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ONTOLOGY REPORT - ANNOTATIONS


Term:4-hydroxyphenyl retinamide
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Accession:CHEBI:42588 term browser browse the term
Definition:A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.
Synonyms:exact_synonym: 15-[(4-hydroxyphenyl)amino]retinal
 related_synonym: 4-HPR;   4-hydroxy(phenyl)retinamide;   Formula=C26H33NO2;   InChI=1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28H,7,10,17H2,1-5H3,(H,27,29)/b9-6+,16-11+,19-8+,20-18+;   InChIKey=AKJHMTWEGVYYSE-FXILSDISSA-N;   N-(4-Hydroxyphenyl)retinamide;   N-(4-hydroxyphenyl)all-trans retinamide;   SMILES=CC(\\C=C\\C1=C(C)CCCC1(C)C)=C/C=C/C(C)=C/C(=O)Nc1ccc(O)cc1;   all-trans-4'-Hydroxyretinanilide;   fenretinida;   fenretinide;   fenretinidum
 xref: CAS:65646-68-6 "ChemIDplus";   DrugBank:DB05076;   KEGG:D04162
 xref_mesh: MESH:D017313
 xref: PDBeChem:FEN;   PMID:20878269 "Europe PMC";   PMID:20978709 "Europe PMC";   PMID:21241664 "Europe PMC";   PMID:21319187 "Europe PMC";   PMID:21674264 "Europe PMC";   PMID:21964808 "Europe PMC";   PMID:22094120 "Europe PMC";   PMID:22162577 "Europe PMC";   PMID:22183330 "Europe PMC";   PMID:22221098 "Europe PMC";   PMID:22280430 "Europe PMC";   PMID:22323082 "Europe PMC";   PMID:22350416 "Europe PMC";   PMID:22382323 "Europe PMC";   PMID:22387538 "Europe PMC";   Reaxys:5769490 "Reaxys"


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  CHEBI ontology 20965
    role 20946
      chemical role 20277
        antioxidant 14261
          4-hydroxyphenyl retinamide 4093
Path 2
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  CHEBI ontology 20965
    subatomic particle 20959
      composite particle 20959
        hadron 20959
          baryon 20959
            nucleon 20959
              atomic nucleus 20959
                atom 20959
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20536
                        carbon atom 20512
                          organic molecular entity 20512
                            organic group 19164
                              organic divalent group 19154
                                organodiyl group 19154
                                  carbonyl group 19124
                                    carbonyl compound 19124
                                      carboxylic acid 18804
                                        carboacyl group 17444
                                          univalent carboacyl group 17444
                                            carbamoyl group 17145
                                              carboxamide 17145
                                                monocarboxylic acid amide 14446
                                                  4-hydroxyphenyl retinamide 4093
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.