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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oleanolic acid
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Accession:CHEBI:37659 term browser browse the term
Definition:A pentacyclic triterpenoid that is olean-12-en-28-oic acid substituted by a beta-hydroxy group at position 3.
Synonyms:related_synonym: 3beta-Hydroxyolean-12-en-28-oic acid;   Astrantiagenin C;   Caryophyllin;   Formula=C30H48O3;   Giganteumgenin C;   InChI=1S/C30H48O3/c1-25(2)14-16-30(24(32)33)17-15-28(6)19(20(30)18-25)8-9-22-27(5)12-11-23(31)26(3,4)21(27)10-13-29(22,28)7/h8,20-23,31H,9-18H2,1-7H3,(H,32,33)/t20-,21-,22+,23-,27-,28+,29+,30-/m0/s1;   InChIKey=MIJYXULNPSFWEK-GTOFXWBISA-N;   Oleanic acid;   SMILES=[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)CC[C@H](O)C(C)(C)[C@]3([H])CC[C@@]12C)C(O)=O;   Virgaureagenin B
 xref: CAS:508-02-1;   KEGG:C17148
 xref_mesh: MESH:D009828
 xref: PMID:15541359;   PMID:24393202;   Wikipedia:Oleanolic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:82828


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oleanolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression ISO Oleanolic Acid results in decreased expression of ABCB11 mRNA; Oleanolic Acid results in decreased expression of ABCB11 protein CTD PMID:23948738 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Oleanolic Acid results in increased expression of ABCG2 mRNA CTD PMID:23948738 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP
ISO
Oleanolic Acid analog inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA] CTD PMID:17922224 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) multiple interactions EXP Oleanolic Acid inhibits the reaction [Ethanol results in increased expression of and results in increased activity of ADH1 protein] CTD PMID:25111957 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of AGER protein] CTD PMID:22386814 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions ISO Oleanolic Acid inhibits the reaction [[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased expression of MMP2 mRNA]; Oleanolic Acid inhibits the reaction [[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased secretion of MMP2 protein]; Oleanolic Acid inhibits the reaction [AKR1B10 protein results in decreased susceptibility to Doxorubicin]; Oleanolic Acid inhibits the reaction [AKR1B10 protein results in increased metabolism of 4-hydroxy-2-nonenal]; Oleanolic Acid inhibits the reaction [AKR1B10 protein results in increased metabolism of 4-oxo-2-nonenal] CTD PMID:25686905, PMID:27417252 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
[Fructose co-treated with Oleanolic Acid] results in increased expression of AKT1 mRNA
Oleanolic Acid analog results in increased phosphorylation of AKT1 protein
CTD PMID:24704288, PMID:26612655 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Atg5 autophagy related 5 increases expression
multiple interactions
ISO Oleanolic Acid analog results in increased expression of ATG5 protein
Oleanolic Acid inhibits the reaction [Cisplatin results in increased expression of ATG5 protein]
CTD PMID:26612655, PMID:31306688 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO Oleanolic Acid analog results in increased expression of BAX protein
[Oleanolic Acid analog binds to Succinic Acid] which results in increased expression of BAX mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in increased expression of BAX protein
CTD PMID:26612655, PMID:31401087 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO Oleanolic Acid analog results in decreased expression of BCL2 protein; Oleanolic Acid results in decreased expression of BCL2 protein
Cisplatin promotes the reaction [Oleanolic Acid results in decreased expression of BCL2 protein]; Oleanolic Acid promotes the reaction [Cisplatin results in decreased expression of BCL2 protein]
CTD PMID:22678527, PMID:26612655, PMID:31306688 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of BCL2L1 mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of BCL2L1 protein CTD PMID:31401087 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Becn1 beclin 1 affects expression ISO Oleanolic Acid analog affects the expression of BECN1 protein CTD PMID:26612655 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Oleanolic Acid results in decreased expression of BIRC5 protein CTD PMID:22678527 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
decreases expression
increases expression
ISO Oleanolic Acid results in increased activity of CASP3 protein
Oleanolic Acid inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
Ascorbic Acid inhibits the reaction [Oleanolic Acid results in increased cleavage of CASP3 protein]; Cisplatin inhibits the reaction [Oleanolic Acid results in increased cleavage of CASP3 protein]; Oleanolic Acid inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
Oleanolic Acid analog results in decreased expression of CASP3 protein
Oleanolic Acid results in increased expression of CASP3 protein
CTD PMID:20005942, PMID:20726234, PMID:22678527, PMID:26612655, PMID:31306688 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO Oleanolic Acid results in increased activity of CASP8 protein CTD PMID:20005942 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 decreases expression
multiple interactions
increases cleavage
ISO Oleanolic Acid analog results in decreased expression of CASP9 protein
Oleanolic Acid inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]
Oleanolic Acid results in increased cleavage of CASP9 protein
CTD PMID:22678527, PMID:26612655, PMID:31306688 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases expression
multiple interactions
EXP
ISO
Oleanolic Acid results in increased expression of CAT mRNA
Oleanolic Acid inhibits the reaction [Ethanol results in increased activity of CAT protein]
Oleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of CAT protein]
CTD PMID:18706400, PMID:20100471, PMID:25111957 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 increases expression
decreases expression
ISO
EXP
Oleanolic Acid results in increased expression of CCND1 mRNA
Oleanolic Acid results in decreased expression of CCND1 protein
CTD PMID:18706400, PMID:20726234 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
decreases expression
EXP
ISO
Oleanolic Acid results in increased expression of CDKN1A mRNA
Oleanolic Acid inhibits the reaction [Cisplatin results in increased expression of CDKN1A protein]
Oleanolic Acid results in decreased expression of CDKN1A protein
CTD PMID:18706400, PMID:22678527, PMID:31306688 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression EXP Oleanolic Acid analog results in decreased expression of COL1A1 mRNA CTD PMID:17922224 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression
multiple interactions
ISO Oleanolic Acid results in increased expression of CXCL2 protein
Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of CXCL2 mRNA]; Oleanolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL2 mRNA]
CTD PMID:25280775, PMID:26513295 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of CXCL1 mRNA] CTD PMID:25280775 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases expression
decreases activity
ISO
EXP
Oleanolic Acid inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]
Oleanolic Acid results in decreased expression of CYP1A2 mRNA
Oleanolic Acid results in decreased activity of CYP1A2 protein
CTD PMID:15043991, PMID:18706400, PMID:23948738 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression ISO Oleanolic Acid results in decreased expression of CYP27A1 mRNA CTD PMID:23948738 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases expression ISO Oleanolic Acid results in decreased expression of CYP2B10 mRNA CTD PMID:23948738 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases expression
ISO
EXP
Oleanolic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein]
Oleanolic Acid inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]
Oleanolic Acid results in decreased expression of CYP2E1 mRNA
CTD PMID:10355542, PMID:18706400, PMID:25111957 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 decreases expression ISO Oleanolic Acid results in decreased expression of CYP2F2 mRNA CTD PMID:18706400 NCBI chr 1:83,933,974...83,947,804
Ensembl chr 1:83,933,942...83,947,821
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Oleanolic Acid results in decreased expression of CYP7A1 mRNA; Oleanolic Acid results in decreased expression of CYP7A1 protein CTD PMID:23948738 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression ISO Oleanolic Acid results in decreased expression of CYP7B1 mRNA CTD PMID:23948738 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression ISO Oleanolic Acid results in decreased expression of CYP8B1 mRNA; Oleanolic Acid results in decreased expression of CYP8B1 protein CTD PMID:23948738 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of DDIT3 mRNA] CTD PMID:25280775 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of GADD45A mRNA] CTD PMID:25280775 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression EXP
ISO
Oleanolic Acid results in increased expression of GCLC mRNA
Oleanolic Acid results in increased expression of GCLC mRNA; Oleanolic Acid results in increased expression of GCLC protein
CTD PMID:18706400, PMID:19283895, PMID:25280775 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Oleanolic Acid results in increased expression of GCLM mRNA CTD PMID:18706400 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide decreases expression ISO Oleanolic Acid results in decreased expression of GHRL protein CTD PMID:20188082 NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066
JBrowse link
G Gnas GNAS complex locus multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols]; 4,4,',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis(benzene-1,3-disulfonate) inhibits the reaction [[[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols]; [[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased abundance of Calcium; [[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased abundance of Cyclic AMP; [[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols; [Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein CTD PMID:23022524 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Gpbar1 G protein-coupled bile acid receptor 1 multiple interactions
increases response to substance
ISO [Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased abundance of Calcium; Oleanolic Acid binds to and results in increased activity of GPBAR1 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols]; 4,4,',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis(benzene-1,3-disulfonate) inhibits the reaction [[[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols]; [[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased abundance of Calcium; [[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased abundance of Cyclic AMP; [[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols; [Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein; Oleanolic Acid binds to and results in increased activity of GPBAR1 protein
GPBAR1 protein results in increased susceptibility to Oleanolic Acid
CTD PMID:23022524, PMID:23041323 NCBI chr 9:81,555,914...81,560,931
Ensembl chr 9:81,559,605...81,560,594
