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ONTOLOGY REPORT - ANNOTATIONS


Term:gabapentin
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Accession:CHEBI:42797 term browser browse the term
Definition:A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
Synonyms:exact_synonym: [1-(aminomethyl)cyclohexyl]acetic acid
 related_synonym: 1-(Aminomethyl)cyclohexaneacetic acid;   Formula=C9H17NO2;   InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12);   InChIKey=UGJMXCAKCUNAIE-UHFFFAOYSA-N;   Neurontin;   SMILES=NCC1(CCCCC1)CC(O)=O;   gabapentina;   gabapentine;   gabapentinum
 alt_id: CHEBI:5237
 xref: Beilstein:2359739 "ChemIDplus";   CAS:60142-96-3 "ChemIDplus";   CAS:60142-96-3 "KEGG DRUG";   DrugBank:DB00996;   Drug_Central:1264 "DrugCentral";   HMDB:HMDB0005015;   KEGG:D00332;   LINCS:LSM-5716
 xref_mesh: MESH:C040029
 xref: PDBeChem:GBN;   PMID:22048285 "Europe PMC";   PMID:22144034 "Europe PMC";   PMID:22240839 "Europe PMC";   PMID:22240859 "Europe PMC";   PMID:22279347 "Europe PMC";   PMID:22296650 "Europe PMC";   PMID:22345405 "Europe PMC";   PMID:22352861 "Europe PMC";   PMID:22419014 "Europe PMC";   PMID:22422817 "Europe PMC";   PMID:22464746 "Europe PMC";   PMID:22467888 "Europe PMC";   PMID:22556282 "Europe PMC";   PMID:22575516 "Europe PMC";   PMID:22612015 "Europe PMC";   PMID:22865488 "Europe PMC";   PMID:22888801 "Europe PMC";   PMID:22934077 "Europe PMC";   PMID:22946876 "Europe PMC";   PMID:23018586 "Europe PMC";   PMID:23053645 "Europe PMC";   Patent:EP1140793;   Patent:US2008103334;   Patent:US2008269326;   Patent:US2009043126;   Patent:US2009292138;   Patent:US2012046272;   Patent:WO2005037784;   Patent:WO2008060572;   Patent:WO2010023694;   Reaxys:2359739 "Reaxys";   VSDB:2975;   Wikipedia:Gabapentin


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gabapentin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aadat aminoadipate aminotransferase JBrowse link 16 32,832,001 32,868,680 RGD:6480464
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Akr7a3 aldo-keto reductase family 7 member A3 JBrowse link 5 157,801,120 157,813,756 RGD:6480464
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:6480464
G Cacna1b calcium voltage-gated channel subunit alpha1 B JBrowse link 3 1,740,026 1,924,959 RGD:6480464
G Cacna1d calcium voltage-gated channel subunit alpha1 D JBrowse link 16 6,110,294 6,405,022 RGD:6480464
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 JBrowse link 4 15,706,974 16,130,848 RGD:6480464
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 JBrowse link 8 116,154,661 116,285,643 RGD:6480464
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 JBrowse link 7 140,311,120 140,324,902 RGD:6480464
G Cp ceruloplasmin JBrowse link 2 104,744,249 104,803,034 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Cyp3a23/3a1 cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 JBrowse link 12 11,053,888 11,082,742 RGD:6480464
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 JBrowse link 5 134,492,734 134,507,158 RGD:6480464
G F10 coagulation factor X JBrowse link 16 81,803,169 81,822,476 RGD:6480464
G G6pc glucose-6-phosphatase, catalytic subunit JBrowse link 10 89,286,009 89,296,213 RGD:6480464
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 JBrowse link 20 1,955,344 1,984,907 RGD:6480464
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 JBrowse link 5 62,276,100 62,621,737 RGD:6480464
G Gsta2 glutathione S-transferase alpha 2 JBrowse link 8 85,640,081 85,645,621 RGD:6480464
G Gstm1 glutathione S-transferase mu 1 JBrowse link 2 210,803,869 210,809,461 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:6480464
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Kyat1 kynurenine aminotransferase 1 JBrowse link 3 8,752,289 8,785,617 RGD:6480464
G Ncl nucleolin JBrowse link 9 93,369,119 93,377,643 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Pnoc prepronociceptin JBrowse link 15 48,805,841 48,833,071 RGD:6480464
G Pon1 paraoxonase 1 JBrowse link 4 30,249,749 30,276,297 RGD:6480464
G Slc22a7 solute carrier family 22 member 7 JBrowse link 9 16,925,321 16,931,119 RGD:6480464
G Slc7a5 solute carrier family 7 member 5 JBrowse link 19 54,693,959 54,722,563 RGD:6480464
G St13 ST13, Hsp70 interacting protein JBrowse link 7 122,585,770 122,635,731 RGD:6480464
G Sult1a1 sulfotransferase family 1A member 1 JBrowse link 1 198,100,586 198,104,106 RGD:6480464
G Tac1 tachykinin, precursor 1 JBrowse link 4 33,638,853 33,646,819 RGD:6480464
G Tkt transketolase JBrowse link 16 6,609,670 6,634,608 RGD:6480464
G Txnrd1 thioredoxin reductase 1 JBrowse link 7 26,946,124 26,984,400 RGD:6480464
G Ugdh UDP-glucose 6-dehydrogenase JBrowse link 14 44,479,614 44,502,845 RGD:6480464
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 JBrowse link 14 22,724,399 22,736,148 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      biological role 19686
        xenobiotic 18322
          gabapentin 39
            gabapentin enacarbil 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      carbon group element atom 19515
                        carbon atom 19508
                          organic molecular entity 19508
                            organic group 18423
                              organic divalent group 18414
                                organodiyl group 18414
                                  carbonyl group 18301
                                    carbonyl compound 18301
                                      carboxylic acid 17966
                                        monocarboxylic acid 17265
                                          fatty acid 15813
                                            short-chain fatty acid 15509
                                              fatty acid 4:0 7001
                                                butyric acid 5277
                                                  gamma-aminobutyric acid 110
                                                    gabapentin 39
                                                      gabapentin enacarbil 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.