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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:physcion
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Accession:CHEBI:38167 term browser browse the term
Definition:A dihydroxyanthraquinone that is 9,10-anthraquinone bearing hydroxy substituents at positions 1 and 8, a methoxy group at position 3, and a methyl group at position 6. It has been widely isolated and characterised from both terrestrial and marine sources.
Synonyms:exact_synonym: 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione
 related_synonym: 1,8-Dihydroxy-3-methoxy-6-methylanthraquinone;   1,8-dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione;   1,8-dihydroxy-3-methyl-6-methoxyanthraquinone;   Emodin monomethyl ether;   Formula=C16H12O5;   InChI=1S/C16H12O5/c1-7-3-9-13(11(17)4-7)16(20)14-10(15(9)19)5-8(21-2)6-12(14)18/h3-6,17-18H,1-2H3;   InChIKey=FFWOKTFYGVYKIR-UHFFFAOYSA-N;   Parienin;   Physcione;   Rheochrysidin;   SMILES=C12=C(C=C(C=C2C(C=3C=C(C=C(C3C1=O)O)OC)=O)C)O;   parietin
 alt_id: CHEBI:68791
 xref: Beilstein:1915778;   CAS:521-61-9;   KEGG:C17045
 xref_mesh: MESH:C008905
 xref: PMID:16272711;   PMID:17091434;   PMID:17125234;   PMID:17397111;   PMID:17917292;   PMID:17949858;   PMID:17978503;   PMID:17978527;   PMID:18556196;   PMID:18612943;   PMID:19402184;   PMID:19463000;   PMID:19505563;   PMID:20024894;   PMID:20205209;   PMID:20392467;   PMID:20532365;   PMID:21106380;   PMID:21117944;   PMID:21253951;   PMID:21273951;   PMID:21725807;   PMID:21765390;   PMID:21840387;   PMID:22850859;   PMID:23993502;   PMID:24071573;   PMID:25574462;   PMID:25860944;   PMID:26144377;   PMID:26707141;   PMID:26836455;   PMID:27231648;   PMID:27352350;   PMID:27490539;   PMID:27548142;   PMID:27657824;   PMID:27694907;   PMID:27904770;   Reaxys:1915778


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physcion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 increases expression EXP physcione results in increased expression of ABCB11 mRNA; physcione results in increased expression of ABCB11 protein CTD PMID:28161596 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression EXP physcione results in decreased expression of ABCB4 mRNA CTD PMID:28161596 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression EXP physcione results in decreased expression of ABCC2 mRNA; physcione results in decreased expression of ABCC2 protein CTD PMID:28161596 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases expression EXP physcione results in decreased expression of ABCC3 mRNA; physcione results in decreased expression of ABCC3 protein CTD PMID:28161596 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
decreases expression
ISO physcione results in increased expression of BAX protein
physcione results in decreased expression of BAX protein
CTD PMID:22285236 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO physcione results in decreased activity of CYP1A2 protein CTD PMID:27633141 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression EXP physcione results in decreased expression of CYP27A1 mRNA CTD PMID:28161596 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases hydroxylation ISO CYP2B6 protein results in increased hydroxylation of physcione CTD PMID:29667811 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases hydroxylation ISO CYP2C19 protein results in increased hydroxylation of physcione CTD PMID:29667811 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression EXP physcione results in decreased expression of CYP8B1 mRNA; physcione results in decreased expression of CYP8B1 protein CTD PMID:28161596 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP physcione results in decreased expression of SLC10A1 mRNA; physcione results in decreased expression of SLC10A1 protein CTD PMID:28161596 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases activity ISO physcione results in decreased activity of SULT1A1 protein CTD PMID:27633141 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of physcione CTD PMID:24854283 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      application 19420
        anti-inflammatory agent 14959
          physcion 13
            physcion 8-gentiobioside 0
            torososide B 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      ketone 16171
                                        cyclic ketone 13874
                                          quinone 8341
                                            acenoquinone 7500
                                              anthraquinone 471
                                                hydroxyanthraquinones 462
                                                  dihydroxyanthraquinone 321
                                                    physcion 13
                                                      physcion 8-gentiobioside 0
                                                      torososide B 0
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