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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:doramapimod
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Accession:CHEBI:40953 term browser browse the term
Definition:A member of the class of pyrazoles that is an immunomodulator used for treatment of rheumatoid arthritis, Crohn's disease and psoriasis.
Synonyms:exact_synonym: N-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea
 related_synonym: 1-(3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea;   1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea;   BIRB 796;   Formula=C31H37N5O3;   InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37);   InChIKey=MVCOAUNKQVWQHZ-UHFFFAOYSA-N;   SMILES=C(=O)(NC=1N(N=C(C1)C(C)(C)C)C=2C=CC(=CC2)C)NC=3C4=C(C=CC=C4)C(=CC3)OCCN5CCOCC5
 alt_id: MESH:C452139
 xref: CAS:285983-48-4;   KEGG:D03736;   LINCS:LSM-1170
 xref_mesh: MESH:C452139
 xref: PDBeChem:B96;   PMID:11896401;   PMID:19244237;   PMID:20655210;   PMID:23685672;   PMID:25358442;   PMID:25589935;   PMID:26044359;   PMID:26232862;   Reaxys:9170597


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doramapimod term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO BIRB 796 results in increased expression of ABCC2 mRNA CTD PMID:21328587 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Actg2 actin gamma 2, smooth muscle increases expression EXP BIRB 796 results in increased expression of ACTG2 mRNA CTD PMID:24303162 NCBI chr 4:115,215,160...115,239,746
Ensembl chr 4:115,215,060...115,239,723
JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide increases expression EXP BIRB 796 results in increased expression of ADH7 mRNA CTD PMID:24303162 NCBI chr 2:243,500,540...243,516,865
Ensembl chr 2:243,502,073...243,516,532
JBrowse link
G Ahsg alpha-2-HS-glycoprotein decreases expression ISO BIRB 796 results in decreased expression of AHSG mRNA CTD PMID:21328587 NCBI chr11:81,711,269...81,717,594 JBrowse link
G Ak5 adenylate kinase 5 increases expression EXP BIRB 796 results in increased expression of AK5 mRNA CTD PMID:24303162 NCBI chr 2:257,671,772...257,864,385
Ensembl chr 2:257,671,772...257,864,385
JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 increases expression ISO BIRB 796 results in increased expression of AKR1B7 mRNA CTD PMID:21328587 NCBI chr 4:61,850,256...61,879,733
Ensembl chr 4:61,850,348...61,862,526
JBrowse link
G Apoa4 apolipoprotein A4 decreases expression ISO BIRB 796 results in decreased expression of APOA4 mRNA CTD PMID:21328587 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G C1qa complement C1q A chain decreases expression ISO BIRB 796 results in decreased expression of C1QA mRNA CTD PMID:21328587 NCBI chr 5:155,261,254...155,264,101
Ensembl chr 5:155,261,250...155,264,143
JBrowse link
G C1qb complement C1q B chain decreases expression ISO BIRB 796 results in decreased expression of C1QB mRNA CTD PMID:21328587 NCBI chr 5:155,246,444...155,251,995
Ensembl chr 5:155,246,447...155,252,003
JBrowse link
G Ca3 carbonic anhydrase 3 decreases expression ISO BIRB 796 results in decreased expression of CAR3 mRNA CTD PMID:21328587 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
JBrowse link
G Cd5l Cd5 molecule-like decreases expression ISO BIRB 796 results in decreased expression of CD5L mRNA CTD PMID:21328587 NCBI chr 2:186,685,104...186,696,117
Ensembl chr 2:186,685,104...186,696,117
JBrowse link
G Cd74 CD74 molecule decreases expression ISO BIRB 796 results in decreased expression of CD74 mRNA CTD PMID:21328587 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 decreases expression EXP BIRB 796 results in decreased expression of CEACAM1 mRNA CTD PMID:24303162 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
G Ces3a carboxylesterase 3a increases expression ISO BIRB 796 results in increased expression of CES3 mRNA CTD PMID:21328587 NCBI chr19:37,070,705...37,079,411 JBrowse link
G Clec1b C-type lectin domain family 1, member B decreases expression ISO BIRB 796 results in decreased expression of CLEC1B mRNA CTD PMID:21328587 NCBI chr 4:163,161,941...163,170,470
Ensembl chr 4:163,162,211...163,170,466
JBrowse link