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Oleanolic Acid inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein] CTD PMID:10355542, PMID:15720792 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Oleanolic Acid results in increased expression of GPX1 mRNA CTD PMID:18706400 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Oleanolic Acid inhibits the reaction [Ethanol results in decreased expression of and results in decreased activity of GSR protein] CTD PMID:25111957 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO Oleanolic Acid results in decreased expression of HDAC1 protein CTD PMID:20726234 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions
decreases response to substance
decreases expression
ISO Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of AGER protein]; Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein]; Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of SELE protein]; Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of TNF protein]; Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 protein]; Oleanolic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of HMGB1 protein]
Oleanolic Acid results in decreased susceptibility to HMGB1 protein
Oleanolic Acid results in decreased expression of HMGB1 protein
CTD PMID:22386814 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
Oleanolic Acid results in increased expression of HMOX1 mRNA
Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of HMOX1 mRNA]
Oleanolic Acid inhibits the reaction [Ethanol results in decreased expression of HMOX1 protein]
CTD PMID:18706400, PMID:19283895, PMID:25111957, PMID:25280775 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO Oleanolic Acid results in increased expression of HSPA1B mRNA CTD PMID:18706400 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
ISO Oleanolic Acid results in decreased expression of ICAM1 protein
Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein]
CTD PMID:20005942, PMID:22386814 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il22 interleukin 22 multiple interactions ISO Oleanolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL22 mRNA] CTD PMID:26513295 NCBI chr 7:61,236,037...61,240,502
Ensembl chr 7:61,236,037...61,240,502
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Oleanolic Acid co-treated with Glucose] results in increased secretion of INS protein CTD PMID:23022524 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insr insulin receptor multiple interactions EXP [Fructose co-treated with Oleanolic Acid] results in increased expression of INSR mRNA CTD PMID:24704288 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP [Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 mRNA; [Fructose co-treated with Oleanolic Acid] results in increased expression of IRS1 protein; Oleanolic Acid inhibits the reaction [Fructose results in increased phosphorylation of IRS1 protein] CTD PMID:24704288 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Lep leptin increases expression ISO Oleanolic Acid results in increased expression of LEP protein CTD PMID:20188082 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression
ISO Cisplatin promotes the reaction [Oleanolic Acid results in increased expression of MAP1LC3B protein]; Oleanolic Acid promotes the reaction [Cisplatin results in increased expression of MAP1LC3B protein]
Oleanolic Acid inhibits the reaction [Cisplatin results in increased expression of MAP1LC3B protein]
CTD PMID:31306688 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO Oleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of MAPK1 protein modified form]
Oleanolic Acid inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein]
Oleanolic Acid analog results in decreased phosphorylation of MAPK1 protein
CTD PMID:20100471, PMID:26612655, PMID:31306688 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases phosphorylation ISO Oleanolic Acid analog results in decreased phosphorylation of MAPK14 protein CTD PMID:26612655 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO Oleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of MAPK3 protein modified form]
Oleanolic Acid inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]
Oleanolic Acid analog results in decreased phosphorylation of MAPK3 protein
CTD PMID:20100471, PMID:26612655, PMID:31306688 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases phosphorylation ISO Oleanolic Acid analog results in decreased phosphorylation of MAPK8 protein CTD PMID:26612655 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO Oleanolic Acid results in decreased expression of MET protein CTD PMID:20726234 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Oleanolic Acid inhibits the reaction [[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased expression of MMP2 mRNA]; Oleanolic Acid inhibits the reaction [[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased secretion of MMP2 protein] CTD PMID:25686905 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mt1 metallothionein 1 increases expression
multiple interactions
EXP
ISO
Oleanolic Acid results in increased expression of MT1 mRNA; Oleanolic Acid results in increased expression of MT1A mRNA; Oleanolic Acid results in increased expression of MT1A protein
Oleanolic Acid promotes the reaction [Phalloidine results in increased expression of MT1 mRNA]
CTD PMID:17637929, PMID:18706400, PMID:25280775 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A increases expression EXP
ISO
Oleanolic Acid results in increased expression of MT2 mRNA; Oleanolic Acid results in increased expression of MT2A mRNA; Oleanolic Acid results in increased expression of MT2A protein CTD PMID:17637929, PMID:18706400 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Oleanolic Acid analog results in decreased phosphorylation of MTOR protein CTD PMID:26612655 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
multiple interactions
EXP
ISO
Oleanolic Acid results in increased expression of MYC mRNA
[Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of MYC mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of MYC protein
