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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyrene
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Accession:CHEBI:39106 term browser browse the term
Definition:An ortho- and peri-fused polycyclic arene consisting of four fused benzene rings, resulting in a flat aromatic system.
Synonyms:related_synonym: Formula=C16H10;   InChI=1S/C16H10/c1-3-11-7-9-13-5-2-6-14-10-8-12(4-1)15(11)16(13)14/h1-10H;   InChIKey=BBEAQIROQSPTKN-UHFFFAOYSA-N;   Pyren;   SMILES=c1cc2ccc3cccc4ccc(c1)c2c34;   benzo[def]phenanthrene;   beta-pyrene
 alt_id: CHEBI:29860;   CHEBI:34940
 xref: Beilstein:1307225;   CAS:129-00-0;   Gmelin:84203;   HMDB:HMDB0042002;   KEGG:C14335
 xref_mesh: MESH:C030984
 xref: PMID:12946434;   PMID:16349406;   PMID:17517702;   PMID:18428918;   PMID:18709924;   PMID:24406158;   PMID:7561049;   Reaxys:1307225;   Wikipedia:Pyrene


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pyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp2 acid phosphatase 2, lysosomal affects expression
multiple interactions
ISO pyrene affects the expression of ACP2 protein
[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of ACP2 protein
CTD PMID:28803881 NCBI chr 3:80,020,346...80,030,365
Ensembl chr 3:80,021,440...80,030,363
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects binding
affects response to substance
increases activity
EXP
ISO
pyrene binds to and results in increased activity of AHR protein; pyrene inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]
pyrene binds to AHR protein
[AHR affects the susceptibility to pyrene] which affects the expression of UGT1A1 mRNA; [AHR affects the susceptibility to pyrene] which affects the expression of UGT1A6A mRNA; AHR gene mutant form promotes the reaction [pyrene results in increased expression of NR1I3 mRNA]
pyrene results in increased activity of AHR protein
[benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene co-treated with pyrene] results in increased activity of AHR protein; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [indeno(1,2,3-cd)pyrene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene] promotes the reaction [pyrene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with pyrene] promotes the reaction [fluoranthene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [chrysene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [benzo(k)fluoranthene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [benzo(j)fluoranthene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; [Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [benz(a)anthracene results in increased activity of AHR protein]; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein; [pyrene co-treated with Benzo(a)pyrene] results in increased activity of AHR protein; [pyrene co-treated with naphthalene] inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; [pyrene co-treated with phenanthrene] inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein]; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein]; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein]; fluoranthene promotes the reaction [pyrene results in increased activity of AHR protein]; pyrene promotes the reaction [fluoranthene results in increased activity of AHR protein]
CTD PMID:3024361, PMID:12850102, PMID:17618724, PMID:17665671, PMID:28710019, PMID:29502740, PMID:30980910 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHRR protein; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein]; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein] CTD PMID:28710019, PMID:30980910 NCBI chr 1:31,603,297...31,698,329
Ensembl chr 1:31,603,297...31,698,329
JBrowse link
G Ar androgen receptor multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein]; pyrene inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; pyrene inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785, PMID:26022396, PMID:30980910 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of ARNT protein; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of ARNT mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ARNT mRNA CTD PMID:28710019 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects expression
ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of BAX protein
pyrene affects the expression of BAX protein
CTD PMID:28803881 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Casp3 caspase 3 increases expression
increases activity
multiple interactions
EXP
ISO
pyrene results in increased expression of CASP3 mRNA
pyrene results in increased activity of CASP3 protein
pyrene results in increased expression of CASP3 protein
[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CASP3 protein
CTD PMID:19815060, PMID:28803881, PMID:31368503 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity EXP pyrene results in increased activity of CASP7 protein CTD PMID:31368503 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Ccna2 cyclin A2 multiple interactions
decreases expression
ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in decreased expression of CCNA2 protein
pyrene results in decreased expression of CCNA2 protein
CTD PMID:28803881 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CCND1 protein
pyrene results in increased expression of CCND1 protein
CTD PMID:28803881 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd63 Cd63 molecule decreases expression EXP pyrene results in decreased expression of CD63 protein CTD PMID:31368503 NCBI chr 7:3,320,250...3,335,583
Ensembl chr 7:3,320,103...3,335,582
JBrowse link
G Cd81 Cd81 molecule decreases expression EXP pyrene results in decreased expression of CD81 protein CTD PMID:31368503 NCBI chr 1:216,237,663...216,253,460
Ensembl chr 1:216,237,697...216,253,311
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
increases expression
ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CDK2 protein
pyrene results in increased expression of CDK2 protein
CTD PMID:28803881 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT protein CTD PMID:28710019 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
affects expression
ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of CYP19A1 protein
pyrene affects the expression of CYP19A1 protein
CTD PMID:28803881 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases hydroxylation
increases activity
ISO
EXP
[Docosahexaenoic Acids co-treated with pyrene] results in decreased expression of CYP1A1 mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of CYP1A1 mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of CYP1A1 protein; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein; [phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1A1 mRNA; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein]
pyrene results in increased expression of CYP1A1 mRNA
pyrene results in increased expression of CYP1A1 mRNA; pyrene results in increased expression of CYP1A1 protein
[fluoranthene co-treated with pyrene co-treated with benz(a)anthracene co-treated with chrysene co-treated with benzo(b)fluoranthene co-treated with benzo(k)fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of CYP1A1 mRNA
CYP1A1 protein results in increased hydroxylation of pyrene
pyrene results in increased activity of CYP1A1 protein
CTD PMID:7750161, PMID:15016593, PMID:15566942, PMID:16906435, PMID:25956473, PMID:26160115, PMID:28710019, PMID:30240548, PMID:30980910 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases hydroxylation
increases expression
multiple interactions
ISO
EXP
CYP1A2 protein results in increased hydroxylation of pyrene
pyrene results in increased expression of CYP1A2 mRNA
pyrene results in increased expression of CYP1A2 mRNA; pyrene results in increased expression of CYP1A2 protein
[fluoranthene co-treated with pyrene co-treated with benz(a)anthracene co-treated with chrysene co-treated with benzo(b)fluoranthene co-treated with benzo(k)fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of CYP1A2 mRNA; pyrene results in increased expression of and results in increased activity of CYP1A2 protein
CTD PMID:7750161, PMID:15016593, PMID:17618724, PMID:26160115, PMID:30240548 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases hydroxylation
increases expression
multiple interactions
ISO CYP1B1 protein results in increased hydroxylation of pyrene
pyrene results in increased expression of CYP1B1 protein
[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1B1 mRNA; pyrene binds to and results in decreased activity of CYP1B1 protein; pyrene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]
CTD PMID:15016593, PMID:15566942, PMID:19365803, PMID:19563207, PMID:30248327 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO
EXP
NR1I3 gene mutant form inhibits the reaction [pyrene results in increased expression of CYP2B10 mRNA]
pyrene results in increased expression of CYP2B1 mRNA
CTD PMID:17618724, PMID:26160115, PMID:30240548 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP pyrene results in increased expression of CYP2B2 mRNA CTD PMID:30240548 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
multiple interactions
ISO pyrene results in increased expression of CYP2B6 mRNA
[pyrene results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA
CTD PMID:26160115 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 affects expression EXP pyrene affects the expression of CYP2C11 mRNA CTD PMID:30240548 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects expression EXP pyrene affects the expression of CYP2C6V1 mRNA CTD PMID:30240548 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression EXP pyrene results in decreased expression of CYP2E1 mRNA CTD PMID:30240548 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP pyrene results in increased expression of CYP3A23-3A1 mRNA CTD PMID:30240548 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein] CTD PMID:30980910 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression EXP pyrene results in decreased expression of GJB1 protein CTD PMID:25268939 NCBI chr  X:71,272,030...71,279,973
Ensembl chr  X:71,272,042...71,279,977
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions
increases expression
ISO [Docosahexaenoic Acids co-treated with pyrene] results in decreased expression of GSTM1 protein
pyrene results in increased expression of GSTM1 mRNA
CTD PMID:25956473, PMID:26160115 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO pyrene results in increased expression of GSTM3 mRNA CTD PMID:26160115 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO pyrene results in increased expression of HSPA1A mRNA CTD PMID:22367790 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO pyrene results in increased expression of ICAM1 protein CTD PMID:22313677 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma affects activity ISO pyrene affects the activity of IFNG protein CTD PMID:9258441 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il4 interleukin 4 increases expression ISO pyrene results in increased expression of IL4 mRNA; pyrene results in increased expression of IL4 protein CTD PMID:10756232 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of NFKB2 protein CTD PMID:30980910 NCBI chr 1:266,050,634...266,059,277
Ensembl chr 1:266,053,002...266,059,256
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity EXP pyrene results in increased activity of NQO1 protein CTD PMID:16906435 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
decreases expression
increases activity
increases response to substance
increases expression
ISO
EXP
AHR gene mutant form promotes the reaction [pyrene results in increased expression of NR1I3 mRNA]; NR1I3 gene mutant form inhibits the reaction [pyrene results in decreased abundance of Glutathione]; NR1I3 gene mutant form inhibits the reaction [pyrene results in increased expression of CYP2B10 mRNA]; pyrene affects the localization of and results in increased activity of NR1I3 protein
pyrene results in decreased expression of NR1I3 mRNA
pyrene results in increased activity of NR1I3 protein
NR1I3 results in increased susceptibility to pyrene
[pyrene results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA
CTD PMID:17618724, PMID:26160115, PMID:28927721, PMID:30240548 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO pyrene results in increased cleavage of PARP1 protein CTD PMID:21132278 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein increases expression EXP pyrene results in increased expression of PDCD6IP protein CTD PMID:31368503 NCBI chr 8:121,916,233...121,973,145
Ensembl chr 8:121,916,185...121,973,125
JBrowse link
G Pgr progesterone receptor multiple interactions ISO pyrene inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein] CTD PMID:26022396 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A increases mutagenesis EXP pyrene results in increased mutagenesis of PIGA CTD PMID:22923490 NCBI chr  X:31,786,823...31,799,751
Ensembl chr  X:31,786,194...31,799,560
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Docosahexaenoic Acids co-treated with pyrene] results in increased expression of PTGS2 mRNA CTD PMID:25956473 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions
increases expression
ISO pyrene results in increased expression of and results in increased activity of SULT1A1 protein
pyrene results in increased expression of SULT1A1 mRNA
CTD PMID:17618724, PMID:26160115 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO [Poly I-C binds to TLR3 protein] which affects the susceptibility to pyrene CTD PMID:23458896 NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO TNF protein promotes the reaction [pyrene results in increased expression of CXCL8 mRNA] CTD PMID:18434080 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO pyrene promotes the reaction [Benzo(a)pyrene results in increased expression of TRP53 protein] CTD PMID:22120587 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tsg101 tumor susceptibility 101 increases expression EXP pyrene results in increased expression of TSG101 protein CTD PMID:31368503 NCBI chr 1:102,941,151...102,971,017
Ensembl chr 1:102,941,231...102,970,950
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO [AHR affects the susceptibility to pyrene] which affects the expression of UGT1A1 mRNA CTD PMID:17618724 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases expression
multiple interactions
ISO pyrene results in decreased expression of UGT1A6 mRNA
[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of UGT1A6 mRNA
CTD PMID:15566942, PMID:26160115 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
1-nitropyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abce1 ATP binding cassette subfamily E member 1 increases expression ISO 1-nitropyrene results in increased expression of ABCE1 mRNA CTD PMID:19041380 NCBI chr19:31,867,960...31,892,863
Ensembl chr19:31,867,981...31,892,863
JBrowse link
G Abcf1 ATP binding cassette subfamily F member 1 increases expression ISO 1-nitropyrene results in increased expression of ABCF1 mRNA CTD PMID:19428942 NCBI chr20:3,309,914...3,322,828
Ensembl chr20:3,309,899...3,322,825
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 increases expression ISO 1-nitropyrene results in increased expression of ADAMTS1 mRNA CTD PMID:19041380 NCBI chr11:25,342,119...25,350,938
Ensembl chr11:25,342,126...25,350,974
JBrowse link
G Adgrg6 adhesion G protein-coupled receptor G6 increases expression ISO 1-nitropyrene results in increased expression of ADGRG6 mRNA CTD PMID:19041380 NCBI chr 1:8,593,342...8,751,540
Ensembl chr 1:8,593,075...8,751,198
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO ADRB2 protein promotes the reaction [1-nitropyrene results in increased secretion of CXCL8 protein] CTD PMID:24904980 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Aff4 AF4/FMR2 family, member 4 increases expression ISO 1-nitropyrene results in increased expression of AFF4 mRNA CTD PMID:19041380 NCBI chr10:38,692,167...38,773,021
Ensembl chr10:38,692,211...38,773,021
JBrowse link
G Aftph aftiphilin increases expression ISO 1-nitropyrene results in increased expression of AFTPH mRNA CTD PMID:19041380 NCBI chr14:104,921,633...104,975,763
Ensembl chr14:104,922,282...104,960,141
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects response to substance
ISO 1-nitropyrene binds to and results in increased activity of AHR protein; [beta-Naphthoflavone binds to and results in increased activity of AHR protein] results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]
AHR affects the susceptibility to 1-nitropyrene
CTD PMID:12117779, PMID:22044530, PMID:28186253 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO 1-nitropyrene results in increased phosphorylation of and results in increased activity of AKT1 protein CTD PMID:17240030 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alcam activated leukocyte cell adhesion molecule increases expression ISO 1-nitropyrene results in increased expression of ALCAM mRNA CTD PMID:19041380 NCBI chr11:50,780,735...50,985,083
Ensembl chr11:50,781,127...50,985,083
JBrowse link
G Ang angiogenin decreases expression ISO 1-nitropyrene results in decreased expression of ANG mRNA CTD PMID:19041380 NCBI chr15:28,022,926...28,028,636 JBrowse link
G Antxr2 ANTXR cell adhesion molecule 2 increases expression ISO 1-nitropyrene results in increased expression of ANTXR2 mRNA CTD PMID:19041380 NCBI chr14:13,191,716...13,331,286
Ensembl chr14:13,192,347...13,274,978
JBrowse link
G Apcdd1 APC down-regulated 1 decreases expression ISO 1-nitropyrene results in decreased expression of APCDD1 mRNA CTD PMID:19041380 NCBI chr18:58,270,398...58,300,982
Ensembl chr18:58,270,410...58,301,002
JBrowse link
G Ar androgen receptor multiple interactions ISO 1-nitropyrene inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arfip1 ADP-ribosylation factor interacting protein 1 increases expression ISO 1-nitropyrene results in increased expression of ARFIP1 mRNA CTD PMID:19041380 NCBI chr 2:183,503,250...183,582,798
Ensembl chr 2:183,504,330...183,582,553
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO 1-nitropyrene results in increased expression of ASNS mRNA CTD PMID:19041380 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atg7 autophagy related 7 multiple interactions
affects response to substance
increases expression
ISO 3-methyladenine inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; [Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; CEBPA protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]; NDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; NDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]; NDUFA2 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; NDUFA2 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]