G Ctss cathepsin S decreases expression ISO BIRB 796 results in decreased expression of CTSS mRNA CTD PMID:21328587 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions ISO BIRB 796 inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein] CTD PMID:14997032 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases secretion ISO BIRB 796 results in decreased secretion of CXCL10 protein CTD PMID:17996064 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO BIRB 796 inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein] CTD PMID:14997032 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 multiple interactions ISO BIRB 796 inhibits the reaction [Lipopolysaccharides results in decreased expression of CXCR1 protein] CTD PMID:14997032 NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 multiple interactions ISO BIRB 796 inhibits the reaction [Lipopolysaccharides results in decreased expression of CXCR2 protein] CTD PMID:14997032 NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression ISO BIRB 796 results in increased expression of CYP2A5 mRNA CTD PMID:21328587 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyss cystatin S decreases expression EXP BIRB 796 results in decreased expression of CYSS mRNA CTD PMID:24303162 NCBI chr 3:144,427,430...144,431,768
Ensembl chr 3:144,427,207...144,431,806
JBrowse link
G Egr1 early growth response 1 increases expression ISO BIRB 796 results in increased expression of EGR1 mRNA CTD PMID:21328587 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb decreases expression ISO BIRB 796 results in decreased expression of FCGR2B mRNA CTD PMID:21328587 NCBI chr13:89,329,298...89,343,916
Ensembl chr13:89,327,794...89,433,815
JBrowse link
G Fgf8 fibroblast growth factor 8 decreases expression EXP BIRB 796 results in decreased expression of FGF8 mRNA CTD PMID:24303162 NCBI chr 1:265,492,949...265,498,965
Ensembl chr 1:265,493,124...265,498,831
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO BIRB 796 results in decreased expression of G6PC mRNA CTD PMID:21328587 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO BIRB 796 results in increased expression of GCLC mRNA CTD PMID:21328587 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression ISO BIRB 796 results in increased expression of GPX2 mRNA CTD PMID:21328587 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Grm8 glutamate metabotropic receptor 8 increases expression EXP BIRB 796 results in increased expression of GRM8 mRNA CTD PMID:24303162 NCBI chr 4:54,474,344...55,409,526
Ensembl chr 4:54,474,136...55,407,922
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO BIRB 796 results in increased expression of GSTA2 mRNA CTD PMID:21328587 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression ISO BIRB 796 results in increased expression of GSTA1 mRNA CTD PMID:21328587 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Gsta6 glutathione S-transferase alpha 6 increases expression ISO BIRB 796 results in increased expression of GSTA2 mRNA CTD PMID:21328587 NCBI chr 9:27,475,273...27,533,939
Ensembl chr 9:27,475,273...27,511,176
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression ISO BIRB 796 results in increased expression of GSTM2 mRNA CTD PMID:21328587 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO BIRB 796 results in increased expression of GSTM3 mRNA CTD PMID:21328587 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Hp haptoglobin decreases expression ISO BIRB 796 results in decreased expression of HP mRNA CTD PMID:21328587 NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804
JBrowse link
G Hpd 4-hydroxyphenylpyruvate dioxygenase decreases expression EXP BIRB 796 results in decreased expression of HPD mRNA CTD PMID:24303162 NCBI chr12:38,828,606...38,839,956
Ensembl chr12:38,828,444...38,839,969
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO BIRB 796 inhibits the reaction [Dinitrofluorobenzene results in increased expression of ICAM1 protein] CTD PMID:19427879 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Kcnk1 potassium two pore domain channel subfamily K member 1 decreases expression EXP BIRB 796 results in decreased expression of KCNK1 mRNA CTD PMID:24303162 NCBI chr19:58,823,836...58,862,926
Ensembl chr19:58,823,814...58,862,926
JBrowse link
G Lmod1 leiomodin 1 increases expression EXP BIRB 796 results in increased expression of LMOD1 mRNA CTD PMID:24303162 NCBI chr13:52,147,099...52,189,835
Ensembl chr13:52,147,555...52,190,228
JBrowse link
G Meig1 meiosis/spermiogenesis associated 1 increases expression ISO BIRB 796 results in increased expression of MEIG1 mRNA CTD PMID:21328587 NCBI chr17:78,813,656...78,829,411
Ensembl chr17:78,817,529...78,829,411
JBrowse link
