP2D6 gene polymorphism affects the methylation of Venlafaxine Hydrochloride
CTD PMID:10774634, PMID:10877013, PMID:10933885, PMID:15632378, PMID:16044105, PMID:16958828, PMID:17803873, PMID:18214456 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Dab2 DAB adaptor protein 2 increases expression EXP Venlafaxine Hydrochloride results in increased expression of DAB2 mRNA CTD PMID:25423262 NCBI chr 2:55,747,353...55,768,848
Ensembl chr 2:55,747,318...55,768,270
JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 increases expression EXP Venlafaxine Hydrochloride results in increased expression of DDAH1 mRNA CTD PMID:25423262 NCBI chr 2:251,634,368...251,766,009
Ensembl chr 2:251,634,431...251,766,014
JBrowse link
G Dmac1 distal membrane arm assembly complex 1 increases expression ISO Venlafaxine Hydrochloride results in increased expression of DMAC1 mRNA CTD PMID:16341940 NCBI chr 5:92,038,050...92,039,146
Ensembl chr 5:92,038,050...92,039,146
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha increases expression EXP Venlafaxine Hydrochloride results in increased expression of DNMT3A mRNA CTD PMID:25423262 NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
JBrowse link
G Dpp4 dipeptidylpeptidase 4 increases expression EXP Venlafaxine Hydrochloride results in increased expression of DPP4 mRNA CTD PMID:25423262 NCBI chr 3:48,291,055...48,372,672
Ensembl chr 3:48,291,055...48,372,672
JBrowse link
G Ednrb endothelin receptor type B increases expression EXP Venlafaxine Hydrochloride results in increased expression of EDNRB mRNA CTD PMID:25423262 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of ENPP1 mRNA CTD PMID:25423262 NCBI chr 1:21,748,201...21,813,205
Ensembl chr 1:21,748,261...21,813,371
JBrowse link
G Epha5 EPH receptor A5 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of EPHA5 mRNA CTD PMID:25423262 NCBI chr14:25,589,312...25,958,258
Ensembl chr14:25,589,762...25,958,227
JBrowse link
G Fmnl1 formin-like 1 increases expression ISO Venlafaxine Hydrochloride results in increased expression of FMNL1 mRNA CTD PMID:16341940 NCBI chr10:91,253,757...91,281,422
Ensembl chr10:91,254,058...91,281,418
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 increases expression EXP Venlafaxine Hydrochloride results in increased expression of GABRB1 mRNA CTD PMID:25423262 NCBI chr14:38,631,192...39,112,598
Ensembl chr14:38,643,385...39,112,600
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 increases expression EXP Venlafaxine Hydrochloride results in increased expression of GABRB2 mRNA CTD PMID:25423262 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gad2 glutamate decarboxylase 2 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of GAD2 mRNA CTD PMID:25423262 NCBI chr17:89,171,576...89,234,770
Ensembl chr17:89,171,250...89,238,040
JBrowse link
G Gas2 growth arrest-specific 2 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of GAS2 mRNA CTD PMID:25423262 NCBI chr 1:107,234,389...107,363,624
Ensembl chr 1:107,262,659...107,363,788
JBrowse link
G Gas6 growth arrest specific 6 increases expression EXP Venlafaxine Hydrochloride results in increased expression of GAS6 mRNA CTD PMID:25423262 NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757
JBrowse link
G Gda guanine deaminase increases expression EXP Venlafaxine Hydrochloride results in increased expression of GDA mRNA CTD PMID:25423262 NCBI chr 1:238,982,542...239,057,663
Ensembl chr 1:238,982,392...239,057,732
JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Venlafaxine Hydrochloride results in increased expression of GFAP mRNA CTD PMID:25423262 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Glp1r glucagon-like peptide 1 receptor decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of GLP1R mRNA CTD PMID:25423262 NCBI chr20:9,586,075...9,626,228
Ensembl chr20:9,586,075...9,626,228
JBrowse link
G Gnao1 G protein subunit alpha o1 increases expression EXP Venlafaxine Hydrochloride results in increased expression of GNAO1 mRNA CTD PMID:25423262 NCBI chr19:11,513,201...11,669,578
Ensembl chr19:11,513,201...11,669,578
JBrowse link
G Gnaq G protein subunit alpha q affects expression EXP Venlafaxine Hydrochloride affects the expression of GNAQ mRNA CTD PMID:25423262 NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 increases expression EXP Venlafaxine Hydrochloride results in increased expression of GRIA1 mRNA CTD PMID:25423262 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of GRIA3 mRNA CTD PMID:25423262 NCBI chr  X:127,561,843...127,829,763
Ensembl chr  X:127,562,660...127,829,753
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A affects expression EXP Venlafaxine Hydrochloride affects the expression of GRIN2A mRNA CTD PMID:25423262 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B affects expression EXP Venlafaxine Hydrochloride affects the expression of GRIN2B mRNA CTD PMID:25423262 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of HCN1 mRNA CTD PMID:25423262 NCBI chr 2:50,099,576...50,499,799
Ensembl chr 2:50,099,576...50,499,799
JBrowse link
G Hook2 hook microtubule-tethering protein 2 increases expression EXP Venlafaxine Hydrochloride results in increased expression of HOOK2 mRNA CTD PMID:25423262 NCBI chr19:26,106,713...26,119,353
Ensembl chr19:26,106,838...26,119,352
JBrowse link
G Il1rapl1 interleukin 1 receptor accessory protein-like 1 increases expression EXP Venlafaxine Hydrochloride results in increased expression of IL1RAPL1 mRNA CTD PMID:25423262 NCBI chr  X:55,439,388...57,004,865
Ensembl chr  X:55,439,578...56,765,893
JBrowse link
G Kcnc2 potassium voltage-gated channel subfamily C member 2 increases expression EXP Venlafaxine Hydrochloride results in increased expression of KCNC2 mRNA CTD PMID:25423262 NCBI chr 7:54,978,453...55,159,362
Ensembl chr 7:54,980,120...55,159,351
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Venlafaxine Hydrochloride results in decreased activity of KCNH2 protein CTD PMID:21158687 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Venlafaxine Hydrochloride affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]; Venlafaxine Hydrochloride affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr 3:41,019,898...41,181,070
Ensembl chr 3:41,019,898...41,181,070
JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions ISO Venlafaxine Hydrochloride affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA] CTD PMID:22164246 NCBI chr 8:33,435,493...33,463,410
