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ONTOLOGY REPORT - ANNOTATIONS


Term:cucurbitacin E
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Accession:CHEBI:3944 term browser browse the term
Definition:A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 1, 5 and 23.
Synonyms:exact_synonym: (4R,23E)-2,16alpha,20-trihydroxy-9beta,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-2,5,23-trien-25-yl acetate
 related_synonym: (23E)-25-acetyloxy-2,16alpha,20-trihydroxy-9beta-methyl-19-nor-10alpha-lanosta-1,5,23-triene-3,11,22-trione;   2,16alpha,20,25-tetrahydroxy-9-methyl-19-nor-9beta,10alpha-lanosta-1,5,23-triene-3,11,22-trione 25-acetate;   Formula=C32H44O8;   InChI=1S/C32H44O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-14,19,21-22,25,34-35,39H,11,15-16H2,1-9H3/b13-12+/t19-,21-,22+,25+,29+,30-,31+,32+/m1/s1;   InChIKey=NDYMQXYDSVBNLL-MUYMLXPFSA-N;   SMILES=[H][C@@]12CC=C3[C@@]([H])(C=C(O)C(=O)C3(C)C)[C@]1(C)C(=O)C[C@]1(C)[C@]([H])([C@H](O)C[C@@]21C)[C@@](C)(O)C(=O)\\C=C\\C(C)(C)OC(C)=O;   alpha-Elaterin;   alpha-Elaterine
 xref: Beilstein:2343323 "ChemIDplus";   CAS:18444-66-1 "ChemIDplus";   CAS:18444-66-1 "KEGG COMPOUND";   KEGG:C08797;   KNApSAcK:C00003686;   LIPID_MAPS_instance:LMST01010107 "LIPID MAPS"
 xref_mesh: MESH:C102326
 xref: PMID:13611647 "Europe PMC";   PMID:15908139 "Europe PMC";   PMID:19177898 "Europe PMC";   PMID:19816711 "Europe PMC";   PMID:20110807 "Europe PMC";   PMID:20347305 "Europe PMC";   PMID:4384331 "Europe PMC";   Reaxys:2343323 "Reaxys"


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cucurbitacin E term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acta2 actin alpha 2, smooth muscle JBrowse link 1 252,537,614 252,550,394 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:6480464
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6480464
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:6480464
G Timp1 TIMP metallopeptidase inhibitor 1 JBrowse link X 1,364,771 1,369,451 RGD:6480464
G Ulk1 unc-51 like autophagy activating kinase 1 JBrowse link 12 51,908,105 51,934,704 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19748
    role 19695
      biological role 19693
        biochemical role 19191
          metabolite 19162
            allelochemical 316
              cucurbitacin 44
                cucurbitacin E 19
                  cucurbitacin E 2-O-beta-D-glucopyranoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19748
    subatomic particle 19744
      composite particle 19744
        hadron 19744
          baryon 19744
            nucleon 19744
              atomic nucleus 19744
                atom 19744
                  main group element atom 19628
                    p-block element atom 19628
                      carbon group element atom 19522
                        carbon atom 19516
                          organic molecular entity 19516
                            organic group 18426
                              organic divalent group 18418
                                organodiyl group 18418
                                  carbonyl group 18306
                                    carbonyl compound 18306
                                      ketone 15922
                                        oxyketone 8455
                                          alpha-oxyketone 8455
                                            alpha-hydroxy ketone 8455
                                              tertiary alpha-hydroxy ketone 8272
                                                cucurbitacin E 19
                                                  cucurbitacin E 2-O-beta-D-glucopyranoside 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.