G Mt1 metallothionein 1 increases expression ISO BIRB 796 results in increased expression of MT1 mRNA CTD PMID:21328587 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mybpc1 myosin binding protein C1 decreases expression EXP BIRB 796 results in decreased expression of MYBPC1 mRNA CTD PMID:24303162 NCBI chr 7:29,086,159...29,171,909
Ensembl chr 7:29,086,156...29,171,783
JBrowse link
G Myh11 myosin heavy chain 11 increases expression EXP BIRB 796 results in increased expression of MYH11 mRNA CTD PMID:24303162 NCBI chr10:764,421...859,184
Ensembl chr10:764,421...859,184
JBrowse link
G Myh3 myosin heavy chain 3 increases expression EXP BIRB 796 results in increased expression of MYH3 mRNA CTD PMID:24303162 NCBI chr10:53,621,375...53,645,194
Ensembl chr10:53,621,375...53,645,194
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO BIRB 796 results in increased expression of NQO1 mRNA CTD PMID:21328587 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Olr59 olfactory receptor 59 increases expression EXP BIRB 796 results in increased expression of OLR59 mRNA CTD PMID:24303162 NCBI chr 1:167,906,030...167,940,688
Ensembl chr 1:167,906,061...167,911,961
JBrowse link
G Otog otogelin decreases expression EXP BIRB 796 results in decreased expression of OTOG mRNA CTD PMID:24303162 NCBI chr 1:102,258,124...102,327,201
Ensembl chr 1:102,258,124...102,327,201
JBrowse link
G Pfn2 profilin 2 increases expression ISO BIRB 796 results in increased expression of PFN2 mRNA CTD PMID:21328587 NCBI chr 2:147,953,858...147,959,692
Ensembl chr 2:147,955,196...148,050,438
JBrowse link
G Pon1 paraoxonase 1 decreases expression EXP BIRB 796 results in decreased expression of PON1 mRNA CTD PMID:24303162 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO BIRB 796 results in increased expression of PPARG mRNA CTD PMID:21328587 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prm2 protamine 2 increases expression ISO BIRB 796 results in increased expression of PRM2 mRNA CTD PMID:21328587 NCBI chr10:4,950,484...4,950,920
Ensembl chr10:4,950,484...4,950,920
JBrowse link
G Rgs4 regulator of G-protein signaling 4 increases expression EXP BIRB 796 results in increased expression of RGS4 mRNA CTD PMID:24303162 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
G RT1-Bb RT1 class II, locus Bb decreases expression ISO BIRB 796 results in decreased expression of H2-AB1 mRNA CTD PMID:21328587 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO BIRB 796 results in increased expression of SLC7A11 mRNA CTD PMID:21328587 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Spock2 SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2 decreases expression EXP BIRB 796 results in decreased expression of SPOCK2 mRNA CTD PMID:24303162 NCBI chr20:29,654,926...29,679,927
Ensembl chr20:29,655,226...29,677,926
JBrowse link
G Spsb1 splA/ryanodine receptor domain and SOCS box containing 1 decreases expression ISO BIRB 796 results in decreased expression of SPSB1 mRNA CTD PMID:21328587 NCBI chr 5:166,913,734...166,978,534
Ensembl chr 5:166,913,735...166,926,636
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO BIRB 796 results in increased expression of SRXN1 mRNA CTD PMID:21328587 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Stmn2 stathmin 2 increases expression EXP BIRB 796 results in increased expression of STMN2 mRNA CTD PMID:24303162 NCBI chr 2:95,424,251...95,471,900
Ensembl chr 2:95,424,251...95,472,115
JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 decreases expression ISO BIRB 796 results in decreased expression of VSIG4 mRNA CTD PMID:21328587 NCBI chr  X:65,370,851...65,400,298
Ensembl chr  X:65,370,851...65,400,298
JBrowse link
G Zfp324 zinc finger protein 324 increases expression ISO BIRB 796 results in increased expression of ZFP324 mRNA CTD PMID:21328587 NCBI chr 1:65,604,342...65,612,196
Ensembl chr 1:65,606,520...65,611,815
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        immunomodulator 13696
          doramapimod 61
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        carboacyl group 17369
                                          univalent carboacyl group 17369
                                            carbamoyl group 17156
                                              carboxamide 17156
                                                monocarboxylic acid amide 14573
                                                  urea 4990
                                                    ureas 4987
                                                      doramapimod 61
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