Ensembl chr 8:33,433,905...33,463,467
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO Venlafaxine Hydrochloride affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr11:35,011,007...35,262,362
Ensembl chr11:35,024,196...35,099,383
JBrowse link
G Kcnk1 potassium two pore domain channel subfamily K member 1 increases expression EXP Venlafaxine Hydrochloride results in increased expression of KCNK1 mRNA CTD PMID:25423262 NCBI chr19:58,823,836...58,862,926
Ensembl chr19:58,823,814...58,862,926
JBrowse link
G Kif1b kinesin family member 1B decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of KIF1B mRNA CTD PMID:25423262 NCBI chr 5:165,994,803...166,133,497
Ensembl chr 5:165,938,576...166,133,491
JBrowse link
G Kif2b kinesin family member 2B decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of KIF2B mRNA CTD PMID:25423262 NCBI chr10:79,095,588...79,097,807
Ensembl chr10:79,095,593...79,097,807
JBrowse link
G Kif5a kinesin family member 5A decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of KIF5A mRNA CTD PMID:25423262 NCBI chr 7:70,515,832...70,552,897
Ensembl chr 7:70,513,343...70,556,827
JBrowse link
G Klf6 Kruppel-like factor 6 increases expression EXP Venlafaxine Hydrochloride results in increased expression of KLF6 mRNA CTD PMID:25423262 NCBI chr17:67,887,939...67,945,052
Ensembl chr17:67,887,939...67,945,037
JBrowse link
G Klhl24 kelch-like family member 24 increases expression EXP Venlafaxine Hydrochloride results in increased expression of KLHL24 mRNA CTD PMID:25423262 NCBI chr11:84,613,101...84,643,674
Ensembl chr11:84,615,760...84,633,504
JBrowse link
G Klk10 kallikrein related-peptidase 10 decreases expression ISO Venlafaxine Hydrochloride results in decreased expression of KLK10 mRNA CTD PMID:16341940 NCBI chr 1:99,718,275...99,722,743
Ensembl chr 1:99,718,907...99,722,284
JBrowse link
G Large1 LARGE xylosyl- and glucuronyltransferase 1 decreases expression ISO Venlafaxine Hydrochloride results in decreased expression of LARGE1 mRNA CTD PMID:16341940 NCBI chr19:12,481,563...12,945,320
Ensembl chr19:12,481,540...12,942,963
JBrowse link
G Lipg lipase G, endothelial type increases expression ISO Venlafaxine Hydrochloride results in increased expression of LIPG mRNA CTD PMID:16341940 NCBI chr18:70,903,528...70,924,434
Ensembl chr18:70,901,710...70,924,708
JBrowse link
G Lman1 lectin, mannose-binding, 1 increases expression EXP Venlafaxine Hydrochloride results in increased expression of LMAN1 mRNA CTD PMID:25423262 NCBI chr18:61,683,377...61,707,344
Ensembl chr18:61,685,117...61,707,317
JBrowse link
G Lmo7 LIM domain 7 decreases expression ISO Venlafaxine Hydrochloride results in decreased expression of LMO7 mRNA CTD PMID:16341940 NCBI chr15:86,242,911...86,458,512
Ensembl chr15:86,243,148...86,457,739
JBrowse link
G Lpl lipoprotein lipase increases expression EXP Venlafaxine Hydrochloride results in increased expression of LPL mRNA CTD PMID:25423262 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 increases expression EXP Venlafaxine Hydrochloride results in increased expression of MAGI2 mRNA CTD PMID:25423262 NCBI chr 4:10,995,241...12,472,423
Ensembl chr 4:10,995,234...11,610,518
JBrowse link
G Map2 microtubule-associated protein 2 increases expression EXP Venlafaxine Hydrochloride results in increased expression of MAP2 mRNA CTD PMID:25423262 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP Venlafaxine Hydrochloride results in increased phosphorylation of MAPK1 protein CTD PMID:18511088 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation EXP Venlafaxine Hydrochloride results in increased phosphorylation of MAPK3 protein CTD PMID:18511088 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mfng MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of MFNG mRNA CTD PMID:25423262 NCBI chr 7:119,978,981...119,996,824
Ensembl chr 7:119,978,983...119,996,824
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of MMP9 mRNA CTD PMID:25423262 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpp2 membrane palmitoylated protein 2 increases expression EXP Venlafaxine Hydrochloride results in increased expression of MPP2 mRNA CTD PMID:25423262 NCBI chr10:89,998,284...90,030,766
Ensembl chr10:89,999,917...90,030,639
JBrowse link
G Mvp major vault protein decreases expression ISO Venlafaxine Hydrochloride results in decreased expression of MVP mRNA CTD PMID:16341940 NCBI chr 1:198,420,813...198,448,612
Ensembl chr 1:198,420,806...198,450,047
JBrowse link
G Myo5a myosin VA decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of MYO5A mRNA CTD PMID:25423262 NCBI chr 8:82,038,966...82,156,507
Ensembl chr 8:82,037,977...82,156,617
JBrowse link
G Nasp nuclear autoantigenic sperm protein increases expression ISO Venlafaxine Hydrochloride results in increased expression of NASP mRNA CTD PMID:16341940 NCBI chr 5:135,446,485...135,472,113
Ensembl chr 5:135,446,962...135,472,116
JBrowse link
G Negr1 neuronal growth regulator 1 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of NEGR1 mRNA CTD PMID:25423262 NCBI chr 2:262,914,240...263,650,441
Ensembl chr 2:262,914,327...263,650,441
JBrowse link
G Nell2 neural EGFL like 2 increases expression EXP Venlafaxine Hydrochloride results in increased expression of NELL2 mRNA CTD PMID:25423262 NCBI chr 7:136,526,497...136,853,820
Ensembl chr 7:136,526,496...136,853,957
JBrowse link
G Neurod1 neuronal differentiation 1 increases expression EXP Venlafaxine Hydrochloride results in increased expression of NEUROD1 mRNA CTD PMID:25423262 NCBI chr 3:66,414,314...66,417,617
Ensembl chr 3:66,414,308...66,417,741
JBrowse link
G Nfix nuclear factor I X increases expression EXP Venlafaxine Hydrochloride results in increased expression of NFIX mRNA CTD PMID:25423262 NCBI chr19:25,818,640...25,914,777
Ensembl chr19:25,821,780...25,914,696
JBrowse link
G Nptxr neuronal pentraxin receptor decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of NPTXR mRNA CTD PMID:25423262 NCBI chr 7:121,011,678...121,029,754
Ensembl chr 7:121,011,680...121,029,754
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of NR3C1 mRNA CTD PMID:11406320 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of NR3C2 mRNA CTD PMID:11406320 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Nsun2 NOP2/Sun RNA methyltransferase 2 decreases expression ISO Venlafaxine Hydrochloride results in decreased expression of NSUN2 mRNA CTD PMID:16341940 NCBI chr 1:36,295,650...36,319,906
