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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:parathion-methyl
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Accession:CHEBI:38746 term browser browse the term
Definition:A C-nitro compound that is 4-nitrophenol substituted by a (dimethoxyphosphorothioyl)oxy group at position 4.
Synonyms:exact_synonym: O,O-dimethyl O-(4-nitrophenyl) phosphorothioate
 related_synonym: Dimethyl p-nitrophenyl thiophosphate;   Dimethyl parathion;   Formula=C8H10NO5PS;   InChI=1S/C8H10NO5PS/c1-12-15(16,13-2)14-8-5-3-7(4-6-8)9(10)11/h3-6H,1-2H3;   InChIKey=RLBIQVVOMOPOHC-UHFFFAOYSA-N;   Methylparathion;   O,O-Dimethyl O-(p-nitrophenyl) thionophosphate;   Phosphorothioic acid, O,O-dimethyl O-(4-nitrophenyl) ester;   Phosphorothioic acid, o,o-dimethyl-o-p-nitrophenyl ester;   SMILES=COP(=S)(OC)Oc1ccc(cc1)[N+]([O-])=O
 xref: Beilstein:1914724;   CAS:298-00-0;   KEGG:C14228
 xref_mesh: MESH:D008743
 xref: PMID:14188063;   PMID:17852161;   PMID:24468856;   PMID:24470377;   PMID:24657944;   PPDB:507;   Pesticides:parathion-methyl


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parathion-methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO
EXP
[Methyl Parathion co-treated with decamethrin] results in decreased activity of ACHE protein; [Methyl Parathion co-treated with Parathion] results in decreased activity of ACHE protein
Methyl Parathion results in decreased activity of ACHE protein
[Methyl Parathion co-treated with Chlorpyrifos] results in decreased activity of ACHE protein; [Methyl Parathion co-treated with NADP] results in decreased activity of ACHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein; [Methyl Parathion co-treated with pralidoxime] results in decreased expression of ACHE protein; Atropine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; CYP2B1 protein affects the reaction [Methyl Parathion results in decreased activity of ACHE protein]; CYP2B2 protein affects the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Memantine inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]; Phenobarbital inhibits the reaction [Methyl Parathion results in decreased activity of ACHE protein]
CTD PMID:1455421, PMID:1512808, PMID:2241428, PMID:3247000, PMID:3975908, PMID:6483827, PMID:7322183, PMID:7966439, PMID:9588345, PMID:10918524, PMID:11405414, PMID:11481665, PMID:11495289, PMID:11684353, PMID:12191869, PMID:12478623, PMID:14514956, PMID:14746346, PMID:15342957, PMID:15591769, PMID:15793557, PMID:16645783, PMID:16766477, PMID:17963125, PMID:19784758, PMID:29540303, PMID:32294493 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Add3 adducin 3 decreases expression
affects expression
increases expression
EXP Methyl Parathion results in decreased expression of ADD3 mRNA
Methyl Parathion affects the expression of ADD3 mRNA
Methyl Parathion results in increased expression of ADD3 mRNA
CTD PMID:19784758 NCBI chr 1:273,854,195...273,961,982
Ensembl chr 1:273,854,248...273,961,982
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 multiple interactions
increases activity
increases expression
ISO AKR1C2 protein affects the susceptibility to [Benzo(a)pyrene co-treated with Methyl Parathion]; Benzo(a)pyrene promotes the reaction [Methyl Parathion results in increased activity of AKR1C2 protein]; Methyl Parathion promotes the reaction [Benzo(a)pyrene results in increased expression of AKR1C2 mRNA]
Methyl Parathion results in increased expression of AKR1C2 mRNA
CTD PMID:19800895 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Alb albumin affects binding ISO Methyl Parathion binds to ALB protein CTD PMID:14700528 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Ar androgen receptor multiple interactions
affects binding
ISO
EXP
Dihydrotestosterone inhibits the reaction [Methyl Parathion results in increased activity of AR protein]; Methyl Parathion inhibits the reaction [Metribolone results in increased activity of AR protein]
Methyl Parathion binds to AR protein
CTD PMID:14565775, PMID:15064155, PMID:18324785 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression EXP Methyl Parathion results in decreased expression of BAX mRNA CTD PMID:29319433 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity
ISO
EXP
[Methyl Parathion co-treated with Parathion] results in decreased activity of BCHE protein
Methyl Parathion results in decreased activity of BCHE protein
[Methyl Parathion co-treated with Chlorpyrifos] results in decreased activity of BCHE protein; [Methyl Parathion co-treated with Diazinon] results in decreased activity of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime] results in decreased expression of BCHE protein
CTD PMID:1512808, PMID:11405414, PMID:11481665, PMID:17963125 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Methyl Parathion results in increased expression of BDNF mRNA; Methyl Parathion results in increased expression of BDNF protein CTD PMID:17893397 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Cat catalase increases activity EXP Methyl Parathion results in increased activity of CAT protein CTD PMID:3975908 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cck cholecystokinin affects expression