CTD PMID:18706400, PMID:31401087 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
increases activity
affects localization
ISO
EXP
NFE2L2 protein affects the reaction [Oleanolic Acid results in increased activity of NQO1 protein]; NFE2L2 protein affects the reaction [Oleanolic Acid results in increased expression of NQO1 protein]; Oleanolic Acid promotes the reaction [Phalloidine results in increased expression of NFE2L2 mRNA]; Phalloidine promotes the reaction [Oleanolic Acid results in increased expression of NFE2L2 mRNA]
Oleanolic Acid results in increased expression of NFE2L2 mRNA; Oleanolic Acid results in increased expression of NFE2L2 protein
Oleanolic Acid inhibits the reaction [Ethanol results in decreased expression of NFE2L2 protein]; Oleanolic Acid promotes the reaction [Ethanol affects the localization of NFE2L2 protein]
Oleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NFE2L2 protein]; Oleanolic Acid promotes the reaction [NFE2L2 protein results in increased expression of SREBF1 mRNA]
Oleanolic Acid results in increased activity of NFE2L2 protein
Oleanolic Acid affects the localization of NFE2L2 protein
CTD PMID:18706400, PMID:19283895, PMID:20100471, PMID:23948738, PMID:25111957, PMID:25280775, PMID:28796629 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of NFKB1 mRNA CTD PMID:31401087 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation ISO Oleanolic Acid analog results in decreased phosphorylation of NFKBIA protein CTD PMID:26612655 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
increases activity
ISO
EXP
NFE2L2 protein affects the reaction [Oleanolic Acid results in increased activity of NQO1 protein]; NFE2L2 protein affects the reaction [Oleanolic Acid results in increased expression of NQO1 protein]; Phalloidine promotes the reaction [Oleanolic Acid results in increased expression of NQO1 mRNA]
Oleanolic Acid results in increased expression of NQO1 mRNA; Oleanolic Acid results in increased expression of NQO1 protein
CTD PMID:18706400, PMID:19283895, PMID:23948738, PMID:25280775 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression ISO Oleanolic Acid results in decreased expression of NR1H4 mRNA CTD PMID:23948738 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases expression ISO Oleanolic Acid results in decreased expression of NR1I3 mRNA CTD PMID:23948738 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Orm1 orosomucoid 1 increases expression EXP Oleanolic Acid results in increased expression of ORM1 mRNA CTD PMID:18706400 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO Oleanolic Acid analog results in increased cleavage of PARP1 protein; Oleanolic Acid results in increased cleavage of PARP1 protein
Oleanolic Acid inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein]
Ascorbic Acid inhibits the reaction [Oleanolic Acid results in increased cleavage of PARP1 protein]; Oleanolic Acid inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein]
CTD PMID:22678527, PMID:26612655, PMID:31306688 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO
EXP
Oleanolic Acid results in increased expression of PCNA mRNA CTD PMID:18706400 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma multiple interactions EXP [Fructose co-treated with Oleanolic Acid] results in increased expression of PIK3C2G mRNA CTD PMID:24704288 NCBI chr 4:173,732,196...174,102,502
Ensembl chr 4:173,732,248...174,102,496
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha decreases expression ISO Oleanolic Acid analog results in decreased expression of PIK3CA protein CTD PMID:26612655 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Oleanolic Acid results in decreased expression of PPARA mRNA CTD PMID:23948738 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO Oleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PRDX1 protein] CTD PMID:20100471 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Pten phosphatase and tensin homolog increases expression ISO Oleanolic Acid results in increased expression of PTEN protein CTD PMID:20726234 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Oleanolic Acid results in increased expression of PTGS2 mRNA
[Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of PTGS2 mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of PTGS2 protein
Oleanolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; Oleanolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
CTD PMID:18706400, PMID:26513295, PMID:31401087 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of RELA mRNA; Oleanolic Acid analog results in decreased expression of and affects the localization of RELA protein
Oleanolic Acid analog results in decreased expression of RELA protein
CTD PMID:26362502, PMID:26612655, PMID:31401087 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sele selectin E multiple interactions ISO Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of SELE protein] CTD PMID:22386814 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO Oleanolic Acid results in decreased expression of SLC10A1 mRNA; Oleanolic Acid results in decreased expression of SLC10A1 protein CTD PMID:23948738 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc51a solute carrier family 51 subunit alpha decreases expression ISO Oleanolic Acid results in decreased expression of SLC51A mRNA CTD PMID:23948738 NCBI chr11:71,533,078...71,547,476
Ensembl chr11:71,533,078...71,547,476
JBrowse link
G Slc51b solute carrier family 51 subunit beta increases expression ISO Oleanolic Acid results in increased expression of SLC51B mRNA; Oleanolic Acid results in increased expression of SLC51B protein CTD PMID:23948738 NCBI chr 8:70,930,196...70,938,559
Ensembl chr 8:70,930,347...70,932,986
