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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dacarbazine
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Accession:CHEBI:4305 term browser browse the term
Definition:A monocarboxylic acid amide that is 1H-imidazole-4-carboxamide which is substituted at position 5 by a 3,3-dimethyltriaz-1-en-1-yl group. It is used for the treatment of metastatic malignant melanoma, and in combination with other drugs for the treatment of Hodgkin's disease and soft-tissue sarcoma.
Synonyms:exact_synonym: 5-(3,3-dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide
 related_synonym: 4-(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)-carboxamide;   4-(dimethyltriazeno)imidazole-5-carboxamide;   5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide;   5-(3,3-dimethyltriazeno)imidazole-4-carboxamide;   DIC;   DTIC;   Di-me-triazenoimidazolecarboxamide;   Dtic-Dome (TN);   Formula=C6H10N6O;   HSDB 3219;   ICDMT;   InChI=1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9);   InChIKey=FDKXTQMXEQVLRF-UHFFFAOYSA-N;   NCI-C04717;   NSC-45388;   SMILES=C=1NC(=C(N1)C(=O)N)N=NN(C)C;   dacarbazina;   dacarbazinum;   deticene
 xref: Beilstein:521487;   CAS:4342-03-4;   DrugBank:DB00851;   Drug_Central:773;   KEGG:C06936;   KEGG:D00288
 xref_mesh: MESH:D003606
 xref: PMID:10751609;   PMID:11318431;   PMID:12195827;   PMID:15010317;   PMID:20082117;   PMID:21471822;   PMID:21654834;   PMID:23029050;   PMID:23318786;   PMID:26940170;   PMID:28096700;   PMID:28250333;   PMID:28387914;   PMID:28419676;   PMID:29076951;   PMID:29184162;   PMID:29287706;   PMID:29296081;   PMID:29305638;   PMID:29344241;   Reaxys:521487;   Wikipedia:Dacarbazine


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dacarbazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases response to substance
decreases response to substance
ISO APEX1 protein mutant form results in increased susceptibility to Dacarbazine
APEX1 protein results in decreased susceptibility to Dacarbazine
CTD PMID:16373707, PMID:19470598 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression ISO Dacarbazine results in increased expression of BIRC5 protein CTD PMID:15577328 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Dacarbazine results in increased cleavage of and results in increased activity of CASP3 protein; TNFSF10 protein promotes the reaction [Dacarbazine results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:17410615 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Dacarbazine results in increased cleavage of and results in increased activity of CASP8 protein; TNFSF10 protein promotes the reaction [Dacarbazine results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:17410615 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cd38 CD38 molecule multiple interactions ISO [Dacarbazine co-treated with IFNA1 protein] results in increased expression of CD38 protein; [Dacarbazine co-treated with IFNA2 protein] results in increased expression of CD38 protein; Dacarbazine promotes the reaction [IFNA1 protein results in increased expression of CD38 protein] CTD PMID:11583285, PMID:14669796, PMID:16078447 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
JBrowse link
G Cd69 Cd69 molecule multiple interactions ISO [Dacarbazine co-treated with IFNA2 protein] results in increased expression of CD69 protein; [Dacarbazine co-treated with Isotretinoin] affects the reaction [IFNA2 protein results in increased expression of CD69 protein]; Dacarbazine affects the reaction [IFNA2 protein results in increased expression of CD69 protein] CTD PMID:14669796, PMID:17973783 NCBI chr 4:163,041,147...163,049,065
Ensembl chr 4:163,041,141...163,049,084
JBrowse link
G Clu clusterin affects response to substance ISO CLU protein affects the susceptibility to Dacarbazine CTD PMID:15955107 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
multiple interactions
ISO CYP1A1 protein results in increased metabolism of Dacarbazine metabolite
O(6)-benzylguanine inhibits the reaction [CYP1A1 protein results in increased metabolism of Dacarbazine metabolite]
CTD PMID:11751525 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
multiple interactions
ISO CYP1A2 protein results in increased metabolism of Dacarbazine metabolite
O(6)-benzylguanine inhibits the reaction [CYP1A2 protein results in increased metabolism of Dacarbazine metabolite]
CTD PMID:11751525 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Epo erythropoietin decreases response to substance ISO EPO protein results in decreased susceptibility to Dacarbazine CTD PMID:15743794 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Dacarbazine co-treated with Dinitrochlorobenzene] results in increased expression of IFNG mRNA CTD PMID:12202904 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Dacarbazine co-treated with Dinitrochlorobenzene] results in increased expression of IL6 mRNA CTD PMID:12202904 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irf1 interferon regulatory factor 1 increases expression
multiple interactions
ISO Dacarbazine results in increased expression of IRF1 mRNA
Isotretinoin promotes the reaction [Dacarbazine results in increased expression of IRF1 mRNA]
CTD PMID:17973783 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 decreases response to substance ISO MAP3K1 protein modified form results in decreased susceptibility to Dacarbazine CTD PMID:15123733 NCBI chr 2:43,329,516...43,393,203
Ensembl chr 2:43,329,516...43,393,207
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases response to substance ISO MAPK1 protein modified form results in decreased susceptibility to Dacarbazine CTD PMID:15123733 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases response to substance ISO MAPK3 protein modified form results in decreased susceptibility to Dacarbazine CTD PMID:15123733 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases response to substance ISO MCL1 protein results in decreased susceptibility to Dacarbazine CTD PMID:12787138 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases activity
decreases response to substance
increases response to substance
affects response to substance
decreases expression
ISO Dacarbazine results in decreased activity of MGMT protein
MGMT protein results in decreased susceptibility to Dacarbazine
MGMT gene mutant form results in increased susceptibility to Dacarbazine
MGMT protein affects the susceptibility to Dacarbazine
Dacarbazine results in decreased expression of MGMT protein
CTD PMID:10751609, PMID:11023546, PMID:12170182, PMID:12494480, PMID:14562026, PMID:15010317, PMID:15870882 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases response to substance ISO SLC2A1 protein results in decreased susceptibility to Dacarbazine CTD PMID:17520257 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Dacarbazine co-treated with Dinitrochlorobenzene] results in increased expression of TNF mRNA CTD PMID:12202904 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO TNFSF10 protein promotes the reaction [Dacarbazine results in increased cleavage of and results in increased activity of CASP3 protein]; TNFSF10 protein promotes the reaction [Dacarbazine results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:17410615 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Vegfa vascular endothelial growth factor A increases secretion
increases expression
decreases response to substance
ISO Dacarbazine results in increased secretion of VEGFA protein
Dacarbazine results in increased expression of VEGFA mRNA; Dacarbazine results in increased expression of VEGFA protein
VEGFA protein results in decreased susceptibility to Dacarbazine
CTD PMID:12939465, PMID:15026559, PMID:15123733 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

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  CHEBI ontology 19816
    role 19764
      application 19426
        pro-agent 8855
          prodrug 8621
            dacarbazine 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            carbamoyl group 17158
                                              carboxamide 17158
                                                monocarboxylic acid amide 14569
                                                  dacarbazine 22
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.