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ONTOLOGY REPORT - ANNOTATIONS


Term:carbidopa (anhydrous)
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Accession:CHEBI:39585 term browser browse the term
Definition:3-(3,4-Dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used (commonly as its hydrate) in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa.
Synonyms:exact_synonym: (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid
 related_synonym: (-)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid;   (S)-carbidopa;   (alphaS)-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid;   Formula=C10H14N2O4;   InChI=1S/C10H14N2O4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6/h2-4,12-14H,5,11H2,1H3,(H,15,16)/t10-/m0/s1;   InChIKey=TZFNLOMSOLWIDK-JTQLQIEISA-N;   L-3-(3,4-dihydroxyphenyl)-2-methyl-2-hydrazinopropionic acid;   L-alpha-methyldopahydrazine;   SMILES=C[C@@](Cc1ccc(O)c(O)c1)(NN)C(O)=O;   carbidopum
 xref: Beilstein:4189448 "Beilstein";   CAS:28860-95-9 "ChemIDplus";   DrugBank:DB00190;   Drug_Central:496 "DrugCentral";   LINCS:LSM-5850;   PDBeChem:142;   Wikipedia:Carbidopa


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carbidopa term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Comt catechol-O-methyltransferase JBrowse link 11 86,715,981 86,735,630 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      biological role 19661
        pharmacological role 18755
          neurotransmitter agent 16393
            dopaminergic agent 5041
              carbidopa (anhydrous) 1
                carbidopa 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic group 18407
                              organic divalent group 18397
                                organodiyl group 18397
                                  carbonyl group 18285
                                    carbonyl compound 18285
                                      carboxylic acid 17940
                                        monocarboxylic acid 17260
                                          carbidopa (anhydrous) 1
                                            carbidopa 1
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