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases expression ISO Oleanolic Acid results in decreased expression of SLCO1A4 mRNA CTD PMID:23948738 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression
multiple interactions
ISO Oleanolic Acid results in decreased expression of SLCO1B2 protein
Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of SLCO1B2 mRNA]
CTD PMID:23948738, PMID:25280775 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Sod1 superoxide dismutase 1 increases expression
multiple interactions
ISO
EXP
Oleanolic Acid results in increased expression of SOD1 mRNA
Oleanolic Acid inhibits the reaction [Ethanol results in decreased expression of SOD1 protein]
CTD PMID:18706400, PMID:25111957 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Oleanolic Acid promotes the reaction [NFE2L2 protein results in increased expression of SREBF1 mRNA] CTD PMID:28796629 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression
multiple interactions
ISO Oleanolic Acid results in increased expression of STAT3 mRNA
Oleanolic Acid inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein]
[Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of STAT3 mRNA
CTD PMID:18706400, PMID:31306688, PMID:31401087 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO Oleanolic Acid analog inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA] CTD PMID:17922224 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO Oleanolic Acid results in increased expression of TNF mRNA
Oleanolic Acid inhibits the reaction [Cisplatin results in increased expression of TNF protein]
Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of TNF protein]
CTD PMID:18706400, PMID:22386814, PMID:31306688 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression ISO Oleanolic Acid results in increased expression of TNFRSF1B mRNA CTD PMID:18706400 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
JBrowse link
G Top1 DNA topoisomerase I decreases activity
decreases expression
ISO Oleanolic Acid results in decreased activity of TOP1 protein
Oleanolic Acid analog results in decreased expression of TOP1 protein
CTD PMID:10860928, PMID:26612655 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686
JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity
decreases expression
ISO Oleanolic Acid results in decreased activity of TOP2A protein
Oleanolic Acid analog results in decreased expression of TOP2A protein
CTD PMID:10860928, PMID:26612655 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 affects binding EXP Oleanolic Acid binds to TRPV1 protein CTD PMID:30496739 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 protein] CTD PMID:22386814 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
kalopanaxsaponin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO alpha-hederin inhibits the reaction [[Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]] which results in increased expression of CYP1A1 mRNA] CTD PMID:10378784 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases expression
decreases activity
ISO alpha-hederin inhibits the reaction [[Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]] which results in increased expression of CYP1A1 mRNA]; alpha-hederin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; alpha-hederin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
alpha-hederin results in decreased expression of CYP1A1 mRNA
alpha-hederin results in decreased activity of CYP1A1 protein
CTD PMID:9861456, PMID:10378784 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
decreases expression
ISO alpha-hederin results in decreased activity of CYP1A2 protein
alpha-hederin results in decreased expression of CYP1A2 mRNA
CTD PMID:9861456 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases expression ISO alpha-hederin results in decreased expression of CYP2B1 mRNA CTD PMID:9861456 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO alpha-hederin results in decreased activity of CYP2E1 protein CTD PMID:9861456 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          metabolite 19294
            eukaryotic metabolite 18943
              plant metabolite 17424
                oleanolic acid 95
                  3beta,6beta,23-trihydroxyolean-12-en-28-oic acid 0
                  4-epihederagenin 0
                  acutoside A 0
                  gypsogenin + 0
                  hederagenin + 5
                  oleanolic acid 3-O-[O-beta-D-glucopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->3)-O-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyranoside] 0
                  oleanolic acid 3-O-beta-D-glucosiduronic acid 0
                  protobassic acid + 0
                  spathodic acid 0
                  spinosic acid A 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        hydroxy carboxylic acid 3607
                                          hydroxy monocarboxylic acid 3607
                                            oleanolic acid 95
                                              3beta,6beta,23-trihydroxyolean-12-en-28-oic acid 0
                                              4-epihederagenin 0
                                              acutoside A 0
                                              gypsogenin + 0
                                              hederagenin + 5
                                              oleanolic acid 3-O-[O-beta-D-glucopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->3)-O-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyranoside] 0
                                              oleanolic acid 3-O-beta-D-glucosiduronic acid 0
                                              protobassic acid + 0
                                              spathodic acid 0
                                              spinosic acid A 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.