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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thiamethoxam
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Accession:CHEBI:39185 term browser browse the term
Definition:An oxadiazane that is tetrahydro-N-nitro-4H-1,3,5-oxadiazin-4-imine bearing (2-chloro-1,3-thiazol-5-yl)methyl and methyl substituents at positions 3 and 5 respectively.
Synonyms:exact_synonym: 3-[(2-chloro-1,3-thiazol-5-yl)methyl]-5-methyl-N-nitro-1,3,5-oxadiazinan-4-imine
 related_synonym: 3-((2-chloro-5-thiazolyl)methyl)tetrahydro-5-methyl-N-nitro-4H-1,3,5-oxadiazin-4-imine;   Formula=C8H10ClN5O3S;   InChI=1S/C8H10ClN5O3S/c1-12-4-17-5-13(8(12)11-14(15)16)3-6-2-10-7(9)18-6/h2H,3-5H2,1H3;   InChIKey=NWWZPOKUUAIXIW-UHFFFAOYSA-N;   SMILES=CN1COCN(Cc2cnc(Cl)s2)C1=N[N+]([O-])=O;   TMX
 xref: Beilstein:8555232;   CAS:153719-23-4;   KEGG:C18513
 xref_mesh: MESH:C416660
 xref: PMID:11695183;   PMID:12075996;   PMID:15716476;   PMID:15716477;   PMID:16652252;   PMID:19459179;   PMID:19481804;   PMID:21681919;   PMID:21713483;   PMID:21870159;   PMID:22065124;   PMID:22404231;   PMID:22461498;   PMID:22489844;   PMID:24700817;   PMID:25132224;   PMID:25348589;   PMID:25528611;   PMID:25529677;   PMID:25626153;   PMID:25655818;   PMID:25710849;   PMID:25825679;   PMID:25884469;   PPDB:631;   Pesticides:thiamethoxam;   Reaxys:8555232;   Wikipedia:Thiamethoxam


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thiamethoxam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa10 annexin A10 increases expression ISO Thiamethoxam results in increased expression of ANXA10 mRNA CTD PMID:32194361 NCBI chr16:29,674,699...29,741,521
Ensembl chr16:29,674,793...29,741,465
JBrowse link
G Ar androgen receptor affects binding ISO Thiamethoxam binds to AR protein CTD PMID:31550567 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arg1 arginase 1 decreases expression ISO Thiamethoxam results in decreased expression of ARG1 mRNA CTD PMID:32194361 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP thiamethoxam results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein] CTD PMID:16981889 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression
increases activity
ISO thiamethoxam results in increased expression of CYP19A1 mRNA
thiamethoxam results in increased activity of CYP19A1 protein
CTD PMID:26464060, PMID:28750898 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO Thiamethoxam results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Thiamethoxam results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Esr1 estrogen receptor 1 affects binding ISO Thiamethoxam binds to ESR1 protein CTD PMID:31550567 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO Thiamethoxam results in decreased expression of G6PC mRNA CTD PMID:32194361 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gpt glutamic--pyruvic transaminase decreases activity EXP thiamethoxam results in decreased activity of GPT protein CTD PMID:29197058 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases activity
ISO [thiamethoxam metabolite results in decreased activity of NOS2 protein] which results in increased chemical synthesis of Formaldehyde CTD PMID:29197058 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity ISO Thiamethoxam results in decreased activity of SLC22A2 protein CTD PMID:31364238 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Thra thyroid hormone receptor alpha affects binding ISO Thiamethoxam binds to THRA protein CTD PMID:31550567 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Tnnt2 troponin T2, cardiac type increases secretion
multiple interactions
EXP Thiamethoxam results in increased secretion of TNNT2 protein
fenugreek seed meal inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]; Polysaccharides inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]
CTD PMID:30520268 NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990
JBrowse link
(E)-thiamethoxam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa10 annexin A10 increases expression ISO Thiamethoxam results in increased expression of ANXA10 mRNA CTD PMID:32194361 NCBI chr16:29,674,699...29,741,521
Ensembl chr16:29,674,793...29,741,465
JBrowse link
G Ar androgen receptor affects binding ISO Thiamethoxam binds to AR protein CTD PMID:31550567 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arg1 arginase 1 decreases expression ISO Thiamethoxam results in decreased expression of ARG1 mRNA CTD PMID:32194361 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP Thiamethoxam results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein] CTD PMID:16981889 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression
increases activity
ISO Thiamethoxam results in increased expression of CYP19A1 mRNA
Thiamethoxam results in increased activity of CYP19A1 protein
CTD PMID:26464060, PMID:28750898 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO Thiamethoxam results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Thiamethoxam results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Esr1 estrogen receptor 1 affects binding ISO Thiamethoxam binds to ESR1 protein CTD PMID:31550567 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO Thiamethoxam results in decreased expression of G6PC mRNA CTD PMID:32194361 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gpt glutamic--pyruvic transaminase decreases activity EXP Thiamethoxam results in decreased activity of GPT protein CTD PMID:29197058 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Nos2 nitric oxide synthase 2 decreases activity
multiple interactions
ISO Thiamethoxam metabolite results in decreased activity of NOS2 protein
[Thiamethoxam metabolite results in decreased activity of NOS2 protein] which results in increased chemical synthesis of Formaldehyde
CTD PMID:29197058 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity ISO Thiamethoxam results in decreased activity of SLC22A2 protein CTD PMID:31364238 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Thra thyroid hormone receptor alpha affects binding ISO Thiamethoxam binds to THRA protein CTD PMID:31550567 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Tnnt2 troponin T2, cardiac type increases secretion
multiple interactions
EXP Thiamethoxam results in increased secretion of TNNT2 protein
fenugreek seed meal inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]; Polysaccharides inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]
CTD PMID:30520268 NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        xenobiotic 18413
          thiamethoxam 14
            (E)-thiamethoxam 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  heteroarene 16467
                                    monocyclic heteroarene 13313
                                      azole 12480
                                        thiazoles 1246
                                          1,3-thiazoles 639
                                            2-chlorothiazole 368
                                              thiamethoxam 14
                                                (E)-thiamethoxam 14
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