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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:profenofos
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Accession:CHEBI:38845 term browser browse the term
Definition:An organophosphate insecticide that has formula C11H15BrClO3PS.
Synonyms:exact_synonym: O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate
 related_synonym: Curacron;   Formula=C11H15BrClO3PS;   InChI=1S/C11H15BrClO3PS/c1-3-7-18-17(14,15-4-2)16-11-6-5-9(12)8-10(11)13/h5-6,8H,3-4,7H2,1-2H3;   InChIKey=QYMMJNLHFKGANY-UHFFFAOYSA-N;   O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl thiophosphate;   Phosphorothioic acid, O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl ester;   SMILES=CCCSP(=O)(OCC)Oc1ccc(Br)cc1Cl
 xref: Beilstein:2150258;   CAS:41198-08-7;   KEGG:C18404
 xref_mesh: MESH:C024273
 xref: PPDB:538


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profenofos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO
EXP
profenofos results in decreased activity of ACHE protein
profenofos metabolite results in decreased activity of ACHE protein
CTD PMID:16978018, PMID:21251949, PMID:30625376 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Alb albumin affects binding ISO profenofos binds to ALB protein CTD PMID:28407546 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Arid1a AT-rich interaction domain 1A decreases expression EXP profenofos results in decreased expression of ARID1A mRNA CTD PMID:17569032 NCBI chr 5:151,904,687...151,977,973
Ensembl chr 5:151,904,684...151,977,636
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO profenofos results in decreased activity of BCHE protein CTD PMID:9890196 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [cypermethrin co-treated with Chlorpyrifos co-treated with profenofos] results in increased cleavage of CASP3 protein CTD PMID:21987380 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase increases expression EXP profenofos results in increased expression of CAT mRNA CTD PMID:23495063 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Chrdl1 chordin-like 1 decreases expression EXP profenofos results in decreased expression of CHRDL1 mRNA CTD PMID:17569032 NCBI chr  X:114,554,359...114,658,975
Ensembl chr  X:114,554,359...114,658,931
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression EXP profenofos results in increased expression of CYP11A1 mRNA CTD PMID:17569032 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression EXP profenofos results in increased expression of CYP17A1 mRNA CTD PMID:17569032 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression EXP profenofos results in decreased expression of CYP19A1 mRNA CTD PMID:18828448 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO profenofos results in decreased activity of CYP1A1 protein CTD PMID:20183062 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases activity
ISO profenofos results in increased expression of CYP1A2 mRNA
profenofos results in decreased activity of CYP1A2 protein
CTD PMID:20183062, PMID:22310298 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
increases metabolic processing
multiple interactions
decreases activity
ISO profenofos results in increased expression of CYP2B6 mRNA
CYP2B6 protein results in increased metabolism of profenofos
[CYP2B6 protein results in increased metabolism of profenofos] which results in increased abundance of 4-bromo-2-chlorophenol
profenofos results in decreased activity of CYP2B6 protein
CTD PMID:22310298, PMID:23415833 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP profenofos results in decreased expression of CYP2C11 mRNA; profenofos results in decreased expression of CYP2C11 protein CTD PMID:18828448 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing
multiple interactions
ISO CYP2C19 protein results in increased metabolism of profenofos
[CYP2C19 protein results in increased metabolism of profenofos] which results in increased abundance of 4-bromo-2-chlorophenol
CTD PMID:23415833 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
ISO profenofos inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
profenofos results in decreased activity of CYP2E1 protein
CTD PMID:22634058 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression EXP profenofos results in decreased expression of CYP3A2 mRNA; profenofos results in decreased expression of CYP3A2 protein CTD PMID:18828448 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Faah fatty acid amide hydrolase decreases activity ISO profenofos results in decreased activity of FAAH protein CTD PMID:11350214 NCBI chr 5:134,852,899...134,872,095
Ensembl chr 5:134,852,875...134,871,775
JBrowse link