ATG7 protein affects the susceptibility to 1-nitropyrene
1-nitropyrene results in increased expression of ATG7 mRNA; 1-nitropyrene results in increased expression of ATG7 protein
ATG7 protein affects the reaction [1-nitropyrene results in increased expression of MAP1LC3B protein]; ATG7 protein affects the reaction [1-nitropyrene results in increased secretion of IL6 protein]
CTD PMID:29078374 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d decreases expression
multiple interactions
ISO 1-nitropyrene results in decreased expression of ATP5H mRNA
[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of ATP5H mRNA]
CTD PMID:29078374 NCBI chr10:103,967,340...103,972,552
Ensembl chr10:103,967,312...103,972,668
JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 increases expression ISO 1-nitropyrene results in increased expression of ATP8B1 mRNA CTD PMID:19041380 NCBI chr18:60,013,388...60,152,920
Ensembl chr18:60,013,382...60,095,354
JBrowse link
G Bad BCL2-associated agonist of cell death increases phosphorylation ISO 1-nitropyrene results in increased phosphorylation of BAD protein CTD PMID:17240030 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO 1-nitropyrene results in increased expression of BAX mRNA
TP53 affects the reaction [1-nitropyrene results in increased expression of BAX mRNA]
CTD PMID:10837373 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression ISO 1-nitropyrene results in increased expression of BCL2A1 mRNA CTD PMID:21540303 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO 1-nitropyrene results in decreased expression of BCL2L1 protein CTD PMID:17240030 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO 1-nitropyrene results in increased expression of BID protein CTD PMID:17240030 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO 1-nitropyrene results in increased expression of BIRC3 mRNA CTD PMID:21540303 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO 1-nitropyrene results in increased expression of BMP2 mRNA CTD PMID:21540303 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bmper BMP-binding endothelial regulator increases expression ISO 1-nitropyrene results in increased expression of BMPER mRNA CTD PMID:19041380 NCBI chr 8:24,369,916...24,615,484
Ensembl chr 8:24,369,916...24,615,479
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression ISO 1-nitropyrene results in decreased expression of BRCA1 mRNA CTD PMID:21540303 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G C1qtnf2 C1q and TNF related 2 decreases expression ISO 1-nitropyrene results in decreased expression of C1QTNF2 mRNA CTD PMID:19041380 NCBI chr10:29,067,102...29,084,035
Ensembl chr10:29,067,102...29,084,035
JBrowse link
G C1rl complement C1r subcomponent like decreases expression ISO 1-nitropyrene results in decreased expression of C1RL mRNA CTD PMID:19041380 NCBI chr 4:157,108,190...157,122,689
Ensembl chr 4:157,107,469...157,123,446
JBrowse link
G Ca6 carbonic anhydrase 6 decreases expression ISO 1-nitropyrene results in decreased expression of CA6 mRNA CTD PMID:19041380 NCBI chr 5:167,226,246...167,244,786
Ensembl chr 5:167,226,246...167,244,786
JBrowse link
G Casp2 caspase 2 increases activity ISO 1-nitropyrene results in increased activity of CASP2 protein CTD PMID:21872649 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO 1-nitropyrene results in increased cleavage of and results in increased activity of CASP3 protein; methyl-beta-cyclodextrin inhibits the reaction [1-nitropyrene results in increased activity of CASP3 protein] CTD PMID:17240030, PMID:21872649 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO 1-nitropyrene results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:17240030 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cbs cystathionine beta synthase increases expression ISO 1-nitropyrene results in increased expression of CBS mRNA CTD PMID:19041380 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Ccdc18 coiled-coil domain containing 18 increases expression ISO 1-nitropyrene results in increased expression of CCDC18 mRNA CTD PMID:19041380 NCBI chr14:1,664,620...1,701,269
NCBI chr14:2,510,184...2,612,070
Ensembl chr14:2,509,363...2,610,929
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 decreases expression ISO 1-nitropyrene results in decreased expression of CCL17 mRNA CTD PMID:19428942 NCBI chr19:10,619,220...10,620,671
Ensembl chr19:10,619,220...10,620,671
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 decreases expression ISO 1-nitropyrene results in decreased expression of CCL19 mRNA CTD PMID:19428942 NCBI chr 5:58,181,025...58,182,969
Ensembl chr 5:58,181,026...58,183,017
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO 1-nitropyrene results in increased expression of CCL20 mRNA CTD PMID:19428942, PMID:19879285, PMID:21540303 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccl21 C-C motif chemokine ligand 21 decreases expression ISO 1-nitropyrene results in decreased expression of CCL21 mRNA CTD PMID:19428942 NCBI chr 5:58,197,678...58,198,782
Ensembl chr 5:58,197,680...58,198,782
JBrowse link
G Ccl24 C-C motif chemokine ligand 24 decreases expression ISO 1-nitropyrene results in decreased expression of CCL24 mRNA CTD PMID:19428942 NCBI chr12:24,131,529...24,152,626
Ensembl chr12:24,148,567...24,152,625
JBrowse link
G Ccl26 C-C motif chemokine ligand 26 decreases expression ISO 1-nitropyrene results in decreased expression of CCL26 mRNA CTD PMID:19428942 NCBI chr12:24,157,182...24,161,870
Ensembl chr12:24,158,766...24,161,869
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO 1-nitropyrene results in increased expression of CCL5 mRNA CTD PMID:19879285 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO 1-nitropyrene results in increased expression of CCN2 mRNA CTD PMID:19041380 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO 1-nitropyrene results in increased expression of CCND1 mRNA CTD PMID:19041380 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccr4 C-C motif chemokine receptor 4 increases expression ISO 1-nitropyrene results in increased expression of CCR4 mRNA CTD PMID:19428942 NCBI chr 8:122,530,152...122,535,959
Ensembl chr 8:122,530,624...122,532,070
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 decreases expression ISO 1-nitropyrene results in decreased expression of CCR6 mRNA CTD PMID:19428942 NCBI chr 1:53,063,380...53,087,519
Ensembl chr 1:53,065,025...53,087,474
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 decreases expression ISO 1-nitropyrene results in decreased expression of CCR7 mRNA CTD PMID:19428942 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456
JBrowse link
G Ccr8 C-C motif chemokine receptor 8 decreases expression ISO 1-nitropyrene results in decreased expression of CCR8 mRNA CTD PMID:19428942 NCBI chr 8:128,779,552...128,782,531
Ensembl chr 8:128,781,395...128,782,456
JBrowse link
G Cd14 CD14 molecule decreases expression ISO 1-nitropyrene results in decreased expression of CD14 mRNA CTD PMID:19041380 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd8b CD8b molecule decreases expression ISO 1-nitropyrene results in decreased expression of CD8B1 mRNA CTD PMID:19041380 NCBI chr 4:99,185,960...99,201,887
Ensembl chr 4:99,185,885...99,202,023
JBrowse link
G Cdh1 cadherin 1 decreases expression ISO 1-nitropyrene results in decreased expression of CDH1 mRNA CTD PMID:19041380 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh13 cadherin 13 increases expression ISO 1-nitropyrene results in increased expression of CDH13 mRNA CTD PMID:19041380 NCBI chr19:50,848,793...51,971,618
Ensembl chr19:50,848,736...51,972,103
JBrowse link
G Cdh3 cadherin 3 decreases expression ISO 1-nitropyrene results in decreased expression of CDH3 mRNA CTD PMID:19041380 NCBI chr19:38,668,957...38,719,801
Ensembl chr19:38,669,230...38,719,677
JBrowse link
G Cdk17 cyclin-dependent kinase 17 increases expression ISO 1-nitropyrene results in increased expression of CDK17 mRNA CTD PMID:19041380 NCBI chr 7:34,001,506...34,088,418
Ensembl chr 7:34,001,506...34,079,616
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO pifithrin results in decreased susceptibility to [1-nitropyrene results in increased expression of CDKN1A protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of CDKN1A protein]
1-nitropyrene results in increased expression of CDKN1A mRNA; 1-nitropyrene results in increased expression of CDKN1A protein
CTD PMID:21540303, PMID:22044530 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
decreases expression
ISO [Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in decreased expression of CEBPA mRNA]; CEBPA protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein] CTD PMID:29078374 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO 1-nitropyrene results in increased expression of CEBPB mRNA CTD PMID:19428942 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta decreases expression ISO 1-nitropyrene results in decreased expression of CEBPD mRNA CTD PMID:19041380 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146
JBrowse link
G Cebpg CCAAT/enhancer binding protein gamma increases expression ISO 1-nitropyrene results in increased expression of CEBPG mRNA CTD PMID:19041380 NCBI chr 1:91,286,956...91,297,459