Ensembl chr 1:36,295,650...36,319,966
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of NTRK2 mRNA CTD PMID:25423262 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of NTRK3 mRNA CTD PMID:25423262 NCBI chr 1:139,890,537...140,262,503
Ensembl chr 1:139,890,560...140,262,503
JBrowse link
G Pdap1 PDGFA associated protein 1 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of PDAP1 mRNA CTD PMID:25423262 NCBI chr12:11,240,775...11,251,002
Ensembl chr12:11,240,761...11,251,004
JBrowse link
G Pde4b phosphodiesterase 4B increases expression EXP Venlafaxine Hydrochloride results in increased expression of PDE4B mRNA CTD PMID:25423262 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
JBrowse link
G Pde4d phosphodiesterase 4D increases expression EXP Venlafaxine Hydrochloride results in increased expression of PDE4D mRNA CTD PMID:25423262 NCBI chr 2:40,219,999...41,468,551
Ensembl chr 2:40,554,146...41,464,264
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of PDIA3 mRNA CTD PMID:25423262 NCBI chr 3:113,376,983...113,400,707
Ensembl chr 3:113,376,983...113,400,707
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 affects expression EXP Venlafaxine Hydrochloride affects the expression of PDPK1 mRNA CTD PMID:25423262 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448
JBrowse link
G Pex2 peroxisomal biogenesis factor 2 affects expression EXP Venlafaxine Hydrochloride affects the expression of PEX2 mRNA CTD PMID:25423262 NCBI chr 2:98,251,756...98,269,185
Ensembl chr 2:98,252,925...98,269,184
JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of PGRMC1 mRNA CTD PMID:25423262 NCBI chr  X:123,205,869...123,213,880
Ensembl chr  X:123,205,869...123,213,882
JBrowse link
G Pim3 Pim-3 proto-oncogene, serine/threonine kinase decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of PIM3 mRNA CTD PMID:25423262 NCBI chr 7:129,856,467...129,863,441
Ensembl chr 7:129,860,114...129,863,441
JBrowse link
G Pou3f2 POU class 3 homeobox 2 increases expression EXP Venlafaxine Hydrochloride results in increased expression of POU3F2 mRNA CTD PMID:25423262 NCBI chr 5:36,677,452...36,683,356
Ensembl chr 5:36,681,528...36,683,356
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha increases expression EXP Venlafaxine Hydrochloride results in increased expression of PPP1CA mRNA CTD PMID:25423262 NCBI chr 1:219,439,953...219,443,570
Ensembl chr 1:219,439,953...219,443,570
JBrowse link
G Ppp1r3a protein phosphatase 1, regulatory subunit 3A increases expression EXP Venlafaxine Hydrochloride results in increased expression of PPP1R3A mRNA CTD PMID:25423262 NCBI chr 4:41,171,486...41,212,116
Ensembl chr 4:41,171,486...41,212,072
JBrowse link
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of PPP1R9B mRNA CTD PMID:25423262 NCBI chr10:82,800,704...82,816,735
Ensembl chr10:82,800,704...82,816,731
JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of PPP3R1 mRNA CTD PMID:25423262 NCBI chr14:100,311,224...100,360,879
Ensembl chr14:100,311,173...100,360,879
JBrowse link
G Prap1 proline-rich acidic protein 1 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of PRAP1 mRNA CTD PMID:25423262 NCBI chr 1:212,558,257...212,562,053
Ensembl chr 1:212,558,257...212,562,051
JBrowse link
G Prdx1 peroxiredoxin 1 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of PRDX1 mRNA CTD PMID:25423262 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Prex2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 decreases expression ISO Venlafaxine Hydrochloride results in decreased expression of PREX2 mRNA CTD PMID:16341940 NCBI chr 5:7,622,668...7,941,715
Ensembl chr 5:7,627,771...7,941,822
JBrowse link
G Prkce protein kinase C, epsilon increases expression EXP Venlafaxine Hydrochloride results in increased expression of PRKCE mRNA CTD PMID:25423262 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
JBrowse link
G Prkg2 protein kinase cGMP-dependent 2 increases expression EXP Venlafaxine Hydrochloride results in increased expression of PRKG2 mRNA CTD PMID:25423262 NCBI chr14:12,217,121...12,313,616
Ensembl chr14:12,218,553...12,315,229
JBrowse link
G Prl prolactin increases expression ISO Venlafaxine Hydrochloride results in increased expression of PRL protein CTD PMID:17606668 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Pyy peptide YY increases expression EXP Venlafaxine Hydrochloride results in increased expression of PYY mRNA CTD PMID:25423262 NCBI chr10:90,047,989...90,049,155
Ensembl chr10:90,047,993...90,049,112
JBrowse link
G Rab14 RAB14, member RAS oncogene family increases expression EXP Venlafaxine Hydrochloride results in increased expression of RAB14 mRNA CTD PMID:25423262 NCBI chr 3:14,373,270...14,395,357
Ensembl chr 3:14,373,275...14,395,362
JBrowse link
G Rab4b RAB4B, member RAS oncogene family increases expression EXP Venlafaxine Hydrochloride results in increased expression of RAB4B mRNA CTD PMID:25423262 NCBI chr 1:83,979,298...83,990,680
Ensembl chr 1:83,979,298...83,990,588
JBrowse link
G Rcc1 regulator of chromosome condensation 1 increases expression ISO Venlafaxine Hydrochloride results in increased expression of RCC1 mRNA CTD PMID:16341940 NCBI chr 5:150,508,840...150,531,062
Ensembl chr 5:150,509,040...150,525,254
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in increased expression of RELA protein] CTD PMID:29852128 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of RIMS1 mRNA CTD PMID:25423262 NCBI chr 9:28,440,408...28,973,246
Ensembl chr 9:28,442,229...28,973,246
JBrowse link
G Ring1 ring finger protein 1 increases expression ISO Venlafaxine Hydrochloride results in increased expression of RING1 mRNA CTD PMID:16341940 NCBI chr20:3,812,287...3,815,834
Ensembl chr20:3,812,287...3,815,834
JBrowse link
G Rph3a rabphilin 3A decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of RPH3A mRNA CTD PMID:25423262 NCBI chr12:41,073,296...41,149,799
Ensembl chr12:41,073,824...41,148,490
JBrowse link
G Sall1 spalt-like transcription factor 1 increases expression ISO Venlafaxine Hydrochloride results in increased expression of SALL1 mRNA CTD PMID:16341940 NCBI chr19:23,387,737...23,405,025
Ensembl chr19:23,389,375...23,405,039
JBrowse link
G Serpini1 serpin family I member 1 increases expression EXP Venlafaxine Hydrochloride results in increased expression of SERPINI1 mRNA CTD PMID:16637596 NCBI chr 2:174,013,058...174,111,693
