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Accession:CHEBI:4450 term browser browse the term
Definition:A synthetic analogue of vasopressin in which 3-mercaptopropionic acid replaces the cysteine residue at position 1 and D-arginine replaces the residue at position 8. An antidiuretic, it increases urine concentration and decreases urine production, and is used (usually as the trihydrate of the acetic acid salt) to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions. It is also used in the diagnosis and treatment of cranial diabetes insipidus and in tests of renal function.
Synonyms:exact_synonym: 1-{[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-D-arginylglycinamide
 related_synonym: 1-(3-mercaptopropionic acid)-8-D-arginine-vasopressin;   1-deamino-8-D-arginine vasopressin;   1-desamino-8-D-arginine vasopressin;   DDAVP;   Formula=C46H64N14O12S2;   InChI=1S/C46H64N14O12S2/c47-35(62)15-14-29-40(67)58-32(22-36(48)63)43(70)59-33(45(72)60-18-5-9-34(60)44(71)56-28(8-4-17-52-46(50)51)39(66)53-23-37(49)64)24-74-73-19-16-38(65)54-30(21-26-10-12-27(61)13-11-26)41(68)57-31(42(69)55-29)20-25-6-2-1-3-7-25/h1-3,6-7,10-13,28-34,61H,4-5,8-9,14-24H2,(H2,47,62)(H2,48,63)(H2,49,64)(H,53,66)(H,54,65)(H,55,69)(H,56,71)(H,57,68)(H,58,67)(H,59,70)(H4,50,51,52)/t28-,29+,30+,31+,32+,33+,34+/m1/s1;   InChIKey=NFLWUMRGJYTJIN-PNIOQBSNSA-N;   SMILES=NC(=N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O;   desmopresina;   desmopressine;   desmopressinum
 xref: Beilstein:4651966;   CAS:16679-58-6;   DrugBank:DB00035;   Drug_Central:817;   KEGG:C06944;   KEGG:D00291
 xref_mesh: MESH:D003894

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desmopressin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aqp2 aquaporin 2 JBrowse link 15 99,579,056 99,584,545 RGD:6480464
G Avpr2 arginine vasopressin receptor 2 JBrowse link X 73,891,765 73,894,428 RGD:6480464
G Cftr cystic fibrosis transmembrane conductance regulator JBrowse link 6 18,170,687 18,322,770 RGD:6480464
G Cul5 cullin 5 JBrowse link 9 53,614,581 53,667,507 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 16 38,089,001 38,246,084 RGD:6480464
G Myl9 myosin, light polypeptide 9, regulatory JBrowse link 2 156,775,408 156,781,657 RGD:6480464
G Nedd4 neural precursor cell expressed, developmentally down-regulated 4 JBrowse link 9 72,662,331 72,749,851 RGD:6480464
G Scnn1b sodium channel, nonvoltage-gated 1 beta JBrowse link 7 121,865,038 121,918,728 RGD:6480464
G Scnn1g sodium channel, nonvoltage-gated 1 gamma JBrowse link 7 121,734,420 121,768,482 RGD:6480464
G Vwf Von Willebrand factor JBrowse link 6 125,552,935 125,686,679 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21260
    role 21244
      application 20679
        pharmaceutical 20060
          diagnostic agent 658
            desmopressin 10
              desmopressin acetate (anhydrous) + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21260
    subatomic particle 21256
      composite particle 21256
        hadron 21256
          baryon 21256
            nucleon 21256
              atomic nucleus 21256
                atom 21256
                  main group element atom 21122
                    p-block element atom 21122
                      carbon group element atom 20893
                        carbon atom 20784
                          organic molecular entity 20784
                            organic group 19177
                              organic divalent group 19167
                                organodiyl group 19167
                                  carbonyl group 19137
                                    carbonyl compound 19137
                                      carboxylic acid 18818
                                        carboacyl group 17470
                                          univalent carboacyl group 17470
                                            carbamoyl group 17163
                                              carboxamide 17163
                                                peptide 9463
                                                  cyclic peptide 8839
                                                    heterodetic cyclic peptide 1475
                                                      desmopressin 10
                                                        desmopressin acetate (anhydrous) + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.