Ensembl chr 1:91,287,917...91,296,656
JBrowse link
G Cenpb centromere protein B decreases expression ISO 1-nitropyrene results in decreased expression of CENPB mRNA CTD PMID:19041380 NCBI chr 3:123,720,888...123,723,520
Ensembl chr 3:123,721,486...123,723,524
JBrowse link
G Clu clusterin decreases expression ISO 1-nitropyrene results in decreased expression of CLU mRNA CTD PMID:19041380 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Commd3 COMM domain containing 3 increases expression ISO 1-nitropyrene results in increased expression of COMMD3 mRNA CTD PMID:19041380 NCBI chr17:85,356,042...85,359,835
Ensembl chr17:85,356,042...85,359,833
JBrowse link
G Coro1c coronin 1C increases expression ISO 1-nitropyrene results in increased expression of CORO1C mRNA CTD PMID:19041380 NCBI chr12:48,481,741...48,554,054
Ensembl chr12:48,481,750...48,554,052
JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO 1-nitropyrene results in increased expression of CSF2 mRNA CTD PMID:21540303 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cth cystathionine gamma-lyase increases expression ISO 1-nitropyrene results in increased expression of CTH mRNA CTD PMID:19041380 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO 1-nitropyrene results in increased expression of CXCL1 mRNA CTD PMID:19041380, PMID:19428942, PMID:19879285 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO 1-nitropyrene results in increased expression of CXCL10 mRNA CTD PMID:19428942, PMID:19879285 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases expression ISO 1-nitropyrene results in increased expression of CXCL11 mRNA CTD PMID:19428942, PMID:19879285 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 decreases expression ISO 1-nitropyrene results in decreased expression of CXCL13 mRNA CTD PMID:19428942 NCBI chr14:15,253,146...15,258,221
Ensembl chr14:15,253,125...15,258,207
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO 1-nitropyrene results in increased expression of CXCL2 mRNA CTD PMID:19041380 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO 1-nitropyrene results in increased expression of CXCL1 mRNA CTD PMID:19041380, PMID:19428942, PMID:19879285 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 decreases expression ISO 1-nitropyrene results in decreased expression of CXCL6 mRNA CTD PMID:19428942 NCBI chr14:18,860,201...18,920,839
Ensembl chr14:18,860,264...18,862,407
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression ISO 1-nitropyrene results in decreased expression of CXCR2 mRNA CTD PMID:19428942 NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases degradation
multiple interactions
increases stability
increases expression
ISO
EXP
1-nitropyrene results in increased degradation of CYP1A1 protein
1-nitropyrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
deguelin inhibits the reaction [1-nitropyrene results in increased stability of CYP1A1 mRNA]; triciribine inhibits the reaction [1-nitropyrene results in increased stability of CYP1A1 mRNA]
1-nitropyrene results in increased expression of CYP1A1 mRNA; 1-nitropyrene results in increased expression of CYP1A1 protein
1-nitropyrene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 1-nitropyrene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; 1-nitropyrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; CYP1A1 protein affects the susceptibility to [Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; Dithiothreitol inhibits the reaction [1-nitropyrene results in increased degradation of CYP1A1 protein]
CTD PMID:12117779, PMID:16280210, PMID:17240030, PMID:18493746, PMID:19961161, PMID:22044530 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects response to substance
multiple interactions
ISO
EXP
CYP1A2 affects the susceptibility to 1-nitropyrene
1-nitropyrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
1-nitropyrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; CYP1A2 affects the reaction [1-nitropyrene results in increased mutagenesis of HPRT1 gene]
CTD PMID:10727902, PMID:18493746 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
increases metabolic processing
ISO 1-nitropyrene results in increased expression of CYP1B1 mRNA
CYP1B1 protein results in increased metabolism of 1-nitropyrene
CTD PMID:11525925, PMID:12117779, PMID:21887816 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO 1-nitropyrene results in increased expression of DDIT3 mRNA CTD PMID:19041380 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 increases expression ISO 1-nitropyrene results in increased expression of DKK1 mRNA CTD PMID:19041380 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein increases expression ISO 1-nitropyrene results in increased expression of DLC1 mRNA CTD PMID:19041380 NCBI chr16:58,776,489...59,247,752
Ensembl chr16:59,077,574...59,247,754
JBrowse link
G Dmtf1 cyclin D binding myb-like transcription factor 1 increases expression ISO 1-nitropyrene results in increased expression of DMTF1 mRNA CTD PMID:19041380 NCBI chr 4:21,862,297...21,902,798
Ensembl chr 4:21,862,313...21,902,762
JBrowse link
G Dner delta/notch-like EGF repeat containing increases expression ISO 1-nitropyrene results in increased expression of DNER mRNA CTD PMID:19041380 NCBI chr 9:91,965,866...92,291,172
Ensembl chr 9:91,965,866...92,291,220
JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO 1-nitropyrene results in increased expression of DUSP10 mRNA CTD PMID:19041380 NCBI chr13:104,284,660...104,321,455
Ensembl chr13:104,284,660...104,321,455
JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression ISO 1-nitropyrene results in increased expression of DUSP6 mRNA CTD PMID:19041380 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
JBrowse link
G Egr1 early growth response 1 increases expression ISO 1-nitropyrene results in increased expression of EGR1 mRNA CTD PMID:21540303 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression ISO 1-nitropyrene results in increased expression of EHHADH mRNA CTD PMID:19041380 NCBI chr11:82,945,104...82,978,364
Ensembl chr11:82,945,104...82,978,364
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 increases expression ISO 1-nitropyrene results in increased expression of EIF4EBP1 mRNA CTD PMID:19041380 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Ereg epiregulin increases expression ISO 1-nitropyrene results in increased expression of EREG mRNA CTD PMID:21887816 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G Esm1 endothelial cell-specific molecule 1 increases expression ISO 1-nitropyrene results in increased expression of ESM1 mRNA CTD PMID:19041380 NCBI chr 2:45,104,392...45,113,130
Ensembl chr 2:45,104,305...45,113,131
JBrowse link
G Etv5 ETS variant transcription factor 5 increases expression ISO 1-nitropyrene results in increased expression of ETV5 mRNA CTD PMID:19041380 NCBI chr11:82,194,657...82,252,145
Ensembl chr11:82,194,657...82,252,139
JBrowse link
G Evi2a ecotropic viral integration site 2A increases expression ISO 1-nitropyrene results in increased expression of EVI2A mRNA CTD PMID:19041380 NCBI chr10:66,870,048...66,873,948
Ensembl chr10:66,870,067...66,873,948
JBrowse link
G Exoc5 exocyst complex component 5 increases expression ISO 1-nitropyrene results in increased expression of EXOC5 mRNA CTD PMID:19041380 NCBI chr15:25,888,757...25,933,302
Ensembl chr15:25,887,070...25,933,268
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO 1-nitropyrene results in increased expression of F3 mRNA CTD PMID:19041380 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fgf5 fibroblast growth factor 5 increases expression ISO 1-nitropyrene results in increased expression of FGF5 mRNA CTD PMID:19041380 NCBI chr14:12,974,921...12,996,046
Ensembl chr14:12,974,921...12,995,584
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO 1-nitropyrene results in increased expression of FOS mRNA CTD PMID:21540303 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G G0s2 G0/G1switch 2 increases expression ISO 1-nitropyrene results in increased expression of G0S2 mRNA CTD PMID:19041380 NCBI chr13:112,004,140...112,005,052
Ensembl chr13:112,004,140...112,005,052
JBrowse link
G Gars glycyl-tRNA synthetase increases expression ISO 1-nitropyrene results in increased expression of GARS1 mRNA CTD PMID:19041380 NCBI chr 4:85,235,122...85,276,085
Ensembl chr 4:85,235,172...85,276,044
JBrowse link
G Gas1 growth arrest-specific 1 decreases expression ISO 1-nitropyrene results in decreased expression of GAS1 mRNA CTD PMID:19041380 NCBI chr17:4,846,116...4,849,350
Ensembl chr17:4,846,789...4,847,940
JBrowse link
G Gbp2 guanylate binding protein 2 decreases expression ISO 1-nitropyrene results in decreased expression of GBP2 mRNA CTD PMID:19041380 NCBI chr 2:248,276,795...248,293,784
Ensembl chr 2:248,276,709...248,293,784
JBrowse link
G Gdap1 ganglioside-induced differentiation-associated-protein 1 increases expression ISO 1-nitropyrene results in increased expression of GDAP1 mRNA CTD PMID:19041380 NCBI chr 5:1,328,963...1,347,946
Ensembl chr 5:1,328,913...1,347,921
JBrowse link
G Glipr1 GLI pathogenesis-related 1 increases expression ISO 1-nitropyrene results in increased expression of GLIPR1 mRNA CTD PMID:19041380 NCBI chr 7:54,767,828...54,778,823
Ensembl chr 7:54,767,827...54,778,848