Ensembl chr 2:174,013,288...174,111,752
JBrowse link
G Sgtb small glutamine rich tetratricopeptide repeat containing beta increases expression EXP Venlafaxine Hydrochloride results in increased expression of SGTB mRNA CTD PMID:25423262 NCBI chr 2:34,185,938...34,222,428
Ensembl chr 2:34,186,091...34,219,802
JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 increases expression EXP Venlafaxine Hydrochloride results in increased expression of SHANK2 mRNA CTD PMID:25423262 NCBI chr 1:217,149,156...217,593,950
Ensembl chr 1:217,151,166...217,592,763
JBrowse link
G Sipa1l1 signal-induced proliferation-associated 1 like 1 increases expression EXP Venlafaxine Hydrochloride results in increased expression of SIPA1L1 mRNA CTD PMID:25423262 NCBI chr 6:106,052,212...106,163,249
Ensembl chr 6:106,039,991...106,163,302
JBrowse link
G Slc26a3 solute carrier family 26 member 3 increases expression EXP Venlafaxine Hydrochloride results in increased expression of SLC26A3 mRNA CTD PMID:25423262 NCBI chr 6:50,725,085...50,766,306
Ensembl chr 6:50,725,085...50,766,300
JBrowse link
G Slc2a4 solute carrier family 2 member 4 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of SLC2A4 mRNA CTD PMID:25423262 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc4a4 solute carrier family 4 member 4 increases expression EXP Venlafaxine Hydrochloride results in increased expression of SLC4A4 mRNA CTD PMID:25423262 NCBI chr14:20,476,258...20,817,042
Ensembl chr14:20,479,323...20,920,286
JBrowse link
G Slc5a1 solute carrier family 5 member 1 increases expression EXP Venlafaxine Hydrochloride results in increased expression of SLC5A1 mRNA CTD PMID:25423262 NCBI chr14:82,910,448...82,975,303
Ensembl chr14:82,909,981...82,975,263
JBrowse link
G Slc6a4 solute carrier family 6 member 4 affects response to substance ISO SLC6A4 gene polymorphism affects the susceptibility to Venlafaxine Hydrochloride CTD PMID:17503984 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Slc6a6 solute carrier family 6 member 6 increases expression EXP Venlafaxine Hydrochloride results in increased expression of SLC6A6 mRNA CTD PMID:25423262 NCBI chr 4:123,638,619...123,713,469
Ensembl chr 4:123,642,210...123,713,464
JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP Venlafaxine Hydrochloride results in increased expression of SOD1 mRNA CTD PMID:10721683 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Spn sialophorin increases expression EXP Venlafaxine Hydrochloride results in increased expression of SPN mRNA CTD PMID:25423262 NCBI chr 1:198,572,999...198,585,664
Ensembl chr 1:198,572,999...198,577,226
JBrowse link
G Sqstm1 sequestosome 1 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of SQSTM1 mRNA CTD PMID:25423262 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Stau2 staufen double-stranded RNA binding protein 2 increases expression EXP Venlafaxine Hydrochloride results in increased expression of STAU2 mRNA CTD PMID:25423262 NCBI chr 5:2,257,910...2,497,429 JBrowse link
G Stk39 serine threonine kinase 39 increases expression EXP Venlafaxine Hydrochloride results in increased expression of STK39 mRNA CTD PMID:25423262 NCBI chr 3:54,359,449...54,625,702
Ensembl chr 3:54,359,451...54,625,414
JBrowse link
G Sv2b synaptic vesicle glycoprotein 2b affects expression EXP Venlafaxine Hydrochloride affects the expression of SV2B mRNA CTD PMID:25423262 NCBI chr 1:136,664,199...136,842,247
Ensembl chr 1:136,664,204...136,842,247
JBrowse link
G Syn2 synapsin II decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of SYN2 mRNA CTD PMID:25423262 NCBI chr 4:147,037,179...147,195,096
Ensembl chr 4:147,037,179...147,195,096
JBrowse link
G Synj2 synaptojanin 2 affects expression EXP Venlafaxine Hydrochloride affects the expression of SYNJ2 mRNA CTD PMID:25423262 NCBI chr 1:46,835,922...46,932,544
Ensembl chr 1:46,835,971...46,932,529
JBrowse link
G Syp synaptophysin increases expression EXP Venlafaxine Hydrochloride results in increased expression of SYP mRNA CTD PMID:17950272 NCBI chr  X:15,694,699...15,709,244
Ensembl chr  X:15,695,566...15,707,436
JBrowse link
G Syt4 synaptotagmin 4 increases expression ISO Venlafaxine Hydrochloride results in increased expression of SYT4 mRNA CTD PMID:16341940 NCBI chr18:24,172,580...24,181,989
Ensembl chr18:24,172,587...24,182,012
JBrowse link
G Tacr3 tachykinin receptor 3 increases expression EXP Venlafaxine Hydrochloride results in increased expression of TACR3 mRNA CTD PMID:25423262 NCBI chr 2:240,021,152...240,118,971
Ensembl chr 2:240,021,152...240,118,971
JBrowse link
G Tcf12 transcription factor 12 decreases expression ISO Venlafaxine Hydrochloride results in decreased expression of TCF12 mRNA CTD PMID:16341940 NCBI chr 8:78,343,634...78,657,738
Ensembl chr 8:78,345,754...78,655,856
JBrowse link
G Tcf4 transcription factor 4 increases expression EXP Venlafaxine Hydrochloride results in increased expression of TCF4 mRNA CTD PMID:25423262 NCBI chr18:65,285,320...65,507,983
Ensembl chr18:65,155,685...65,507,977
JBrowse link
G Thbd thrombomodulin decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of THBD mRNA CTD PMID:25423262 NCBI chr 3:142,748,673...142,752,325
Ensembl chr 3:142,748,674...142,752,325
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in increased expression of TP53 protein] CTD PMID:29852128 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trim13 tripartite motif-containing 13 decreases expression ISO Venlafaxine Hydrochloride results in decreased expression of TRIM13 mRNA CTD PMID:16341940 NCBI chr15:41,897,191...41,936,545
Ensembl chr15:41,927,241...41,935,718
JBrowse link
G Tshr thyroid stimulating hormone receptor increases expression EXP Venlafaxine Hydrochloride results in increased expression of TSHR mRNA CTD PMID:25423262 NCBI chr 6:115,170,290...115,306,871
Ensembl chr 6:115,170,865...115,306,871
JBrowse link
G Txn2 thioredoxin 2 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of TXN2 mRNA CTD PMID:25423262 NCBI chr 7:119,144,350...119,158,173
Ensembl chr 7:119,144,351...119,158,201
JBrowse link
G Ube2q1 ubiquitin conjugating enzyme E2 Q1 decreases expression ISO Venlafaxine Hydrochloride results in decreased expression of UBE2Q1 mRNA CTD PMID:16341940 NCBI chr 2:189,106,039...189,115,110
Ensembl chr 2:189,106,039...189,115,108
JBrowse link
