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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cirsiliol
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Accession:CHEBI:3719 term browser browse the term
Definition:A dimethoxyflavone that is flavone substituted by methoxy groups at positions 6 and 7 and hydroxy groups at positions 5, 3' and 4' respectively.
Synonyms:exact_synonym: 2-(3,4-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxy-4H-1-benzopyran-4-one
 related_synonym: 3',4',5-trihydroxy-6,7-dimethoxyflavone;   6,7-dimethoxy-5,3',4'-trihydroxyflavone;   Formula=C17H14O7;   InChI=1S/C17H14O7/c1-22-14-7-13-15(16(21)17(14)23-2)11(20)6-12(24-13)8-3-4-9(18)10(19)5-8/h3-7,18-19,21H,1-2H3;   InChIKey=IMEYGBIXGJLUIS-UHFFFAOYSA-N;   SMILES=COc1cc2oc(cc(=O)c2c(O)c1OC)-c1ccc(O)c(O)c1
 xref: CAS:34334-69-5;   KEGG:C10033;   KNApSAcK:C00001033;   LIPID_MAPS_instance:LMPK12111227
 xref_mesh: MESH:C039824
 xref: PMID:23902763;   PMID:24689280;   PMID:25140335;   Reaxys:1354524


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cirsiliol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases metabolic processing
increases expression
ISO cirsiliol results in decreased activity of CYP1A1 protein
CYP1A1 protein results in increased metabolism of cirsiliol
cirsiliol results in increased expression of CYP1A1 mRNA
CTD PMID:19601638, PMID:21482471 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
decreases activity
increases metabolic processing
ISO cirsiliol results in increased expression of CYP1B1 mRNA
cirsiliol results in decreased activity of CYP1B1 protein
CYP1B1 protein results in increased metabolism of cirsiliol
CTD PMID:19601638, PMID:21482471 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          metabolite 19294
            flavone 73
              cirsiliol 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  oxacycle 17200
                                    benzopyran 10142
                                      1-benzopyran 9858
                                        flavonoid 6376
                                          flavones 4169
                                            methoxyflavone 416
                                              dimethoxyflavone 28
                                                cirsiliol 2
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