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ONTOLOGY REPORT - ANNOTATIONS


Term:desmopressin
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Accession:CHEBI:4450 term browser browse the term
Definition:A synthetic analogue of vasopressin in which 3-mercaptopropionic acid replaces the cysteine residue at position 1 and D-arginine replaces the residue at position 8. An antidiuretic, it increases urine concentration and decreases urine production, and is used (usually as the trihydrate of the acetic acid salt) to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions. It is also used in the diagnosis and treatment of cranial diabetes insipidus and in tests of renal function.
Synonyms:exact_synonym: 1-{[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-D-arginylglycinamide
 related_synonym: 1-(3-mercaptopropionic acid)-8-D-arginine-vasopressin;   1-deamino-8-D-arginine vasopressin;   1-desamino-8-D-arginine vasopressin;   DDAVP;   Formula=C46H64N14O12S2;   InChI=1S/C46H64N14O12S2/c47-35(62)15-14-29-40(67)58-32(22-36(48)63)43(70)59-33(45(72)60-18-5-9-34(60)44(71)56-28(8-4-17-52-46(50)51)39(66)53-23-37(49)64)24-74-73-19-16-38(65)54-30(21-26-10-12-27(61)13-11-26)41(68)57-31(42(69)55-29)20-25-6-2-1-3-7-25/h1-3,6-7,10-13,28-34,61H,4-5,8-9,14-24H2,(H2,47,62)(H2,48,63)(H2,49,64)(H,53,66)(H,54,65)(H,55,69)(H,56,71)(H,57,68)(H,58,67)(H,59,70)(H4,50,51,52)/t28-,29+,30+,31+,32+,33+,34+/m1/s1;   InChIKey=NFLWUMRGJYTJIN-PNIOQBSNSA-N;   SMILES=NC(=N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O;   desmopresina;   desmopressine;   desmopressinum
 xref: Beilstein:4651966;   CAS:16679-58-6;   DrugBank:DB00035;   Drug_Central:817;   KEGG:C06944;   KEGG:D00291
 xref_mesh: MESH:D003894


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desmopressin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AQP2 aquaporin 2 JBrowse link 12 49,950,737 49,958,878 RGD:6480464
G AVPR2 arginine vasopressin receptor 2 JBrowse link X 153,902,625 153,907,166 RGD:6480464
G CFTR CF transmembrane conductance regulator JBrowse link 7 117,480,025 117,668,665 RGD:6480464
G CUL5 cullin 5 JBrowse link 11 108,008,733 108,107,766 RGD:6480464
G GSK3B glycogen synthase kinase 3 beta JBrowse link 3 119,821,321 120,095,823 RGD:6480464
G MYL9 myosin light chain 9 JBrowse link 20 36,541,519 36,551,447 RGD:6480464
G NEDD4 NEDD4 E3 ubiquitin protein ligase JBrowse link 15 55,826,917 55,993,612 RGD:6480464
G SCNN1B sodium channel epithelial 1 subunit beta JBrowse link 16 23,278,231 23,381,295 RGD:6480464
G SCNN1G sodium channel epithelial 1 subunit gamma JBrowse link 16 23,182,745 23,216,883 RGD:6480464
G VWF von Willebrand factor JBrowse link 12 5,948,877 6,124,670 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23841
    role 23728
      application 23139
        pharmaceutical 22676
          diagnostic agent 741
            desmopressin 10
              desmopressin acetate (anhydrous) + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 23841
    subatomic particle 23792
      composite particle 23792
        hadron 23792
          baryon 23792
            nucleon 23792
              atomic nucleus 23792
                atom 23792
                  main group element atom 23610
                    p-block element atom 23610
                      carbon group element atom 23328
                        carbon atom 23285
                          organic molecular entity 23285
                            organic group 21924
                              organic divalent group 21896
                                organodiyl group 21896
                                  carbonyl group 21869
                                    carbonyl compound 21869
                                      carboxylic acid 20925
                                        carboacyl group 19069
                                          univalent carboacyl group 19069
                                            carbamoyl group 18431
                                              carboxamide 18431
                                                peptide 9818
                                                  cyclic peptide 9181
                                                    heterodetic cyclic peptide 1445
                                                      desmopressin 10
                                                        desmopressin acetate (anhydrous) + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.