JBrowse link
G Golga4 golgin A4 increases expression ISO 1-nitropyrene results in increased expression of GOLGA4 mRNA CTD PMID:19041380 NCBI chr 8:127,171,221...127,248,938
Ensembl chr 8:127,171,537...127,248,538
JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 increases expression ISO 1-nitropyrene results in increased expression of GPT2 mRNA CTD PMID:19041380 NCBI chr19:22,599,003...22,633,529
Ensembl chr19:22,590,881...22,632,071
JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist increases expression ISO 1-nitropyrene results in increased expression of GREM1 mRNA CTD PMID:19041380 NCBI chr 3:105,203,309...105,214,989
Ensembl chr 3:105,203,309...105,214,989
JBrowse link
G Gsdmc gasdermin C decreases expression ISO 1-nitropyrene results in decreased expression of GSDMC mRNA CTD PMID:19041380 NCBI chr 7:104,474,418...104,492,373
Ensembl chr 7:104,474,418...104,486,710
JBrowse link
G Habp2 hyaluronan binding protein 2 decreases expression ISO 1-nitropyrene results in decreased expression of HABP2 mRNA CTD PMID:19041380 NCBI chr 1:277,068,715...277,104,567
Ensembl chr 1:277,068,761...277,104,566
JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression ISO 1-nitropyrene results in increased expression of HBEGF mRNA CTD PMID:19041380 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO 1-nitropyrene results in increased expression of HIF1A mRNA CTD PMID:19041380 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmga2 high mobility group AT-hook 2 increases expression ISO 1-nitropyrene results in increased expression of HMGA2 mRNA CTD PMID:19041380 NCBI chr 7:65,159,944...65,275,408
Ensembl chr 7:65,159,944...65,275,408
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 1-nitropyrene results in increased expression of HMOX1 protein CTD PMID:28633978 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 multiple interactions ISO CYP1A2 affects the reaction [1-nitropyrene results in increased mutagenesis of HPRT1 gene] CTD PMID:10727902 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
JBrowse link
G Hras HRas proto-oncogene, GTPase affects expression
increases expression
EXP
ISO
1-nitropyrene affects the expression of HRAS mRNA
1-nitropyrene results in increased expression of HRAS mRNA
CTD PMID:9891514, PMID:11201684, PMID:11911274 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO 1-nitropyrene results in increased expression of HSPA5 protein
Dicumarol inhibits the reaction [1-nitropyrene results in increased expression of HSPA5 protein]
CTD PMID:19460413 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Iars1 isoleucyl-tRNA synthetase 1 increases expression ISO 1-nitropyrene results in increased expression of IARS1 mRNA CTD PMID:19041380 NCBI chr17:15,356,016...15,402,680
Ensembl chr17:15,355,529...15,402,649
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO 1-nitropyrene results in increased expression of ICAM1 mRNA CTD PMID:21540303 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression ISO 1-nitropyrene results in increased expression of IFRD1 mRNA CTD PMID:19041380 NCBI chr 6:60,132,025...60,151,354
Ensembl chr 6:60,132,024...60,151,420
JBrowse link
G Il10rb interleukin 10 receptor subunit beta decreases expression ISO 1-nitropyrene results in decreased expression of IL10RB mRNA CTD PMID:19428942 NCBI chr11:31,560,301...31,582,457
Ensembl chr11:31,560,530...31,582,457
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO 1-nitropyrene results in increased expression of IL1A mRNA CTD PMID:19428942, PMID:21540303 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta increases secretion ISO 1-nitropyrene results in increased secretion of IL1B protein CTD PMID:19041380 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il36rn interleukin 36 receptor antagonist decreases expression ISO 1-nitropyrene results in decreased expression of IL36RN mRNA CTD PMID:19428942 NCBI chr 3:1,385,256...1,392,275
Ensembl chr 3:1,385,654...1,392,275
JBrowse link
G Il6 interleukin 6 increases expression
increases secretion
multiple interactions
ISO 1-nitropyrene results in increased expression of IL6 mRNA
1-nitropyrene results in increased secretion of IL6 protein
3-methyladenine inhibits the reaction [1-nitropyrene results in increased secretion of IL6 protein]; [Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in increased secretion of IL6 protein]; ATG7 protein affects the reaction [1-nitropyrene results in increased secretion of IL6 protein]
CTD PMID:19041380, PMID:19879285, PMID:29078374 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ina internexin neuronal intermediate filament protein, alpha increases expression ISO 1-nitropyrene results in increased expression of INA mRNA CTD PMID:19041380 NCBI chr 1:266,782,835...266,794,389
Ensembl chr 1:266,781,617...266,794,431
JBrowse link
G Inhbb inhibin subunit beta B increases expression ISO 1-nitropyrene results in increased expression of INHBB mRNA CTD PMID:19041380 NCBI chr13:35,436,532...35,442,222
Ensembl chr13:35,436,532...35,442,222
JBrowse link
G Inpp4b inositol polyphosphate-4-phosphatase type II B increases expression ISO 1-nitropyrene results in increased expression of INPP4B mRNA CTD PMID:19041380 NCBI chr19:29,592,889...30,341,528
Ensembl chr19:29,597,905...29,968,424
JBrowse link
G Ipo7 importin 7 increases expression ISO 1-nitropyrene results in increased expression of IPO7 mRNA CTD PMID:19041380 NCBI chr 1:174,655,939...174,696,173
Ensembl chr 1:174,655,939...174,696,173
JBrowse link
G Irf1 interferon regulatory factor 1 increases expression ISO 1-nitropyrene results in increased expression of IRF1 mRNA CTD PMID:21540303 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Itgb4 integrin subunit beta 4 decreases expression ISO 1-nitropyrene results in decreased expression of ITGB4 mRNA CTD PMID:19041380 NCBI chr10:104,524,000...104,560,180
Ensembl chr10:104,523,996...104,561,078
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO 1-nitropyrene results in increased expression of JUN mRNA CTD PMID:21540303 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kctd15 potassium channel tetramerization domain containing 15 increases expression ISO 1-nitropyrene results in increased expression of KCTD15 mRNA CTD PMID:19041380 NCBI chr 1:90,506,697...90,522,217
Ensembl chr 1:90,506,697...90,520,344
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions
increases mutagenesis
ISO [1-nitropyrene co-treated with KC 400] results in increased mutagenesis of KRAS gene; [1-nitropyrene co-treated with Polychlorinated Biphenyls] results in increased mutagenesis of KRAS gene; [Bleomycin co-treated with 1-nitropyrene] results in increased mutagenesis of KRAS gene
1-nitropyrene results in increased mutagenesis of KRAS gene
CTD PMID:9726818, PMID:10396879, PMID:11746253, PMID:12616606 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Krt34 keratin 34 increases expression ISO 1-nitropyrene results in increased expression of KRT34 mRNA CTD PMID:19041380 NCBI chr10:87,950,364...87,954,055
Ensembl chr10:87,950,001...87,954,055
JBrowse link
G Lcor ligand dependent nuclear receptor corepressor increases expression ISO 1-nitropyrene results in increased expression of LCOR mRNA CTD PMID:19041380 NCBI chr 1:260,775,091...260,839,549
Ensembl chr 1:260,732,485...260,830,854
JBrowse link
G Lig4 DNA ligase 4 increases expression ISO 1-nitropyrene results in increased expression of LIG4 mRNA CTD PMID:19041380 NCBI chr16:85,331,771...85,339,496
Ensembl chr16:85,331,866...85,337,769
JBrowse link
G Lman1 lectin, mannose-binding, 1 increases expression ISO 1-nitropyrene results in increased expression of LMAN1 mRNA CTD PMID:19041380 NCBI chr18:61,683,377...61,707,344
Ensembl chr18:61,685,117...61,707,317
JBrowse link
G Lrrc17 leucine rich repeat containing 17 decreases expression ISO 1-nitropyrene results in decreased expression of LRRC17 mRNA CTD PMID:19041380 NCBI chr 4:10,108,184...10,138,652
Ensembl chr 4:10,108,192...10,138,652
JBrowse link
G Lta lymphotoxin alpha decreases expression ISO 1-nitropyrene results in decreased expression of LTA mRNA CTD PMID:19428942 NCBI chr20:4,851,889...4,854,677
Ensembl chr20:4,852,496...4,854,677
JBrowse link
G Ltb lymphotoxin beta increases expression ISO 1-nitropyrene results in increased expression of LTB mRNA CTD PMID:19428942, PMID:19879285 NCBI chr20:5,184,631...5,186,476
Ensembl chr20:5,184,515...5,186,503
JBrowse link
G Lurap1l leucine rich adaptor protein 1-like increases expression ISO 1-nitropyrene results in increased expression of LURAP1L mRNA CTD PMID:19041380 NCBI chr 5:98,468,039...98,515,126
Ensembl chr 5:98,469,047...98,515,125
JBrowse link
G Mak16 MAK16 homolog increases expression ISO 1-nitropyrene results in increased expression of MAK16 mRNA CTD PMID:19041380 NCBI chr16:64,729,254...64,737,807
Ensembl chr16:64,729,221...64,737,807
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions
ISO 1-nitropyrene results in increased expression of MAP1LC3B mRNA; 1-nitropyrene results in increased expression of MAP1LC3B protein
ATG7 protein affects the reaction [1-nitropyrene results in increased expression of MAP1LC3B protein]