G Ucp3 uncoupling protein 3 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of UCP3 mRNA CTD PMID:25423262 NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206
JBrowse link
G Unc13b unc-13 homolog B decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of UNC13B mRNA CTD PMID:25423262 NCBI chr 5:58,505,449...58,714,396
Ensembl chr 5:58,505,500...58,715,576
JBrowse link
G Vamp1 vesicle-associated membrane protein 1 decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of VAMP1 mRNA CTD PMID:25423262 NCBI chr 4:157,726,941...157,733,644
Ensembl chr 4:157,726,941...157,733,643
JBrowse link
G Vcpip1 valosin containing protein interacting protein 1 increases expression EXP Venlafaxine Hydrochloride results in increased expression of VCPIP1 mRNA CTD PMID:25423262 NCBI chr 5:9,231,180...9,257,821
Ensembl chr 5:9,230,984...9,257,934
JBrowse link
G Vdac1 voltage-dependent anion channel 1 increases expression EXP Venlafaxine Hydrochloride results in increased expression of VDAC1 mRNA CTD PMID:25423262 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826
JBrowse link
G Vegfb vascular endothelial growth factor B decreases expression EXP Venlafaxine Hydrochloride results in decreased expression of VEGFB mRNA CTD PMID:25423262 NCBI chr 1:222,237,000...222,242,786
Ensembl chr 1:222,239,022...222,242,644
JBrowse link
G Wdfy1 WD repeat and FYVE domain containing 1 increases expression EXP Venlafaxine Hydrochloride results in increased expression of WDFY1 mRNA CTD PMID:25423262 NCBI chr 9:85,477,070...85,528,885
Ensembl chr 9:85,475,841...85,528,869
JBrowse link
G Zfp24 zinc finger protein 24 increases expression EXP Venlafaxine Hydrochloride results in increased expression of ZFP24 mRNA CTD PMID:25423262 NCBI chr18:15,910,175...15,921,757
Ensembl chr18:15,914,399...15,921,734
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          cofactor 15548
            chloride 8363
              chloride salt 8363
                organic chloride salt 666
                  hydrochloride 436
                    (1R,2S)-tranylcypromine hydrochloride + 0
                    (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride 1
                    (1S,2R)-5-methoxy-1-methyl-2-(propylamino)tetralin hydrochloride 0
                    (1S,2R)-tranylcypromine hydrochloride + 0
                    (2R,3S)-EHNA hydrochloride 0
                    (3S)-3-\{[3',4'-difluoro-5-(\{4'-fluoro-6-[(3S)-pyrrolidinium-3-yloxy][biphenyl]-3-yl\}carbamoyl)[biphenyl]-2-yl]oxy\}pyrrolidinium dichloride 0
                    (R)-DRF053 hydrochloride hydrate 0
                    (R)-adrenaline hydrochloride 0
                    (R)-cyclopentolate hydrochloride 0
                    (R)-cycrimine hydrochloride 0
                    (R)-donepezil hydrochloride + 42
                    (R)-fluoxetine hydrochloride + 1
                    (R)-nefopam hydrochloride + 0
                    (R)-prasugrel hydrochloride + 1
                    (R)-tetrindole hydrochloride + 0
                    (R,R)-tramadol hydrochloride + 0
                    (R,S,S,S)-nebivolol hydrochloride + 0
                    (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane dihydrochloride 0
                    (S)-cyclopentolate hydrochloride 0
                    (S)-cycrimine hydrochloride 0
                    (S)-donepezil hydrochloride + 42
                    (S)-fluoxetine hydrochloride + 1
                    (S)-nefopam hydrochloride + 0
                    (S)-prasugrel hydrochloride + 1
                    (S)-ropivacaine hydrochloride (anhydrous) + 0
                    (S)-tetrindole hydrochloride + 0
                    (S)-verapamil hydrochloride + 0
                    (S,R,R,R)-nebivolol hydrochloride + 0
                    (S,S)-tramadol hydrochloride + 0
                    (aminooxy)acetic acid hemihydrochloride 0
                    1,2-dimethylhydrazine dihydrochloride 0
                    1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride 0
                    1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride 0
                    1-benzyl-2-chloromethylimidazole hydrochloride 0
                    1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride + 0
                    2-(chloromethyl)-4,5-dihydro-1H-imidazole hydrochloride 0
                    2-(chloromethyl)pyridine hydrochloride 0
                    2-dimethylaminoethyl chloride hydrochloride 0
                    2-methyl-6-(phenylethynyl)pyridine hydrochloride 0
                    3,6-diamino-10-methylacridinium chloride.HCl + 0
                    3,6-diaminoacridine dihydrochloride + 0
                    3,6-diaminoacridine monohydrochloride + 0
                    3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol hydrochloride 0
                    4-\{2-[(2-hydroxybenzyl)amino]ethyl\}-2,5-dimethoxybenzonitrile.HCl 0
                    4-fluoro-N-\{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl\}benzamide hydrochloride 1
                    5-aminolevulinic acid hydrochloride 0
                    9-aminoacridine hydrochloride 0
                    BRACO-19 0
                    Bismark brown Y 0
                    CGP 78608 hydrochloride 0
                    D-lysine hydrochloride 0
                    DND-22 dye 0
                    DuP-714 0
                    E-3810 0
                    FR901469 hydrochloride 0
                    GR 127935 hydrochloride 0
                    GS4012 0
                    Hoffman's violet 0
                    L-cysteine hydrochloride + 0
                    L-lysine hydrochloride 0
                    LY-310762 hydrochloride 0
                    Mefloquine hydrochloride 0
                    Methyl violet 2B 0
                    N(6)-\{2-[(1,2-diphenylhydrazinyl)carbonyl]-2-hydroxyhexanoyl\}-6-aminohexylammonium chloride 0
                    N(6)-acetimidoyl-L-lysine dihydrochloride 0
                    N(gamma)-nitro-L-arginine methyl ester hydrochloride 0
                    N,N'-(p-xylylidene)bis(aminoguanidine) dihydrochloride 0
                    N-(1-naphthyl)ethylenediamine dihydrochloride 0
                    N-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-2-(2,6-dimethoxyphenoxy)ethanamine hydrochloride 0
                    N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide hydrochloride 0
                    N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide dihydrochloride 0
