Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


go back to main search page
Accession:CHEBI:4046 term browser browse the term
Definition:The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
Synonyms:exact_synonym: 4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine
 related_synonym: 1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine;   1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine;   4-(5-dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine;   4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine;   4-Dibenzo[a,d]cyclohepten-5-ylidene-1-methyl-piperidine;   5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene;   Formula=C21H21N;   InChI=1S/C21H21N/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21/h2-11H,12-15H2,1H3;   InChIKey=JJCFRYNCJDLXIK-UHFFFAOYSA-N;   SMILES=CN1CCC(CC1)=C1c2ccccc2C=Cc2ccccc12;   ciproheptadina;   cyproheptadinum
 alt_id: CHEBI:111005;   CHEBI:605605
 xref: Beilstein:1348386 "Beilstein";   CAS:129-03-3 "ChemIDplus";   CAS:129-03-3 "KEGG COMPOUND";   CAS:129-03-3 "NIST Chemistry WebBook";   DrugBank:DB00434;   Drug_Central:765 "DrugCentral";   KEGG:C06935;   KEGG:D07765;   LINCS:LSM-5419
 xref_mesh: MESH:D003533
 xref: PMID:10843226 "ChEMBL";   Patent:US3014911;   Wikipedia:Cyproheptadine

show annotations for term's descendants       view all columns           Sort by:
cyproheptadine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gh1 growth hormone 1 JBrowse link 10 94,486,204 94,488,181 RGD:6480464
G Htr2a 5-hydroxytryptamine receptor 2A JBrowse link 15 56,666,152 56,732,469 RGD:6480464
G Htr7 5-hydroxytryptamine receptor 7 JBrowse link 1 254,547,964 254,671,811 RGD:6480464
G Kcnn2 potassium calcium-activated channel subfamily N member 2 JBrowse link 18 39,331,894 39,479,574 RGD:6480464
G Pomc proopiomelanocortin JBrowse link 6 28,382,937 28,388,771 RGD:6480464
G Prl prolactin JBrowse link 17 39,814,236 39,824,299 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Slc22a5 solute carrier family 22 member 5 JBrowse link 10 39,201,101 39,228,090 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19754
    role 19701
      application 19353
        pharmaceutical 19222
          drug 19222
            anti-allergic agent 3789
              cyproheptadine 8
                cyproheptadine hydrochloride (anhydrous) + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19754
    subatomic particle 19752
      composite particle 19752
        hadron 19752
          baryon 19752
            nucleon 19752
              atomic nucleus 19752
                atom 19752
                  main group element atom 19637
                    main group molecular entity 19637
                      s-block molecular entity 19397
                        hydrogen molecular entity 19386
                          hydrides 18356
                            inorganic hydride 17216
                              pnictogen hydride 17180
                                nitrogen hydride 17014
                                  azane 16706
                                    ammonia 16703
                                      organic amino compound 16702
                                        tertiary amino compound 8585
                                          tertiary amine 603
                                            cyproheptadine 8
                                              cyproheptadine hydrochloride (anhydrous) + 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.