CTD PMID:29078374 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO 1-nitropyrene results in increased phosphorylation of MAPK1 protein CTD PMID:17240030 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO 1-nitropyrene results in increased phosphorylation of MAPK3 protein CTD PMID:17240030 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk6 mitogen-activated protein kinase 6 increases expression ISO 1-nitropyrene results in increased expression of MAPK6 mRNA CTD PMID:19041380 NCBI chr 8:82,328,013...82,351,108
Ensembl chr 8:82,328,020...82,351,108
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO 1-nitropyrene results in increased phosphorylation of MAPK8 protein CTD PMID:17240030 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mars1 methionyl-tRNA synthetase 1 increases expression ISO 1-nitropyrene results in increased expression of MARS1 mRNA CTD PMID:19041380 NCBI chr 7:70,585,011...70,602,425
Ensembl chr 7:70,585,013...70,602,310
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression
multiple interactions
ISO 1-nitropyrene results in increased expression of MDM2 mRNA; 1-nitropyrene results in increased expression of MDM2 protein; 1-nitropyrene results in increased expression of MDM2 protein modified form
nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein modified form]; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein modified form]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein]; TP53 affects the reaction [1-nitropyrene results in increased expression of MDM2 mRNA]
CTD PMID:10837373, PMID:22044530 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mettl7a methyltransferase like 7A decreases expression ISO 1-nitropyrene results in decreased expression of METTL7A mRNA CTD PMID:19041380 NCBI chr 7:141,973,447...142,021,344
Ensembl chr 7:141,973,553...141,981,432
JBrowse link
G Mlph melanophilin increases expression ISO 1-nitropyrene results in increased expression of MLPH mRNA CTD PMID:19041380 NCBI chr 9:98,072,965...98,108,429
Ensembl chr 9:98,073,038...98,108,433
JBrowse link
G Mob4 MOB family member 4, phocein increases expression ISO 1-nitropyrene results in increased expression of MOB4 mRNA CTD PMID:19041380 NCBI chr 9:61,720,583...61,744,532
Ensembl chr 9:61,720,583...61,744,531
JBrowse link
G Mocos molybdenum cofactor sulfurase increases expression ISO 1-nitropyrene results in increased expression of MOCOS mRNA CTD PMID:19041380 NCBI chr18:16,590,086...16,636,312
Ensembl chr18:16,590,197...16,636,084
JBrowse link
G Mospd1 motile sperm domain containing 1 increases expression ISO 1-nitropyrene results in increased expression of MOSPD1 mRNA CTD PMID:19041380 NCBI chr  X:157,745,939...157,774,505
Ensembl chr  X:157,759,624...157,773,108
JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like increases expression ISO 1-nitropyrene results in increased expression of MTHFD1L mRNA CTD PMID:19041380 NCBI chr 1:40,529,092...40,719,232
Ensembl chr 1:40,529,045...40,719,391
JBrowse link
G Mtmr2 myotubularin related protein 2 increases expression ISO 1-nitropyrene results in increased expression of MTMR2 mRNA CTD PMID:19041380 NCBI chr 8:12,283,471...12,334,014
Ensembl chr 8:12,284,528...12,333,316
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO 1-nitropyrene results in increased expression of MYC mRNA CTD PMID:10928071 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ndufa1 NADH:ubiquinone oxidoreductase subunit A1 decreases expression
multiple interactions
ISO 1-nitropyrene results in decreased expression of NDUFA1 mRNA
1-nitropyrene results in decreased expression of NDUFA1 mRNA; 1-nitropyrene results in decreased expression of NDUFA1 protein
[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA1 mRNA]
[Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA1 mRNA]; NDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; NDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]
CTD PMID:29078374 NCBI chr  X:123,803,109...123,806,760
Ensembl chr  X:124,513,269...124,516,705
Ensembl chr  X:124,513,269...124,516,705
JBrowse link
G Ndufa2 NADH:ubiquinone oxidoreductase subunit A2 multiple interactions
decreases expression
ISO 3-methyladenine inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA2 mRNA]; NDUFA2 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; NDUFA2 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]; Taurine promotes the reaction [3-methyladenine inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA2 mRNA]]
[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA2 mRNA]
1-nitropyrene results in decreased expression of NDUFA2 mRNA; 1-nitropyrene results in decreased expression of NDUFA2 protein
CTD PMID:29078374 NCBI chr18:29,585,671...29,587,760
Ensembl chr18:29,585,671...29,587,760
JBrowse link
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 multiple interactions
decreases expression
ISO [3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFC2 mRNA] CTD PMID:29078374 NCBI chr 1:162,369,801...162,376,024
Ensembl chr 1:162,369,801...162,376,023
JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 decreases expression
multiple interactions
ISO 1-nitropyrene results in decreased expression of NDUFS4 mRNA
[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFS4 mRNA]
CTD PMID:29078374 NCBI chr 2:46,372,488...46,476,162
Ensembl chr 2:46,372,518...46,476,203
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO 1-nitropyrene results in increased expression of and affects the localization of and results in increased activity of NFE2L2 protein CTD PMID:28633978 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression
multiple interactions
increases activity
ISO 1-nitropyrene results in increased expression of NFKB1 mRNA
NFKBIA protein inhibits the reaction [1-nitropyrene results in increased activity of NFKB1 protein]
CTD PMID:12393170, PMID:21540303 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO NFKBIA protein inhibits the reaction [1-nitropyrene results in increased activity of NFKB1 protein]; NFKBIA protein inhibits the reaction [1-nitropyrene results in increased activity of RELA protein]; NFKBIA protein inhibits the reaction [1-nitropyrene results in increased expression of CXCL8 mRNA] CTD PMID:12393170 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Noc3l NOC3-like DNA replication regulator increases expression ISO 1-nitropyrene results in increased expression of NOC3L mRNA CTD PMID:19041380 NCBI chr 1:257,469,538...257,498,844
Ensembl chr 1:257,469,538...257,498,844
JBrowse link
G Nrg1 neuregulin 1 increases expression ISO 1-nitropyrene results in increased expression of NRG1 mRNA CTD PMID:19041380 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434
JBrowse link
G Nt5e 5' nucleotidase, ecto increases expression ISO 1-nitropyrene results in increased expression of NT5E mRNA CTD PMID:19041380 NCBI chr 8:95,969,002...96,012,733
Ensembl chr 8:95,968,652...96,012,696
JBrowse link
G Ntn3 netrin 3 decreases expression ISO 1-nitropyrene results in decreased expression of NTN3 mRNA CTD PMID:19041380 NCBI chr10:13,577,725...13,580,821
Ensembl chr10:13,577,725...13,580,821
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A decreases expression ISO 1-nitropyrene results in decreased expression of OAS1 mRNA CTD PMID:19041380 NCBI chr12:41,200,680...41,211,393
Ensembl chr12:41,200,718...41,211,909
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like increases expression ISO 1-nitropyrene results in increased expression of OASL mRNA CTD PMID:19041380 NCBI chr12:47,444,138...47,456,680
Ensembl chr12:47,444,104...47,456,894
JBrowse link
G Osbpl6 oxysterol binding protein-like 6 increases expression ISO 1-nitropyrene results in increased expression of OSBPL6 mRNA CTD PMID:19041380 NCBI chr 3:63,257,646...63,455,105
Ensembl chr 3:63,353,178...63,454,967
JBrowse link
G Oxr1 oxidation resistance 1 increases expression ISO 1-nitropyrene results in increased expression of OXR1 mRNA CTD PMID:19041380 NCBI chr 7:80,351,774...80,788,094
Ensembl chr 7:80,351,774...80,788,094
JBrowse link
G Pcdhb8 protocadherin beta 8 decreases expression ISO 1-nitropyrene results in decreased expression of PCDHB5 mRNA CTD PMID:19041380 NCBI chr18:30,435,119...30,437,458
Ensembl chr18:30,435,119...30,437,458
JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) increases expression ISO 1-nitropyrene results in increased expression of PCK2 mRNA CTD PMID:19041380 NCBI chr15:34,216,735...34,224,357
Ensembl chr15:34,216,833...34,224,193
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression ISO 1-nitropyrene results in decreased expression of PDGFRB mRNA CTD PMID:19041380 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pdgfrl platelet-derived growth factor receptor-like decreases expression ISO 1-nitropyrene results in decreased expression of PDGFRL mRNA CTD PMID:19041380 NCBI chr16:54,386,269...54,450,426
Ensembl chr16:54,386,288...54,450,426
JBrowse link
G Pdpn podoplanin decreases expression ISO 1-nitropyrene results in decreased expression of PDPN mRNA CTD PMID:19041380 NCBI chr 5:161,947,137...161,981,441
Ensembl chr 5:161,947,137...161,981,441
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein increases expression ISO 1-nitropyrene results in increased expression of PICALM mRNA CTD PMID:19041380 NCBI chr 1:154,377,229...154,458,966
Ensembl chr 1:154,377,247...154,458,425
JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha increases expression ISO 1-nitropyrene results in increased expression of PIK3C2A mRNA CTD PMID:19041380 NCBI chr 1:185,210,922...185,326,314