                    N-\{2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethyl\}-N-propylpropan-1-amine hydrochloride 1
                    N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-1-propanamine hydrochloride (1:1) 0
                    NSC 23766 trihydrochloride 0
                    Naftifine hydrochloride 0
                    Naratriptan hydrochloride 0
                    PD-153035 hydrochloride 0
                    PF-670462 1
                    RS 39604 hydrochloride 0
                    SB 224289 hydrochloride 0
                    SIS3 0
                    SKF-96365 hydrochloride 14
                    ZM 323881 hydrochloride 0
                    acebutolol hydrochloride 0
                    aclacinomycin T hydrochloride 0
                    acridine half-mustard dihydrochloride 0
                    acridine orange 3
                    acridine red 3B 0
                    acridine yellow 0
                    alectinib hydrochloride 0
                    alfuzosin hydrochloride 0
                    alosetron hydrochloride 0
                    alprenolol hydrochloride 0
                    alverine hydrochloride 0
                    alvocidib hydrochloride 0
                    amantadine hydrochloride 0
                    amiloride hydrochloride + 0
                    amineptine hydrochloride 0
                    amodiaquine hydrochloride 0
                    amorolfine hydrochloride 0
                    anagrelide hydrochloride 0
                    ancitabine hydrochloride 0
                    anileridine dihydrochloride 0
                    apomorphine hydrochloride 0
                    apraclonidine hydrochloride 0
                    arsphenamine 0
                    atomoxetine hydrochloride 1
                    auramine O 35
                    azelastine hydrochloride 0
                    bacampicillin hydrochloride 0
                    bambuterol hydrochloride + 0
                    benazepril hydrochloride 0
                    benserazide hydrochloride 0
                    benzphetamine hydrochloride 0
                    bepridil hydrochloride 0
                    bepridil hydrochloride monohydrate 0
                    betaxolol hydrochloride + 0
                    betazole dihydrochloride 0
                    bevantolol hydrochloride + 0
                    biliverdin hydrochloride 0
                    biperiden hydrochloride 0
                    bleomycin hydrochloride 0
                    bromazine hydrochloride + 0
                    bromhexine hydrochloride 0
                    buclizine dihydrochloride 0
                    buprenorphine hydrochlorie 0
                    buspirone hydrochloride 0
                    butenafine hydrochloride 0
                    cadaverine dihydrochloride 0
                    cariprazine hydrochloride 0
                    carmoxirole hydrochloride 0
                    carteolol hydrochloride 0
                    cefepime hydrochloride 0
                    cefmenoxime hydrochloride 0
                    cefotiam dihydrochloride 0
                    cefotiam hexetil dihydrochloride 0
                    chlordiazepoxide hydrochloride 0
                    chloroprocaine hydrochloride 0
                    chlorpromazine hydrochloride 0
                    cimetidine hydrochloride 0
                    cinacalcet hydrochloride 0
                    cinanserin hydrochloride 0
                    cinchocaine hydrochloride 0
                    ciprofloxacin dihydrochloride 0
                    ciprofloxacin hydrochloride (anhydrous) + 0
                    clenbuterol hydrochloride + 0
                    clomipramine hydrochloride 0
                    cocaine hydrochloride 0
                    colesevelam hydrochloride 3
                    colestipol hydrochloride 0
                    conivaptan hydrochloride 0
                    cyclazosin hydrochloride 0
                    cyclizine hydrochloride 0
                    cyclobenzaprine hydrochloride 0
                    cycloguanil hydrochloride 0
                    cyclopentolate hydrochloride + 0
                    cycrimine hydrochloride + 0
                    cyproheptadine hydrochloride (anhydrous) + 0
                    daclatasvir hydrochloride 0
                    demeclocycline hydrochloride 0
                    desipramine hydrochloride 0
                    dexpropranolol hydrochloride 0
                    dexrazoxane hydrochloride 0
                    dextropropoxyphene hydrochloride 0
                    dexverapamil hydrochloride + 0
                    dicyclomine hydrochloride 0
                    diethylpropion hydrochloride 0
                    difenoxin hydrochloride 0
                    diltiazem hydrochloride 0
                    diphenhydramine hydrochloride 0
                    diphenoxylate hydrochloride 0
                    diphenylpyraline hydrochloride 0
                    dipivefrin hydrochloride 0
                    dobutamine hydrochloride 0
                    dorzolamide hydrochloride 2
                    dothiepin hydrochloride + 0
                    doxapram hydrochloride (anhydrous) + 0
                    doxycycline HCl + 0
                    duloxetine hydrochloride + 11
                    dyclonine hydrochloride 0
                    eflornithine hydrochloride monohydrate 0
                    emetine dihydrochloride + 0
                    emetine dihydrochloride hydrate 0
                    encainide hydrochloride 0
                    ent-diltiazem hydrochloride 0
                    ent-tamsulosin hydrochloride + 0
                    epinastine hydrochloride 0
                    eprazinone hydrochloride 0
                    erlotinib hydrochloride 127
                    esmolol hydrochloride 0
                    esoxybutynin chloride 0
                    ethambutol dihydrochloride 0
                    ethidium homodimer 0
                    ethylenediamine dihydrochloride 0
                    famotidine hydrochloride 0
                    fenfluramine hydrochloride + 0
                    fingolimod hydrochloride 57
                    flavoxate hydrochloride 0
                    gemcitabine hydrochloride 0
                    gevotroline hydrochloride 0
                    glycinexylidide hydrochloride 0
