Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cyclosporin A
go back to main search page
Accession:CHEBI:4031 term browser browse the term
Definition:A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Synonyms:exact_synonym: 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
 related_synonym: (R-[R*,R*-(E)])-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl);   1,11-cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(E)-(2S,3R,4R)-2-amino-3-hydroxy-N,4-dimethyloct-6-enoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine];   30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone;   Antibiotic S 7481F1;   Cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-((3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl)-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methylleucyl);   Cyclosporine;   Formula=C62H111N11O12;   Gengraf;   InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42+,43-,44+,45-,46+,47+,49+,50-,51+,52-/m1/s1;   InChIKey=PMATZTZNYRCHOR-CGLBZJNRSA-N;   Neoral;   SMILES=CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\\C=C\\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C;   Sandimmune;   ciclosporin;   ciclosporina;   ciclosporine;   ciclosporinum
 alt_id: CHEBI:63586;   CHEBI:91802
 xref: Beilstein:3647785;   CAS:59865-13-3;   DrugBank:DB00091;   Drug_Central:760;   KEGG:C05086;   KEGG:D00184;   KNApSAcK:C00001517;   LINCS:LSM-1703
 xref_mesh: MESH:D016572
 xref: PMID:11058832;   PMID:11069928;   PMID:11079273;   PMID:11080188;   PMID:11238591;   PMID:11256490;   PMID:11278005;   PMID:11315347;   PMID:11370709;   PMID:11406057;   PMID:11426833;   PMID:11442023;   PMID:11481617;   PMID:11493684;   PMID:11529914;   PMID:11557554;   PMID:11564166;   PMID:11676831;   PMID:11870366;   PMID:12021257;   PMID:12050171;   PMID:12603598;   PMID:12761440;   PMID:12929192;   PMID:12950728;   PMID:14521916;   PMID:14621732;   PMID:14638917;   PMID:14672695;   PMID:14682659;   PMID:14743390;   PMID:15030555;   PMID:15175101;   PMID:15210365;   PMID:15306697;   PMID:15383526;   PMID:15541012;   PMID:15613074;   PMID:15626898;   PMID:15657176;   PMID:1566062;   PMID:15711594;   PMID:15811524;   PMID:15962181;   PMID:16372476;   PMID:16404634;   PMID:16724420;   PMID:16801218;   PMID:16898534;   PMID:17032751;   PMID:17083576;   PMID:17117422;   PMID:17192032;   PMID:17220244;   PMID:17229932;   PMID:17265451;   PMID:17446460;   PMID:17603747;   PMID:18076075;   PMID:18171316;   PMID:18191430;   PMID:18217899;   PMID:18259730;   PMID:18299432;   PMID:18359899;   PMID:18583716;   PMID:18597363;   PMID:18790203;   PMID:18818682;   PMID:18931077;   PMID:18975184;   PMID:19282398;   PMID:19589783;   PMID:21752960;   PMID:23620378;   Patent:US4117118;   Reaxys:3647785;   VSDB:1765;   Wikipedia:Ciclosporin


show annotations for term's descendants           Sort by:
 





Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            cyclosporin A 8281
              cyclosporin A derivative + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                peptide 9392
                                                  cyclic peptide 8721
                                                    homodetic cyclic peptide 8310
                                                      cyclosporin A 8281
                                                        cyclosporin A derivative + 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.