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ONTOLOGY REPORT - ANNOTATIONS


Term:costunolide
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Accession:CHEBI:3900 term browser browse the term
Definition:A germacranolide with anthelminthic, antiparasitic and antiviral activities.
Synonyms:exact_synonym: (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2(3H)-one
 related_synonym: (10S,1R)-3,7-dimethyl-11-methylene-13-oxabicyclo[8.3.0]trideca-2,6-dien-12-one;   (3aS,6E,10E)-3-Methylene-6,10-dimethyl-2,3,3abeta,4,5,8,9,11aalpha-octahydrocyclodeca[b]furan-2-one;   (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2(3H)-one;   (E,E)-6-alpha-Hydroxygermacra-1(10),4,11(13)-trien-12-oic acid gamma-lactone;   (E,E)-germacra-1(10),4,11(13)-trien-12-oic acid, 6-alpha-hydroxy-gamma-lactone;   Costunlide;   Costunolid;   Costus lactone;   Formula=C15H20O2;   InChI=1S/C15H20O2/c1-10-5-4-6-11(2)9-14-13(8-7-10)12(3)15(16)17-14/h5,9,13-14H,3-4,6-8H2,1-2H3/b10-5+,11-9+/t13-,14+/m0/s1;   InChIKey=HRYLQFBHBWLLLL-AHNJNIBGSA-N;   SMILES=[C@H]12C=C(CCC=C(CC[C@H]2C(C(O1)=O)=C)C)C
 alt_id: CHEBI:545296
 xref: Beilstein:14451 "Beilstein";   CAS:553-21-9 "ChemIDplus";   CAS:553-21-9 "KEGG COMPOUND";   KEGG:C09382;   KNApSAcK:C00003240
 xref_mesh: MESH:C002602
 xref: PMID:11534769 "Europe PMC";   PMID:11912066 "Europe PMC";   PMID:14510592 "ChEMBL";   PMID:18409040 "Europe PMC";   PMID:6476889 "Europe PMC";   Patent:KR20000066932;   Reaxys:14451 "Reaxys";   Wikipedia:Costunolide


show annotations for term's descendants       view all columns           Sort by:
 
costunolide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Pcna proliferating cell nuclear antigen JBrowse link 3 124,880,698 124,884,570 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      biological role 19661
        biochemical role 19179
          metabolite 19151
            costunolide 6
              3beta-hydroxycostunolide 0
              6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic group 18407
                              organic divalent group 18397
                                organodiyl group 18397
                                  carbonyl group 18285
                                    carbonyl compound 18285
                                      carboxylic ester 13969
                                        lactone 5865
                                          terpene lactone 1744
                                            sesquiterpene lactone 1597
                                              germacranolide 6
                                                costunolide 6
                                                  3beta-hydroxycostunolide 0
                                                  6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate 0
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