G Faahl fatty-acid amide hydrolase-like decreases activity ISO profenofos results in decreased activity of FAAH protein CTD PMID:11350214 NCBI chr 5:134,330,204...134,349,400
Ensembl chr 5:134,331,929...134,348,995
JBrowse link
G Gch1 GTP cyclohydrolase 1 decreases expression EXP profenofos results in decreased expression of GCH1 mRNA CTD PMID:17569032 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A decreases expression EXP profenofos results in decreased expression of GRIN2A mRNA CTD PMID:17569032 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Hao2 hydroxyacid oxidase 2 increases expression EXP profenofos results in increased expression of HAO2 mRNA CTD PMID:17569032 NCBI chr 2:200,785,492...200,808,868
Ensembl chr 2:200,778,122...200,808,857
JBrowse link
G Hp haptoglobin increases expression EXP profenofos results in increased expression of HP mRNA CTD PMID:17569032 NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804
JBrowse link
G Lamc1 laminin subunit gamma 1 decreases expression EXP profenofos results in decreased expression of LAMC1 mRNA CTD PMID:17569032 NCBI chr13:70,656,727...70,783,515
Ensembl chr13:70,658,707...70,783,515
JBrowse link
G Mcam melanoma cell adhesion molecule decreases expression EXP profenofos results in decreased expression of MCAM mRNA CTD PMID:17569032 NCBI chr 8:48,472,824...48,481,005
Ensembl chr 8:48,472,824...48,481,001
JBrowse link
G Ms4a6a membrane spanning 4-domains A6A increases expression EXP profenofos results in increased expression of MS4A6A mRNA CTD PMID:17569032 NCBI chr 1:227,919,284...227,932,637
Ensembl chr 1:227,919,301...227,932,603
JBrowse link
G Myo1d myosin ID decreases expression EXP profenofos results in decreased expression of MYO1D mRNA CTD PMID:17569032 NCBI chr10:67,866,939...68,142,864
Ensembl chr10:67,866,940...68,142,864
JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases activity ISO profenofos results in decreased activity of NCEH1 protein CTD PMID:16978018 NCBI chr 2:112,868,834...112,932,622
Ensembl chr 2:112,868,707...112,934,953
JBrowse link
G Nell1 neural EGFL like 1 decreases expression EXP profenofos results in decreased expression of NELL1 mRNA CTD PMID:17569032 NCBI chr 1:105,348,577...106,218,970
Ensembl chr 1:105,349,069...106,218,958
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression ISO profenofos results in increased expression of NR1I3 mRNA CTD PMID:22310298 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nrbf2 nuclear receptor binding factor 2 decreases expression EXP profenofos results in decreased expression of NRBF2 mRNA CTD PMID:17569032 NCBI chr20:22,728,145...22,746,477
Ensembl chr20:22,728,208...22,746,474
JBrowse link
G Pdzrn3 PDZ domain containing RING finger 3 increases expression EXP profenofos results in increased expression of PDZRN3 mRNA CTD PMID:17569032 NCBI chr 4:133,717,139...133,951,282
Ensembl chr 4:133,717,139...133,951,264
JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression EXP profenofos results in increased expression of RGS2 mRNA CTD PMID:17569032 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
G Rwdd2b RWD domain containing 2B increases expression EXP profenofos results in increased expression of RWDD2B mRNA CTD PMID:17569032 NCBI chr11:27,085,708...27,094,364
Ensembl chr11:27,085,711...27,094,364
JBrowse link
G Slc1a1 solute carrier family 1 member 1 decreases expression EXP profenofos results in decreased expression of SLC1A1 mRNA CTD PMID:17569032 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP profenofos results in increased expression of SOD1 mRNA CTD PMID:23495063 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Star steroidogenic acute regulatory protein increases expression EXP profenofos results in increased expression of STAR mRNA CTD PMID:17569032 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      application 19420
        agrochemical 14503
          profenofos 37
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      chalcogen 19391
                        oxygen atom 19353
                          oxygen molecular entity 19353
                            hydroxides 19103
                              oxoacid 18235
                                pnictogen oxoacid 10181
                                  phosphorus oxoacid 9072
                                    phosphoric acids 7831
                                      phosphoric acid 7831
                                        phosphoric acid derivative 7511
                                          phosphate 7511
                                            organic phosphate 7510
                                              organic thiophosphate 2874
                                                profenofos 37
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