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Accession:CHEBI:4450 term browser browse the term
Definition:A synthetic analogue of vasopressin in which 3-mercaptopropionic acid replaces the cysteine residue at position 1 and D-arginine replaces the residue at position 8. An antidiuretic, it increases urine concentration and decreases urine production, and is used (usually as the trihydrate of the acetic acid salt) to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions. It is also used in the diagnosis and treatment of cranial diabetes insipidus and in tests of renal function.
Synonyms:exact_synonym: 1-{[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-D-arginylglycinamide
 related_synonym: 1-(3-mercaptopropionic acid)-8-D-arginine-vasopressin;   1-deamino-8-D-arginine vasopressin;   1-desamino-8-D-arginine vasopressin;   DDAVP;   Formula=C46H64N14O12S2;   InChI=1S/C46H64N14O12S2/c47-35(62)15-14-29-40(67)58-32(22-36(48)63)43(70)59-33(45(72)60-18-5-9-34(60)44(71)56-28(8-4-17-52-46(50)51)39(66)53-23-37(49)64)24-74-73-19-16-38(65)54-30(21-26-10-12-27(61)13-11-26)41(68)57-31(42(69)55-29)20-25-6-2-1-3-7-25/h1-3,6-7,10-13,28-34,61H,4-5,8-9,14-24H2,(H2,47,62)(H2,48,63)(H2,49,64)(H,53,66)(H,54,65)(H,55,69)(H,56,71)(H,57,68)(H,58,67)(H,59,70)(H4,50,51,52)/t28-,29+,30+,31+,32+,33+,34+/m1/s1;   InChIKey=NFLWUMRGJYTJIN-PNIOQBSNSA-N;   SMILES=NC(=N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O;   desmopresina;   desmopressine;   desmopressinum
 xref: Beilstein:4651966 "Beilstein";   CAS:16679-58-6 "ChemIDplus";   CAS:16679-58-6 "KEGG COMPOUND";   DrugBank:DB00035;   Drug_Central:817 "DrugCentral";   KEGG:C06944;   KEGG:D00291
 xref_mesh: MESH:D003894

show annotations for term's descendants       view all columns           Sort by:
desmopressin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aqp2 aquaporin 2 JBrowse link 7 141,237,802 141,242,837 RGD:6480464
G Avpr2 arginine vasopressin receptor 2 JBrowse link X 156,889,006 156,892,707 RGD:6480464
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:6480464
G Cul5 cullin 5 JBrowse link 8 58,199,992 58,255,149 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Myl9 myosin light chain 9 JBrowse link 3 152,857,573 152,863,961 RGD:6480464
G Nedd4 NEDD4 E3 ubiquitin protein ligase JBrowse link 8 79,323,408 79,408,842 RGD:6480464
G Scnn1b sodium channel epithelial 1 subunit beta JBrowse link 1 191,829,547 191,883,991 RGD:6480464
G Scnn1g sodium channel epithelial 1 subunit gamma JBrowse link 1 191,704,397 191,738,271 RGD:6480464
G Vwf von Willebrand factor JBrowse link 4 158,085,059 158,219,525 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19754
    role 19701
      application 19353
        pharmaceutical 19222
          diagnostic agent 654
            desmopressin 10
              desmopressin acetate (anhydrous) + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19754
    subatomic particle 19752
      composite particle 19752
        hadron 19752
          baryon 19752
            nucleon 19752
              atomic nucleus 19752
                atom 19752
                  main group element atom 19637
                    p-block element atom 19637
                      carbon group element atom 19528
                        carbon atom 19517
                          organic molecular entity 19517
                            organic group 18422
                              organic divalent group 18414
                                organodiyl group 18414
                                  carbonyl group 18303
                                    carbonyl compound 18303
                                      carboxylic acid 17971
                                        carboacyl group 17091
                                          univalent carboacyl group 17091
                                            carbamoyl group 16813
                                              carboxamide 16813
                                                peptide 9359
                                                  cyclic peptide 8721
                                                    heterodetic cyclic peptide 1437
                                                      desmopressin 10
                                                        desmopressin acetate (anhydrous) + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.