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ONTOLOGY REPORT - ANNOTATIONS


Term:digitoxigenin
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Accession:CHEBI:42219 term browser browse the term
Definition:A 5beta-cardenolide that is 5beta-cardanolide with hydroxy substituents at the 3beta- and 14beta-positions and double bond unsaturation at C(20)-C(22).
Synonyms:exact_synonym: 3beta,14-dihydroxy-5beta-card-20(22)-enolide
 related_synonym: Cerberigenin;   Echujetin;   Evonogenin;   Formula=C23H34O4;   InChI=1S/C23H34O4/c1-21-8-5-16(24)12-15(21)3-4-19-18(21)6-9-22(2)17(7-10-23(19,22)26)14-11-20(25)27-13-14/h11,15-19,24,26H,3-10,12-13H2,1-2H3/t15-,16+,17-,18+,19-,21+,22-,23+/m1/s1;   InChIKey=XZTUSOXSLKTKJQ-CESUGQOBSA-N;   SMILES=[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@]([H])(CC[C@]34O)C3=CC(=O)OC3)[C@@]1(C)CC[C@H](O)C2;   Thevetigenin
 alt_id: CHEBI:38073;   CHEBI:42214
 xref: Beilstein:95448 "Beilstein";   CAS:143-62-4 "ChemIDplus";   LIPID_MAPS_instance:LMST01120001 "LIPID MAPS"
 xref_mesh: MESH:D004073
 xref: PDBeChem:DTX;   PMID:10438974 "Europe PMC";   Wikipedia:Digitoxigenin


show annotations for term's descendants       view all columns           Sort by:
 
digitoxigenin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccl4 C-C motif chemokine ligand 4 JBrowse link 10 70,870,926 70,886,357 RGD:6480464
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:6480464
G Il6r interleukin 6 receptor JBrowse link 2 189,196,180 189,255,987 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464
digitoxin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 10 106,856,097 106,864,419 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccnb1 cyclin B1 JBrowse link 2 30,782,133 30,791,106 RGD:6480464
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:6480464
G Chek1 checkpoint kinase 1 JBrowse link 8 39,181,162 39,201,588 RGD:6480464
G Chek2 checkpoint kinase 2 JBrowse link 12 51,845,574 51,878,098 RGD:6480464
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6480464
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:6480464
G Esr2 estrogen receptor 2 JBrowse link 6 99,163,953 99,214,711 RGD:6480464
G Fancd2 FA complementation group D2 JBrowse link 4 145,489,869 145,551,479 RGD:6480464
G Fanci FA complementation group I JBrowse link 1 141,116,565 141,172,997 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6480464
G Pgr progesterone receptor JBrowse link 8 7,128,656 7,187,796 RGD:6480464
G Thra thyroid hormone receptor alpha JBrowse link 10 86,657,285 86,684,935 RGD:6480464
G Thrb thyroid hormone receptor beta JBrowse link 15 8,890,578 9,239,815 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 2 219,071,193 219,090,931 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19734
    chemical entity 19732
      molecular entity 19729
        polyatomic entity 19639
          heteroatomic molecular entity 19550
            hydroxides 19042
              organic hydroxy compound 18618
                alcohol 14946
                  secondary alcohol 7051
                    3beta-hydroxy steroid 1986
                      digitoxigenin 33
                        digitoxigenin 3-O-[beta-D-glucosyl-(1->4)-alpha-L-acofrioside] 0
                        digitoxin + 29
                        evomonoside 0
                        neriifolin + 0
                        thevetin B 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19734
    subatomic particle 19730
      composite particle 19730
        hadron 19730
          baryon 19730
            nucleon 19730
              atomic nucleus 19730
                atom 19730
                  main group element atom 19614
                    p-block element atom 19614
                      carbon group element atom 19506
                        carbon atom 19500
                          organic molecular entity 19500
                            organic group 18414
                              organic divalent group 18406
                                organodiyl group 18406
                                  carbonyl group 18295
                                    carbonyl compound 18295
                                      carboxylic ester 13982
                                        lactone 5873
                                          steroid lactone 364
                                            cardanolide 41
                                              5beta-cardanolide 41
                                                digitoxigenin 33
                                                  digitoxigenin 3-O-[beta-D-glucosyl-(1->4)-alpha-L-acofrioside] 0
                                                  digitoxin + 29
                                                  evomonoside 0
                                                  neriifolin + 0
                                                  thevetin B 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.