increases expression
decreases expression
EXP Methyl Parathion affects the expression of CCK mRNA
Methyl Parathion results in increased expression of CCK mRNA
Methyl Parathion results in decreased expression of CCK mRNA
CTD PMID:19784758 NCBI chr 8:130,120,525...130,127,515
Ensembl chr 8:130,120,523...130,127,392
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Methyl Parathion results in increased expression of CDKN1A mRNA CTD PMID:18418871 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 decreases activity
decreases expression
EXP Methyl Parathion results in decreased activity of CHRM1 protein
Methyl Parathion results in decreased expression of CHRM1 protein
CTD PMID:14746346, PMID:16645783, PMID:17666426, PMID:18650256 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 decreases activity
decreases expression
EXP Methyl Parathion results in decreased activity of CHRM2 protein
Methyl Parathion results in decreased expression of CHRM2 protein
CTD PMID:14746346, PMID:16645783, PMID:17666426, PMID:18650256 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 decreases activity EXP Methyl Parathion results in decreased activity of CHRM3 protein CTD PMID:17666426 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 decreases activity EXP Methyl Parathion results in decreased activity of CHRM4 protein CTD PMID:17666426 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006
JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit increases expression EXP Methyl Parathion results in increased expression of CHRNA6 mRNA CTD PMID:18977431 NCBI chr16:68,860,018...68,866,718
Ensembl chr16:68,860,018...68,866,718
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit affects expression EXP Methyl Parathion affects the expression of CHRNA7 mRNA CTD PMID:18977431 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity ISO Methyl Parathion results in increased activity of CYP19A1 protein CTD PMID:16996190 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO Methyl Parathion results in increased expression of CYP1A1 mRNA
Methyl Parathion inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]
CTD PMID:19800895 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP CYP2B1 protein affects the reaction [Methyl Parathion results in decreased activity of ACHE protein] CTD PMID:11684353 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP CYP2B2 protein affects the reaction [Methyl Parathion results in decreased activity of ACHE protein] CTD PMID:11684353 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases metabolic processing EXP CYP2C11 protein results in increased metabolism of Methyl Parathion CTD PMID:22271348 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases metabolic processing EXP CYP3A23-3A1 protein results in increased metabolism of Methyl Parathion CTD PMID:22271348 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Methyl Parathion results in increased expression of FOS mRNA CTD PMID:17893397 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 increases expression EXP Methyl Parathion results in increased expression of GABBR2 mRNA CTD PMID:19784758 NCBI chr 5:62,276,100...62,621,737
Ensembl chr 5:62,276,100...62,621,737
JBrowse link
G Gabrr2 gamma-aminobutyric acid type A receptor subunit rho 2 increases expression EXP Methyl Parathion results in increased expression of GABRR2 mRNA CTD PMID:19784758 NCBI chr 5:48,303,366...48,341,571
Ensembl chr 5:48,303,366...48,341,642
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Methyl Parathion results in increased expression of GADD45A mRNA CTD PMID:18418871 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gp1bb glycoprotein Ib platelet subunit beta increases expression EXP Methyl Parathion results in increased expression of GP1BB mRNA CTD PMID:19784758 NCBI chr11:86,520,992...86,522,169
Ensembl chr11:86,520,992...86,522,169
JBrowse link
G Gsr glutathione-disulfide reductase affects expression EXP Methyl Parathion affects the expression of GSR protein CTD PMID:18571824 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions
increases expression
ISO GSTA1 protein affects the metabolism of and results in decreased alkylation of Methyl Parathion
Methyl Parathion results in increased expression of GSTA1 mRNA; Methyl Parathion results in increased expression of GSTA1 protein
CTD PMID:15103050, PMID:21907274 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gstt1 glutathione S-transferase theta 1 multiple interactions ISO GSTT1 protein affects the metabolism of and results in decreased alkylation of Methyl Parathion CTD PMID:15103050 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Gusb glucuronidase, beta decreases activity EXP Methyl Parathion results in decreased activity of GUSB protein CTD PMID:3008131, PMID:3008132 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Methyl Parathion results in increased expression of IL1B mRNA CTD PMID:26948828 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression ISO Methyl Parathion results in increased expression of IL6 mRNA CTD PMID:26948828 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lcat lecithin cholesterol acyltransferase decreases activity