                    hydrabamine dihydrochloride 0
                    hydralazine hydrochloride 0
                    hydrocortamate hydrochloride 0
                    hydromorphone hydrochloride 0
                    hydroxyzine hydrochloride 0
                    imipramine hydrochloride 0
                    irinotecan hydrochloride (anhydrous) + 0
                    ivabradine hydrochloride 0
                    ketamine hydrochloride + 0
                    levobunolol hydrochloride 0
                    levopropoxyphene hydrochloride 0
                    lidocaine hydrochloride + 0
                    lofepramine hydrochloride 0
                    lomefloxacin hydrochloride 0
                    loperamide hydrochloride 0
                    lorcaserin hydrochloride + 0
                    lurasidone hydrochloride 3
                    magenta II + 0
                    mechlorethamine hydrochloride 0
                    medetomidine hydrochloride + 0
                    memantine hydrochloride 0
                    mepivacaine hydrochloride 0
                    metformin hydrochloride + 0
                    methadone hydrochloride 0
                    methamphetamine hydrochloride 0
                    methapyrilene hydrochloride 0
                    methdilazine hydrochloride 0
                    methixene hydrochloride 0
                    methoctramine tetrahydrochloride 13
                    methoxyphenamine hydrochloride 0
                    methyl 5-aminolevulinate hydrochloride 0
                    methylamine hydrochloride 0
                    methylphenidate hydrochloride 0
                    metoclopramide dihydrochloride monohydrate 0
                    metoclopramide hydrochloride + 0
                    metronidazole hydrochloride 0
                    mexiletine hydrochloride 0
                    mianserin hydrochloride 0
                    midazolam hydrochloride 0
                    midodrine hydrochloride 0
                    minaprine hydrochloride 0
                    minocycline hydrochloride 0
                    mitoguazone hydrochloride + 0
                    mitoxantrone dihydrochloride 0
                    monoethylglycinexylidide hydrochloride 0
                    moricizine hydrochloride 0
                    morphine hydrochloride + 0
                    moxifloxacin hydrochloride 0
                    myrophine hydrochloride 0
                    nalbuphine hydrochloride 0
                    naloxone hydrochloride 0
                    naltrexone hydrochloride + 0
                    nefazodone hydrochloride 0
                    neticonazole hydrochloride 0
                    neutral red 0
                    new fuchsin + 0
                    nimustine hydrochloride 0
                    olodaterol hydrochloride + 0
                    orphenadrine hydrochloride 0
                    oxybuprocaine hydrochloride 0
                    oxybutynin chloride 0
                    oxycodone hydrochloride + 0
                    oxymetazoline hydrochloride 0
                    oxythiamine chloride hydrochloride 0
                    palonosetron hydrochloride + 0
                    pararosaniline + 0
                    paroxetine hydrochloride 0
                    pazopanib hydrochloride 0
                    pethidine hydrochloride 0
                    phenazopyridine hydrochloride 0
                    phenylephrine hydrochloride 0
                    phenylhydrazine hydrochloride 0
                    pibutidine hydrochloride 0
                    pilocarpine hydrochloride 0
                    pipamperone dihydrochloride 0
                    pirenzepine hydrochloride 0
                    pivmecillinam hydrochloride 0
                    poly(allylamine hydrochloride) 0
                    poly(diallylmethylammonium chloride) macromolecule + 0
                    poly\{3-[(S)-5-amino-5-carboxyl-3-oxapentyl]-2,5-thiophenylene hydrochloride\} macromolecule + 0
                    polyhexamethylene biguanide hydrochloride 0
                    pramipexole hydrochloride anhydrous + 0
                    prazosin hydrochloride 0
                    prilocaine hydrochloride 0
                    prinomastat hydrochloride 0
                    procainamide hydrochloride 0
                    procarbazine hydrochloride 0
                    procyclidine hydrochloride 0
                    profenamine hydrochloride 0
                    promazine hydrochloride 0
                    promethazine hydrochloride 0
                    propafenone hydrochloride 0
                    propiomazine hydrochloride 0
                    propranolol hydrochloride 0
                    protriptyline hydrochloride 0
                    pseudoephedrine hydrochloride 0
                    pyridoxal hydrochloride 0
                    pyridoxamine dihydrochloride 0
                    pyridoxamine hydrochloride 0
                    pyridoxine hydrochloride 0
                    quinacrine mustard dihydrochloride 0
                    quinapril hydrochloride 18
                    quininib hydrochloride 0
                    raloxifene hydrochloride 0
                    ranitidine hydrochloride 0
                    remifentanil hydrochloride 0
                    retaspimycin hydrochloride 0
                    rilpivirine hydrochloride + 0
                    rolapitant hydrochloride (anhydrous) + 0
                    rosanilin + 0
                    sapropterin dihydrochloride 0
                    selegiline hydrochloride 0
                    sertraline hydrochloride 0
                    sotalol hydrochloride 0
                    spectinomycin dihydrochloride 0
                    spectinomycin hydrochloride hydrate 0
                    spirit blue 0
                    strychnine hydrochloride 0
                    synthalin 0
                    talampicillin hydrochloride 0
                    tamsulosin hydrochloride + 0
                    telavancin hydrochloride 0
                    terazosin hydrochloride dihydrate 0
                    terbinafine hydrochloride 0
                    tetrahydrozoline hydrochloride 0
                    thiamine hydrochloride + 0
                    thiocyclam hydrochloride 0
                    thioridazine hydrochloride 0
                    tiagabine hydrochloride 0
