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ONTOLOGY REPORT - ANNOTATIONS


Term:phorbol 13-acetate 12-myristate
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Accession:CHEBI:37537 term browser browse the term
Definition:A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted to the corresponding acetate and myristate esters.
Synonyms:exact_synonym: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-acetoxy-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl tetradecanoate
 related_synonym: 12-O-Tetradecanoylphorbol 13-acetate;   12-Tetradecanoylphorbol 13-acetate;   Formula=C36H56O8;   InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1;   InChIKey=PHEDXBVPIONUQT-RGYGYFBISA-N;   PMA;   SMILES=C=1[C@]2([C@]3([C@@]([C@H](OC(=O)CCCCCCCCCCCCC)[C@H]([C@@]2([C@]4([C@@](C(=O)C(=C4)C)(CC1CO)O)[H])O)C)(C3(C)C)OC(=O)C)[H])[H];   TPA;   phorbol 12-tetradecanoate 13-acetate;   tetradecanoylphorbol acetate
 alt_id: CHEBI:745;   CHEBI:746
 xref: Beilstein:2407201;   CAS:16561-29-8;   KEGG:C05151;   KNApSAcK:C00003491
 xref_mesh: MESH:D013755
 xref: PMID:18541361;   PMID:22696070;   PMID:25649981;   PMID:25918710;   PMID:26826276;   PMID:26894087;   PMID:3593207;   Wikipedia:12-O-Tetradecanoylphorbol-13-acetate


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phorbol 13-acetate 12-myristate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G INS insulin JBrowse link 18 46,324,047 46,324,933 RGD:6480464
G MAPK1 mitogen-activated protein kinase 1 JBrowse link 26 31,013,607 31,132,998 RGD:6480464
G MAPK3 mitogen-activated protein kinase 3 JBrowse link 6 18,109,184 18,115,728 RGD:6480464
G SLC6A9 solute carrier family 6 member 9 JBrowse link 15 16,235,342 16,267,161 RGD:6480464
G SOD1 superoxide dismutase 1 JBrowse link 31 26,540,291 26,544,212 RGD:6480464

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    role 225
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            antineoplastic agent 72
              phorbol 13-acetate 12-myristate 5
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  CHEBI ontology 225
    subatomic particle 225
      composite particle 225
        hadron 225
          baryon 225
            nucleon 225
              atomic nucleus 225
                atom 225
                  main group element atom 218
                    p-block element atom 218
                      carbon group element atom 207
                        carbon atom 206
                          organic molecular entity 206
                            organic group 154
                              organic divalent group 153
                                organodiyl group 153
                                  carbonyl group 153
                                    carbonyl compound 153
                                      ketone 48
                                        oxyketone 14
                                          alpha-oxyketone 14
                                            alpha-hydroxy ketone 14
                                              tertiary alpha-hydroxy ketone 13
                                                phorbol 5
                                                  phorbol ester 5
                                                    phorbol 13-acetate 12-myristate 5
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