multiple interactions
ISO Methyl Parathion results in decreased activity of LCAT protein
Methyl Parathion inhibits the reaction [[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters]
CTD PMID:4847537 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
JBrowse link
G Maoa monoamine oxidase A increases activity EXP Methyl Parathion results in increased activity of MAOA protein CTD PMID:11495289 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO Methyl Parathion results in increased expression of MDM2 mRNA CTD PMID:18418871 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Methyl Parathion results in decreased expression of MKI67 protein CTD PMID:18418871 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases methylation ISO Methyl Parathion results in increased methylation of NFE2L2 promoter CTD PMID:29540303 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Ngf nerve growth factor affects expression EXP Methyl Parathion affects the expression of NGF mRNA; Methyl Parathion affects the expression of NGF protein CTD PMID:17893397 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase increases methylation ISO Methyl Parathion results in increased methylation of OGG1 promoter CTD PMID:29540303 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G P2rx1 purinergic receptor P2X 1 increases expression EXP Methyl Parathion results in increased expression of P2RX1 mRNA CTD PMID:19784758 NCBI chr10:59,566,268...59,581,328
Ensembl chr10:59,566,223...59,581,325
JBrowse link
G Pon1 paraoxonase 1 multiple interactions
decreases expression
ISO Methyl Parathion results in decreased expression of and results in decreased activity of PON1 protein
Methyl Parathion results in decreased expression of PON1 mRNA
CTD PMID:26948828 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 decreases expression ISO Methyl Parathion results in decreased expression of RIPK1 mRNA CTD PMID:26688254 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 decreases expression
increases expression
affects expression
EXP Methyl Parathion results in decreased expression of SRSF5 mRNA
Methyl Parathion results in increased expression of SRSF5 mRNA
Methyl Parathion affects the expression of SRSF5 mRNA
CTD PMID:19784758 NCBI chr 6:104,611,026...104,640,033
Ensembl chr 6:104,611,026...104,615,302
JBrowse link
G St14 ST14 transmembrane serine protease matriptase affects expression
increases expression
decreases expression
EXP Methyl Parathion affects the expression of ST14 mRNA
Methyl Parathion results in increased expression of ST14 mRNA
Methyl Parathion results in decreased expression of ST14 mRNA
CTD PMID:19784758 NCBI chr 8:32,240,113...32,280,813
Ensembl chr 8:32,240,133...32,280,869
JBrowse link
G Tgm1 transglutaminase 1 decreases expression EXP Methyl Parathion results in decreased expression of TGM1 mRNA CTD PMID:19784758 NCBI chr15:34,378,136...34,393,150
Ensembl chr15:34,378,148...34,392,066
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 increases expression
affects expression
EXP Methyl Parathion results in increased expression of TIMP3 mRNA
Methyl Parathion affects the expression of TIMP3 mRNA
CTD PMID:19784758 NCBI chr 7:23,543,125...23,594,170
Ensembl chr 7:23,544,215...23,594,133
JBrowse link
G Tnf tumor necrosis factor increases expression
decreases expression
ISO
EXP
Methyl Parathion results in increased expression of TNF mRNA
Methyl Parathion results in decreased expression of TNF mRNA
CTD PMID:26948828, PMID:29319433 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Methyl Parathion results in increased expression of TP53 mRNA CTD PMID:18418871 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        agrochemical 14499
          parathion-methyl 50
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      chalcogen 19399
                        oxygen atom 19361
                          oxygen molecular entity 19361
                            hydroxides 19107
                              oxoacid 18241
                                pnictogen oxoacid 10179
                                  phosphorus oxoacid 9071
                                    phosphoric acids 7830
                                      phosphoric acid 7830
                                        phosphoric acid derivative 7511
                                          phosphate 7511
                                            organic phosphate 7510
                                              organic thiophosphate 2873
                                                parathion-methyl 50
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.