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Accession:CHEBI:3698 term browser browse the term
Definition:A pyridazinodiazepine resulting from the formal condensation of the carboxy group of cilazaprilat with ethanol. It is a drug used in the treatment of hypertension and heart failure.
Synonyms:exact_synonym: (1S,9S)-9-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
 related_synonym: Dynorm;   Formula=C22H31N3O5;   InChI=1S/C22H31N3O5/c1-2-30-22(29)18(13-12-16-8-4-3-5-9-16)23-17-10-6-14-24-15-7-11-19(21(27)28)25(24)20(17)26/h3-5,8-9,17-19,23H,2,6-7,10-15H2,1H3,(H,27,28)/t17-,18-,19-/m0/s1;   InChIKey=HHHKFGXWKKUNCY-FHWLQOOXSA-N;   Ro 34-2848;   SMILES=C1CC[C@@H](C(N2N1CCC[C@H]2C(=O)O)=O)N[C@H](C(OCC)=O)CCC3=CC=CC=C3;   Vascace;   Vascase;   cilazapril anhydrous;   cilazaprilum;   inhibace
 xref: CAS:88768-40-5 "ChemIDplus";   DrugBank:DB01340;   Drug_Central:641 "DrugCentral";   HMDB:HMDB0015433;   KEGG:D07699
 xref_mesh: MESH:D017315
 xref: PMID:18297254 "Europe PMC";   PMID:1836986 "Europe PMC";   PMID:21760854 "Europe PMC";   PMID:24383331 "Europe PMC";   PMID:24754013 "Europe PMC";   PMID:25272892 "Europe PMC";   PMID:28334985 "Europe PMC";   PMID:28445944 "Europe PMC";   PMID:31531043 "Europe PMC";   Wikipedia:Cilazapril

show annotations for term's descendants       view all columns           Sort by:
cilazapril monohydrate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:6480464
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:6480464
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:6480464
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:6480464
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:6480464
G Nppa natriuretic peptide A JBrowse link 5 164,808,407 164,809,716 RGD:6480464
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:6480464
G Slc15a1 solute carrier family 15 member 1 JBrowse link 15 106,800,081 106,844,668 RGD:6480464
G Slc15a2 solute carrier family 15 member 2 JBrowse link 11 66,932,664 66,961,708 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19754
    role 19701
      application 19353
        pro-agent 8831
          prodrug 8620
            cilazapril 10
              cilazapril monohydrate 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19754
    subatomic particle 19752
      composite particle 19752
        hadron 19752
          baryon 19752
            nucleon 19752
              atomic nucleus 19752
                atom 19752
                  main group element atom 19637
                    p-block element atom 19637
                      carbon group element atom 19528
                        carbon atom 19517
                          organic molecular entity 19517
                            organic group 18422
                              organic divalent group 18414
                                organodiyl group 18414
                                  carbonyl group 18303
                                    carbonyl compound 18303
                                      carboxylic acid 17971
                                        amino acid 12465
                                          alpha-amino acid 7692
                                            non-proteinogenic alpha-amino acid 1518
                                              Cilazaprilat 10
                                                cilazapril 10
                                                  cilazapril monohydrate 10
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.