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ONTOLOGY REPORT - ANNOTATIONS


Term:D-cycloserine
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Accession:CHEBI:40009 term browser browse the term
Definition:A 4-amino-1,2-oxazolidin-3-one that has R configuration. It is an antibiotic produced by Streptomyces garyphalus or S. orchidaceus and is used as part of a multi-drug regimen for the treatment of tuberculosis when resistance to, or toxicity from, primary drugs has developed. An analogue of D-alanine, it interferes with bacterial cell wall synthesis in the cytoplasm by competitive inhibition of L-alanine racemase (which forms D-alanine from L-alanine) and D-alanine--D-alanine ligase (which incorporates D-alanine into the pentapeptide required for peptidoglycan formation and bacterial cell wall synthesis).
Synonyms:related_synonym: (+)-4-Amino-3-isoxazolidinone;   (4R)-4-aminoisoxazolidin-3-one;   (R)-4-AMINO-ISOXAZOLIDIN-3-ONE;   D-4-amino-3-isoxazolidinone;   D-4-amino-3-isoxazolidone;   DCS;   Formula=C3H6N2O2;   InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1;   InChIKey=DYDCUQKUCUHJBH-UWTATZPHSA-N;   PA 94;   Ro-1-9213;   SMILES=[H][C@@]1(N)CONC1=O;   Seromycin;   alpha-Cycloserine;   cicloserina;   cyclo-D-serine;   cycloserine;   cycloserinum;   orientomycin
 alt_id: CHEBI:4030
 xref: Beilstein:80798 "Beilstein";   CAS:68-41-7 "ChemIDplus";   CAS:68-41-7 "NIST Chemistry WebBook";   DrugBank:DB00260;   Drug_Central:759 "DrugCentral";   HMDB:HMDB0014405;   KEGG:D00877;   LINCS:LSM-5932;   LIPID_MAPS_instance:LMPK14000007 "LIPID MAPS"
 xref_mesh: MESH:D003523
 xref: MetaCyc:CPD-2482;   PDBeChem:4AX;   PMID:12076471 "Europe PMC";   PMID:17707326 "Europe PMC";   PMID:18316423 "Europe PMC";   PMID:18486041 "Europe PMC";   PMID:18930757 "Europe PMC";   PMID:22234379 "Europe PMC";   PMID:22368237 "Europe PMC";   PMID:22632472 "Europe PMC";   PMID:22892161 "Europe PMC";   PMID:23174090 "Europe PMC";   PMID:23416058 "Europe PMC";   PMID:23438729 "Europe PMC";   PMID:23523746 "Europe PMC";   PMID:23542909 "Europe PMC";   PMID:23656850 "Europe PMC";   PMID:23685206 "Europe PMC";   PMID:4555420 "Europe PMC";   PMID:5006234 "Europe PMC";   Patent:US2772280;   Patent:US2840565;   Reaxys:80798 "Reaxys";   Wikipedia:Cycloserine
 cyclic_relationship: is_conjugate_base_of CHEBI:75929;   is_enantiomer_of CHEBI:75592;   is_tautomer_of CHEBI:74159


show annotations for term's descendants       view all columns           Sort by:
 
D-cycloserine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Homer1 homer scaffold protein 1 JBrowse link 2 22,909,550 23,012,303 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      biological role 19686
        biochemical role 19190
          metabolite 19162
            D-cycloserine 7
              DL-cycloserine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      carbon group element atom 19515
                        carbon atom 19508
                          organic molecular entity 19508
                            organic group 18423
                              organic divalent group 18414
                                organodiyl group 18414
                                  carbonyl group 18301
                                    carbonyl compound 18301
                                      carboxylic acid 17966
                                        carboacyl group 17073
                                          univalent carboacyl group 17073
                                            carbamoyl group 16800
                                              carboxamide 16800
                                                hydroxamic acid 6248
                                                  hydroxamic acid ester 128
                                                    4-amino-1,2-oxazolidin-3-one 7
                                                      D-cycloserine 7
                                                        DL-cycloserine 0
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