Ensembl chr 1:185,210,922...185,326,314
JBrowse link
G Pir pirin decreases expression ISO 1-nitropyrene results in decreased expression of PIR mRNA CTD PMID:19041380 NCBI chr  X:31,852,322...31,968,152
Ensembl chr  X:31,852,323...31,968,152
JBrowse link
G Plekhb1 pleckstrin homology domain containing B1 decreases expression ISO 1-nitropyrene results in decreased expression of PLEKHB1 mRNA CTD PMID:19041380 NCBI chr 1:165,665,905...165,683,753
Ensembl chr 1:165,665,909...165,680,206
JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit increases expression ISO 1-nitropyrene results in increased expression of POLA1 mRNA CTD PMID:19041380 NCBI chr  X:62,382,604...62,698,830
Ensembl chr  X:62,382,608...62,698,830
JBrowse link
G Polr2e RNA polymerase II, I and III subunit E decreases expression ISO 1-nitropyrene results in decreased expression of POLR2E mRNA CTD PMID:19041380 NCBI chr 7:12,532,785...12,536,797
Ensembl chr 7:12,532,895...12,536,791
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases expression ISO 1-nitropyrene results in increased expression of PRKAA1 mRNA CTD PMID:19041380 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha increases expression ISO 1-nitropyrene results in increased expression of PRKAR1A mRNA CTD PMID:19041380 NCBI chr10:97,940,705...97,959,199
Ensembl chr10:97,940,705...97,957,336
JBrowse link
G Prkch protein kinase C, eta increases expression ISO 1-nitropyrene results in increased expression of PRKCH mRNA CTD PMID:19041380 NCBI chr 6:96,479,243...96,677,368
Ensembl chr 6:96,479,430...96,676,225
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit increases expression ISO 1-nitropyrene results in increased expression of PRKDC protein CTD PMID:28633978 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Prmt3 protein arginine methyltransferase 3 increases expression ISO 1-nitropyrene results in increased expression of PRMT3 mRNA CTD PMID:19041380 NCBI chr 1:105,113,595...105,200,253
Ensembl chr 1:105,113,595...105,200,470
JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression ISO 1-nitropyrene results in increased expression of PSAT1 mRNA CTD PMID:19041380 NCBI chr 1:233,124,089...233,145,941
Ensembl chr 1:233,124,092...233,145,941
JBrowse link
G Psmb9 proteasome 20S subunit beta 9 decreases expression ISO 1-nitropyrene results in decreased expression of PSMB9 mRNA CTD PMID:19041380 NCBI chr20:3,973,424...3,978,845
Ensembl chr20:3,973,420...3,978,845
JBrowse link
G Psmd5 proteasome 26S subunit, non-ATPase 5 increases expression ISO 1-nitropyrene results in increased expression of PSMD5 mRNA CTD PMID:19041380 NCBI chr 3:13,916,199...13,937,031
Ensembl chr 3:13,916,203...13,933,658
JBrowse link
G Psme4 proteasome activator subunit 4 increases expression ISO 1-nitropyrene results in increased expression of PSME4 mRNA CTD PMID:19041380 NCBI chr14:115,166,165...115,269,041
Ensembl chr14:115,166,416...115,269,056
JBrowse link
G Ptcd2 pentatricopeptide repeat domain 2 increases expression ISO 1-nitropyrene results in increased expression of PTCD2 mRNA CTD PMID:19041380 NCBI chr 2:29,570,581...29,598,328
Ensembl chr 2:29,570,538...29,598,277
JBrowse link
G Pthlh parathyroid hormone-like hormone increases expression ISO 1-nitropyrene results in increased expression of PTHLH mRNA CTD PMID:19041380 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Ptn pleiotrophin decreases expression ISO 1-nitropyrene results in decreased expression of PTN mRNA CTD PMID:19041380 NCBI chr 4:64,239,156...64,330,996
Ensembl chr 4:64,239,158...64,330,996
JBrowse link
G Ptprb protein tyrosine phosphatase, receptor type, B increases expression ISO 1-nitropyrene results in increased expression of PTPRB mRNA CTD PMID:19041380 NCBI chr 7:59,326,484...59,431,114
Ensembl chr 7:59,326,518...59,425,718
JBrowse link
G Rab20 RAB20, member RAS oncogene family decreases expression ISO 1-nitropyrene results in decreased expression of RAB20 mRNA CTD PMID:19041380 NCBI chr16:83,358,116...83,382,326
Ensembl chr16:83,358,116...83,382,326
JBrowse link
G Rab26 RAB26, member RAS oncogene family decreases expression ISO 1-nitropyrene results in decreased expression of RAB26 mRNA CTD PMID:19041380 NCBI chr10:13,894,271...13,898,578
Ensembl chr10:13,893,290...13,898,855
JBrowse link
G Rab34 RAB34, member RAS oncogene family decreases expression ISO 1-nitropyrene results in decreased expression of RAB34 mRNA CTD PMID:19041380 NCBI chr10:65,448,111...65,452,178
Ensembl chr10:65,448,950...65,452,177
JBrowse link
G Ramp1 receptor activity modifying protein 1 decreases expression ISO 1-nitropyrene results in decreased expression of RAMP1 mRNA CTD PMID:19041380 NCBI chr 9:98,313,632...98,364,206
Ensembl chr 9:98,313,632...98,364,205
JBrowse link
G Ranbp6 RAN binding protein 6 increases expression ISO 1-nitropyrene results in increased expression of RANBP6 mRNA CTD PMID:19041380 NCBI chr 1:247,980,976...247,985,553
Ensembl chr 1:247,982,180...247,985,497
JBrowse link
G Rasa2 RAS p21 protein activator 2 increases expression ISO 1-nitropyrene results in increased expression of RASA2 mRNA CTD PMID:19041380 NCBI chr 8:104,417,827...104,542,313
Ensembl chr 8:104,414,567...104,542,317
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases activity
multiple interactions
ISO 1-nitropyrene results in increased activity of RELA protein
NFKBIA protein inhibits the reaction [1-nitropyrene results in increased activity of RELA protein]
CTD PMID:12393170 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G RGD1306227 similar to 4833420G17Rik protein increases expression ISO 1-nitropyrene results in increased expression of C5ORF34 mRNA CTD PMID:19041380 NCBI chr 2:52,333,396...52,355,044
Ensembl chr 2:52,333,396...52,355,042
JBrowse link
G Riox2 ribosomal oxygenase 2 increases expression ISO 1-nitropyrene results in increased expression of RIOX2 mRNA CTD PMID:19041380 NCBI chr11:43,006,190...43,028,722
Ensembl chr11:43,006,757...43,022,565
JBrowse link
G Rnd3 Rho family GTPase 3 increases expression ISO 1-nitropyrene results in increased expression of RND3 mRNA CTD PMID:19041380 NCBI chr 3:36,643,374...36,660,727
Ensembl chr 3:36,642,587...36,660,758
JBrowse link
G Sacs sacsin molecular chaperone increases expression ISO 1-nitropyrene results in increased expression of SACS mRNA CTD PMID:19041380 NCBI chr15:41,448,078...41,530,412
Ensembl chr15:41,448,064...41,530,398
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression
decreases response to substance
ISO 1-nitropyrene results in decreased expression of SCD1 mRNA; 1-nitropyrene results in decreased expression of SCD1 protein
SCD1 protein results in decreased susceptibility to 1-nitropyrene
CTD PMID:21872649 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha decreases expression ISO 1-nitropyrene results in decreased expression of SCNN1A mRNA CTD PMID:19041380 NCBI chr 4:157,834,339...157,860,472
Ensembl chr 4:157,836,912...157,860,049
JBrowse link
G Sectm1b secreted and transmembrane 1B decreases expression ISO 1-nitropyrene results in decreased expression of SECTM1 mRNA CTD PMID:19041380 NCBI chr10:110,251,363...110,260,577
Ensembl chr10:110,251,363...110,259,985
JBrowse link
G Sele selectin E increases expression ISO 1-nitropyrene results in increased expression of SELE mRNA CTD PMID:21540303 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Serpinb8 serpin family B member 8 increases expression ISO 1-nitropyrene results in increased expression of SERPINB8 mRNA CTD PMID:19041380 NCBI chr13:27,876,662...27,914,038
Ensembl chr13:27,889,345...27,914,006
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO 1-nitropyrene results in increased expression of SERPINE1 mRNA CTD PMID:19041380 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sh3kbp1 SH3 domain-containing kinase-binding protein 1 increases expression ISO 1-nitropyrene results in increased expression of SH3KBP1 mRNA CTD PMID:19041380 NCBI chr  X:37,790,004...38,196,365
Ensembl chr  X:37,790,586...38,196,204
JBrowse link
G Sh3rf1 SH3 domain containing ring finger 1 increases expression ISO 1-nitropyrene results in increased expression of SH3RF1 mRNA CTD PMID:19041380 NCBI chr16:32,062,425...32,227,526
Ensembl chr16:32,062,336...32,227,491
JBrowse link
G Slmap sarcolemma associated protein increases expression ISO 1-nitropyrene results in increased expression of SLMAP mRNA CTD PMID:19041380 NCBI chr16:2,112,271...2,227,336
Ensembl chr16:2,112,274...2,227,309
JBrowse link
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 increases expression ISO 1-nitropyrene results in increased expression of SMURF2 mRNA CTD PMID:19041380 NCBI chr10:95,018,050...95,118,107
Ensembl chr10:95,018,059...95,062,987
JBrowse link
G Snca synuclein alpha decreases expression ISO 1-nitropyrene results in decreased expression of SNCA mRNA CTD PMID:19041380 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Snx14 sorting nexin 14 increases expression ISO 1-nitropyrene results in increased expression of SNX14 mRNA CTD PMID:19041380 NCBI chr 8:96,018,943...96,088,405
Ensembl chr 8:96,023,445...96,088,405
JBrowse link
G Sox21 SRY-box transcription factor 21 decreases expression ISO 1-nitropyrene results in decreased expression of SOX21 mRNA CTD PMID:19041380 NCBI chr15:103,438,674...103,441,405
Ensembl chr15:103,440,212...103,441,030