                    ticlopidine hydrochloride 0
                    tilorone dihydrochloride 0
                    tipiracil hydrochloride + 0
                    tirofiban hydrochloride 0
                    trazodone hydrochloride 0
                    triethanolamine hydrochloride 0
                    trifluoperazine hydrochloride 0
                    triflupromazine hydrochloride 0
                    trimethylamine hydrochloride 0
                    triprolidine hydrochloride (anh.) + 0
                    tropisetron hydrochloride 0
                    vanoxerine dihydrochloride 10
                    venlafaxine hydrochloride 176
                    vilazodone hydrochloride 0
                    xylazine hydrochloride 0
                    ziprasidone hydrochloride hydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      halogen 18074
                        chlorine atom 17866
                          chlorine molecular entity 17866
                            elemental chlorine 8382
                              monoatomic chlorine 8363
                                chloride 8363
                                  chloride salt 8363
                                    organic chloride salt 666
                                      hydrochloride 436
                                        (1R,2S)-tranylcypromine hydrochloride + 0
                                        (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride 1
                                        (1S,2R)-5-methoxy-1-methyl-2-(propylamino)tetralin hydrochloride 0
                                        (1S,2R)-tranylcypromine hydrochloride + 0
                                        (2R,3S)-EHNA hydrochloride 0
                                        (3S)-3-\{[3',4'-difluoro-5-(\{4'-fluoro-6-[(3S)-pyrrolidinium-3-yloxy][biphenyl]-3-yl\}carbamoyl)[biphenyl]-2-yl]oxy\}pyrrolidinium dichloride 0
                                        (R)-DRF053 hydrochloride hydrate 0
                                        (R)-adrenaline hydrochloride 0
                                        (R)-cyclopentolate hydrochloride 0
                                        (R)-cycrimine hydrochloride 0
                                        (R)-donepezil hydrochloride + 42
                                        (R)-fluoxetine hydrochloride + 1
                                        (R)-nefopam hydrochloride + 0
                                        (R)-prasugrel hydrochloride + 1
                                        (R)-tetrindole hydrochloride + 0
                                        (R,R)-tramadol hydrochloride + 0
                                        (R,S,S,S)-nebivolol hydrochloride + 0
                                        (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane dihydrochloride 0
                                        (S)-cyclopentolate hydrochloride 0
                                        (S)-cycrimine hydrochloride 0
                                        (S)-donepezil hydrochloride + 42
                                        (S)-fluoxetine hydrochloride + 1
                                        (S)-nefopam hydrochloride + 0
                                        (S)-prasugrel hydrochloride + 1
                                        (S)-ropivacaine hydrochloride (anhydrous) + 0
                                        (S)-tetrindole hydrochloride + 0
                                        (S)-verapamil hydrochloride + 0
                                        (S,R,R,R)-nebivolol hydrochloride + 0
                                        (S,S)-tramadol hydrochloride + 0
                                        (aminooxy)acetic acid hemihydrochloride 0
                                        1,2-dimethylhydrazine dihydrochloride 0
                                        1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride 0
                                        1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride 0
                                        1-benzyl-2-chloromethylimidazole hydrochloride 0
                                        1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride + 0
                                        2-(chloromethyl)-4,5-dihydro-1H-imidazole hydrochloride 0
                                        2-(chloromethyl)pyridine hydrochloride 0
                                        2-dimethylaminoethyl chloride hydrochloride 0
                                        2-methyl-6-(phenylethynyl)pyridine hydrochloride 0
                                        3,6-diamino-10-methylacridinium chloride.HCl + 0
                                        3,6-diaminoacridine dihydrochloride + 0
                                        3,6-diaminoacridine monohydrochloride + 0
                                        3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol hydrochloride 0
                                        4-\{2-[(2-hydroxybenzyl)amino]ethyl\}-2,5-dimethoxybenzonitrile.HCl 0
                                        4-fluoro-N-\{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl\}benzamide hydrochloride 1
                                        5-aminolevulinic acid hydrochloride 0
                                        9-aminoacridine hydrochloride 0
                                        BRACO-19 0
                                        Bismark brown Y 0
                                        CGP 78608 hydrochloride 0
                                        D-lysine hydrochloride 0
                                        DND-22 dye 0
                                        DuP-714 0
                                        E-3810 0
                                        FR901469 hydrochloride 0
                                        GR 127935 hydrochloride 0
                                        GS4012 0
                                        Hoffman's violet 0
                                        L-cysteine hydrochloride + 0
                                        L-lysine hydrochloride 0
                                        LY-310762 hydrochloride 0
                                        Mefloquine hydrochloride 0
                                        Methyl violet 2B 0
                                        N(6)-\{2-[(1,2-diphenylhydrazinyl)carbonyl]-2-hydroxyhexanoyl\}-6-aminohexylammonium chloride 0