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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ethidium
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Accession:CHEBI:42478 term browser browse the term
Definition:The fluorescent compound widely used in experimental cell biology and biochemistry to reveal double-stranded DNA and RNA.
Synonyms:related_synonym: 3,8-diamino-5-ethyl-6-phenylphenanthridinium;   Formula=C21H20N3;   InChI=1S/C21H19N3/c1-2-24-20-13-16(23)9-11-18(20)17-10-8-15(22)12-19(17)21(24)14-6-4-3-5-7-14/h3-13,23H,2,22H2,1H3/p+1;   InChIKey=QTANTQQOYSUMLC-UHFFFAOYSA-O;   SMILES=CC[n+]1c(-c2ccccc2)c2cc(N)ccc2c2ccc(N)cc12;   ethidium cation;   homidium
 xref: Beilstein:3627183;   CAS:3546-21-2;   Gmelin:981639
 xref_mesh: MESH:D004996
 xref: PDBeChem:ET


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ethidium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Ethidium inhibits the reaction [Estradiol results in increased expression of BCL2 mRNA] CTD PMID:15897899 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Ethidium inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA] CTD PMID:15897899 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO Ethidium inhibits the reaction [Estradiol results in increased expression of CCNE1 mRNA] CTD PMID:15897899 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccne2 cyclin E2 multiple interactions ISO Ethidium inhibits the reaction [Estradiol results in increased expression of CCNE2 mRNA] CTD PMID:15897899 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Cd59 CD59 molecule increases mutagenesis ISO Ethidium results in increased mutagenesis of CD59 protein CTD PMID:17045307 NCBI chr 3:94,010,481...94,028,660
Ensembl chr 3:94,010,475...94,028,621
JBrowse link
G Gja1 gap junction protein, alpha 1 increases uptake EXP GJA1 protein results in increased uptake of Ethidium CTD PMID:26926986 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Ethidium inhibits the reaction [sodium arsenate results in increased expression of IL1A protein]; Ethidium inhibits the reaction [tributyltin results in increased expression of IL1A protein] CTD PMID:8875956, PMID:10571731 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I decreases expression ISO Ethidium results in decreased expression of COX1 protein CTD PMID:18823003 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II decreases expression ISO Ethidium results in decreased expression of COX2 mRNA CTD PMID:22712077 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b decreases expression ISO Ethidium results in decreased expression of CYTB mRNA CTD PMID:22712077 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 decreases expression ISO Ethidium results in decreased expression of ND1 mRNA CTD PMID:22712077 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
JBrowse link
G Mt-nd4 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 decreases expression ISO Ethidium results in decreased expression of ND4 mRNA CTD PMID:22712077 NCBI chr MT:10,160...11,537
Ensembl chr MT:10,160...11,537
JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression ISO Ethidium results in increased expression of NRF1 mRNA CTD PMID:22712077 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341
JBrowse link
G P2rx7 purinergic receptor P2X 7 decreases transport
increases transport
ISO P2RX7 gene polymorphism results in decreased transport of Ethidium
P2RX7 protein results in increased transport of Ethidium
CTD PMID:16263709 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions
increases uptake
affects uptake
ISO 1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Quinine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]
SLC22A1 protein affects the uptake of Ethidium
CTD PMID:19357179 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 affects uptake
multiple interactions
increases uptake
ISO SLC22A2 protein affects the uptake of Ethidium
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Ethidium inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]
CTD PMID:19357179 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a3 solute carrier family 22 member 3 increases uptake
multiple interactions
ISO SLC22A3 protein results in increased uptake of Ethidium
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Quinine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]
CTD PMID:19357179 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Ethidium results in increased expression of TFAM mRNA CTD PMID:22712077 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19718
      application 19363
        dye 1289
          fluorescent dye 443
            fluorochrome 217
              ethidium 18
                ethidium bromide 0
                ethidium homodimer 0
                ethidium homodimer tetracation + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19550
                        carbon atom 19539
                          organic molecular entity 19539
                            organic molecule 19461
                              organic cyclic compound 19232
                                organic heterocyclic compound 18404
                                  organic heteropolycyclic compound 17812
                                    organic heterotricyclic compound 14569
                                      dibenzopyridine 154
                                        phenanthridines 51
                                          phenanthridine 18
                                            ethidium 18
                                              ethidium bromide 0
                                              ethidium homodimer 0
                                              ethidium homodimer tetracation + 0
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