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO 1-nitropyrene results in decreased expression of SPP1 mRNA CTD PMID:19428942 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO 1-nitropyrene results in increased expression of STC2 mRNA CTD PMID:19041380 NCBI chr10:16,542,909...16,552,675
Ensembl chr10:16,542,882...16,553,295
JBrowse link
G Tacstd2 tumor-associated calcium signal transducer 2 decreases expression ISO 1-nitropyrene results in decreased expression of TACSTD2 mRNA CTD PMID:19041380 NCBI chr 4:98,341,187...98,342,887
Ensembl chr 4:98,341,188...98,342,887
JBrowse link
G Tagln transgelin increases expression ISO 1-nitropyrene results in increased expression of TAGLN mRNA CTD PMID:19041380 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tars1 threonyl-tRNA synthetase 1 increases expression ISO 1-nitropyrene results in increased expression of TARS1 mRNA CTD PMID:19041380 NCBI chr 2:61,394,632...61,414,115
Ensembl chr 2:61,394,770...61,414,102
JBrowse link
G Tax1bp1 Tax1 binding protein 1 increases expression ISO 1-nitropyrene results in increased expression of TAX1BP1 mRNA CTD PMID:19041380 NCBI chr 4:82,776,720...82,832,586
Ensembl chr 4:82,776,746...82,833,773
JBrowse link
G Thbd thrombomodulin increases expression ISO 1-nitropyrene results in increased expression of THBD mRNA CTD PMID:19041380 NCBI chr 3:142,748,673...142,752,325
Ensembl chr 3:142,748,674...142,752,325
JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO [Poly I-C binds to TLR3 protein] which affects the susceptibility to 1-nitropyrene CTD PMID:23458896 NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
JBrowse link
G Tmpo thymopoietin increases expression ISO 1-nitropyrene results in increased expression of TMPO mRNA CTD PMID:19041380 NCBI chr 7:31,847,412...31,872,416
Ensembl chr 7:31,847,410...31,872,423
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
increases secretion
ISO 1-nitropyrene results in increased expression of TNF mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1-nitropyrene results in increased expression of TNF mRNA]; MK 2206 inhibits the reaction [1-nitropyrene results in increased expression of TNF mRNA]
1-nitropyrene results in increased secretion of TNF protein
CTD PMID:19041380, PMID:19428942, PMID:19879285, PMID:21540303, PMID:28633978 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnpo1 transportin 1 increases expression ISO 1-nitropyrene results in increased expression of TNPO1 mRNA CTD PMID:19041380 NCBI chr 2:29,056,219...29,126,882
Ensembl chr 2:29,056,219...29,121,104
JBrowse link
G Top1 DNA topoisomerase I increases expression ISO 1-nitropyrene results in increased expression of TOP1 mRNA CTD PMID:19041380 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686
JBrowse link
G Top2b DNA topoisomerase II beta increases expression ISO 1-nitropyrene results in increased expression of TOP2B mRNA CTD PMID:19041380 NCBI chr15:10,262,972...10,319,741
Ensembl chr15:10,262,651...10,320,233
JBrowse link
G Tp53 tumor protein p53 increases expression
increases phosphorylation
decreases expression
affects localization
affects response to substance
affects expression
multiple interactions
ISO
EXP
1-nitropyrene results in increased expression of TP53 protein; 1-nitropyrene results in increased expression of TP53 protein modified form
1-nitropyrene results in increased phosphorylation of TRP53 protein
1-nitropyrene results in decreased expression of TRP53 mRNA
1-nitropyrene results in increased expression of TRP53 mRNA
1-nitropyrene affects the localization of TRP53 protein
TP53 affects the susceptibility to 1-nitropyrene
1-nitropyrene affects the expression of TP53 mRNA
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide results in decreased susceptibility to [Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; [beta-Naphthoflavone binds to and results in increased activity of AHR protein] results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]; CYP1A1 protein affects the susceptibility to [Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein modified form]; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein modified form]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein modified form]]; Tetrachlorodibenzodioxin results in decreased susceptibility to [nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; TP53 affects the reaction [1-nitropyrene results in increased expression of BAX mRNA]; TP53 affects the reaction [1-nitropyrene results in increased expression of MDM2 mRNA]
CTD PMID:10837373, PMID:10928071, PMID:11201684, PMID:11911274, PMID:17240030, PMID:22044530 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO 1-nitropyrene results in increased expression of TRIB3 mRNA CTD PMID:19041380 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Trim23 tripartite motif-containing 23 increases expression ISO 1-nitropyrene results in increased expression of TRIM23 mRNA CTD PMID:19041380 NCBI chr 2:34,255,300...34,288,140
Ensembl chr 2:34,255,305...34,288,139
JBrowse link
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 increases expression ISO 1-nitropyrene results in increased expression of TRPM7 mRNA CTD PMID:19041380 NCBI chr 3:119,258,189...119,347,084
Ensembl chr 3:119,259,467...119,330,345
JBrowse link
G Trub1 TruB pseudouridine synthase family member 1 increases expression ISO 1-nitropyrene results in increased expression of TRUB1 mRNA CTD PMID:19041380 NCBI chr 1:278,311,362...278,418,347
Ensembl chr 1:278,311,244...278,418,336
JBrowse link
G Ubash3b ubiquitin associated and SH3 domain containing, B increases expression ISO 1-nitropyrene results in increased expression of UBASH3B mRNA CTD PMID:19041380 NCBI chr 8:45,224,053...45,375,450
Ensembl chr 8:45,223,992...45,375,435
JBrowse link
G Usp15 ubiquitin specific peptidase 15 increases expression ISO 1-nitropyrene results in increased expression of USP15 mRNA CTD PMID:19041380 NCBI chr 7:66,595,707...66,687,707
Ensembl chr 7:66,595,742...66,687,278
JBrowse link
G Vcan versican increases expression ISO 1-nitropyrene results in increased expression of VCAN mRNA CTD PMID:19041380 NCBI chr 2:18,490,102...18,587,340
Ensembl chr 2:18,490,102...18,565,842
JBrowse link
G Virma vir like m6A methyltransferase associated increases expression ISO 1-nitropyrene results in increased expression of VIRMA mRNA CTD PMID:19041380 NCBI chr 5:25,042,743...25,121,403
Ensembl chr 5:25,042,710...25,120,264
JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 increases expression ISO 1-nitropyrene results in increased expression of WARS1 mRNA CTD PMID:19041380 NCBI chr 6:132,771,026...132,802,262
Ensembl chr 6:132,771,021...132,802,210
JBrowse link
G Wdfy3 WD repeat and FYVE domain containing 3 increases expression ISO 1-nitropyrene results in increased expression of WDFY3 mRNA CTD PMID:19041380 NCBI chr14:9,169,409...9,384,835
Ensembl chr14:9,141,512...9,381,870
JBrowse link
G Wnt2 Wnt family member 2 increases expression ISO 1-nitropyrene results in increased expression of WNT2 mRNA CTD PMID:21540303 NCBI chr 4:45,286,845...45,332,899
Ensembl chr 4:45,292,437...45,332,420
JBrowse link
G Xcr1 X-C motif chemokine receptor 1 decreases expression ISO 1-nitropyrene results in decreased expression of XCR1 mRNA CTD PMID:19428942 NCBI chr 8:132,911,474...132,919,110
Ensembl chr 8:132,911,486...132,919,110
JBrowse link
G Xpot exportin for tRNA increases expression ISO 1-nitropyrene results in increased expression of XPOT mRNA CTD PMID:19041380 NCBI chr 7:63,688,646...63,728,988
Ensembl chr 7:63,690,053...63,728,988
JBrowse link
G Zdhhc11 zinc finger, DHHC-type containing 11 increases expression ISO 1-nitropyrene results in increased expression of ZDHHC11 mRNA CTD PMID:19041380 NCBI chr 1:31,906,049...31,936,603
Ensembl chr 1:31,906,064...31,936,537
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 increases expression ISO 1-nitropyrene results in increased expression of ZEB1 mRNA CTD PMID:19041380 NCBI chr17:54,656,627...54,714,920
Ensembl chr17:54,658,463...54,714,914
JBrowse link
G Zfp62 zinc finger protein 62 increases expression ISO 1-nitropyrene results in increased expression of ZFP62 mRNA CTD PMID:19041380 NCBI chr10:34,477,108...34,493,941
Ensembl chr10:34,489,940...34,493,088
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        probe 486
          fluorescent probe 419
            pyrene 283
              1-nitropyrene 247
              8-methoxypyrene-1,3,6-trisulfonic acid 0
              Alexa Fluor 405 0
              pyranine 0
              pyranine(3-) + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            organic hydride 18269
                              organic fundamental parent 18269
                                hydrocarbon 17988
                                  cyclic hydrocarbon 17075
                                    arene 17071
                                      polycyclic arene 16889
                                        ortho- and peri-fused polycyclic arene 16155
                                          pyrene 283
                                            1-nitropyrene 247
                                            8-methoxypyrene-1,3,6-trisulfonic acid 0
                                            Alexa Fluor 405 0
                                            pyranine 0
                                            pyranine(3-) + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.