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ONTOLOGY REPORT - ANNOTATIONS


Term:duvoglustat
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Accession:CHEBI:44369 term browser browse the term
Definition:An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration.
Synonyms:exact_synonym: (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol
 related_synonym: 1,5-Deoxy-1,5-imino-D-mannitol;   1,5-Dideoxy-1,5-imino-D-glucitol;   1-DEOXYNOJIRIMYCIN;   1-Deoxymannojirimycin;   5-amino-1,5-dideoxy-D-glucopyranose;   BAY-H-5595;   D-1-deoxynojirimycin;   DNJ;   Formula=C6H13NO4;   InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1;   InChIKey=LXBIFEVIBLOUGU-JGWLITMVSA-N;   Moranolin;   Moranoline;   SMILES=OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
 alt_id: CHEBI:132398;   CHEBI:132867;   CHEBI:76525
 xref: CAS:19130-96-2 "ChemIDplus";   CAS:19130-96-2 "KEGG COMPOUND";   DrugBank:DB03206;   HMDB:HMDB0035359;   KEGG:C16843;   KEGG:D09605;   KNApSAcK:C00029420
 xref_mesh: MESH:D017485
 xref: MetaCyc:1-DEOXYNOJIRIMYCIN;   PDBeChem:NOJ;   PMID:23265519 "Europe PMC";   PMID:23391926 "Europe PMC";   PMID:23536174 "Europe PMC";   PMID:23561072 "Europe PMC";   PMID:23570294 "Europe PMC";   PMID:23648852 "Europe PMC";   PMID:23755289 "Europe PMC";   PMID:23909841 "Europe PMC";   PMID:24050301 "Europe PMC";   PMID:26292150 "Europe PMC";   PMID:26867190 "Europe PMC";   PMID:26927057 "Europe PMC";   PMID:27160849 "Europe PMC";   PMID:27294120 "Europe PMC";   Reaxys:1524395 "Reaxys";   Wikipedia:1-Deoxynojirimycin


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duvoglustat term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acaca acetyl-CoA carboxylase alpha JBrowse link 10 71,519,392 71,719,910 RGD:6480464
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:6480464
G Cebpa CCAAT/enhancer binding protein alpha JBrowse link 1 91,363,492 91,366,164 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Fasn fatty acid synthase JBrowse link 10 109,987,735 110,005,901 RGD:6480464
G Fbp2 fructose-bisphosphatase 2 JBrowse link 17 372,554 389,918 RGD:6480464
G G6pc glucose-6-phosphatase, catalytic subunit JBrowse link 10 89,286,009 89,296,213 RGD:6480464
G Gck glucokinase JBrowse link 14 86,149,146 86,191,589 RGD:6480464
G Gpt glutamic--pyruvic transaminase JBrowse link 7 117,759,083 117,761,932 RGD:6480464
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:6480464
G Lpl lipoprotein lipase JBrowse link 16 22,537,687 22,561,487 RGD:6480464
G Pc pyruvate carboxylase JBrowse link 1 219,759,157 219,859,854 RGD:6480464
G Pck1 phosphoenolpyruvate carboxykinase 1 JBrowse link 3 171,213,936 171,219,885 RGD:6480464
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 JBrowse link X 37,329,779 37,343,410 RGD:6480464
G Pdk1 pyruvate dehydrogenase kinase 1 JBrowse link 3 58,530,870 58,561,494 RGD:6480464
G Pfkp phosphofructokinase, platelet JBrowse link 17 68,510,765 68,574,387 RGD:6480464
G Pklr pyruvate kinase L/R JBrowse link 2 188,449,158 188,458,034 RGD:6480464
G Ppargc1b PPARG coactivator 1 beta JBrowse link 18 56,626,725 56,650,524 RGD:6480464
miglustat term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Canx calnexin JBrowse link 10 35,800,942 35,833,939 RGD:6480464
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:6480464
G Pawr pro-apoptotic WT1 regulator JBrowse link 7 51,273,764 51,353,700 RGD:6480464
G St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 JBrowse link 4 177,065,266 177,195,942 RGD:6480464
G Ugcg UDP-glucose ceramide glucosyltransferase JBrowse link 5 76,376,722 76,419,564 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      biological role 19661
        pharmacological role 18755
          anti-obesity agent 166
            duvoglustat 26
              4-O-alpha-D-glucopyranosylmoranoline 0
              N-nonyldeoxynojirimycin 0
              miglustat 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic molecule 19402
                              organic cyclic compound 19158
                                organic heterocyclic compound 18245
                                  organic heteromonocyclic compound 16350
                                    piperidines 7422
                                      hydroxypiperidine 413
                                        2-(hydroxymethyl)piperidine-3,4,5-triol 26
                                          duvoglustat 26
                                            4-O-alpha-D-glucopyranosylmoranoline 0
                                            N-nonyldeoxynojirimycin 0
                                            miglustat 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.